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Complement component 1s

January 01, 1970

Complement component 1s (EC 3.4.21.42, C1 esterase, activated complement C1s, complement C overbar 1r, C1s) is a protein involved in the complement system. C1s is part of the C1 complex.[5][6][7][8] In humans, it is encoded by the C1S gene.[9]

C1S
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesC1S, EDSPD2, complement C1s
External IDsOMIM: 120580 MGI: 3644269 HomoloGene: 1314 GeneCards: C1S
EC number3.4.21.42
Orthologs
SpeciesHumanMouse
Entrez

716

317677

Ensembl

ENSG00000182326

ENSMUSG00000079343

UniProt

P09871

Q8CFG8

RefSeq (mRNA)

NM_001734
NM_201442
NM_001346850

NM_173864

RefSeq (protein)

NP_001333779
NP_001725
NP_958850

NP_776289

Location (UCSC)Chr 12: 6.99 – 7.07 MbChr 6: 124.6 – 124.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

C1s cleaves C4 and C2, which eventually leads to the production of the classical pathway C3-convertase.

Classical pathway. (Some labels are in Polish.)

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182326 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079343 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sim RB (1981). "The human complement system serine proteases and their proenzymes". Proteolytic Enzymes, Part C. Methods in Enzymology. Vol. 80 Pt C. pp. 26–42. doi:10.1016/s0076-6879(81)80006-7. ISBN 9780121819804. PMID 6281620.
  6. ^ Mackinnon CM, Carter PE, Smyth SJ, Dunbar B, Fothergill JE (December 1987). "Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence". European Journal of Biochemistry. 169 (3): 547–53. doi:10.1111/j.1432-1033.1987.tb13644.x. PMID 3500856.
  7. ^ Müller-Eberhard HJ (1988). "Molecular organization and function of the complement system". Annual Review of Biochemistry. 57: 321–47. doi:10.1146/annurev.bi.57.070188.001541. PMID 3052276.
  8. ^ Skoog MT, Mehdi S, Wiseman JS, Bey P (June 1989). "The specificity of two proteinases that cleave adjacent to arginine, C1 esterase and acrosin, for peptide p-nitroanilide substrates". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 996 (1–2): 89–94. doi:10.1016/0167-4838(89)90099-x. PMID 2500154.
  9. ^ "Entrez Gene: C1S Complement component 1, s subcomponent".

Further reading edit

  • Luo C, Thielens NM, Gagnon J, Gal P, Sarvari M, Tseng Y, Tosi M, Zavodszky P, Arlaud GJ, Schumaker VN (May 1992). "Recombinant human complement subcomponent C1s lacking beta-hydroxyasparagine, sialic acid, and one of its two carbohydrate chains still reassembles with C1q and C1r to form a functional C1 complex". Biochemistry. 31 (17): 4254–62. doi:10.1021/bi00132a015. PMID 1533159.
  • Illy C, Thielens NM, Gagnon J, Arlaud GJ (July 1991). "Effect of lactoperoxidase-catalyzed iodination on the Ca(2+)-dependent interactions of human C1s. Location of the iodination sites". Biochemistry. 30 (29): 7135–41. doi:10.1021/bi00243a014. PMID 1854725.
  • Hess D, Schaller J, Rickli EE (March 1991). "Identification of the disulfide bonds of human complement C1s". Biochemistry. 30 (11): 2827–33. doi:10.1021/bi00225a014. PMID 2007122.
  • Thielens NM, Van Dorsselaer A, Gagnon J, Arlaud GJ (April 1990). "Chemical and functional characterization of a fragment of C1-s containing the epidermal growth factor homology region". Biochemistry. 29 (14): 3570–8. doi:10.1021/bi00466a021. PMID 2141278.
  • Busby TF, Ingham KC (May 1990). "NH2-terminal calcium-binding domain of human complement C1s- mediates the interaction of C1r- with C1q". Biochemistry. 29 (19): 4613–8. doi:10.1021/bi00471a016. PMID 2372546.
  • Kusumoto H, Hirosawa S, Salier JP, Hagen FS, Kurachi K (October 1988). "Human genes for complement components C1r and C1s in a close tail-to-tail arrangement". Proceedings of the National Academy of Sciences of the United States of America. 85 (19): 7307–11. Bibcode:1988PNAS...85.7307K. doi:10.1073/pnas.85.19.7307. PMC 282175. PMID 2459702.
  • Katz Y, Strunk RC (March 1989). "Synthesis and regulation of C1 inhibitor in human skin fibroblasts". Journal of Immunology. 142 (6): 2041–5. doi:10.4049/jimmunol.142.6.2041. PMID 2537870.
  • Tosi M, Duponchel C, Meo T, Couture-Tosi E (August 1989). "Complement genes C1r and C1s feature an intronless serine protease domain closely related to haptoglobin". Journal of Molecular Biology. 208 (4): 709–14. doi:10.1016/0022-2836(89)90161-7. PMID 2553984.
  • Tosi M, Duponchel C, Meo T, Julier C (December 1987). "Complete cDNA sequence of human complement Cls and close physical linkage of the homologous genes Cls and Clr". Biochemistry. 26 (26): 8516–24. doi:10.1021/bi00400a004. PMID 2831944.
  • Nguyen VC, Tosi M, Gross MS, Cohen-Haguenauer O, Jegou-Foubert C, de Tand MF, Meo T, Frézal J (April 1988). "Assignment of the complement serine protease genes C1r and C1s to chromosome 12 region 12p13". Human Genetics. 78 (4): 363–8. doi:10.1007/BF00291737. PMID 2834284. S2CID 30582112.
  • Spycher SE, Nick H, Rickli EE (April 1986). "Human complement component C1s. Partial sequence determination of the heavy chain and identification of the peptide bond cleaved during activation". European Journal of Biochemistry. 156 (1): 49–57. doi:10.1111/j.1432-1033.1986.tb09546.x. PMID 3007145.
  • Mackinnon CM, Carter PE, Smyth SJ, Dunbar B, Fothergill JE (December 1987). "Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence". European Journal of Biochemistry. 169 (3): 547–53. doi:10.1111/j.1432-1033.1987.tb13644.x. PMID 3500856.
  • Kauffman D, Hofmann T, Bennick A, Keller P (May 1986). "Basic proline-rich proteins from human parotid saliva: complete covalent structures of proteins IB-1 and IB-6". Biochemistry. 25 (9): 2387–92. doi:10.1021/bi00357a013. PMID 3521730.
  • Bock SC, Skriver K, Nielsen E, Thøgersen HC, Wiman B, Donaldson VH, Eddy RL, Marrinan J, Radziejewska E, Huber R (July 1986). "Human C1 inhibitor: primary structure, cDNA cloning, and chromosomal localization". Biochemistry. 25 (15): 4292–301. doi:10.1021/bi00363a018. PMID 3756141.
  • Carter PE, Dunbar B, Fothergill JE (December 1983). "The serine proteinase chain of human complement component C1s. Cyanogen bromide cleavage and N-terminal sequences of the fragments". The Biochemical Journal. 215 (3): 565–71. doi:10.1042/bj2150565. PMC 1152437. PMID 6362661.
  • Nilsson T, Sjöholm I, Wiman B (September 1983). "Structural and circular-dichroism studies on the interaction between human C1-esterase inhibitor and C1s". The Biochemical Journal. 213 (3): 617–24. doi:10.1042/bj2130617. PMC 1152176. PMID 6604523.
  • Rossi V, Gaboriaud C, Lacroix M, Ulrich J, Fontecilla-Camps JC, Gagnon J, Arlaud GJ (June 1995). "Structure of the catalytic region of human complement protease C1s: study by chemical cross-linking and three-dimensional homology modeling". Biochemistry. 34 (22): 7311–21. doi:10.1021/bi00022a004. PMID 7779774.
  • Bersch B, Hernandez JF, Marion D, Arlaud GJ (February 1998). "Solution structure of the epidermal growth factor (EGF)-like module of human complement protease C1r, an atypical member of the EGF family". Biochemistry. 37 (5): 1204–14. doi:10.1021/bi971851v. PMID 9477945.
  • Endo Y, Takahashi M, Nakao M, Saiga H, Sekine H, Matsushita M, Nonaka M, Fujita T (November 1998). "Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates". Journal of Immunology. 161 (9): 4924–30. doi:10.4049/jimmunol.161.9.4924. PMID 9794427.
  • Inoue N, Saito T, Masuda R, Suzuki Y, Ohtomi M, Sakiyama H (October 1998). "Selective complement C1s deficiency caused by homozygous four-base deletion in the C1s gene". Human Genetics. 103 (4): 415–8. doi:10.1007/s004390050843. PMID 9856483. S2CID 7689382.

External links edit


 

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

January 01, 1970
complement, component, esterase, activated, complement, complement, overbar, protein, involved, complement, system, part, complex, humans, encoded, gene, c1savailable, structurespdbortholog, search, pdbe, rcsblist, codes1elv, 1nzi, 4j1y, 4lmf, 4lor, 4los, 4lot. Complement component 1s EC 3 4 21 42 C1 esterase activated complement C1s complement C overbar 1r C1s is a protein involved in the complement system C1s is part of the C1 complex 5 6 7 8 In humans it is encoded by the C1S gene 9 C1SAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes1ELV 1NZI 4J1Y 4LMF 4LOR 4LOS 4LOTIdentifiersAliasesC1S EDSPD2 complement C1sExternal IDsOMIM 120580 MGI 3644269 HomoloGene 1314 GeneCards C1SEC number3 4 21 42Gene location Human Chr Chromosome 12 human 1 Band12p13 31Start6 988 259 bp 1 End7 071 032 bp 1 Gene location Mouse Chr Chromosome 6 mouse 2 Band6 6 F2Start124 601 584 bp 2 End124 613 044 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inpericardiumright lobe of liverparietal pleuragallbladdergastric mucosatibial nerveleft uterine tubesynovial jointcanal of the cervixright coronary arteryTop expressed inmorulawhite adipose tissuebone marrowadrenal glandurinary bladderovarylensislet of Langerhanssuperior frontal gyrusspleenMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioncalcium ion binding peptidase activity serine type peptidase activity protein binding hydrolase activity metal ion binding identical protein binding serine type endopeptidase activityCellular componentblood microparticle extracellular exosome extracellular region extracellular spaceBiological processproteolysis complement activation classical pathway immune system process innate immune response complement activation lectin pathway complement activation regulation of complement activationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez716317677EnsemblENSG00000182326ENSMUSG00000079343UniProtP09871Q8CFG8RefSeq mRNA NM 001734NM 201442NM 001346850NM 173864RefSeq protein NP 001333779NP 001725NP 958850NP 776289Location UCSC Chr 12 6 99 7 07 MbChr 6 124 6 124 61 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse C1s cleaves C4 and C2 which eventually leads to the production of the classical pathway C3 convertase Classical pathway Some labels are in Polish Contents 1 See also 2 References 3 Further reading 4 External linksSee also editC1q another part of the C1 complex C1r another part of the C1 complex MASP 2 a protein similar to C1s part of the lectin pathwayReferences edit a b c GRCh38 Ensembl release 89 ENSG00000182326 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000079343 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Sim RB 1981 The human complement system serine proteases and their proenzymes Proteolytic Enzymes Part C Methods in Enzymology Vol 80 Pt C pp 26 42 doi 10 1016 s0076 6879 81 80006 7 ISBN 9780121819804 PMID 6281620 Mackinnon CM Carter PE Smyth SJ Dunbar B Fothergill JE December 1987 Molecular cloning of cDNA for human complement component C1s The complete amino acid sequence European Journal of Biochemistry 169 3 547 53 doi 10 1111 j 1432 1033 1987 tb13644 x PMID 3500856 Muller Eberhard HJ 1988 Molecular organization and function of the complement system Annual Review of Biochemistry 57 321 47 doi 10 1146 annurev bi 57 070188 001541 PMID 3052276 Skoog MT Mehdi S Wiseman JS Bey P June 1989 The specificity of two proteinases that cleave adjacent to arginine C1 esterase and acrosin for peptide p nitroanilide substrates Biochimica et Biophysica Acta BBA Protein Structure and Molecular Enzymology 996 1 2 89 94 doi 10 1016 0167 4838 89 90099 x PMID 2500154 Entrez Gene C1S Complement component 1 s subcomponent Further reading editLuo C Thielens NM Gagnon J Gal P Sarvari M Tseng Y Tosi M Zavodszky P Arlaud GJ Schumaker VN May 1992 Recombinant human complement subcomponent C1s lacking beta hydroxyasparagine sialic acid and one of its two carbohydrate chains still reassembles with C1q and C1r to form a functional C1 complex Biochemistry 31 17 4254 62 doi 10 1021 bi00132a015 PMID 1533159 Illy C Thielens NM Gagnon J Arlaud GJ July 1991 Effect of lactoperoxidase catalyzed iodination on the Ca 2 dependent interactions of human C1s Location of the iodination sites Biochemistry 30 29 7135 41 doi 10 1021 bi00243a014 PMID 1854725 Hess D Schaller J Rickli EE March 1991 Identification of the disulfide bonds of human complement C1s Biochemistry 30 11 2827 33 doi 10 1021 bi00225a014 PMID 2007122 Thielens NM Van Dorsselaer A Gagnon J Arlaud GJ April 1990 Chemical and functional characterization of a fragment of C1 s containing the epidermal growth factor homology region Biochemistry 29 14 3570 8 doi 10 1021 bi00466a021 PMID 2141278 Busby TF Ingham KC May 1990 NH2 terminal calcium binding domain of human complement C1s mediates the interaction of C1r with C1q Biochemistry 29 19 4613 8 doi 10 1021 bi00471a016 PMID 2372546 Kusumoto H Hirosawa S Salier JP Hagen FS Kurachi K October 1988 Human genes for complement components C1r and C1s in a close tail to tail arrangement Proceedings of the National Academy of Sciences of the United States of America 85 19 7307 11 Bibcode 1988PNAS 85 7307K doi 10 1073 pnas 85 19 7307 PMC 282175 PMID 2459702 Katz Y Strunk RC March 1989 Synthesis and regulation of C1 inhibitor in human skin fibroblasts Journal of Immunology 142 6 2041 5 doi 10 4049 jimmunol 142 6 2041 PMID 2537870 Tosi M Duponchel C Meo T Couture Tosi E August 1989 Complement genes C1r and C1s feature an intronless serine protease domain closely related to haptoglobin Journal of Molecular Biology 208 4 709 14 doi 10 1016 0022 2836 89 90161 7 PMID 2553984 Tosi M Duponchel C Meo T Julier C December 1987 Complete cDNA sequence of human complement Cls and close physical linkage of the homologous genes Cls and Clr Biochemistry 26 26 8516 24 doi 10 1021 bi00400a004 PMID 2831944 Nguyen VC Tosi M Gross MS Cohen Haguenauer O Jegou Foubert C de Tand MF Meo T Frezal J April 1988 Assignment of the complement serine protease genes C1r and C1s to chromosome 12 region 12p13 Human Genetics 78 4 363 8 doi 10 1007 BF00291737 PMID 2834284 S2CID 30582112 Spycher SE Nick H Rickli EE April 1986 Human complement component C1s Partial sequence determination of the heavy chain and identification of the peptide bond cleaved during activation European Journal of Biochemistry 156 1 49 57 doi 10 1111 j 1432 1033 1986 tb09546 x PMID 3007145 Mackinnon CM Carter PE Smyth SJ Dunbar B Fothergill JE December 1987 Molecular cloning of cDNA for human complement component C1s The complete amino acid sequence European Journal of Biochemistry 169 3 547 53 doi 10 1111 j 1432 1033 1987 tb13644 x PMID 3500856 Kauffman D Hofmann T Bennick A Keller P May 1986 Basic proline rich proteins from human parotid saliva complete covalent structures of proteins IB 1 and IB 6 Biochemistry 25 9 2387 92 doi 10 1021 bi00357a013 PMID 3521730 Bock SC Skriver K Nielsen E Thogersen HC Wiman B Donaldson VH Eddy RL Marrinan J Radziejewska E Huber R July 1986 Human C1 inhibitor primary structure cDNA cloning and chromosomal localization Biochemistry 25 15 4292 301 doi 10 1021 bi00363a018 PMID 3756141 Carter PE Dunbar B Fothergill JE December 1983 The serine proteinase chain of human complement component C1s Cyanogen bromide cleavage and N terminal sequences of the fragments The Biochemical Journal 215 3 565 71 doi 10 1042 bj2150565 PMC 1152437 PMID 6362661 Nilsson T Sjoholm I Wiman B September 1983 Structural and circular dichroism studies on the interaction between human C1 esterase inhibitor and C1s The Biochemical Journal 213 3 617 24 doi 10 1042 bj2130617 PMC 1152176 PMID 6604523 Rossi V Gaboriaud C Lacroix M Ulrich J Fontecilla Camps JC Gagnon J Arlaud GJ June 1995 Structure of the catalytic region of human complement protease C1s study by chemical cross linking and three dimensional homology modeling Biochemistry 34 22 7311 21 doi 10 1021 bi00022a004 PMID 7779774 Bersch B Hernandez JF Marion D Arlaud GJ February 1998 Solution structure of the epidermal growth factor EGF like module of human complement protease C1r an atypical member of the EGF family Biochemistry 37 5 1204 14 doi 10 1021 bi971851v PMID 9477945 Endo Y Takahashi M Nakao M Saiga H Sekine H Matsushita M Nonaka M Fujita T November 1998 Two lineages of mannose binding lectin associated serine protease MASP in vertebrates Journal of Immunology 161 9 4924 30 doi 10 4049 jimmunol 161 9 4924 PMID 9794427 Inoue N Saito T Masuda R Suzuki Y Ohtomi M Sakiyama H October 1998 Selective complement C1s deficiency caused by homozygous four base deletion in the C1s gene Human Genetics 103 4 415 8 doi 10 1007 s004390050843 PMID 9856483 S2CID 7689382 External links editComplement C1s at the U S National Library of Medicine Medical Subject Headings MeSH Human C1S genome location and C1S gene details page in the UCSC Genome Browser Portal nbsp Biology nbsp This article on a gene on human chromosome 12 is a stub You can help Wikipedia by expanding it vte Retrieved from https en 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