For use polysubstance use of drugs that are not chemically linked together, see Combination drug.
This article is missing information about things that blur the line with ordinary combination meds: co-salts such as dimenhydrinate linked via an ionic bond, co-crystals held together by H-bonds. Please expand the article to include this information. Further details may exist on the talk page.(December 2022)
A codrug or "mutual prodrug" consists of two synergistic drugs chemically linked together to a single molecule, in order to improve the drug delivery properties of one or both drugs.[1][2]
An effective codrug should be pharmacologically inactive in its own right but should release the constituent drugs upon biochemical breakage of the chemical linkage at the target tissue where their therapeutic effects are needed. As such, the chemical linkage (usually a covalent bond) should be subjectable to biodegradation, such as hydrolysis, by an enzymatic or non-enzymatic mechanism. The differential distribution of enzymes capable of catalyzing the breakage of the chemical linkage in different tissues may be exploited to achieve tissue-specific metabolism of the codrug to release the constituent drugs.
The constituent drugs are indicated for the same disease but may exert different therapeutic effects via disparate mechanisms of action.
Development of Anticancer Codrugs [3]: The disadvantages associated with the co-delivery of physically combined chemotherapeutic drugs/agents often suffer from poor solubility, less membrane permeability, unimproved bioavailability, as well as poor selectivity for the targeted cells. Simply we can say that physically combine drugs always struggles with less improved pharmacokinetic properties. Where selectivity is a major issue in the complex environment of a targeted cell. Several codrugs reported in the literature for the anticancer drug delivery with improved pharmacokinetic properties may provide ideas to the pharmaceutical scientist for further drug development in various diseases. Codrug of butyric acid and ATRA,Codrug of ATRA and histone deacetylase inhibitors,5-Fluorouracil (5-FU) and cytarabine (Ara-C) codrug,Paclitaxel and captopril codrug,5-Fluorouracil and diazeniumdiolate codrug,
^W. M. Lau (2008). "Scope and Limitations of the Co-Drug Approach to Topical Drug Delivery". Current Pharmaceutical Design. 14 (8): 794–802. doi:10.2174/138161208784007653. PMID 18393881.
^N. Das (2010). "Codrug: An efficient approach for drug optimization". European Journal of Pharmaceutical Sciences. 41 (5): 571–588. doi:10.1016/j.ejps.2010.09.014. PMID 20888411.
codrug, polysubstance, drugs, that, chemically, linked, together, combination, drug, this, article, missing, information, about, things, that, blur, line, with, ordinary, combination, meds, salts, such, dimenhydrinate, linked, ionic, bond, crystals, held, toge. For use polysubstance use of drugs that are not chemically linked together see Combination drug This article is missing information about things that blur the line with ordinary combination meds co salts such as dimenhydrinate linked via an ionic bond co crystals held together by H bonds Please expand the article to include this information Further details may exist on the talk page December 2022 A codrug or mutual prodrug consists of two synergistic drugs chemically linked together to a single molecule in order to improve the drug delivery properties of one or both drugs 1 2 An effective codrug should be pharmacologically inactive in its own right but should release the constituent drugs upon biochemical breakage of the chemical linkage at the target tissue where their therapeutic effects are needed As such the chemical linkage usually a covalent bond should be subjectable to biodegradation such as hydrolysis by an enzymatic or non enzymatic mechanism The differential distribution of enzymes capable of catalyzing the breakage of the chemical linkage in different tissues may be exploited to achieve tissue specific metabolism of the codrug to release the constituent drugs The constituent drugs are indicated for the same disease but may exert different therapeutic effects via disparate mechanisms of action Motivation editThis section does not cite any sources Please help improve this section by adding citations to reliable sources Unsourced material may be challenged and removed December 2022 Learn how and when to remove this template message Development of Anticancer Codrugs 3 The disadvantages associated with the co delivery of physically combined chemotherapeutic drugs agents often suffer from poor solubility less membrane permeability unimproved bioavailability as well as poor selectivity for the targeted cells Simply we can say that physically combine drugs always struggles with less improved pharmacokinetic properties Where selectivity is a major issue in the complex environment of a targeted cell Several codrugs reported in the literature for the anticancer drug delivery with improved pharmacokinetic properties may provide ideas to the pharmaceutical scientist for further drug development in various diseases Codrug of butyric acid and ATRA Codrug of ATRA and histone deacetylase inhibitors 5 Fluorouracil 5 FU and cytarabine Ara C codrug Paclitaxel and captopril codrug 5 Fluorouracil and diazeniumdiolate codrug Common codrugs editSee also Combination drug Common combination drugs and Synergy Drug synergy Benorylate esterified paracetamol and acetylsalicylic acid Cod THC THC linked to codeine by a carbonate bridge Fenethylline amphetamine chemically linked with theophylline Lisdexamfetamine a substituted amphetamine with an amide linkage formed by the condensation of dextroamphetamine with the carboxylate group of the essential amino acid L lysine 3 dubious discuss Sulfasalazine sulfapyridine chemically linked to 5 aminosalicylic acid coupled with an azo linkage It is on the World Health Organization s List of Essential Medicines Sultamicillin esterified ampicillin sulbactam References edit W M Lau 2008 Scope and Limitations of the Co Drug Approach to Topical Drug Delivery Current Pharmaceutical Design 14 8 794 802 doi 10 2174 138161208784007653 PMID 18393881 N Das 2010 Codrug An efficient approach for drug optimization European Journal of Pharmaceutical Sciences 41 5 571 588 doi 10 1016 j ejps 2010 09 014 PMID 20888411 Blick SK Keating GM 2007 Lisdexamfetamine Paediatric Drugs 9 2 129 135 discussion 136 138 doi 10 2165 00148581 200709020 00007 PMID 17407369 S2CID 260863254 nbsp This pharmacology related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Codrug amp oldid 1182784992, wikipedia, wiki, book, books, library,
