Class I PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that possess a common protein domain structure, substrate specificity, and method of activation. Class I PI 3-kinases are further divided into two subclasses, class IA PI 3-kinases and class IB PI 3-kinases.
Stein RC (September 2001). . Endocr. Relat. Cancer. 8 (3): 237–48. CiteSeerX10.1.1.324.8135. doi:10.1677/erc.0.0080237. PMID 11566615. S2CID 568427. Archived from the original on 2008-05-21. Retrieved 2008-09-24.
Foster FM, Traer CJ, Abraham SM, Fry MJ (August 2003). "The phosphoinositide (PI) 3-kinase family". J. Cell Sci. 116 (Pt 15): 3037–40. doi:10.1242/jcs.00609. PMID 12829733.
Vanhaesebroeck B, Waterfield MD (November 1999). (PDF). Exp. Cell Res. 253 (1): 239–54. doi:10.1006/excr.1999.4701. PMID 10579926. Archived from the original (PDF) on January 2, 2006.
class, kinases, subgroup, enzyme, family, phosphoinositide, kinase, that, possess, common, protein, domain, structure, substrate, specificity, method, activation, further, divided, into, subclasses, class, kinases, class, kinases, contents, class, kinases, cla. Class I PI 3 kinases are a subgroup of the enzyme family phosphoinositide 3 kinase that possess a common protein domain structure substrate specificity and method of activation Class I PI 3 kinases are further divided into two subclasses class IA PI 3 kinases and class IB PI 3 kinases Contents 1 Class IA PI 3 kinases 2 Class IB PI 3 kinases 3 See also 4 ReferencesClass IA PI 3 kinases editClass IA PI 3 kinases are activated by receptor tyrosine kinases RTKs There are three catalytic subunits that are classified as class IA PI 3 kinases citation needed p110a p110b p110dThere are currently five regulatory subunits that are known to associate with class IA PI 3 kinases catalytic subunits citation needed p85a and p85b p55a and p55g p50aClass IB PI 3 kinases editClass IB PI 3 kinases are activated by G protein coupled receptors GPCRs The only known class IB PI 3 kinase catalytic subunit is p110g There are two known regulatory subunits for p110g p101 p84 p87PIKAP See also editPhosphoinositide 3 kinase Class I Phosphoinositide 3 kinase inhibitorReferences editStein RC September 2001 Prospects for phosphoinositide 3 kinase inhibition as a cancer treatment Endocr Relat Cancer 8 3 237 48 CiteSeerX 10 1 1 324 8135 doi 10 1677 erc 0 0080237 PMID 11566615 S2CID 568427 Archived from the original on 2008 05 21 Retrieved 2008 09 24 Foster FM Traer CJ Abraham SM Fry MJ August 2003 The phosphoinositide PI 3 kinase family J Cell Sci 116 Pt 15 3037 40 doi 10 1242 jcs 00609 PMID 12829733 Vanhaesebroeck B Waterfield MD November 1999 Signaling by distinct classes of phosphoinositide 3 kinases PDF Exp Cell Res 253 1 239 54 doi 10 1006 excr 1999 4701 PMID 10579926 Archived from the original PDF on January 2 2006 Portal nbsp Biology This EC 2 7 enzyme related article is a stub You can help Wikipedia by expanding it vte nbsp This cell biology article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Class I PI 3 kinases amp oldid 1185202857, wikipedia, wiki, book, books, library,
