Congenital smooth muscle hamartoma is typically a skin colored or lightly pigmented patch or plaque with hypertrichosis.[1]: 627 [2] Congenital smooth muscle hamartoma was originally reported in 1969 by Sourreil et al.[3]
Although the clinical presentation of congenital smooth muscle hamartoma varies, it typically takes the form of an irregularly shaped, skin-colored, or slightly hyperpigmented patch or plaque on the trunk or extremities that is accompanied by noticeable vellus hairs. Often, it is located in the lumbosacral region.[4]
Causesedit
Congenital smooth muscle hamartoma most likely arises from an abnormal development that occurs during mesodermal maturation, primarily in the arrector pili muscle.[5] It is hypothesized that hypertrichosis results from the CD34 + dermal dendritic cells in the hamartoma stimulating the bulge's epithelial cells.[6]
There have been reports of familial cases recently, which raise the possibility of a genetic susceptibility.[7]
Rarely do diffuse forms of congenital smooth cell hamartoma cause the skin to fold.[5] It may indicate systemic involvement and is described as a symptom of the Michelin tire infant syndrome.[8]
Diagnosisedit
Histologically, the main characteristics of CSMH include reticular dermal smooth muscle hyperplasia with differently orientated, clearly defined bundles of smooth muscle[9][10] that may extend into subcutaneous adipose tissue. Hair follicles and smooth muscle proliferation are frequently tightly related.[11] Increased epidermal pigment is a sign of hyperpigmentation.[9][10] Immunohistochemical methods have recently clarified a few CSMH markers. It has been observed that CD34-positive dermal dendritic cells are an inherent component of smooth muscle hamartomas.[6] Furthermore, to distinguish clearly between skin cancers of myofibroblastic or fibroblastic origin and spindled smooth muscle cell soft tissue tumors, the cytoskeletal protein h-caldesmon has been employed as a smooth muscle cell-specific marker.[12]
^Janicke, Elise C.; Nazareth, Michael R.; Rothman, Ilene L. (2014-01-03). "Generalized Smooth Muscle Hamartoma with Multiple Congenital Anomalies without the "Michelin Tire Baby" Phenotype". Pediatric Dermatology. 31 (6). Wiley: 731–733. doi:10.1111/pde.12280. ISSN 0736-8046. PMID 24383769. S2CID 39284436.
^ abPrendiville, Julie; Esterly, Nancy B. (1987). "Congenital smooth muscle hamartoma". The Journal of Pediatrics. 110 (5). Elsevier BV: 742–744. doi:10.1016/s0022-3476(87)80015-x. ISSN 0022-3476. PMID 3572626.
^ abTruhan, A. P. (1985-09-01). "Hypertrichotic skin-colored patches in an infant. Congenital smooth-muscle hamartoma (CSMH)". Archives of Dermatology. 121 (9). American Medical Association (AMA): 1997, 1200–1. doi:10.1001/archderm.121.9.1997. ISSN 0003-987X. PMID 4037849.
^Huffman, D W; Mallory, S B (June 1989). "Congenital smooth muscle hamartoma". American Family Physician. 39 (6): 117–120. PMID 2729037.
^D'Addario, Stephen F.; Morgan, Michael; Talley, Lori; Smoller, Bruce R. (2002-07-25). "h-Caldesmon as a specific marker of smooth muscle cell differentiation in some soft tissue tumors of the skin". Journal of Cutaneous Pathology. 29 (7). Wiley: 426–429. doi:10.1034/j.1600-0560.2002.290707.x. ISSN 0303-6987. PMID 12139638. S2CID 22091736.
Further readingedit
Schmidt, Christopher S; Bentz, Michael L (2005). "Congenital Smooth Muscle Hamartoma: The Importance of Differentiation From Melanocytic Nevi". Journal of Craniofacial Surgery. 16 (5). Ovid Technologies (Wolters Kluwer Health): 926–929. doi:10.1097/01.scs.0000181049.99071.23. ISSN 1049-2275. PMID 16192884.
congenital, smooth, muscle, hamartoma, typically, skin, colored, lightly, pigmented, patch, plaque, with, hypertrichosis, originally, reported, 1969, sourreil, other, namescsmhspecialtydermatology, contents, signs, symptoms, causes, diagnosis, also, references. Congenital smooth muscle hamartoma is typically a skin colored or lightly pigmented patch or plaque with hypertrichosis 1 627 2 Congenital smooth muscle hamartoma was originally reported in 1969 by Sourreil et al 3 Congenital smooth muscle hamartomaOther namesCSMHSpecialtyDermatology Contents 1 Signs and symptoms 2 Causes 3 Diagnosis 4 See also 5 References 6 Further reading 7 External linksSigns and symptoms editAlthough the clinical presentation of congenital smooth muscle hamartoma varies it typically takes the form of an irregularly shaped skin colored or slightly hyperpigmented patch or plaque on the trunk or extremities that is accompanied by noticeable vellus hairs Often it is located in the lumbosacral region 4 Causes editCongenital smooth muscle hamartoma most likely arises from an abnormal development that occurs during mesodermal maturation primarily in the arrector pili muscle 5 It is hypothesized that hypertrichosis results from the CD34 dermal dendritic cells in the hamartoma stimulating the bulge s epithelial cells 6 There have been reports of familial cases recently which raise the possibility of a genetic susceptibility 7 Rarely do diffuse forms of congenital smooth cell hamartoma cause the skin to fold 5 It may indicate systemic involvement and is described as a symptom of the Michelin tire infant syndrome 8 Diagnosis editHistologically the main characteristics of CSMH include reticular dermal smooth muscle hyperplasia with differently orientated clearly defined bundles of smooth muscle 9 10 that may extend into subcutaneous adipose tissue Hair follicles and smooth muscle proliferation are frequently tightly related 11 Increased epidermal pigment is a sign of hyperpigmentation 9 10 Immunohistochemical methods have recently clarified a few CSMH markers It has been observed that CD34 positive dermal dendritic cells are an inherent component of smooth muscle hamartomas 6 Furthermore to distinguish clearly between skin cancers of myofibroblastic or fibroblastic origin and spindled smooth muscle cell soft tissue tumors the cytoskeletal protein h caldesmon has been employed as a smooth muscle cell specific marker 12 See also editSkin lesion List of cutaneous conditionsReferences edit James William Berger Timothy Elston Dirk 2005 Andrews Diseases of the Skin Clinical Dermatology 10th ed Saunders ISBN 0 7216 2921 0 Rapini Ronald P Bolognia Jean L Jorizzo Joseph L 2007 Dermatology 2 Volume Set St Louis Mosby pp 1835 6 ISBN 978 1 4160 2999 1 Goldman Mitchel P Kaplan Richard P Heng Madalene C Y 1987 Congenital Smooth Muscle Hamartoma International Journal of Dermatology 26 7 Wiley 448 452 doi 10 1111 j 1365 4362 1987 tb00589 x ISSN 0011 9059 PMID 3654038 S2CID 7812091 Metzker A Amir J Rotem A Merlob P 1984 Congenital Smooth Muscle Hamartoma of the Skin Pediatric Dermatology 2 1 Wiley 45 48 doi 10 1111 j 1525 1470 1984 tb00441 x ISSN 0736 8046 PMID 6504777 S2CID 263416250 a b Raboudi Asma Litaiem Noureddine 2023 06 26 Congenital Smooth Muscle Hamartoma StatPearls Publishing PMID 31424772 Retrieved 2024 02 17 a b Koizumi Kodama Tsuji Matsumura Nabeshima Ohkawara 1999 CD34 positive dendritic cells are an intrinsic part of smooth muscle hamartoma British Journal of Dermatology 140 1 Oxford University Press OUP 172 174 doi 10 1046 j 1365 2133 1999 02633 x ISSN 0007 0963 PMID 10215795 S2CID 28839250 Garcia Gavin Juan Perez Perez Lidia Allegue Francisco Perez Pedrosa Alberto Ortiz Rey Jose Antonio Zulaica Ander 2012 05 01 Multiple congenital familial smooth muscle hamartoma in two siblings Dermatology Online Journal 18 5 doi 10 5070 D39N52G204 ISSN 1087 2108 Janicke Elise C Nazareth Michael R Rothman Ilene L 2014 01 03 Generalized Smooth Muscle Hamartoma with Multiple Congenital Anomalies without the Michelin Tire Baby Phenotype Pediatric Dermatology 31 6 Wiley 731 733 doi 10 1111 pde 12280 ISSN 0736 8046 PMID 24383769 S2CID 39284436 a b Prendiville Julie Esterly Nancy B 1987 Congenital smooth muscle hamartoma The Journal of Pediatrics 110 5 Elsevier BV 742 744 doi 10 1016 s0022 3476 87 80015 x ISSN 0022 3476 PMID 3572626 a b Truhan A P 1985 09 01 Hypertrichotic skin colored patches in an infant Congenital smooth muscle hamartoma CSMH Archives of Dermatology 121 9 American Medical Association AMA 1997 1200 1 doi 10 1001 archderm 121 9 1997 ISSN 0003 987X PMID 4037849 Huffman D W Mallory S B June 1989 Congenital smooth muscle hamartoma American Family Physician 39 6 117 120 PMID 2729037 D Addario Stephen F Morgan Michael Talley Lori Smoller Bruce R 2002 07 25 h Caldesmon as a specific marker of smooth muscle cell differentiation in some soft tissue tumors of the skin Journal of Cutaneous Pathology 29 7 Wiley 426 429 doi 10 1034 j 1600 0560 2002 290707 x ISSN 0303 6987 PMID 12139638 S2CID 22091736 Further reading editSchmidt Christopher S Bentz Michael L 2005 Congenital Smooth Muscle Hamartoma The Importance of Differentiation From Melanocytic Nevi Journal of Craniofacial Surgery 16 5 Ovid Technologies Wolters Kluwer Health 926 929 doi 10 1097 01 scs 0000181049 99071 23 ISSN 1049 2275 PMID 16192884 Copi Luana Rocco Pereira Peraro Thais de Freitas Copi Igor Caldas Adriana Cristina 2019 Congenital smooth muscle hamartoma Anais Brasileiros de Dermatologia 94 3 FapUNIFESP SciELO 376 377 doi 10 1590 abd1806 4841 20198249 ISSN 1806 4841 PMID 31365679 External links editStatPearls Dermatology Advisor Retrieved from https en wikipedia org w index php title Congenital smooth muscle hamartoma amp oldid 1208530131, wikipedia, wiki, book, books, library,
