Many vertebrate homeobox-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform (BP1) functions as a repressor of the beta-globin gene while the other isoform lacks that function.[5]
References
^ abcGRCh38: Ensembl release 89: ENSG00000108813 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000020871 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Nakamura S, Stock DW, Wydner KL, et al. (1997). "Genomic analysis of a new mammalian distal-less gene: Dlx7". Genomics. 38 (3): 314–24. doi:10.1006/geno.1996.0634. PMID 8975708.
Quinn LM, Johnson BV, Nicholl J, et al. (1997). "Isolation and identification of homeobox genes from the human placenta including a novel member of the Distal-less family, DLX4". Gene. 187 (1): 55–61. doi:10.1016/S0378-1119(96)00706-8. PMID 9073066.
Morasso MI, Yonescu R, Griffin CA, Sargent TD (1997). "Localization of human DLX8 to chromosome 17q21.3-q22 by fluorescence in situ hybridization". Mamm. Genome. 8 (4): 302–3. doi:10.1007/s003359900427. PMID 9096128. S2CID 7448287.
Price JA, Bowden DW, Wright JT, et al. (1998). "Identification of a mutation in DLX3 associated with tricho-dento-osseous (TDO) syndrome". Hum. Mol. Genet. 7 (3): 563–9. doi:10.1093/hmg/7.3.563. PMID 9467018.
Quinn LM, Latham SE, Kalionis B (1998). "A distal-less class homeobox gene, DLX4, is a candidate for regulating epithelial-mesenchymal cell interactions in the human placenta". Placenta. 19 (1): 87–93. doi:10.1016/S0143-4004(98)90103-5. PMID 9481790.
Quinn LM, Kilpatrick LM, Latham SE, Kalionis B (1998). "Homeobox genes DLX4 and HB24 are expressed in regions of epithelial-mesenchymal cell interaction in the adult human endometrium". Mol. Hum. Reprod. 4 (5): 497–501. doi:10.1093/molehr/4.5.497. PMID 9665637.
Quinn LM, Latham SE, Kalionis B (2000). "The homeobox genes MSX2 and MOX2 are candidates for regulating epithelial-mesenchymal cell interactions in the human placenta". Placenta. 21 Suppl A: S50–4. doi:10.1053/plac.1999.0514. PMID 10831122.
Haga SB, Fu S, Karp JE, et al. (2000). "BP1, a new homeobox gene, is frequently expressed in acute leukemias". Leukemia. 14 (11): 1867–75. doi:10.1038/sj.leu.2401912. PMID 11069021.
Masuda Y, Sasaki A, Shibuya H, et al. (2001). "Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function". J. Biol. Chem. 276 (7): 5331–8. doi:10.1074/jbc.M008590200. PMID 11084035.
Fu S, Stevenson H, Strovel JW, et al. (2002). "Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene". Gene. 278 (1–2): 131–9. doi:10.1016/S0378-1119(01)00716-8. PMID 11707330.
Sumiyama K, Irvine SQ, Stock DW, et al. (2002). "Genomic structure and functional control of the Dlx3-7 bigene cluster". Proc. Natl. Acad. Sci. U.S.A. 99 (2): 780–5. Bibcode:2002PNAS...99..780S. doi:10.1073/pnas.012584999. PMC117382. PMID 11792834.
Chase MB, Fu S, Haga SB, et al. (2002). "BP1, a Homeodomain-Containing Isoform of DLX4, Represses the β-Globin Gene". Mol. Cell. Biol. 22 (8): 2505–14. doi:10.1128/MCB.22.8.2505-2514.2002. PMC133721. PMID 11909945.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Neufing PJ, Kalionis B, Horsfall DJ, et al. (2003). "Expression and localization of homeodomain proteins DLX4/HB9 in normal and malignant human breast tissues". Anticancer Res. 23 (2B): 1479–88. PMID 12820413.
Zoueva OP, Rodgers GP (2004). "Inhibition of beta protein 1 expression enhances beta-globin promoter activity and beta-globin mRNA levels in the human erythroleukemia (K562) cell line". Exp. Hematol. 32 (8): 700–8. doi:10.1016/j.exphem.2004.05.024. PMID 15308321.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Mpollo MS, Beaudoin M, Berg PE, et al. (2006). "BP1 is a negative modulator of definitive erythropoiesis". Nucleic Acids Res. 34 (18): 5232–7. doi:10.1093/nar/gkl680. PMC1636446. PMID 17003054.
Murthi P, Said JM, Doherty VL, et al. (2007). "Homeobox gene DLX4 expression is increased in idiopathic human fetal growth restriction". Mol. Hum. Reprod. 12 (12): 763–9. doi:10.1093/molehr/gal087. PMID 17062780.
Tomida S, Yanagisawa K, Koshikawa K, et al. (2007). "Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach". Oncogene. 26 (31): 4600–8. doi:10.1038/sj.onc.1210242. PMID 17260014.
dlx4, homeobox, protein, protein, that, humans, encoded, gene, identifiersaliases, dlx7, dlx8, dlx9, ofc15, distal, less, homeobox, 4external, idsomim, 601911, 94904, homologene, 7292, genecards, gene, location, human, chromosome, human, band17q21, 33start49, . Homeobox protein DLX 4 is a protein that in humans is encoded by the DLX4 gene 5 DLX4IdentifiersAliasesDLX4 BP1 DLX7 DLX8 DLX9 Dlx 4 OFC15 distal less homeobox 4External IDsOMIM 601911 MGI 94904 HomoloGene 7292 GeneCards DLX4Gene location Human Chr Chromosome 17 human 1 Band17q21 33Start49 968 970 bp 1 End49 974 959 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 D 11 59 01 cMStart95 031 273 bp 2 End95 037 089 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insynovial jointperiodontal fibersynovial membraneplacentafrontal polepancreatic ductal cellskin of abdomenmonocyteright lunggumsTop expressed inhair folliclemolarstellate reticulumlipspermatidskin of backknee jointskin of abdomensubmandibular glandesophagusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding protein binding RNA polymerase II cis regulatory region sequence specific DNA binding DNA binding transcription repressor activity RNA polymerase II specific DNA binding transcription factor activity sequence specific DNA binding DNA binding transcription factor activity RNA polymerase II specificCellular componentnucleusBiological processmulticellular organism development negative regulation of transcription by RNA polymerase II regulation of transcription DNA templated regulation of transcription by RNA polymerase IISources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez174813394EnsemblENSG00000108813ENSMUSG00000020871UniProtQ92988P70436RefSeq mRNA NM 001934NM 138281NM 007867RefSeq protein NP 001925NP 612138NP 031893Location UCSC Chr 17 49 97 49 97 MbChr 11 95 03 95 04 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 References 3 Further reading 4 External linksFunction EditMany vertebrate homeobox containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes Members of the Dlx gene family contain a homeobox that is related to that of Distal less Dll a gene expressed in the head and limbs of the developing fruit fly The Distal less Dlx family of genes comprises at least 6 different members DLX1 DLX6 The DLX proteins are postulated to play a role in forebrain and craniofacial development Three transcript variants have been described for this gene however the full length nature of one variant has not been described Studies of the two splice variants revealed that one encoded isoform BP1 functions as a repressor of the beta globin gene while the other isoform lacks that function 5 References Edit a b c GRCh38 Ensembl release 89 ENSG00000108813 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000020871 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene DLX4 distal less homeobox 4 Further reading EditNakamura S Stock DW Wydner KL et al 1997 Genomic analysis of a new mammalian distal less gene Dlx7 Genomics 38 3 314 24 doi 10 1006 geno 1996 0634 PMID 8975708 Quinn LM Johnson BV Nicholl J et al 1997 Isolation and identification of homeobox genes from the human placenta including a novel member of the Distal less family DLX4 Gene 187 1 55 61 doi 10 1016 S0378 1119 96 00706 8 PMID 9073066 Morasso MI Yonescu R Griffin CA Sargent TD 1997 Localization of human DLX8 to chromosome 17q21 3 q22 by fluorescence in situ hybridization Mamm Genome 8 4 302 3 doi 10 1007 s003359900427 PMID 9096128 S2CID 7448287 Price JA Bowden DW Wright JT et al 1998 Identification of a mutation in DLX3 associated with tricho dento osseous TDO syndrome Hum Mol Genet 7 3 563 9 doi 10 1093 hmg 7 3 563 PMID 9467018 Quinn LM Latham SE Kalionis B 1998 A distal less class homeobox gene DLX4 is a candidate for regulating epithelial mesenchymal cell interactions in the human placenta Placenta 19 1 87 93 doi 10 1016 S0143 4004 98 90103 5 PMID 9481790 Quinn LM Kilpatrick LM Latham SE Kalionis B 1998 Homeobox genes DLX4 and HB24 are expressed in regions of epithelial mesenchymal cell interaction in the adult human endometrium Mol Hum Reprod 4 5 497 501 doi 10 1093 molehr 4 5 497 PMID 9665637 Quinn LM Latham SE Kalionis B 2000 The homeobox genes MSX2 and MOX2 are candidates for regulating epithelial mesenchymal cell interactions in the human placenta Placenta 21 Suppl A S50 4 doi 10 1053 plac 1999 0514 PMID 10831122 Haga SB Fu S Karp JE et al 2000 BP1 a new homeobox gene is frequently expressed in acute leukemias Leukemia 14 11 1867 75 doi 10 1038 sj leu 2401912 PMID 11069021 Masuda Y Sasaki A Shibuya H et al 2001 Dlxin 1 a novel protein that binds Dlx5 and regulates its transcriptional function J Biol Chem 276 7 5331 8 doi 10 1074 jbc M008590200 PMID 11084035 Fu S Stevenson H Strovel JW et al 2002 Distinct functions of two isoforms of a homeobox gene BP1 and DLX7 in the regulation of the beta globin gene Gene 278 1 2 131 9 doi 10 1016 S0378 1119 01 00716 8 PMID 11707330 Sumiyama K Irvine SQ Stock DW et al 2002 Genomic structure and functional control of the Dlx3 7 bigene cluster Proc Natl Acad Sci U S A 99 2 780 5 Bibcode 2002PNAS 99 780S doi 10 1073 pnas 012584999 PMC 117382 PMID 11792834 Chase MB Fu S Haga SB et al 2002 BP1 a Homeodomain Containing Isoform of DLX4 Represses the b Globin Gene Mol Cell Biol 22 8 2505 14 doi 10 1128 MCB 22 8 2505 2514 2002 PMC 133721 PMID 11909945 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Neufing PJ Kalionis B Horsfall DJ et al 2003 Expression and localization of homeodomain proteins DLX4 HB9 in normal and malignant human breast tissues Anticancer Res 23 2B 1479 88 PMID 12820413 Zoueva OP Rodgers GP 2004 Inhibition of beta protein 1 expression enhances beta globin promoter activity and beta globin mRNA levels in the human erythroleukemia K562 cell line Exp Hematol 32 8 700 8 doi 10 1016 j exphem 2004 05 024 PMID 15308321 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Mpollo MS Beaudoin M Berg PE et al 2006 BP1 is a negative modulator of definitive erythropoiesis Nucleic Acids Res 34 18 5232 7 doi 10 1093 nar gkl680 PMC 1636446 PMID 17003054 Murthi P Said JM Doherty VL et al 2007 Homeobox gene DLX4 expression is increased in idiopathic human fetal growth restriction Mol Hum Reprod 12 12 763 9 doi 10 1093 molehr gal087 PMID 17062780 Tomida S Yanagisawa K Koshikawa K et al 2007 Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach Oncogene 26 31 4600 8 doi 10 1038 sj onc 1210242 PMID 17260014 External links EditDLX4 protein human at the US National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain This article on a gene on human chromosome 17 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title DLX4 amp oldid 1136348684, wikipedia, wiki, book, books, library,
