This gene encodes a member of the DNase family. The protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000163687 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000025279 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Rodriguez AM, Rodin D, Nomura H, Morton CC, Weremowicz S, Schneider MC (June 1997). "Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I". Genomics. 42 (3): 507–13. doi:10.1006/geno.1997.4748. PMID 9205125.
^Baron WF, Pan CQ, Spencer SA, Ryan AM, Lazarus RA, Baker KP (July 1998). "Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages". Gene. 215 (2): 291–301. doi:10.1016/S0378-1119(98)00281-9. PMID 9714828.
^Shiokawa D, Hirai M, Tanuma S (March 1998). "cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein". Apoptosis. 3 (2): 89–95. doi:10.1023/A:1009692807692. PMID 14646506. S2CID 2071259.
^Al-Mayouf SM, Sunker A, Abdwani R, Abrawi SA, Almurshedi F, Alhashmi N, et al. (October 2011). "Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus". Nature Genetics. 43 (12): 1186–8. doi:10.1038/ng.975. PMID 22019780. S2CID 205358301.
^Westra HJ, Martínez-Bonet M, Onengut-Gumuscu S, Lee A, Luo Y, Teslovich N, et al. (October 2018). "Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes". Nature Genetics. 50 (10): 1366–1374. doi:10.1038/s41588-018-0216-7. PMC6364548. PMID 30224649.
Further readingedit
Tanuma S, Shiokawa D (September 1994). "Multiple forms of nuclear deoxyribonuclease in rat thymocytes". Biochemical and Biophysical Research Communications. 203 (2): 789–97. doi:10.1006/bbrc.1994.2252. PMID 8093058.
Zeng Z, Parmelee D, Hyaw H, Coleman TA, Su K, Zhang J, et al. (February 1997). "Cloning and characterization of a novel human DNase". Biochemical and Biophysical Research Communications. 231 (2): 499–504. doi:10.1006/bbrc.1996.5923. PMID 9070308.
Shiokawa D, Tanuma S (January 2001). "Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis". Biochemistry. 40 (1): 143–52. doi:10.1021/bi001041a. PMID 11141064.
Wilber A, Lu M, Schneider MC (July 2002). "Deoxyribonuclease I-like III is an inducible macrophage barrier to liposomal transfection". Molecular Therapy. 6 (1): 35–42. doi:10.1006/mthe.2002.0625. PMID 12095301.
Boulares AH, Zoltoski AJ, Sherif ZA, Yakovlev AG, Smulson ME (August 2002). "The Poly(ADP-ribose) polymerase-1-regulated endonuclease DNAS1L3 is required for etoposide-induced internucleosomal DNA fragmentation and increases etoposide cytotoxicity in transfected osteosarcoma cells". Cancer Research. 62 (15): 4439–44. PMID 12154052.
Shiokawa D, Shika Y, Tanuma S (December 2003). "Identification of two functional nuclear localization signals in DNase gamma and their roles in its apoptotic DNase activity". The Biochemical Journal. 376 (Pt 2): 377–81. doi:10.1042/BJ20030820. PMC1223774. PMID 12943533.
Boulares AH, Ren T (January 2004). "Mechanism of acetaminophen-induced apoptosis in cultured cells: roles of caspase-3, DNA fragmentation factor, and the Ca2+ and Mg2+ endonuclease DNAS1L3". Basic & Clinical Pharmacology & Toxicology. 94 (1): 19–29. doi:10.1111/j.1742-7843.2004.pto_940105.x. PMID 14725611.
Okamoto M, Okamoto N, Yashiro H, Shiokawa D, Sunaga S, Yoshimori A, et al. (February 2005). "Involvement of DNase gamma in the resected double-strand DNA breaks in immunoglobulin genes". Biochemical and Biophysical Research Communications. 327 (1): 76–83. doi:10.1016/j.bbrc.2004.11.142. PMID 15629432.
Boulares H, Zoltoski A, Kandan S, Akbulut T, Yakovlev A, Oumouna M (March 2006). "Correlation between decreased sensitivity of the Daudi lymphoma cells to VP-16-induced apoptosis and deficiency in DNAS1L3 expression". Biochemical and Biophysical Research Communications. 341 (2): 653–62. doi:10.1016/j.bbrc.2006.01.014. PMID 16427601.
This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.
dnase1l3, deoxyribonuclease, gamma, enzyme, that, humans, encoded, gene, identifiersaliases, dhp2, dnas1l3, sleb16, deoxyribonuclease, like, deoxyribonuclease, like, 3external, idsomim, 602244, 1314633, homologene, 3630, genecards, gene, location, human, chrom. Deoxyribonuclease gamma is an enzyme that in humans is encoded by the DNASE1L3 gene 5 6 7 8 DNASE1L3IdentifiersAliasesDNASE1L3 DHP2 DNAS1L3 LSD SLEB16 deoxyribonuclease I like 3 deoxyribonuclease 1 like 3External IDsOMIM 602244 MGI 1314633 HomoloGene 3630 GeneCards DNASE1L3Gene location Human Chr Chromosome 3 human 1 Band3p14 3Start58 192 257 bp 1 End58 214 697 bp 1 Gene location Mouse Chr Chromosome 14 mouse 2 Band14 14 A1Start14 475 200 bp 2 End14 505 240 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inperiodontal fiberspleenspongy boneliverright lobe of liverright adrenal glandappendixrectumpalpebral conjunctivasynovial jointTop expressed inleft lobe of liverspleenplacentalipthymussecondary oocyteesophagusjejunumsubcutaneous adipose tissueduodenumMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding calcium ion binding nuclease activity endonuclease activity endodeoxyribonuclease activity hydrolase activity deoxyribonuclease activity deoxyribonuclease I activityCellular componentextracellular region endoplasmic reticulum nucleusBiological processDNA metabolic process DNA catabolic process programmed cell death involved in cell development apoptotic process programmed cell death apoptotic DNA fragmentation DNA catabolic process endonucleolytic neutrophil activation involved in immune response regulation of acute inflammatory response regulation of neutrophil mediated cytotoxicitySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez177613421EnsemblENSG00000163687ENSMUSG00000025279UniProtQ13609O55070RefSeq mRNA NM 004944NM 001256560NM 007870RefSeq protein NP 001243489NP 004935NP 031896Location UCSC Chr 3 58 19 58 21 MbChr 14 14 48 14 51 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene encodes a member of the DNase family The protein hydrolyzes DNA is not inhibited by actin and mediates the breakdown of DNA during apoptosis Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized 8 Homozygosity for a null allele results in systemic lupus erythematosus 9 A loss of function allele in DNASE1L3 is associated with rheumatoid arthritis 10 References edit a b c GRCh38 Ensembl release 89 ENSG00000163687 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000025279 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Rodriguez AM Rodin D Nomura H Morton CC Weremowicz S Schneider MC June 1997 Identification localization and expression of two novel human genes similar to deoxyribonuclease I Genomics 42 3 507 13 doi 10 1006 geno 1997 4748 PMID 9205125 Baron WF Pan CQ Spencer SA Ryan AM Lazarus RA Baker KP July 1998 Cloning and characterization of an actin resistant DNase I like endonuclease secreted by macrophages Gene 215 2 291 301 doi 10 1016 S0378 1119 98 00281 9 PMID 9714828 Shiokawa D Hirai M Tanuma S March 1998 cDNA cloning of human DNase gamma chromosomal localization of its gene and enzymatic properties of recombinant protein Apoptosis 3 2 89 95 doi 10 1023 A 1009692807692 PMID 14646506 S2CID 2071259 a b Entrez Gene DNASE1L3 deoxyribonuclease I like 3 Al Mayouf SM Sunker A Abdwani R Abrawi SA Almurshedi F Alhashmi N et al October 2011 Loss of function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus Nature Genetics 43 12 1186 8 doi 10 1038 ng 975 PMID 22019780 S2CID 205358301 Westra HJ Martinez Bonet M Onengut Gumuscu S Lee A Luo Y Teslovich N et al October 2018 Fine mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes Nature Genetics 50 10 1366 1374 doi 10 1038 s41588 018 0216 7 PMC 6364548 PMID 30224649 Further reading editTanuma S Shiokawa D September 1994 Multiple forms of nuclear deoxyribonuclease in rat thymocytes Biochemical and Biophysical Research Communications 203 2 789 97 doi 10 1006 bbrc 1994 2252 PMID 8093058 Zeng Z Parmelee D Hyaw H Coleman TA Su K Zhang J et al February 1997 Cloning and characterization of a novel human DNase Biochemical and Biophysical Research Communications 231 2 499 504 doi 10 1006 bbrc 1996 5923 PMID 9070308 Shiokawa D Tanuma S January 2001 Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis Biochemistry 40 1 143 52 doi 10 1021 bi001041a PMID 11141064 Wilber A Lu M Schneider MC July 2002 Deoxyribonuclease I like III is an inducible macrophage barrier to liposomal transfection Molecular Therapy 6 1 35 42 doi 10 1006 mthe 2002 0625 PMID 12095301 Boulares AH Zoltoski AJ Sherif ZA Yakovlev AG Smulson ME August 2002 The Poly ADP ribose polymerase 1 regulated endonuclease DNAS1L3 is required for etoposide induced internucleosomal DNA fragmentation and increases etoposide cytotoxicity in transfected osteosarcoma cells Cancer Research 62 15 4439 44 PMID 12154052 Shiokawa D Shika Y Tanuma S December 2003 Identification of two functional nuclear localization signals in DNase gamma and their roles in its apoptotic DNase activity The Biochemical Journal 376 Pt 2 377 81 doi 10 1042 BJ20030820 PMC 1223774 PMID 12943533 Boulares AH Ren T January 2004 Mechanism of acetaminophen induced apoptosis in cultured cells roles of caspase 3 DNA fragmentation factor and the Ca2 and Mg2 endonuclease DNAS1L3 Basic amp Clinical Pharmacology amp Toxicology 94 1 19 29 doi 10 1111 j 1742 7843 2004 pto 940105 x PMID 14725611 Okamoto M Okamoto N Yashiro H Shiokawa D Sunaga S Yoshimori A et al February 2005 Involvement of DNase gamma in the resected double strand DNA breaks in immunoglobulin genes Biochemical and Biophysical Research Communications 327 1 76 83 doi 10 1016 j bbrc 2004 11 142 PMID 15629432 Boulares H Zoltoski A Kandan S Akbulut T Yakovlev A Oumouna M March 2006 Correlation between decreased sensitivity of the Daudi lymphoma cells to VP 16 induced apoptosis and deficiency in DNAS1L3 expression Biochemical and Biophysical Research Communications 341 2 653 62 doi 10 1016 j bbrc 2006 01 014 PMID 16427601 nbsp This article on a gene on human chromosome 3 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title DNASE1L3 amp oldid 1142696597, wikipedia, wiki, book, books, library,
