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Wikipedia

DAPK1

April 15, 2024

Death-associated protein kinase 1 is an enzyme that in humans is encoded by the DAPK1 gene.[5]

DAPK1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDAPK1, DAPK, death associated protein kinase 1, ROCO3
External IDsOMIM: 600831 MGI: 1916885 HomoloGene: 3626 GeneCards: DAPK1
Orthologs
SpeciesHumanMouse
Entrez

1612

69635

Ensembl

ENSG00000196730

ENSMUSG00000021559

UniProt

P53355

Q80YE7

RefSeq (mRNA)

NM_001288729
NM_001288730
NM_001288731
NM_004938

NM_001285917
NM_029653
NM_134062

RefSeq (protein)

NP_001275658
NP_001275659
NP_001275660
NP_004929

NP_001272846
NP_083929
NP_598823

Location (UCSC)Chr 9: 87.5 – 87.71 MbChr 13: 60.75 – 60.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.[6]

In melanocytic cells DAPK1 gene expression may be regulated by MITF.[7]

As a drug target edit

Depletion of DAPK1 results in inhibition of tumor cell count and volume growth in cellular and animal models of triple receptor-negative breast cancer, from individuals with p53-mutant cancers.[8] This has not been demonstrated in actual patients.

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196730 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021559 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J, Kimchi A, Huebner K (Sep 1995). "Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively". Genomics. 29 (1): 305–7. doi:10.1006/geno.1995.1255. PMID 8530096.
  6. ^ "Entrez Gene: DAPK1 death-associated protein kinase 1".
  7. ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
  8. ^ Zhao J, Zhao D, Poage GM, Mazumdar A, Zhang Y, Hill JL, Hartman ZC, Savage MI, Mills GB, Brown PH (Jul 2015). "Death-associated protein kinase 1 promotes growth of p53-mutant cancers". The Journal of Clinical Investigation. 125 (7): 2707–20. doi:10.1172/JCI70805. PMC 4563671. PMID 26075823.

Further reading edit

  • Deiss LP, Feinstein E, Berissi H, Cohen O, Kimchi A (Jan 1995). "Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death". Genes & Development. 9 (1): 15–30. doi:10.1101/gad.9.1.15. PMID 7828849.
  • Inbal B, Shani G, Cohen O, Kissil JL, Kimchi A (Feb 2000). "Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis". Molecular and Cellular Biology. 20 (3): 1044–54. doi:10.1128/MCB.20.3.1044-1054.2000. PMC 85221. PMID 10629061.
  • Jin Y, Blue EK, Dixon S, Hou L, Wysolmerski RB, Gallagher PJ (Oct 2001). "Identification of a new form of death-associated protein kinase that promotes cell survival". The Journal of Biological Chemistry. 276 (43): 39667–78. doi:10.1074/jbc.M101886200. PMC 2823794. PMID 11485996.
  • Shohat G, Spivak-Kroizman T, Cohen O, Bialik S, Shani G, Berrisi H, Eisenstein M, Kimchi A (Dec 2001). "The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism". The Journal of Biological Chemistry. 276 (50): 47460–7. doi:10.1074/jbc.M105133200. PMID 11579085.
  • Soria JC, Rodriguez M, Liu DD, Lee JJ, Hong WK, Mao L (Jan 2002). "Aberrant promoter methylation of multiple genes in bronchial brush samples from former cigarette smokers". Cancer Research. 62 (2): 351–5. PMID 11809677.
  • Larramendy ML, Niini T, Elonen E, Nagy B, Ollila J, Vihinen M, Knuutila S (Jun 2002). "Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis". Haematologica. 87 (6): 569–77. PMID 12031912.
  • Hasegawa M, Nelson HH, Peters E, Ringstrom E, Posner M, Kelsey KT (Jun 2002). "Patterns of gene promoter methylation in squamous cell cancer of the head and neck". Oncogene. 21 (27): 4231–6. doi:10.1038/sj.onc.1205528. PMID 12082610. S2CID 24566542.
  • Jin Y, Blue EK, Dixon S, Shao Z, Gallagher PJ (Dec 2002). "A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK". The Journal of Biological Chemistry. 277 (49): 46980–6. doi:10.1074/jbc.M208585200. PMC 2824503. PMID 12351649.
  • Wang WJ, Kuo JC, Yao CC, Chen RH (Oct 2002). "DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals". The Journal of Cell Biology. 159 (1): 169–79. doi:10.1083/jcb.200204050. PMC 2173490. PMID 12370243.
  • Nakatsuka S, Takakuwa T, Tomita Y, Hoshida Y, Nishiu M, Yamaguchi M, Nishii K, Yang WI, Aozasa K (Jan 2003). "Hypermethylation of death-associated protein (DAP) kinase CpG island is frequent not only in B-cell but also in T- and natural killer (NK)/T-cell malignancies". Cancer Science. 94 (1): 87–91. doi:10.1111/j.1349-7006.2003.tb01357.x. PMID 12708480. S2CID 11818957.
  • Tian JH, Das S, Sheng ZH (Jul 2003). "Ca2+-dependent phosphorylation of syntaxin-1A by the death-associated protein (DAP) kinase regulates its interaction with Munc18". The Journal of Biological Chemistry. 278 (28): 26265–74. doi:10.1074/jbc.M300492200. PMID 12730201.
  • Gonzalez-Gomez P, Bello MJ, Alonso ME, Lomas J, Arjona D, Amiñoso C, De Campos JM, Isla A, Gutierrez M, Rey JA (2004). "Frequent death-associated protein-kinase promoter hypermethylation in brain metastases of solid tumors". Oncology Reports. 10 (4): 1031–3. doi:10.3892/or.10.4.1031. PMID 12792765.
  • Matsumoto H, Nagao M, Ogawa S, Kanehiro H, Hisanaga M, Ko S, Ikeda N, Fujii H, Koyama F, Mukogawa T, Nakajima Y (2003). "Prognostic significance of death-associated protein-kinase expression in hepatocellular carcinomas". Anticancer Research. 23 (2B): 1333–41. PMID 12820391.
  • Henshall DC, Araki T, Schindler CK, Shinoda S, Lan JQ, Simon RP (Sep 2003). "Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures". Journal of Neurochemistry. 86 (5): 1260–70. doi:10.1046/j.1471-4159.2003.01934.x. PMID 12911633. S2CID 21971958.
  • Voso MT, Scardocci A, Guidi F, Zini G, Di Mario A, Pagano L, Hohaus S, Leone G (Jan 2004). "Aberrant methylation of DAP-kinase in therapy-related acute myeloid leukemia and myelodysplastic syndromes". Blood. 103 (2): 698–700. doi:10.1182/blood-2003-07-2249. PMID 14504087.
  • Jin Y, Gallagher PJ (Dec 2003). "Antisense depletion of death-associated protein kinase promotes apoptosis". The Journal of Biological Chemistry. 278 (51): 51587–93. doi:10.1074/jbc.M309165200. PMC 2823796. PMID 14530257.
  • Kim WS, Son HJ, Park JO, Song SY, Park C (Dec 2003). "Promoter methylation and down-regulation of DAPK is associated with gastric atrophy". International Journal of Molecular Medicine. 12 (6): 827–30. doi:10.3892/ijmm.12.6.827. PMID 14612952.
  • Bai T, Tanaka T, Yukawa K, Maeda M, Umesaki N (Mar 2004). "Reduced expression of death-associated protein kinase in human uterine and ovarian carcinoma cells". Oncology Reports. 11 (3): 661–5. doi:10.3892/or.11.3.661. PMID 14767518.


 

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

April 15, 2024
dapk1, death, associated, protein, kinase, enzyme, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1ig1, 1jkk, 1jkl, 1jks, 1jkt, 1p4f, 1wvx, 1wvy, 1yr5, 2w4j, 2w4k, 2x0g, 2xuu, 2xzs, 2y0a, 2y4p, 2y4v, 2yak, 3dfc, 3dg. Death associated protein kinase 1 is an enzyme that in humans is encoded by the DAPK1 gene 5 DAPK1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1IG1 1JKK 1JKL 1JKS 1JKT 1P4F 1WVX 1WVY 1YR5 2W4J 2W4K 2X0G 2XUU 2XZS 2Y0A 2Y4P 2Y4V 2YAK 3DFC 3DGK 3EH9 3EHA 3F5G 3F5U 3GU4 3GU5 3GU6 3GU7 3GU8 3GUB 3ZXT 4B4L 4PF4 4TL0 4TXC 4UV0 4YO4 4YPD 5AUW 5AUU 5AV1 5AUY 5AUT 5AUX 5AUV 5AUZ 5AV0 5AV4 5AV2 5AV3IdentifiersAliasesDAPK1 DAPK death associated protein kinase 1 ROCO3External IDsOMIM 600831 MGI 1916885 HomoloGene 3626 GeneCards DAPK1Gene location Human Chr Chromosome 9 human 1 Band9q21 33Start87 497 228 bp 1 End87 708 634 bp 1 Gene location Mouse Chr Chromosome 13 mouse 2 Band13 B2 13 32 53 cMStart60 749 761 bp 2 End60 911 005 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed ingerminal epitheliumpalpebral conjunctivaplacentamiddle temporal gyrusparietal pleuracorpus epididymisgallbladderpancreatic ductal cellmonocytemetanephrosTop expressed insacculeleft lung lobeolfactory tuberclesubiculumpiriform cortexpineal glandhabenularight lung lobenucleus accumbenscingulate gyrusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiontransferase activity nucleotide binding GTP binding syntaxin 1 binding kinase activity protein binding identical protein binding calmodulin dependent protein kinase activity protein serine threonine kinase activity calmodulin binding ATP binding protein kinase activityCellular componentplasma membrane actin cytoskeleton cytoskeleton cytoplasm nucleusBiological processregulation of apoptotic process negative regulation of translation phosphorylation negative regulation of apoptotic process positive regulation of cysteine type endopeptidase activity involved in apoptotic process regulation of autophagy negative regulation of extrinsic apoptotic signaling pathway via death domain receptors apoptotic signaling pathway protein autophosphorylation regulation of translation extrinsic apoptotic signaling pathway via death domain receptors signal transduction apoptotic process regulation of NMDA receptor activity protein phosphorylation positive regulation of autophagy intracellular signal transduction cellular response to interferon gamma cellular response to hydroperoxideSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez161269635EnsemblENSG00000196730ENSMUSG00000021559UniProtP53355Q80YE7RefSeq mRNA NM 001288729NM 001288730NM 001288731NM 004938NM 001285917NM 029653NM 134062RefSeq protein NP 001275658NP 001275659NP 001275660NP 004929NP 001272846NP 083929NP 598823Location UCSC Chr 9 87 5 87 71 MbChr 13 60 75 60 91 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 As a drug target 3 References 4 Further readingFunction editDeath associated protein kinase 1 is a positive mediator of gamma interferon induced programmed cell death DAPK1 encodes a structurally unique 160 kD calmodulin dependent serine threonine kinase that carries 8 ankyrin repeats and 2 putative P loop consensus sites It is a tumor suppressor candidate 6 In melanocytic cells DAPK1 gene expression may be regulated by MITF 7 As a drug target editDepletion of DAPK1 results in inhibition of tumor cell count and volume growth in cellular and animal models of triple receptor negative breast cancer from individuals with p53 mutant cancers 8 This has not been demonstrated in actual patients References edit a b c GRCh38 Ensembl release 89 ENSG00000196730 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000021559 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Feinstein E Druck T Kastury K Berissi H Goodart SA Overhauser J Kimchi A Huebner K Sep 1995 Assignment of DAP1 and DAPK genes that positively mediate programmed cell death triggered by IFN gamma to chromosome regions 5p12 2 and 9q34 1 respectively Genomics 29 1 305 7 doi 10 1006 geno 1995 1255 PMID 8530096 Entrez Gene DAPK1 death associated protein kinase 1 Hoek KS Schlegel NC Eichhoff OM Widmer DS Praetorius C Einarsson SO Valgeirsdottir S Bergsteinsdottir K Schepsky A Dummer R Steingrimsson E Dec 2008 Novel MITF targets identified using a two step DNA microarray strategy Pigment Cell amp Melanoma Research 21 6 665 76 doi 10 1111 j 1755 148X 2008 00505 x PMID 19067971 S2CID 24698373 Zhao J Zhao D Poage GM Mazumdar A Zhang Y Hill JL Hartman ZC Savage MI Mills GB Brown PH Jul 2015 Death associated protein kinase 1 promotes growth of p53 mutant cancers The Journal of Clinical Investigation 125 7 2707 20 doi 10 1172 JCI70805 PMC 4563671 PMID 26075823 Further reading editDeiss LP Feinstein E Berissi H Cohen O Kimchi A Jan 1995 Identification of a novel serine threonine kinase and a novel 15 kD protein as potential mediators of the gamma interferon induced cell death Genes amp Development 9 1 15 30 doi 10 1101 gad 9 1 15 PMID 7828849 Inbal B Shani G Cohen O Kissil JL Kimchi A Feb 2000 Death associated protein kinase related protein 1 a novel serine threonine kinase involved in apoptosis Molecular and Cellular Biology 20 3 1044 54 doi 10 1128 MCB 20 3 1044 1054 2000 PMC 85221 PMID 10629061 Jin Y Blue EK Dixon S Hou L Wysolmerski RB Gallagher PJ Oct 2001 Identification of a new form of death associated protein kinase that promotes cell survival The Journal of Biological Chemistry 276 43 39667 78 doi 10 1074 jbc M101886200 PMC 2823794 PMID 11485996 Shohat G Spivak Kroizman T Cohen O Bialik S Shani G Berrisi H Eisenstein M Kimchi A Dec 2001 The pro apoptotic function of death associated protein kinase is controlled by a unique inhibitory autophosphorylation based mechanism The Journal of Biological Chemistry 276 50 47460 7 doi 10 1074 jbc M105133200 PMID 11579085 Soria JC Rodriguez M Liu DD Lee JJ Hong WK Mao L Jan 2002 Aberrant promoter methylation of multiple genes in bronchial brush samples from former cigarette smokers Cancer Research 62 2 351 5 PMID 11809677 Larramendy ML Niini T Elonen E Nagy B Ollila J Vihinen M Knuutila S Jun 2002 Overexpression of translocation associated fusion genes of FGFRI MYC NPMI and DEK but absence of the translocations in acute myeloid leukemia A microarray analysis Haematologica 87 6 569 77 PMID 12031912 Hasegawa M Nelson HH Peters E Ringstrom E Posner M Kelsey KT Jun 2002 Patterns of gene promoter methylation in squamous cell cancer of the head and neck Oncogene 21 27 4231 6 doi 10 1038 sj onc 1205528 PMID 12082610 S2CID 24566542 Jin Y Blue EK Dixon S Shao Z Gallagher PJ Dec 2002 A death associated protein kinase DAPK interacting protein DIP 1 is an E3 ubiquitin ligase that promotes tumor necrosis factor induced apoptosis and regulates the cellular levels of DAPK The Journal of Biological Chemistry 277 49 46980 6 doi 10 1074 jbc M208585200 PMC 2824503 PMID 12351649 Wang WJ Kuo JC Yao CC Chen RH Oct 2002 DAP kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals The Journal of Cell Biology 159 1 169 79 doi 10 1083 jcb 200204050 PMC 2173490 PMID 12370243 Nakatsuka S Takakuwa T Tomita Y Hoshida Y Nishiu M Yamaguchi M Nishii K Yang WI Aozasa K Jan 2003 Hypermethylation of death associated protein DAP kinase CpG island is frequent not only in B cell but also in T and natural killer NK T cell malignancies Cancer Science 94 1 87 91 doi 10 1111 j 1349 7006 2003 tb01357 x PMID 12708480 S2CID 11818957 Tian JH Das S Sheng ZH Jul 2003 Ca2 dependent phosphorylation of syntaxin 1A by the death associated protein DAP kinase regulates its interaction with Munc18 The Journal of Biological Chemistry 278 28 26265 74 doi 10 1074 jbc M300492200 PMID 12730201 Gonzalez Gomez P Bello MJ Alonso ME Lomas J Arjona D Aminoso C De Campos JM Isla A Gutierrez M Rey JA 2004 Frequent death associated protein kinase promoter hypermethylation in brain metastases of solid tumors Oncology Reports 10 4 1031 3 doi 10 3892 or 10 4 1031 PMID 12792765 Matsumoto H Nagao M Ogawa S Kanehiro H Hisanaga M Ko S Ikeda N Fujii H Koyama F Mukogawa T Nakajima Y 2003 Prognostic significance of death associated protein kinase expression in hepatocellular carcinomas Anticancer Research 23 2B 1333 41 PMID 12820391 Henshall DC Araki T Schindler CK Shinoda S Lan JQ Simon RP Sep 2003 Expression of death associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures Journal of Neurochemistry 86 5 1260 70 doi 10 1046 j 1471 4159 2003 01934 x PMID 12911633 S2CID 21971958 Voso MT Scardocci A Guidi F Zini G Di Mario A Pagano L Hohaus S Leone G Jan 2004 Aberrant methylation of DAP kinase in therapy related acute myeloid leukemia and myelodysplastic syndromes Blood 103 2 698 700 doi 10 1182 blood 2003 07 2249 PMID 14504087 Jin Y Gallagher PJ Dec 2003 Antisense depletion of death associated protein kinase promotes apoptosis The Journal of Biological Chemistry 278 51 51587 93 doi 10 1074 jbc M309165200 PMC 2823796 PMID 14530257 Kim WS Son HJ Park JO Song SY Park C Dec 2003 Promoter methylation and down regulation of DAPK is associated with gastric atrophy International Journal of Molecular Medicine 12 6 827 30 doi 10 3892 ijmm 12 6 827 PMID 14612952 Bai T Tanaka T Yukawa K Maeda M Umesaki N Mar 2004 Reduced expression of death associated protein kinase in human uterine and ovarian carcinoma cells Oncology Reports 11 3 661 5 doi 10 3892 or 11 3 661 PMID 14767518 Portal nbsp Biology nbsp This article on a gene on human chromosome 9 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title DAPK1 amp oldid 1191317970, wikipedia, wiki, book, books, library,

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