Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene.[5]
Referencesedit
^ abcGRCm38: Ensembl release 89: ENSMUSG00000036095 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Goto K, Kondo H (August 1993). "Molecular cloning and expression of a 90-kDa diacylglycerol kinase that predominantly localizes in neurons". Proceedings of the National Academy of Sciences of the United States of America. 90 (16): 7598–602. Bibcode:1993PNAS...90.7598G. doi:10.1073/pnas.90.16.7598. PMC47189. PMID 7689223.
Caricasole A, Bettini E, Sala C, Roncarati R, Kobayashi N, Caldara F, Goto K, Terstappen GC (February 2002). "Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties". The Journal of Biological Chemistry. 277 (7): 4790–6. doi:10.1074/jbc.M110249200. PMID 11719522.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.
dgkb, diacylglycerol, kinase, beta, enzyme, that, humans, encoded, gene, identifiersaliases, dagk2, beta, diacylglycerol, kinase, betaexternal, idsomim, 604070, 2442474, homologene, 37875, genecards, gene, location, mouse, chromosome, mouse, band12, a3start37,. Diacylglycerol kinase beta is an enzyme that in humans is encoded by the DGKB gene 4 5 DGKBIdentifiersAliasesDGKB DAGK2 DGK DGK BETA diacylglycerol kinase betaExternal IDsOMIM 604070 MGI 2442474 HomoloGene 37875 GeneCards DGKBGene location Mouse Chr Chromosome 12 mouse 1 Band12 12 A3Start37 867 725 bp 1 End38 684 238 bp 1 RNA expression patternBgeeHumanMouse ortholog n aTop expressed inolfactory tuberclemammillary bodysuperior frontal gyruspiriform cortexglobus pallidusnucleus accumbenstemporal lobeamygdalahippocampus propervisual cortexBioGPSMore reference expression dataGene ontologyMolecular functiontransferase activity nucleotide binding calcium ion binding ATP binding metal ion binding kinase activity diacylglycerol kinase activity NAD kinase activityCellular componentcytoplasm nucleus cytosol plasma membrane Schaffer collateral CA1 synapse glutamatergic synapseBiological processplatelet activation protein kinase C activating G protein coupled receptor signaling pathway intracellular signal transduction phosphorylation glycerolipid metabolic process lipid phosphorylation metabolism signal transduction response to bacterium modulation of chemical synaptic transmission regulation of postsynapse organization diacylglycerol metabolic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1607217480EnsemblENSG00000136267ENSMUSG00000036095UniProtQ9Y6T7Q6NS52RefSeq mRNA NM 004080NM 145695NM 178681NM 001361686NM 001361688RefSeq protein NP 663733NP 001337634NP 001337635NP 001337636NP 001337637NP 001337638NP 001337640NP 001337641NP 001337643NP 001337644NP 001337645NP 001337646NP 001337647NP 001337648NP 001337649NP 001337650NP 001337651NP 001337652NP 001337653NP 848796NP 001348615NP 001348617Location UCSC n aChr 12 37 87 38 68 MbPubMed search 2 3 WikidataView Edit HumanView Edit MouseFunction editDiacylglycerol kinases DGKs are regulators of the intracellular concentration of the second messenger diacylglycerol DAG and thus play a key role in cellular processes Nine mammalian isotypes have been identified which are encoded by separate genes Mammalian DGK isozymes contain a conserved catalytic kinase domain and a cysteine rich domain CRD The protein encoded by this gene is a diacylglycerol kinase beta isotype Two alternatively spliced transcript variants have been found for this gene 5 References edit a b c GRCm38 Ensembl release 89 ENSMUSG00000036095 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Goto K Kondo H August 1993 Molecular cloning and expression of a 90 kDa diacylglycerol kinase that predominantly localizes in neurons Proceedings of the National Academy of Sciences of the United States of America 90 16 7598 602 Bibcode 1993PNAS 90 7598G doi 10 1073 pnas 90 16 7598 PMC 47189 PMID 7689223 a b Entrez Gene DGKB diacylglycerol kinase beta 90kDa Further reading editCaricasole A Bettini E Sala C Roncarati R Kobayashi N Caldara F Goto K Terstappen GC February 2002 Molecular cloning and characterization of the human diacylglycerol kinase beta DGKbeta gene alternative splicing generates DGKbeta isotypes with different properties The Journal of Biological Chemistry 277 7 4790 6 doi 10 1074 jbc M110249200 PMID 11719522 Nagase T Ishikawa K Suyama M Kikuno R Miyajima N Tanaka A Kotani H Nomura N Ohara O October 1998 Prediction of the coding sequences of unidentified human genes XI The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro DNA Research 5 5 277 86 doi 10 1093 dnares 5 5 277 PMID 9872452 nbsp This article on a gene on human chromosome 7 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title DGKB amp oldid 1079525230, wikipedia, wiki, book, books, library,
