Cystitis glandularis is the transformation of mucosal cells lining the urinary bladder. They undergo glandular metaplasia, a process in which irritated tissues take on a different form, in this case that of a gland.[1] The main importance is in the findings of test results, in this case histopathology. They must distinguish a benign metaplastic change from the cancerous condition urothelial cell carcinoma.[2] It is a very common finding in bladder biopsies and cystectomies, and most often found in the trigone area. Cystitis glandularis lesions are usually present as small microscopic foci; however, occasionally it can form raised intramucosal or polypoid lesions. The cystitis glandularis lesions are within the submucosa.
There are two main types of cystitis glandularis, non-mucinous and mucinous (intestinal). The difference is in the cellular production of mucin, a normal feature of colonic and intestinal epithelial cells but not of urothelial cells.[3] Another distinction is made between focal areas and diffuse involvement of the bladder. Whereas focal areas are more common, diffuse involvement is seen in chronically irritated bladders, such as in paraplegics or those with bladder stones or indwelling catheters. Individuals with diffuse intestinal-type cystitis glandularis are at increased risk for developing bladder cancer.[citation needed]
Related lesionsedit
Cystitis glandularis arises from and merges with Von Brunn's nests, which are groups of urothelial cells (cells of urinary tract) within the lamina propria and submucosa, formed from budding from the surface mucosa. They are considered normal. Cystitis cystica is a similar lesion to cystitis glandularis, where the central area of the Von Brunn's nests have degenerated, leaving cystic lesions. Other metaplastic entities in the urinary bladder include squamous metaplasia and nephrogenic adenoma.[citation needed]
^Yi X, Lu H, Wu Y, Shen Y, Meng Q, Cheng J, Tang Y, Wu F, Ou R, Jiang S, Bai X, Xie K (October 2014). "Cystitis glandularis: A controversial premalignant lesion". Oncology Letters. 8 (4): 1662–1664. doi:10.3892/ol.2014.2360. PMC4156188. PMID 25202387.
^. www.auanet.org. Archived from the original on 2019-05-06. Retrieved 2019-05-06.
^"Cystitis vs UTI: What's the difference?". 2023-11-21. Retrieved 2023-12-05.
Further readingedit
Wikimedia Commons has media related to Cystitis glandularis.
Bostwick DG, Cheng L (2008). "Cystitis cystica and cystitis glandularis". Urologic Surgical Pathology (2nd ed.). Mosby Elsevier. ISBN978-0-323-07614-2.
January 01, 1970
cystitis, glandularis, transformation, mucosal, cells, lining, urinary, bladder, they, undergo, glandular, metaplasia, process, which, irritated, tissues, take, different, form, this, case, that, gland, main, importance, findings, test, results, this, case, hi. Cystitis glandularis is the transformation of mucosal cells lining the urinary bladder They undergo glandular metaplasia a process in which irritated tissues take on a different form in this case that of a gland 1 The main importance is in the findings of test results in this case histopathology They must distinguish a benign metaplastic change from the cancerous condition urothelial cell carcinoma 2 It is a very common finding in bladder biopsies and cystectomies and most often found in the trigone area Cystitis glandularis lesions are usually present as small microscopic foci however occasionally it can form raised intramucosal or polypoid lesions The cystitis glandularis lesions are within the submucosa Cystitis glandularis at trigone Contents 1 Types 2 Related lesions 3 See also 4 References 5 Further readingTypes editThere are two main types of cystitis glandularis non mucinous and mucinous intestinal The difference is in the cellular production of mucin a normal feature of colonic and intestinal epithelial cells but not of urothelial cells 3 Another distinction is made between focal areas and diffuse involvement of the bladder Whereas focal areas are more common diffuse involvement is seen in chronically irritated bladders such as in paraplegics or those with bladder stones or indwelling catheters Individuals with diffuse intestinal type cystitis glandularis are at increased risk for developing bladder cancer citation needed Related lesions editCystitis glandularis arises from and merges with Von Brunn s nests which are groups of urothelial cells cells of urinary tract within the lamina propria and submucosa formed from budding from the surface mucosa They are considered normal Cystitis cystica is a similar lesion to cystitis glandularis where the central area of the Von Brunn s nests have degenerated leaving cystic lesions Other metaplastic entities in the urinary bladder include squamous metaplasia and nephrogenic adenoma citation needed See also editHemorrhagic cystitisReferences edit Yi X Lu H Wu Y Shen Y Meng Q Cheng J Tang Y Wu F Ou R Jiang S Bai X Xie K October 2014 Cystitis glandularis A controversial premalignant lesion Oncology Letters 8 4 1662 1664 doi 10 3892 ol 2014 2360 PMC 4156188 PMID 25202387 Cystitis Glandularis American Urological Association www auanet org Archived from the original on 2019 05 06 Retrieved 2019 05 06 Cystitis vs UTI What s the difference 2023 11 21 Retrieved 2023 12 05 Further reading edit nbsp Wikimedia Commons has media related to Cystitis glandularis Bostwick DG Cheng L 2008 Cystitis cystica and cystitis glandularis Urologic Surgical Pathology 2nd ed Mosby Elsevier ISBN 978 0 323 07614 2 Retrieved from https en wikipedia org w index php title Cystitis glandularis amp oldid 1193261026, wikipedia, wiki, book, books, library,
