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Wikipedia

DNAJA1

April 14, 2024

DnaJ homolog subfamily A member 1 is a protein that in humans is encoded by the DNAJA1 gene.[5][6][7]

DNAJA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDNAJA1, DJ-2, DjA1, HDJ2, HSDJ, HSJ2, HSPF4, NEDD7, hDJ-2, HSJ-2, DnaJ heat shock protein family (Hsp40) member A1
External IDsOMIM: 602837 MGI: 1270129 HomoloGene: 55588 GeneCards: DNAJA1
Orthologs
SpeciesHumanMouse
Entrez

3301

15502

Ensembl

ENSG00000086061

ENSMUSG00000028410

UniProt

P31689

P63037

RefSeq (mRNA)

NM_001539
NM_001314039

NM_001164671
NM_001164672
NM_008298

RefSeq (protein)

NP_001300968
NP_001530

NP_001158143
NP_001158144
NP_032324

Location (UCSC)Chr 9: 33.03 – 33.04 MbChr 4: 40.72 – 40.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions edit

DNAJA1 has been shown to interact with PTTG1.[8]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000086061 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028410 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chellaiah A, Davis A, Mohanakumar T (August 1993). "Cloning of a unique human homologue of the Escherichia coli DNAJ heat shock protein". Biochim Biophys Acta. 1174 (1): 111–3. doi:10.1016/0167-4781(93)90103-k. PMID 8334160.
  6. ^ Ohtsuka K, Hata M (January 2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress & Chaperones. 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 (inactive 2024-03-28). PMC 312896. PMID 11147971.{{cite journal}}: CS1 maint: DOI inactive as of March 2024 (link)
  7. ^ "Entrez Gene: DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1".
  8. ^ Pei L (January 1999). "Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells". J. Biol. Chem. 274 (5). UNITED STATES: 3151–8. doi:10.1074/jbc.274.5.3151. ISSN 0021-9258. PMID 9915854.

Further reading edit

  • Oh S, Iwahori A, Kato S (1993). "Human cDNA encoding DnaJ protein homologue". Biochim. Biophys. Acta. 1174 (1): 114–6. doi:10.1016/0167-4781(93)90104-l. PMID 8334161.
  • Kanazawa M, Terada K, Kato S, Mori M (1997). "HSDJ, a human homolog of DnaJ, is farnesylated and is involved in protein import into mitochondria". J. Biochem. 121 (5): 890–5. doi:10.1093/oxfordjournals.jbchem.a021670. PMID 9192730.
  • Davis AR, Alevy YG, Chellaiah A, et al. (1998). "Characterization of HDJ-2, a human 40 kD heat shock protein". Int. J. Biochem. Cell Biol. 30 (11): 1203–21. doi:10.1016/S1357-2725(98)00091-0. PMID 9839446.
  • Pei L (1999). "Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells". J. Biol. Chem. 274 (5): 3151–8. doi:10.1074/jbc.274.5.3151. PMID 9915854.
  • Meacham GC, Lu Z, King S, et al. (1999). "The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis". EMBO J. 18 (6): 1492–505. doi:10.1093/emboj/18.6.1492. PMC 1171238. PMID 10075921.
  • Terada K, Mori M (2000). "Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70". J. Biol. Chem. 275 (32): 24728–34. doi:10.1074/jbc.M002021200. PMID 10816573.
  • Jana NR, Tanaka M, Wang G, Nukina N (2000). "Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity". Hum. Mol. Genet. 9 (13): 2009–18. doi:10.1093/hmg/9.13.2009. PMID 10942430.
  • Bao YP, Cook LJ, O'Donovan D, et al. (2002). "Mammalian, yeast, bacterial, and chemical chaperones reduce aggregate formation and death in a cell model of oculopharyngeal muscular dystrophy". J. Biol. Chem. 277 (14): 12263–9. doi:10.1074/jbc.M109633200. PMID 11796717.
  • Hernández MP, Chadli A, Toft DO (2002). "HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor". J. Biol. Chem. 277 (14): 11873–81. doi:10.1074/jbc.M111445200. PMID 11809754.
  • Imai Y, Soda M, Hatakeyama S, et al. (2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity". Mol. Cell. 10 (1): 55–67. doi:10.1016/S1097-2765(02)00583-X. PMID 12150907.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hanai R, Mashima K (2004). "Characterization of two isoforms of a human DnaJ homologue, HSJ2". Mol. Biol. Rep. 30 (3): 149–53. doi:10.1023/A:1024916223616. PMID 12974469. S2CID 24105834.
  • Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  • Marschang P, Brich J, Weeber EJ, et al. (2004). "Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1". Mol. Cell. Biol. 24 (9): 3782–93. doi:10.1128/MCB.24.9.3782-3793.2004. PMC 387731. PMID 15082773.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Hu Y, Zhou Z, Huang X, et al. (2005). "Expression of a novel DnaJA1 alternative splicing in human testis and sperm". Int. J. Androl. 27 (6): 343–9. doi:10.1111/j.1365-2605.2004.00492.x. PMID 15595953.


 

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

April 14, 2024
dnaja1, dnaj, homolog, subfamily, member, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2lo1, 2m6yidentifiersaliases, dja1, hdj2, hsdj, hsj2, hspf4, nedd7, dnaj, heat, shock, protein, family, hsp40, member. DnaJ homolog subfamily A member 1 is a protein that in humans is encoded by the DNAJA1 gene 5 6 7 DNAJA1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2LO1 2M6YIdentifiersAliasesDNAJA1 DJ 2 DjA1 HDJ2 HSDJ HSJ2 HSPF4 NEDD7 hDJ 2 HSJ 2 DnaJ heat shock protein family Hsp40 member A1External IDsOMIM 602837 MGI 1270129 HomoloGene 55588 GeneCards DNAJA1Gene location Human Chr Chromosome 9 human 1 Band9p21 1Start33 025 273 bp 1 End33 039 907 bp 1 Gene location Mouse Chr Chromosome 4 mouse 2 Band4 4 A5Start40 722 150 bp 2 End40 737 149 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inoocytebronchial epithelial cellganglionic eminenceamniotic fluidsecondary oocytestromal cell of endometriumlower lobe of lungsuperior vestibular nucleusprefrontal cortexparietal pleuraTop expressed inmorulafacial motor nucleusganglionic eminenceanterior horn of spinal cordRegion I of hippocampus properneural tubetrigeminal ganglionvisual cortexcingulate gyrussuperior frontal gyrusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionchaperone binding heat shock protein binding unfolded protein binding C3HC4 type RING finger domain binding metal ion binding low density lipoprotein particle receptor binding Hsp70 protein binding protein binding G protein coupled receptor binding ATP binding ubiquitin protein ligase binding Tat protein binding ATPase activator activityCellular componentcytoplasm membrane intracellular membrane bounded organelle ubiquitin ligase complex mitochondrion cytoplasmic side of endoplasmic reticulum membrane endoplasmic reticulum perinuclear region of cytoplasm extracellular exosome nucleus microtubule cytoskeleton cytosolBiological processflagellated sperm motility androgen receptor signaling pathway regulation of protein transport negative regulation of apoptotic process response to heat toxin transport negative regulation of protein ubiquitination response to unfolded protein protein folding spermatogenesis positive regulation of apoptotic process protein localization to mitochondrion negative regulation of JUN kinase activity negative regulation of establishment of protein localization to mitochondrion negative regulation of nitrosative stress induced intrinsic apoptotic signaling pathway positive regulation of ATP dependent activitySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez330115502EnsemblENSG00000086061ENSMUSG00000028410UniProtP31689P63037RefSeq mRNA NM 001539NM 001314039NM 001164671NM 001164672NM 008298RefSeq protein NP 001300968NP 001530NP 001158143NP 001158144NP 032324Location UCSC Chr 9 33 03 33 04 MbChr 4 40 72 40 74 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseInteractions editDNAJA1 has been shown to interact with PTTG1 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000086061 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000028410 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Chellaiah A Davis A Mohanakumar T August 1993 Cloning of a unique human homologue of the Escherichia coli DNAJ heat shock protein Biochim Biophys Acta 1174 1 111 3 doi 10 1016 0167 4781 93 90103 k PMID 8334160 Ohtsuka K Hata M January 2001 Mammalian HSP40 DNAJ homologs cloning of novel cDNAs and a proposal for their classification and nomenclature Cell Stress amp Chaperones 5 2 98 112 doi 10 1379 1466 1268 2000 005 lt 0098 mhdhco gt 2 0 co 2 inactive 2024 03 28 PMC 312896 PMID 11147971 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint DOI inactive as of March 2024 link Entrez Gene DNAJA1 DnaJ Hsp40 homolog subfamily A member 1 Pei L January 1999 Pituitary tumor transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells J Biol Chem 274 5 UNITED STATES 3151 8 doi 10 1074 jbc 274 5 3151 ISSN 0021 9258 PMID 9915854 Further reading editOh S Iwahori A Kato S 1993 Human cDNA encoding DnaJ protein homologue Biochim Biophys Acta 1174 1 114 6 doi 10 1016 0167 4781 93 90104 l PMID 8334161 Kanazawa M Terada K Kato S Mori M 1997 HSDJ a human homolog of DnaJ is farnesylated and is involved in protein import into mitochondria J Biochem 121 5 890 5 doi 10 1093 oxfordjournals jbchem a021670 PMID 9192730 Davis AR Alevy YG Chellaiah A et al 1998 Characterization of HDJ 2 a human 40 kD heat shock protein Int J Biochem Cell Biol 30 11 1203 21 doi 10 1016 S1357 2725 98 00091 0 PMID 9839446 Pei L 1999 Pituitary tumor transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells J Biol Chem 274 5 3151 8 doi 10 1074 jbc 274 5 3151 PMID 9915854 Meacham GC Lu Z King S et al 1999 The Hdj 2 Hsc70 chaperone pair facilitates early steps in CFTR biogenesis EMBO J 18 6 1492 505 doi 10 1093 emboj 18 6 1492 PMC 1171238 PMID 10075921 Terada K Mori M 2000 Human DnaJ homologs dj2 and dj3 and bag 1 are positive cochaperones of hsc70 J Biol Chem 275 32 24728 34 doi 10 1074 jbc M002021200 PMID 10816573 Jana NR Tanaka M Wang G Nukina N 2000 Polyglutamine length dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N terminal huntingtin their role in suppression of aggregation and cellular toxicity Hum Mol Genet 9 13 2009 18 doi 10 1093 hmg 9 13 2009 PMID 10942430 Bao YP Cook LJ O Donovan D et al 2002 Mammalian yeast bacterial and chemical chaperones reduce aggregate formation and death in a cell model of oculopharyngeal muscular dystrophy J Biol Chem 277 14 12263 9 doi 10 1074 jbc M109633200 PMID 11796717 Hernandez MP Chadli A Toft DO 2002 HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor J Biol Chem 277 14 11873 81 doi 10 1074 jbc M111445200 PMID 11809754 Imai Y Soda M Hatakeyama S et al 2002 CHIP is associated with Parkin a gene responsible for familial Parkinson s disease and enhances its ubiquitin ligase activity Mol Cell 10 1 55 67 doi 10 1016 S1097 2765 02 00583 X PMID 12150907 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Hanai R Mashima K 2004 Characterization of two isoforms of a human DnaJ homologue HSJ2 Mol Biol Rep 30 3 149 53 doi 10 1023 A 1024916223616 PMID 12974469 S2CID 24105834 Lehner B Semple JI Brown SE et al 2004 Analysis of a high throughput yeast two hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region Genomics 83 1 153 67 doi 10 1016 S0888 7543 03 00235 0 PMID 14667819 Bouwmeester T Bauch A Ruffner H et al 2004 A physical and functional map of the human TNF alpha NF kappa B signal transduction pathway Nat Cell Biol 6 2 97 105 doi 10 1038 ncb1086 PMID 14743216 S2CID 11683986 Marschang P Brich J Weeber EJ et al 2004 Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1 Mol Cell Biol 24 9 3782 93 doi 10 1128 MCB 24 9 3782 3793 2004 PMC 387731 PMID 15082773 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Rush J Moritz A Lee KA et al 2005 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells Nat Biotechnol 23 1 94 101 doi 10 1038 nbt1046 PMID 15592455 S2CID 7200157 Hu Y Zhou Z Huang X et al 2005 Expression of a novel DnaJA1 alternative splicing in human testis and sperm Int J Androl 27 6 343 9 doi 10 1111 j 1365 2605 2004 00492 x PMID 15595953 nbsp This article on a gene on human chromosome 9 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title DNAJA1 amp oldid 1215990516, wikipedia, wiki, book, books, library,

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