COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC, a soluble form of COL25A1 containing the extracellular collagen domains that associates with senile plaques in Alzheimer disease (AD; MIM 104300) brains (Osada et al., 2005).[supplied by OMIM][6]
^ abcGRCh38: Ensembl release 89: ENSG00000188517 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000058897 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abHashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DM, Iwatsubo T (Apr 2002). "CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV". EMBO J. 21 (7): 1524–34. doi:10.1093/emboj/21.7.1524. PMC125364. PMID 11927537.
^ ab"Entrez Gene: COL25A1 collagen, type XXV, alpha 1".
Further readingedit
Kakuyama H, Söderberg L, Horigome K, et al. (2006). "CLAC binds to aggregated Abeta and Abeta fragments, and attenuates fibril elongation". Biochemistry. 44 (47): 15602–9. doi:10.1021/bi051263e. PMID 16300410.
Osada Y, Hashimoto T, Nishimura A, et al. (2005). "CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils". J. Biol. Chem. 280 (9): 8596–605. doi:10.1074/jbc.M413340200. PMID 15615705.
Söderberg L, Kakuyama H, Möller A, et al. (2005). "Characterization of the Alzheimer's disease-associated CLAC protein and identification of an amyloid beta-peptide-binding site". J. Biol. Chem. 280 (2): 1007–15. doi:10.1074/jbc.M403628200. PMID 15522881.
Kowa H, Sakakura T, Matsuura Y, et al. (2004). "Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits". Am. J. Pathol. 165 (1): 273–81. doi:10.1016/s0002-9440(10)63295-6. PMC1618534. PMID 15215182.
Söderberg L, Zhukareva V, Bogdanovic N, et al. (2004). "Molecular identification of AMY, an Alzheimer disease amyloid-associated protein". J. Neuropathol. Exp. Neurol. 62 (11): 1108–17. doi:10.1093/jnen/62.11.1108. PMID 14656069.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.
collagen, type, alpha, collagen, alpha, chain, protein, that, humans, encoded, col25a1, gene, col25a1identifiersaliasescol25a1, clac, clac, clacp, cfeom5, collagen, type, alpha, collagen, type, alpha, chainexternal, idsomim, 610004, 1924268, homologene, 57111,. Collagen alpha 1 XXV chain is a protein that in humans is encoded by the COL25A1 gene 5 6 COL25A1IdentifiersAliasesCOL25A1 AMY CLAC CLAC P CLACP CFEOM5 Collagen type XXV alpha 1 collagen type XXV alpha 1 collagen type XXV alpha 1 chainExternal IDsOMIM 610004 MGI 1924268 HomoloGene 57111 GeneCards COL25A1Gene location Human Chr Chromosome 4 human 1 Band4q25Start108 808 725 bp 1 End109 302 752 bp 1 Gene location Mouse Chr Chromosome 3 mouse 2 Band3 3 G3Start129 925 150 bp 2 End130 393 526 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inspermjejunal mucosaAchilles tendonsubcutaneous adipose tissueanterior pituitarysural nerveleft lobe of thyroid glandright lobe of thyroid glandgallbladderhypothalamusTop expressed inmedian eminencemedial dorsal nucleusarcuate nucleussubstantia nigrahabenulasuperior colliculuslateral geniculate nucleuslateral hypothalamusventromedial nucleusventral tegmental areaMore reference expression dataBioGPSn aGene ontologyMolecular functionheparin binding amyloid beta binding extracellular matrix structural constituent extracellular matrix structural constituent conferring tensile strengthCellular componentintegral component of membrane extracellular region plasma membrane collagen endoplasmic reticulum lumen membrane extracellular space integral component of plasma membrane extracellular matrix collagen containing extracellular matrixBiological processaxonogenesis involved in innervation extracellular matrix organizationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez8457077018EnsemblENSG00000188517ENSMUSG00000058897UniProtQ9BXS0Q99MQ5RefSeq mRNA NM 001256074NM 032518NM 198721NM 001244952NM 029838NM 198711RefSeq protein NP 001243003NP 115907NP 942014NP 001231881NP 084114NP 942004Location UCSC Chr 4 108 81 109 3 MbChr 3 129 93 130 39 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseCOL25A1 is a brain specific membrane bound collagen Proteolytic processing releases CLAC a soluble form of COL25A1 containing the extracellular collagen domains that associates with senile plaques in Alzheimer disease AD MIM 104300 brains Osada et al 2005 supplied by OMIM 6 Interactions editCollagen type XXV alpha 1 has been shown to interact with Amyloid precursor protein 5 References edit a b c GRCh38 Ensembl release 89 ENSG00000188517 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000058897 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Hashimoto T Wakabayashi T Watanabe A Kowa H Hosoda R Nakamura A Kanazawa I Arai T Takio K Mann DM Iwatsubo T Apr 2002 CLAC a novel Alzheimer amyloid plaque component derived from a transmembrane precursor CLAC P collagen type XXV EMBO J 21 7 1524 34 doi 10 1093 emboj 21 7 1524 PMC 125364 PMID 11927537 a b Entrez Gene COL25A1 collagen type XXV alpha 1 Further reading editKakuyama H Soderberg L Horigome K et al 2006 CLAC binds to aggregated Abeta and Abeta fragments and attenuates fibril elongation Biochemistry 44 47 15602 9 doi 10 1021 bi051263e PMID 16300410 Soderberg L Dahlqvist C Kakuyama H et al 2005 Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates FEBS J 272 9 2231 6 doi 10 1111 j 1742 4658 2005 04647 x hdl 10616 39314 PMID 15853808 S2CID 26505595 Osada Y Hashimoto T Nishimura A et al 2005 CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils J Biol Chem 280 9 8596 605 doi 10 1074 jbc M413340200 PMID 15615705 Soderberg L Kakuyama H Moller A et al 2005 Characterization of the Alzheimer s disease associated CLAC protein and identification of an amyloid beta peptide binding site J Biol Chem 280 2 1007 15 doi 10 1074 jbc M403628200 PMID 15522881 Kowa H Sakakura T Matsuura Y et al 2004 Mostly separate distributions of CLAC versus Abeta40 or thioflavin S reactivities in senile plaques reveal two distinct subpopulations of beta amyloid deposits Am J Pathol 165 1 273 81 doi 10 1016 s0002 9440 10 63295 6 PMC 1618534 PMID 15215182 Soderberg L Zhukareva V Bogdanovic N et al 2004 Molecular identification of AMY an Alzheimer disease amyloid associated protein J Neuropathol Exp Neurol 62 11 1108 17 doi 10 1093 jnen 62 11 1108 PMID 14656069 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 nbsp This article on a gene on human chromosome 4 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Collagen type XXV alpha 1 amp oldid 1186242758, wikipedia, wiki, book, books, library,
