Cystica profunda

Cystica profunda is a rare disease of the gut lining. It is characterized by formation of mucin cysts in the muscle layers of the gut lining, and it can occur anywhere along the gastrointestinal tract.^{[citation needed]}

When the condition occurs in the stomach, it may be termed gastritis cystica profunda, and in the small intestine, enteritis cystica profunda.^[1]

When it occurs in the colon, it is termed colitis cystica profunda. Colitis cystica profunda is benign, but it may mimic a tumor.^[2] When it occurs in the rectum it may be termed colitis cystica profunda, or termed proctitis cystica profunda. Some consider this synonymous, or closely related to solitary rectal ulcer syndrome, a consequence of internal rectal intussusception.^{[citation needed]}

It can have benign columnar epithelium and mucosal cysts deep to the muscularis mucosa on microscopy. Hence it can be mistaken for an invasive adenocarcinoma.^{[citation needed]}

See also

• Solitary rectal ulcer syndrome

References

1. Ng, CF; Hull, DA; Feakins, RM; Baithun, S; Dorudi, S (Jan 2004). "Enteritis cystica profunda". Journal of the Royal Society of Medicine. 97 (1): 29–30. doi:10.1177/014107680409700110. PMC 1079265. PMID 14702364.
2. Sarzo, G; Finco, C; Parise, P; Vecchiato, M; Savastano, S; Luongo, B; Degregori, S; Bocus, P; Marino, F; Poletti, A; De Lazzari, F; Merigliano, S (Nov–Dec 2005). "Colitis cystica profunda of the rectum: report of a case and review of the literature". Chirurgia Italiana. 57 (6): 789–98. PMID 16400778.