Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000115844 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000023391 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ozcelik T, Porteus MH, Rubenstein JL, Francke U (Sep 1992). "DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2". Genomics. 13 (4): 1157–61. doi:10.1016/0888-7543(92)90031-M. PMID 1354641.
^ abcZhang, H; Hu G; Wang H; Sciavolino P; Iler N; Shen M M; Abate-Shen C (May 1997). "Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism". Mol. Cell. Biol. UNITED STATES. 17 (5): 2920–32. doi:10.1128/mcb.17.5.2920. ISSN 0270-7306. PMC232144. PMID 9111364.
Further readingedit
Harris SE, Guo D, Harris MA, et al. (2003). "Transcriptional regulation of BMP-2 activated genes in osteoblasts using gene expression microarray analysis: role of Dlx2 and Dlx5 transcription factors". Front. Biosci. 8 (6): s1249–65. doi:10.2741/1170. PMID 12957859.
Qiu M, Bulfone A, Martinez S, et al. (1995). "Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain". Genes Dev. 9 (20): 2523–38. doi:10.1101/gad.9.20.2523. PMID 7590232.
Selski DJ, Thomas NE, Coleman PD, Rogers KE (1993). "The human brain homeogene, DLX-2: cDNA sequence and alignment with the murine homologue". Gene. 132 (2): 301–3. doi:10.1016/0378-1119(93)90212-L. PMID 7901126.
Simeone A, Acampora D, Pannese M, et al. (1994). "Cloning and characterization of two members of the vertebrate Dlx gene family". Proc. Natl. Acad. Sci. U.S.A. 91 (6): 2250–4. Bibcode:1994PNAS...91.2250S. doi:10.1073/pnas.91.6.2250. PMC43348. PMID 7907794.
McGuinness T, Porteus MH, Smiga S, et al. (1996). "Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus". Genomics. 35 (3): 473–85. doi:10.1006/geno.1996.0387. PMID 8812481.
Zhang H, Hu G, Wang H, et al. (1997). "Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism". Mol. Cell. Biol. 17 (5): 2920–32. doi:10.1128/mcb.17.5.2920. PMC232144. PMID 9111364.
Yu G, Zerucha T, Ekker M, Rubenstein JL (2002). "Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins". Brain Res. Dev. Brain Res. 130 (2): 217–30. doi:10.1016/S0165-3806(01)00239-5. PMID 11675124.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Espinoza HM, Ganga M, Vadlamudi U, et al. (2005). "Protein kinase C phosphorylation modulates N- and C-terminal regulatory activities of the PITX2 homeodomain protein". Biochemistry. 44 (10): 3942–54. doi:10.1021/bi048362x. PMID 15751970.
This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.
dlx2, homeobox, protein, protein, that, humans, encoded, gene, identifiersaliases, tes1, aw121999, distal, less, homeobox, 2external, idsomim, 126255, 94902, homologene, 3244, genecards, gene, location, human, chromosome, human, band2q31, 1start172, end172, ge. Homeobox protein DLX 2 is a protein that in humans is encoded by the DLX2 gene 5 6 DLX2IdentifiersAliasesDLX2 TES 1 TES1 AW121999 Dlx 2 distal less homeobox 2External IDsOMIM 126255 MGI 94902 HomoloGene 3244 GeneCards DLX2Gene location Human Chr Chromosome 2 human 1 Band2q31 1Start172 099 438 bp 1 End172 102 900 bp 1 Gene location Mouse Chr Chromosome 2 mouse 2 Band2 C2 2 42 65 cMStart71 373 752 bp 2 End71 377 098 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inspermganglionic eminenceperiodontal fiberpericardiumBrodmann area 23middle temporal gyrussuperior frontal gyrusoccipital lobestromal cell of endometriumprefrontal cortexTop expressed inmedial ganglionic eminencemolarolfactory bulbhair follicleenteric nervous systemurethrafemale urethramale urethramaxillary prominencesuprachiasmatic nucleusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding sequence specific DNA binding RNA polymerase II transcription regulatory region sequence specific DNA binding DNA binding transcription factor activity DNA binding transcription activator activity RNA polymerase II specific chromatin binding protein binding single stranded RNA binding DNA binding transcription factor activity RNA polymerase II specific RNA polymerase II cis regulatory region sequence specific DNA bindingCellular componentnucleusBiological processcerebral cortex GABAergic interneuron differentiation proximal distal pattern formation cell differentiation regulation of transcription DNA templated regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II branching morphogenesis of a nerve embryonic skeletal system development multicellular organism development odontogenesis of dentin containing tooth cerebral cortex GABAergic interneuron fate commitment cartilage development brain development negative regulation of oligodendrocyte differentiation forebrain neuron differentiation embryonic cranial skeleton morphogenesis olfactory bulb development hippocampus development subpallium development negative regulation of Notch signaling pathway positive regulation of transcription by RNA polymerase II positive regulation of cell differentiation negative regulation of photoreceptor cell differentiation positive regulation of amacrine cell differentiation transcription DNA templatedSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez174613392EnsemblENSG00000115844ENSMUSG00000023391UniProtQ07687P40764RefSeq mRNA NM 004405NM 010054RefSeq protein NP 004396NP 004396 1NP 034184Location UCSC Chr 2 172 1 172 1 MbChr 2 71 37 71 38 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseMany vertebrate homeo box containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes Members of the Dlx gene family contain a homeobox that is related to that of Distal less Dll a gene expressed in the head and limbs of the developing fruit fly The Distal less Dlx family of genes comprises at least 6 different members DLX1 DLX6 The DLX proteins are postulated to play a role in forebrain and craniofacial development This gene is located in a tail to tail configuration with another member of the gene family on the long arm of chromosome 2 6 Interactions editDLX2 has been shown to interact with DLX5 7 MSX1 7 and Msh homeobox 2 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000115844 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000023391 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Ozcelik T Porteus MH Rubenstein JL Francke U Sep 1992 DLX2 TES1 a homeobox gene of the Distal less family assigned to conserved regions on human and mouse chromosomes 2 Genomics 13 4 1157 61 doi 10 1016 0888 7543 92 90031 M PMID 1354641 a b Entrez Gene DLX2 distal less homeobox 2 a b c Zhang H Hu G Wang H Sciavolino P Iler N Shen M M Abate Shen C May 1997 Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism Mol Cell Biol UNITED STATES 17 5 2920 32 doi 10 1128 mcb 17 5 2920 ISSN 0270 7306 PMC 232144 PMID 9111364 Further reading editHarris SE Guo D Harris MA et al 2003 Transcriptional regulation of BMP 2 activated genes in osteoblasts using gene expression microarray analysis role of Dlx2 and Dlx5 transcription factors Front Biosci 8 6 s1249 65 doi 10 2741 1170 PMID 12957859 Qiu M Bulfone A Martinez S et al 1995 Null mutation of Dlx 2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain Genes Dev 9 20 2523 38 doi 10 1101 gad 9 20 2523 PMID 7590232 Selski DJ Thomas NE Coleman PD Rogers KE 1993 The human brain homeogene DLX 2 cDNA sequence and alignment with the murine homologue Gene 132 2 301 3 doi 10 1016 0378 1119 93 90212 L PMID 7901126 Simeone A Acampora D Pannese M et al 1994 Cloning and characterization of two members of the vertebrate Dlx gene family Proc Natl Acad Sci U S A 91 6 2250 4 Bibcode 1994PNAS 91 2250S doi 10 1073 pnas 91 6 2250 PMC 43348 PMID 7907794 McGuinness T Porteus MH Smiga S et al 1996 Sequence organization and transcription of the Dlx 1 and Dlx 2 locus Genomics 35 3 473 85 doi 10 1006 geno 1996 0387 PMID 8812481 Zhang H Hu G Wang H et al 1997 Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism Mol Cell Biol 17 5 2920 32 doi 10 1128 mcb 17 5 2920 PMC 232144 PMID 9111364 Yu G Zerucha T Ekker M Rubenstein JL 2002 Evidence that GRIP a PDZ domain protein which is expressed in the embryonic forebrain co activates transcription with DLX homeodomain proteins Brain Res Dev Brain Res 130 2 217 30 doi 10 1016 S0165 3806 01 00239 5 PMID 11675124 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Espinoza HM Ganga M Vadlamudi U et al 2005 Protein kinase C phosphorylation modulates N and C terminal regulatory activities of the PITX2 homeodomain protein Biochemistry 44 10 3942 54 doi 10 1021 bi048362x PMID 15751970 nbsp This article on a gene on human chromosome 2 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title DLX2 amp oldid 1136352802, wikipedia, wiki, book, books, library,
