DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it has a homolog on the X chromosome (DDX3X). The gene mutation causes male infertility, Sertoli cell-only syndrome or severe hypospermatogenesis, suggesting that this gene plays a key role in the spermatogenic process. Alternative splicing of this gene generates 2 transcripts, which differ only in the length of the 3' UTR.[6]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000067048 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000069045 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lahn BT, Page DC (Nov 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID 9381176.
^ ab"Entrez Gene: DDX3Y DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked".
Further readingedit
Foresta C, Ferlin A, Moro E (2000). "Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility". Hum. Mol. Genet. 9 (8): 1161–9. doi:10.1093/hmg/9.8.1161. PMID 10767340.
Shen P, Wang F, Underhill PA, et al. (2000). "Population genetic implications from sequence variation in four Y chromosome genes". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7354–9. Bibcode:2000PNAS...97.7354S. doi:10.1073/pnas.97.13.7354. PMC16549. PMID 10861003.
Session DR, Lee GS, Wolgemuth DJ (2001). "Characterization of D1Pas1, a mouse autosomal homologue of the human AZFa region DBY, as a nuclear protein in spermatogenic cells". Fertil. Steril. 76 (4): 804–11. doi:10.1016/S0015-0282(01)01996-3. PMID 11591417.
Kim YS, Lee SG, Park SH, Song K (2002). "Gene structure of the human DDX3 and chromosome mapping of its related sequences". Mol. Cells. 12 (2): 209–14. PMID 11710523.
Vogt MH, van den Muijsenberg JW, Goulmy E, et al. (2002). "The DBY gene codes for an HLA-DQ5-restricted human male-specific minor histocompatibility antigen involved in graft-versus-host disease". Blood. 99 (8): 3027–32. doi:10.1182/blood.V99.8.3027. PMID 11929796.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. Bibcode:2003Natur.423..825S. doi:10.1038/nature01722. PMID 12815422.
Zorn E, Miklos DB, Floyd BH, et al. (2004). "Minor histocompatibility antigen DBY elicits a coordinated B and T cell response after allogeneic stem cell transplantation". J. Exp. Med. 199 (8): 1133–42. doi:10.1084/jem.20031560. PMC1361263. PMID 15096539.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Ditton HJ, Zimmer J, Kamp C, et al. (2005). "The AZFa gene DBY (DDX3Y) is widely transcribed but the protein is limited to the male germ cells by translation control". Hum. Mol. Genet. 13 (19): 2333–41. doi:10.1093/hmg/ddh240. PMID 15294876.
Sekiguchi T, Iida H, Fukumura J, Nishimoto T (2004). "Human DDX3Y, the Y-encoded isoform of RNA helicase DDX3, rescues a hamster temperature-sensitive ET24 mutant cell line with a DDX3X mutation". Exp. Cell Res. 300 (1): 213–22. doi:10.1016/j.yexcr.2004.07.005. PMID 15383328.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Ficarro SB, Salomon AR, Brill LM, et al. (2005). "Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites". Rapid Commun. Mass Spectrom. 19 (1): 57–71. Bibcode:2005RCMS...19...57F. doi:10.1002/rcm.1746. PMID 15570572.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967. S2CID 9746088.
This protein-related article is a stub. You can help Wikipedia by expanding it.
ddx3y, dependent, helicase, enzyme, that, humans, encoded, gene, identifiersaliases, dead, helicase, linked, dead, helicase, linkedexternal, idsomim, 400010, 1349406, homologene, 55839, genecards, gene, location, human, chromosome, human, bandyq11, 221start12,. ATP dependent RNA helicase DDX3Y is an enzyme that in humans is encoded by the DDX3Y gene 5 6 DDX3YIdentifiersAliasesDDX3Y DBY DEAD box helicase 3 Y linked DEAD box helicase 3 Y linkedExternal IDsOMIM 400010 MGI 1349406 HomoloGene 55839 GeneCards DDX3YGene location Human Chr Y chromosome human 1 BandYq11 221Start12 904 108 bp 1 End12 920 478 bp 1 Gene location Mouse Chr Y chromosome mouse 2 BandY YpterStart1 260 771 bp 2 End1 286 629 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inspermendothelial cellright lungcaput epididymisseminal vesiculacorpus epididymisspongy bonerectumprostatecerebellar vermisTop expressed inmedian eminencedorsomedial hypothalamic nucleusmammillary bodyhabenulaarcuate nucleussubcutaneous adipose tissueleft lung loberetinal pigment epitheliumdorsal tegmental nucleuslateral hypothalamusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding nucleotide binding hydrolase activity ATP binding helicase activity RNA binding nucleic acid bindingCellular componentcytoplasmic ribonucleoprotein granule membrane nucleus cytoplasm cytosol nucleolusBiological processtranslational initiation regulation of gene expression RNA secondary structure unwinding chromosome segregationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez865326900EnsemblENSG00000067048ENSMUSG00000069045UniProtO15523Q62095RefSeq mRNA NM 001122665NM 001302552NM 004660NM 001324195NM 012008RefSeq protein NP 001116137NP 001289481NP 001311124NP 004651NP 036138Location UCSC Chr Y 12 9 12 92 MbChr Y 1 26 1 29 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseDEAD box proteins characterized by the conserved motif Asp Glu Ala Asp DEAD are putative RNA helicases They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation nuclear and mitochondrial splicing and ribosome and spliceosome assembly Based on their distribution patterns some members of this family are believed to be involved in embryogenesis spermatogenesis and cellular growth and division This gene encodes a DEAD box protein and it has a homolog on the X chromosome DDX3X The gene mutation causes male infertility Sertoli cell only syndrome or severe hypospermatogenesis suggesting that this gene plays a key role in the spermatogenic process Alternative splicing of this gene generates 2 transcripts which differ only in the length of the 3 UTR 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000067048 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000069045 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Lahn BT Page DC Nov 1997 Functional coherence of the human Y chromosome Science 278 5338 675 80 Bibcode 1997Sci 278 675L doi 10 1126 science 278 5338 675 PMID 9381176 a b Entrez Gene DDX3Y DEAD Asp Glu Ala Asp box polypeptide 3 Y linked Further reading editForesta C Ferlin A Moro E 2000 Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility Hum Mol Genet 9 8 1161 9 doi 10 1093 hmg 9 8 1161 PMID 10767340 Shen P Wang F Underhill PA et al 2000 Population genetic implications from sequence variation in four Y chromosome genes Proc Natl Acad Sci U S A 97 13 7354 9 Bibcode 2000PNAS 97 7354S doi 10 1073 pnas 97 13 7354 PMC 16549 PMID 10861003 Session DR Lee GS Wolgemuth DJ 2001 Characterization of D1Pas1 a mouse autosomal homologue of the human AZFa region DBY as a nuclear protein in spermatogenic cells Fertil Steril 76 4 804 11 doi 10 1016 S0015 0282 01 01996 3 PMID 11591417 Kim YS Lee SG Park SH Song K 2002 Gene structure of the human DDX3 and chromosome mapping of its related sequences Mol Cells 12 2 209 14 PMID 11710523 Vogt MH van den Muijsenberg JW Goulmy E et al 2002 The DBY gene codes for an HLA DQ5 restricted human male specific minor histocompatibility antigen involved in graft versus host disease Blood 99 8 3027 32 doi 10 1182 blood V99 8 3027 PMID 11929796 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Skaletsky H Kuroda Kawaguchi T Minx PJ et al 2003 The male specific region of the human Y chromosome is a mosaic of discrete sequence classes Nature 423 6942 825 37 Bibcode 2003Natur 423 825S doi 10 1038 nature01722 PMID 12815422 Zorn E Miklos DB Floyd BH et al 2004 Minor histocompatibility antigen DBY elicits a coordinated B and T cell response after allogeneic stem cell transplantation J Exp Med 199 8 1133 42 doi 10 1084 jem 20031560 PMC 1361263 PMID 15096539 Brill LM Salomon AR Ficarro SB et al 2004 Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry Anal Chem 76 10 2763 72 doi 10 1021 ac035352d PMID 15144186 Ditton HJ Zimmer J Kamp C et al 2005 The AZFa gene DBY DDX3Y is widely transcribed but the protein is limited to the male germ cells by translation control Hum Mol Genet 13 19 2333 41 doi 10 1093 hmg ddh240 PMID 15294876 Sekiguchi T Iida H Fukumura J Nishimoto T 2004 Human DDX3Y the Y encoded isoform of RNA helicase DDX3 rescues a hamster temperature sensitive ET24 mutant cell line with a DDX3X mutation Exp Cell Res 300 1 213 22 doi 10 1016 j yexcr 2004 07 005 PMID 15383328 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Ficarro SB Salomon AR Brill LM et al 2005 Automated immobilized metal affinity chromatography nano liquid chromatography electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites Rapid Commun Mass Spectrom 19 1 57 71 Bibcode 2005RCMS 19 57F doi 10 1002 rcm 1746 PMID 15570572 Rush J Moritz A Lee KA et al 2005 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells Nat Biotechnol 23 1 94 101 doi 10 1038 nbt1046 PMID 15592455 S2CID 7200157 Pope SN Lee IR 2005 Yeast two hybrid identification of prostatic proteins interacting with human sex hormone binding globulin J Steroid Biochem Mol Biol 94 1 3 203 8 doi 10 1016 j jsbmb 2005 01 007 PMID 15862967 S2CID 9746088 nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title DDX3Y amp oldid 1187454215, wikipedia, wiki, book, books, library,
