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Wikipedia

DCTN1

January 30, 2023

Dynactin subunit 1 is a protein that in humans is encoded by the DCTN1 gene.[5]

DCTN1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDCTN1, DAP-150, DP-150, P135, dynactin subunit 1
External IDsOMIM: 601143 MGI: 107745 HomoloGene: 3011 GeneCards: DCTN1
Orthologs
SpeciesHumanMouse
Entrez

1639

13191

Ensembl

ENSG00000204843

ENSMUSG00000031865

UniProt

Q14203

O08788

RefSeq (mRNA)

NM_001198866
NM_001198867
NM_007835
NM_001347310

RefSeq (protein)

NP_001185795
NP_001185796
NP_001334239
NP_031861

Location (UCSC)Chr 2: 74.36 – 74.39 MbChr 6: 83.14 – 83.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 23 subunits (11 individual proteins ranging in size from 22 to 150 kD).[6] Dynactin binds to cytoplasmic dynein, dynein cargo adaptors, and microtubules.[7] It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis.

This subunit is commonly referred to p150-glued.[5] It is present in two copies per dynactin complex and forms an ≈75 nm long flexible arm that extends from the main body of dynactin.[6] The p150-glued arm contains binding sites for microtubules,[8] the microtubule plus tip binding protein EB1,[9] and the N-terminus of the dynein intermediate chain.[10][11]

Alternative splicing of this gene results in at least 2 functionally distinct isoforms: a ubiquitously expressed one and a brain-specific one. Based on its cytogenetic location, this gene is considered as a candidate gene for limb-girdle muscular dystrophy.[12]

Interactions

DCTN1 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000204843 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031865 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Holzbaur EL, Hammarback JA, Paschal BM, Kravit NG, Pfister KK, Vallee RB (June 1991). "Homology of a 150K cytoplasmic dynein-associated polypeptide with the Drosophila gene Glued". Nature. 351 (6327): 579–83. Bibcode:1991Natur.351..579H. doi:10.1038/351579a0. PMID 1828535. S2CID 4263574.
  6. ^ a b Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP (March 2015). "The structure of the dynactin complex and its interaction with dynein". Science. 347 (6229): 1441–1446. Bibcode:2015Sci...347.1441U. doi:10.1126/science.aaa4080. PMC 4413427. PMID 25814576.
  7. ^ Cianfrocco MA, DeSantis ME, Leschziner AE, Reck-Peterson SL (2015). "Mechanism and regulation of cytoplasmic dynein". Annual Review of Cell and Developmental Biology. 31: 83–108. doi:10.1146/annurev-cellbio-100814-125438. PMC 4644480. PMID 26436706.
  8. ^ Waterman-Storer CM, Karki S, Holzbaur EL (February 1995). "The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1)". Proceedings of the National Academy of Sciences of the United States of America. 92 (5): 1634–8. Bibcode:1995PNAS...92.1634W. doi:10.1073/pnas.92.5.1634. PMC 42574. PMID 7878030.
  9. ^ Berrueta L, Tirnauer JS, Schuyler SC, Pellman D, Bierer BE (April 1999). "The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain". Current Biology. 9 (8): 425–8. doi:10.1016/S0960-9822(99)80190-0. PMID 10226031. S2CID 14191776.
  10. ^ Karki S, Holzbaur EL (December 1995). "Affinity chromatography demonstrates a direct binding between cytoplasmic dynein and the dynactin complex". The Journal of Biological Chemistry. 270 (48): 28806–11. doi:10.1074/jbc.270.48.28806. PMID 7499404.
  11. ^ Vaughan KT, Vallee RB (December 1995). "Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued". The Journal of Cell Biology. 131 (6 Pt 1): 1507–16. doi:10.1083/jcb.131.6.1507. PMC 2120689. PMID 8522607.
  12. ^ "Entrez Gene: DCTN1 dynactin 1 (p150, glued homolog, Drosophila)".
  13. ^ Kim JC, Badano JL, Sibold S, Esmail MA, Hill J, Hoskins BE, Leitch CC, Venner K, Ansley SJ, Ross AJ, Leroux MR, Katsanis N, Beales PL (May 2004). "The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression". Nature Genetics. 36 (5): 462–70. doi:10.1038/ng1352. PMID 15107855.
  14. ^ Liu JJ, Ding J, Kowal AS, Nardine T, Allen E, Delcroix JD, Wu C, Mobley W, Fuchs E, Yang Y (October 2003). "BPAG1n4 is essential for retrograde axonal transport in sensory neurons". The Journal of Cell Biology. 163 (2): 223–9. doi:10.1083/jcb.200306075. PMC 2173519. PMID 14581450.
  15. ^ Sahni M, Zhou XM, Bakiri L, Schlessinger J, Baron R, Levy JB (December 1996). "Identification of a novel 135-kDa Grb2-binding protein in osteoclasts". The Journal of Biological Chemistry. 271 (51): 33141–7. doi:10.1074/jbc.271.51.33141. PMID 8955163.
  16. ^ Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (October 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Current Biology. 12 (20): 1792–5. doi:10.1016/s0960-9822(02)01221-6. PMID 12401177. S2CID 14031165.

Further reading

  • Waterman-Storer CM, Karki S, Holzbaur EL (February 1995). "The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1)". Proceedings of the National Academy of Sciences of the United States of America. 92 (5): 1634–8. Bibcode:1995PNAS...92.1634W. doi:10.1073/pnas.92.5.1634. PMC 42574. PMID 7878030.
  • Paschal BM, Holzbaur EL, Pfister KK, Clark S, Meyer DI, Vallee RB (July 1993). "Characterization of a 50-kDa polypeptide in cytoplasmic dynein preparations reveals a complex with p150GLUED and a novel actin". The Journal of Biological Chemistry. 268 (20): 15318–23. doi:10.1016/S0021-9258(18)82472-3. PMID 8325901.
  • Vaughan KT, Vallee RB (December 1995). "Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued". The Journal of Cell Biology. 131 (6 Pt 1): 1507–16. doi:10.1083/jcb.131.6.1507. PMC 2120689. PMID 8522607.
  • Holzbaur EL, Tokito MK (February 1996). "Localization of the DCTN1 gene encoding p150Glued to human chromosome 2p13 by fluorescence in situ hybridization". Genomics. 31 (3): 398–9. doi:10.1006/geno.1996.0068. PMID 8838327.
  • Tokito MK, Howland DS, Lee VM, Holzbaur EL (August 1996). "Functionally distinct isoforms of dynactin are expressed in human neurons". Molecular Biology of the Cell. 7 (8): 1167–80. doi:10.1091/mbc.7.8.1167. PMC 275970. PMID 8856662.
  • Sahni M, Zhou XM, Bakiri L, Schlessinger J, Baron R, Levy JB (December 1996). "Identification of a novel 135-kDa Grb2-binding protein in osteoclasts". The Journal of Biological Chemistry. 271 (51): 33141–7. doi:10.1074/jbc.271.51.33141. PMID 8955163.
  • Blangy A, Arnaud L, Nigg EA (August 1997). "Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin-related motor HsEg5 to the dynactin subunit p150". The Journal of Biological Chemistry. 272 (31): 19418–24. doi:10.1074/jbc.272.31.19418. PMID 9235942.
  • Korthaus D, Wedemeyer N, Lengeling A, Ronsiek M, Jockusch H, Schmitt-John T (July 1997). "Integrated radiation hybrid map of human chromosome 2p13: possible involvement of dynactin in neuromuscular diseases". Genomics. 43 (2): 242–4. doi:10.1006/geno.1997.4789. PMID 9244444.
  • Waterman-Storer CM, Karki SB, Kuznetsov SA, Tabb JS, Weiss DG, Langford GM, Holzbaur EL (October 1997). "The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport". Proceedings of the National Academy of Sciences of the United States of America. 94 (22): 12180–5. Bibcode:1997PNAS...9412180W. doi:10.1073/pnas.94.22.12180. PMC 23743. PMID 9342383.
  • Engelender S, Sharp AH, Colomer V, Tokito MK, Lanahan A, Worley P, Holzbaur EL, Ross CA (December 1997). "Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin". Human Molecular Genetics. 6 (13): 2205–12. doi:10.1093/hmg/6.13.2205. PMID 9361024.
  • Li SH, Gutekunst CA, Hersch SM, Li XJ (February 1998). "Interaction of huntingtin-associated protein with dynactin P150Glued". The Journal of Neuroscience. 18 (4): 1261–9. doi:10.1523/JNEUROSCI.18-04-01261.1998. PMC 6792727. PMID 9454836.
  • Karki S, LaMonte B, Holzbaur EL (August 1998). "Characterization of the p22 subunit of dynactin reveals the localization of cytoplasmic dynein and dynactin to the midbody of dividing cells". The Journal of Cell Biology. 142 (4): 1023–34. doi:10.1083/jcb.142.4.1023. PMC 2132867. PMID 9722614.
  • Collin GB, Nishina PM, Marshall JD, Naggert JK (November 1998). "Human DCTN1: genomic structure and evaluation as a candidate for Alström syndrome". Genomics. 53 (3): 359–64. doi:10.1006/geno.1998.5542. PMID 9799602.
  • Tokito MK, Holzbaur EL (November 1998). "The genomic structure of DCTN1, a candidate gene for limb-girdle muscular dystrophy (LGMD2B)". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1442 (2–3): 432–6. doi:10.1016/S0167-4781(98)00195-X. PMID 9805007.
  • Bingham JB, Schroer TA (February 1999). "Self-regulated polymerization of the actin-related protein Arp1". Current Biology. 9 (4): 223–6. doi:10.1016/S0960-9822(99)80095-5. PMID 10074429. S2CID 208851.
  • Heimann K, Percival JM, Weinberger R, Gunning P, Stow JL (April 1999). "Specific isoforms of actin-binding proteins on distinct populations of Golgi-derived vesicles". The Journal of Biological Chemistry. 274 (16): 10743–50. doi:10.1074/jbc.274.16.10743. PMID 10196146.
  • Eckley DM, Gill SR, Melkonian KA, Bingham JB, Goodson HV, Heuser JE, Schroer TA (October 1999). "Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the arp1 minifilament pointed end". The Journal of Cell Biology. 147 (2): 307–20. doi:10.1083/jcb.147.2.307. PMC 2174220. PMID 10525537.
  • Karki S, Tokito MK, Holzbaur EL (February 2000). "A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1". The Journal of Biological Chemistry. 275 (7): 4834–9. doi:10.1074/jbc.275.7.4834. PMID 10671518.
  • Vancoillie G, Lambert J, Haeghen YV, Westbroek W, Mulder A, Koerten HK, Mommaas AM, Van Oostveldt P, Naeyaert JM (December 2000). "Colocalization of dynactin subunits P150Glued and P50 with melanosomes in normal human melanocytes". Pigment Cell Research. 13 (6): 449–57. doi:10.1034/j.1600-0749.2000.130607.x. PMID 11153697.

External links

  • GeneReviews/NIH/NCBI/UW entry on Perry syndrome


 

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

January 30, 2023
dctn1, dynactin, subunit, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1txq, 2coy, 2hkn, 2hkq, 2hl3, 2hl5, 2hqh, 3e2u, 3tq7identifiersaliases, p135, dynactin, subunit, 1external, idsomim, 601143, 107745, . Dynactin subunit 1 is a protein that in humans is encoded by the DCTN1 gene 5 DCTN1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7IdentifiersAliasesDCTN1 DAP 150 DP 150 P135 dynactin subunit 1External IDsOMIM 601143 MGI 107745 HomoloGene 3011 GeneCards DCTN1Gene location Human Chr Chromosome 2 human 1 Band2p13 1Start74 361 154 bp 1 End74 392 087 bp 1 Gene location Mouse Chr Chromosome 6 mouse 2 Band6 C3 6 35 94 cMStart83 142 902 bp 2 End83 177 099 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inprefrontal cortexnucleus accumbensamygdalaputamencaudate nucleusanterior pituitaryBrodmann area 9hypothalamussural nerveleft ventricleTop expressed inentorhinal cortexsuperior frontal gyruscerebellar cortexliphippocampus propersuperior colliculusesophagusdorsomedial hypothalamic nucleusmedulla oblongataprimary motor cortexMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding cytoskeletal motor activity microtubule binding tubulin binding dynein complex binding protein kinase binding tau protein bindingCellular componentcytoplasm centrosome membrane dynactin complex retromer complex cell leading edge dynein complex microtubule cytoskeleton kinetochore microtubule organizing center nucleus nuclear envelope centriole spindle cytosol actin cytoskeleton microtubule plus end spindle pole cell cortex region cell cortex microtubule associated complex axon neuron projection neuronal cell body intermediate filament cytoskeleton centriolar subdistal appendageBiological processantigen processing and presentation of exogenous peptide antigen via MHC class II nervous system development endoplasmic reticulum to Golgi vesicle mediated transport transport along microtubule IRE1 mediated unfolded protein response retrograde transport endosome to Golgi G2 M transition of mitotic cell cycle melanosome transport centriole centriole cohesion positive regulation of microtubule polymerization microtubule anchoring at centrosome nuclear membrane disassembly positive regulation of microtubule nucleation ciliary basal body plasma membrane docking non motile cilium assembly mitotic cell cycle establishment of mitotic spindle orientation regulation of mitotic spindle organization cell cycle cell division regulation of G2 M transition of mitotic cell cycle transport neuromuscular junction development ventral spinal cord development neuromuscular process motor behavior neuron cellular homeostasis axonal transport maintenance of synapse structure positive regulation of neuromuscular junction development neuron projection maintenanceSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez163913191EnsemblENSG00000204843ENSMUSG00000031865UniProtQ14203O08788RefSeq mRNA NM 001135040NM 001135041NM 001190836NM 001190837NM 004082NM 023019NM 001378991NM 001378992NM 001198866NM 001198867NM 007835NM 001347310RefSeq protein NP 001128512NP 001128513NP 001177765NP 001177766NP 004073NP 075408NP 001365920NP 001365921NP 001185795NP 001185796NP 001334239NP 031861Location UCSC Chr 2 74 36 74 39 MbChr 6 83 14 83 18 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further reading 5 External linksFunction EditThis gene encodes the largest subunit of dynactin a macromolecular complex consisting of 23 subunits 11 individual proteins ranging in size from 22 to 150 kD 6 Dynactin binds to cytoplasmic dynein dynein cargo adaptors and microtubules 7 It is involved in a diverse array of cellular functions including ER to Golgi transport the centripetal movement of lysosomes and endosomes spindle formation chromosome movement nuclear positioning and axonogenesis This subunit is commonly referred to p150 glued 5 It is present in two copies per dynactin complex and forms an 75 nm long flexible arm that extends from the main body of dynactin 6 The p150 glued arm contains binding sites for microtubules 8 the microtubule plus tip binding protein EB1 9 and the N terminus of the dynein intermediate chain 10 11 Alternative splicing of this gene results in at least 2 functionally distinct isoforms a ubiquitously expressed one and a brain specific one Based on its cytogenetic location this gene is considered as a candidate gene for limb girdle muscular dystrophy 12 Interactions EditDCTN1 has been shown to interact with BBS4 13 Dystonin 14 Grb2 15 and RAB6A 16 References Edit a b c GRCh38 Ensembl release 89 ENSG00000204843 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000031865 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Holzbaur EL Hammarback JA Paschal BM Kravit NG Pfister KK Vallee RB June 1991 Homology of a 150K cytoplasmic dynein associated polypeptide with the Drosophila gene Glued Nature 351 6327 579 83 Bibcode 1991Natur 351 579H doi 10 1038 351579a0 PMID 1828535 S2CID 4263574 a b Urnavicius L Zhang K Diamant AG Motz C Schlager MA Yu M Patel NA Robinson CV Carter AP March 2015 The structure of the dynactin complex and its interaction with dynein Science 347 6229 1441 1446 Bibcode 2015Sci 347 1441U doi 10 1126 science aaa4080 PMC 4413427 PMID 25814576 Cianfrocco MA DeSantis ME Leschziner AE Reck Peterson SL 2015 Mechanism and regulation of cytoplasmic dynein Annual Review of Cell and Developmental Biology 31 83 108 doi 10 1146 annurev cellbio 100814 125438 PMC 4644480 PMID 26436706 Waterman Storer CM Karki S Holzbaur EL February 1995 The p150Glued component of the dynactin complex binds to both microtubules and the actin related protein centractin Arp 1 Proceedings of the National Academy of Sciences of the United States of America 92 5 1634 8 Bibcode 1995PNAS 92 1634W doi 10 1073 pnas 92 5 1634 PMC 42574 PMID 7878030 Berrueta L Tirnauer JS Schuyler SC Pellman D Bierer BE April 1999 The APC associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain Current Biology 9 8 425 8 doi 10 1016 S0960 9822 99 80190 0 PMID 10226031 S2CID 14191776 Karki S Holzbaur EL December 1995 Affinity chromatography demonstrates a direct binding between cytoplasmic dynein and the dynactin complex The Journal of Biological Chemistry 270 48 28806 11 doi 10 1074 jbc 270 48 28806 PMID 7499404 Vaughan KT Vallee RB December 1995 Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued The Journal of Cell Biology 131 6 Pt 1 1507 16 doi 10 1083 jcb 131 6 1507 PMC 2120689 PMID 8522607 Entrez Gene DCTN1 dynactin 1 p150 glued homolog Drosophila Kim JC Badano JL Sibold S Esmail MA Hill J Hoskins BE Leitch CC Venner K Ansley SJ Ross AJ Leroux MR Katsanis N Beales PL May 2004 The Bardet Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression Nature Genetics 36 5 462 70 doi 10 1038 ng1352 PMID 15107855 Liu JJ Ding J Kowal AS Nardine T Allen E Delcroix JD Wu C Mobley W Fuchs E Yang Y October 2003 BPAG1n4 is essential for retrograde axonal transport in sensory neurons The Journal of Cell Biology 163 2 223 9 doi 10 1083 jcb 200306075 PMC 2173519 PMID 14581450 Sahni M Zhou XM Bakiri L Schlessinger J Baron R Levy JB December 1996 Identification of a novel 135 kDa Grb2 binding protein in osteoclasts The Journal of Biological Chemistry 271 51 33141 7 doi 10 1074 jbc 271 51 33141 PMID 8955163 Short B Preisinger C Schaletzky J Kopajtich R Barr FA October 2002 The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes Current Biology 12 20 1792 5 doi 10 1016 s0960 9822 02 01221 6 PMID 12401177 S2CID 14031165 Further reading EditWaterman Storer CM Karki S Holzbaur EL February 1995 The p150Glued component of the dynactin complex binds to both microtubules and the actin related protein centractin Arp 1 Proceedings of the National Academy of Sciences of the United States of America 92 5 1634 8 Bibcode 1995PNAS 92 1634W doi 10 1073 pnas 92 5 1634 PMC 42574 PMID 7878030 Paschal BM Holzbaur EL Pfister KK Clark S Meyer DI Vallee RB July 1993 Characterization of a 50 kDa polypeptide in cytoplasmic dynein preparations reveals a complex with p150GLUED and a novel actin The Journal of Biological Chemistry 268 20 15318 23 doi 10 1016 S0021 9258 18 82472 3 PMID 8325901 Vaughan KT Vallee RB December 1995 Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued The Journal of Cell Biology 131 6 Pt 1 1507 16 doi 10 1083 jcb 131 6 1507 PMC 2120689 PMID 8522607 Holzbaur EL Tokito MK February 1996 Localization of the DCTN1 gene encoding p150Glued to human chromosome 2p13 by fluorescence in situ hybridization Genomics 31 3 398 9 doi 10 1006 geno 1996 0068 PMID 8838327 Tokito MK Howland DS Lee VM Holzbaur EL August 1996 Functionally distinct isoforms of dynactin are expressed in human neurons Molecular Biology of the Cell 7 8 1167 80 doi 10 1091 mbc 7 8 1167 PMC 275970 PMID 8856662 Sahni M Zhou XM Bakiri L Schlessinger J Baron R Levy JB December 1996 Identification of a novel 135 kDa Grb2 binding protein in osteoclasts The Journal of Biological Chemistry 271 51 33141 7 doi 10 1074 jbc 271 51 33141 PMID 8955163 Blangy A Arnaud L Nigg EA August 1997 Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin related motor HsEg5 to the dynactin subunit p150 The Journal of Biological Chemistry 272 31 19418 24 doi 10 1074 jbc 272 31 19418 PMID 9235942 Korthaus D Wedemeyer N Lengeling A Ronsiek M Jockusch H Schmitt John T July 1997 Integrated radiation hybrid map of human chromosome 2p13 possible involvement of dynactin in neuromuscular diseases Genomics 43 2 242 4 doi 10 1006 geno 1997 4789 PMID 9244444 Waterman Storer CM Karki SB Kuznetsov SA Tabb JS Weiss DG Langford GM Holzbaur EL October 1997 The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport Proceedings of the National Academy of Sciences of the United States of America 94 22 12180 5 Bibcode 1997PNAS 9412180W doi 10 1073 pnas 94 22 12180 PMC 23743 PMID 9342383 Engelender S Sharp AH Colomer V Tokito MK Lanahan A Worley P Holzbaur EL Ross CA December 1997 Huntingtin associated protein 1 HAP1 interacts with the p150Glued subunit of dynactin Human Molecular Genetics 6 13 2205 12 doi 10 1093 hmg 6 13 2205 PMID 9361024 Li SH Gutekunst CA Hersch SM Li XJ February 1998 Interaction of huntingtin associated protein with dynactin P150Glued The Journal of Neuroscience 18 4 1261 9 doi 10 1523 JNEUROSCI 18 04 01261 1998 PMC 6792727 PMID 9454836 Karki S LaMonte B Holzbaur EL August 1998 Characterization of the p22 subunit of dynactin reveals the localization of cytoplasmic dynein and dynactin to the midbody of dividing cells The Journal of Cell Biology 142 4 1023 34 doi 10 1083 jcb 142 4 1023 PMC 2132867 PMID 9722614 Collin GB Nishina PM Marshall JD Naggert JK November 1998 Human DCTN1 genomic structure and evaluation as a candidate for Alstrom syndrome Genomics 53 3 359 64 doi 10 1006 geno 1998 5542 PMID 9799602 Tokito MK Holzbaur EL November 1998 The genomic structure of DCTN1 a candidate gene for limb girdle muscular dystrophy LGMD2B Biochimica et Biophysica Acta BBA Gene Structure and Expression 1442 2 3 432 6 doi 10 1016 S0167 4781 98 00195 X PMID 9805007 Bingham JB Schroer TA February 1999 Self regulated polymerization of the actin related protein Arp1 Current Biology 9 4 223 6 doi 10 1016 S0960 9822 99 80095 5 PMID 10074429 S2CID 208851 Heimann K Percival JM Weinberger R Gunning P Stow JL April 1999 Specific isoforms of actin binding proteins on distinct populations of Golgi derived vesicles The Journal of Biological Chemistry 274 16 10743 50 doi 10 1074 jbc 274 16 10743 PMID 10196146 Eckley DM Gill SR Melkonian KA Bingham JB Goodson HV Heuser JE Schroer TA October 1999 Analysis of dynactin subcomplexes reveals a novel actin related protein associated with the arp1 minifilament pointed end The Journal of Cell Biology 147 2 307 20 doi 10 1083 jcb 147 2 307 PMC 2174220 PMID 10525537 Karki S Tokito MK Holzbaur EL February 2000 A dynactin subunit with a highly conserved cysteine rich motif interacts directly with Arp1 The Journal of Biological Chemistry 275 7 4834 9 doi 10 1074 jbc 275 7 4834 PMID 10671518 Vancoillie G Lambert J Haeghen YV Westbroek W Mulder A Koerten HK Mommaas AM Van Oostveldt P Naeyaert JM December 2000 Colocalization of dynactin subunits P150Glued and P50 with melanosomes in normal human melanocytes Pigment Cell Research 13 6 449 57 doi 10 1034 j 1600 0749 2000 130607 x PMID 11153697 External links EditGeneReviews NIH NCBI UW entry on Perry syndrome This article on a gene on human chromosome 2 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title DCTN1 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