Centromere-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centromere-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000138778 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000045328 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Testa JR, Zhou JY, Bell DW, Yen TJ (Mar 1995). "Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24→q25 and 1q32→q41, respectively, by fluorescence in situ hybridization". Genomics. 23 (3): 691–3. doi:10.1006/geno.1994.1558. PMID 7851898.
^ ab"Entrez Gene: CENPE centromere protein E, 312kDa".
Yen TJ, Li G, Schaar BT, Szilak I, Cleveland DW (1992). "CENP-E is a putative kinetochore motor that accumulates just before mitosis". Nature. 359 (6395): 536–9. Bibcode:1992Natur.359..536Y. doi:10.1038/359536a0. PMID 1406971. S2CID 4306312.
Yen TJ, Compton DA, Wise D, Zinkowski RP, Brinkley BR, Earnshaw WC, et al. (1991). "CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase". EMBO J. 10 (5): 1245–54. doi:10.1002/j.1460-2075.1991.tb08066.x. PMC452779. PMID 2022189.
Thrower DA, Jordan MA, Schaar BT, Yen TJ, Wilson L (1995). "Mitotic HeLa cells contain a CENP-E-associated minus end-directed microtubule motor". EMBO J. 14 (5): 918–26. doi:10.1002/j.1460-2075.1995.tb07073.x. PMC398164. PMID 7889940.
Wood KW, Sakowicz R, Goldstein LS, Cleveland DW (1997). "CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment". Cell. 91 (3): 357–66. doi:10.1016/S0092-8674(00)80419-5. PMID 9363944. S2CID 12216144.
Cooke CA, Schaar B, Yen TJ, Earnshaw WC (1998). "Localization of CENP-E in the fibrous corona and outer plate of mammalian kinetochores from prometaphase through anaphase". Chromosoma. 106 (7): 446–55. doi:10.1007/s004120050266. PMID 9391217. S2CID 18884489.
Zecevic M, Catling AD, Eblen ST, Renzi L, Hittle JC, Yen TJ, et al. (1998). "Active MAP kinase in mitosis: localization at kinetochores and association with the motor protein CENP-E". J. Cell Biol. 142 (6): 1547–58. doi:10.1083/jcb.142.6.1547. PMC2141767. PMID 9744883.
Chan GK, Schaar BT, Yen TJ (1998). "Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1". J. Cell Biol. 143 (1): 49–63. doi:10.1083/jcb.143.1.49. PMC2132809. PMID 9763420.
Chan GK, Jablonski SA, Sudakin V, Hittle JC, Yen TJ (1999). "Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC". J. Cell Biol. 146 (5): 941–54. doi:10.1083/jcb.146.5.941. PMC2169490. PMID 10477750.
Ashar HR, James L, Gray K, Carr D, Black S, Armstrong L, et al. (2000). "Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules". J. Biol. Chem. 275 (39): 30451–7. doi:10.1074/jbc.M003469200. PMID 10852915.
Uren AG, Wong L, Pakusch M, Fowler KJ, Burrows FJ, Vaux DL, et al. (2001). "Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype". Curr. Biol. 10 (21): 1319–28. Bibcode:2000CBio...10.1319U. doi:10.1016/S0960-9822(00)00769-7. PMID 11084331. S2CID 18455745.
Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC311086. PMID 11337467.
Liu ST, Chan GK, Hittle JC, Fujii G, Lees E, Yen TJ (2003). "Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores". Mol. Biol. Cell. 14 (4): 1638–51. doi:10.1091/mbc.02-05-0074. PMC153128. PMID 12686615.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Garcia-Saez I, Blot D, Kahn R, Kozielski F (2005). "Crystallization and preliminary crystallographic analysis of the motor domain of human kinetochore-associated protein CENP-E using an automated crystallization procedure". Acta Crystallogr. D. 60 (Pt 6): 1158–60. doi:10.1107/S0907444904009564. PMID 15159587.
Tanudji M, Shoemaker J, L'Italien L, Russell L, Chin G, Schebye XM (2005). "Gene silencing of CENP-E by small interfering RNA in HeLa cells leads to missegregation of chromosomes after a mitotic delay". Mol. Biol. Cell. 15 (8): 3771–81. doi:10.1091/mbc.E03-07-0482. PMC491836. PMID 15181147.
Garcia-Saez I, Yen T, Wade RH, Kozielski F (2004). "Crystal structure of the motor domain of the human kinetochore protein CENP-E". J. Mol. Biol. 340 (5): 1107–16. doi:10.1016/j.jmb.2004.05.053. PMID 15236970.
Kurasawa Y, Earnshaw WC, Mochizuki Y, Dohmae N, Todokoro K (2005). "Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation". EMBO J. 23 (16): 3237–48. doi:10.1038/sj.emboj.7600347. PMC514520. PMID 15297875.
Mao Y, Desai A, Cleveland DW (2005). "Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling". J. Cell Biol. 170 (6): 873–80. doi:10.1083/jcb.200505040. PMC2171436. PMID 16144904.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC1459365. PMID 16565220.
This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.
centromere, protein, centromere, associated, protein, protein, that, humans, encoded, cenpe, gene, cenpeavailable, structurespdbortholog, search, pdbe, rcsblist, codes1t5cidentifiersaliasescenpe, cenp, kif10, ppp1r61, mcph13, external, idsomim, 117143, 1098230. Centromere associated protein E is a protein that in humans is encoded by the CENPE gene 5 6 CENPEAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes1T5CIdentifiersAliasesCENPE CENP E KIF10 PPP1R61 MCPH13 Centromere protein EExternal IDsOMIM 117143 MGI 1098230 HomoloGene 20429 GeneCards CENPEGene location Human Chr Chromosome 4 human 1 Band4q24Start103 105 349 bp 1 End103 198 445 bp 1 Gene location Mouse Chr Chromosome 3 mouse 2 Band3 G3 3 62 55 cMStart134 918 298 bp 2 End134 979 372 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inoocytesecondary oocyteganglionic eminencespongy bonebone marrowstromal cell of endometriumbone marrow cellsrectumappendixAchilles tendonTop expressed insecondary oocytemaxillary prominenceabdominal wallvas deferensmorularenal corpuscledermisPaneth cellprimitive streakcondyleMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionnucleotide binding ATPase activity ATP binding protein binding microtubule motor activity microtubule binding kinetochore bindingCellular componentspindle kinesin complex chromosome nucleus outer kinetochore chromosome centromeric region membrane midbody microtubule kinetochore condensed chromosome centromeric region microtubule cytoskeleton mitotic spindle midzone cytoskeleton cytoplasm cytosol kinetochore microtubule nucleoplasm spindle midzoneBiological processregulation of mitotic metaphase anaphase transition cell cycle positive regulation of protein kinase activity multicellular organism development cell division antigen processing and presentation of exogenous peptide antigen via MHC class II kinetochore assembly microtubule based movement sister chromatid cohesion retrograde vesicle mediated transport Golgi to endoplasmic reticulum metaphase plate congression lateral attachment of mitotic spindle microtubules to kinetochore mitotic cell cycle mitotic spindle organization mitotic chromosome movement towards spindle pole microtubule plus end directed mitotic chromosome migration chromosome segregation mitotic metaphase plate congression attachment of mitotic spindle microtubules to kinetochoreSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1062229841EnsemblENSG00000138778ENSMUSG00000045328UniProtQ02224Q6RT24RefSeq mRNA NM 001286734NM 001813NM 173762RefSeq protein NP 001273663NP 001804NP 776123Location UCSC Chr 4 103 11 103 2 MbChr 3 134 92 134 98 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseCentromere associated protein E is a kinesin like motor protein that accumulates in the G2 phase of the cell cycle Unlike other centromere associated proteins it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and or spindle elongation 6 CENPE is also called Kinesin 7 Contents 1 Clinical significance 2 See also 3 References 4 Further readingClinical significance editMutations in CENPE result in autosomal recessive primary microcephaly type 13 which includes skeletal abnormalities and immunodeficiency 7 See also editCENPF CENPJ CENPTReferences edit a b c GRCh38 Ensembl release 89 ENSG00000138778 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000045328 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Testa JR Zhou JY Bell DW Yen TJ Mar 1995 Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24 q25 and 1q32 q41 respectively by fluorescence in situ hybridization Genomics 23 3 691 3 doi 10 1006 geno 1994 1558 PMID 7851898 a b Entrez Gene CENPE centromere protein E 312kDa OMIM Entry 616051 MICROCEPHALY 13 PRIMARY AUTOSOMAL RECESSIVE MCPH13 www omim org Retrieved 2020 01 25 Further reading editYen TJ Li G Schaar BT Szilak I Cleveland DW 1992 CENP E is a putative kinetochore motor that accumulates just before mitosis Nature 359 6395 536 9 Bibcode 1992Natur 359 536Y doi 10 1038 359536a0 PMID 1406971 S2CID 4306312 Yen TJ Compton DA Wise D Zinkowski RP Brinkley BR Earnshaw WC et al 1991 CENP E a novel human centromere associated protein required for progression from metaphase to anaphase EMBO J 10 5 1245 54 doi 10 1002 j 1460 2075 1991 tb08066 x PMC 452779 PMID 2022189 Thrower DA Jordan MA Schaar BT Yen TJ Wilson L 1995 Mitotic HeLa cells contain a CENP E associated minus end directed microtubule motor EMBO J 14 5 918 26 doi 10 1002 j 1460 2075 1995 tb07073 x PMC 398164 PMID 7889940 Wood KW Sakowicz R Goldstein LS Cleveland DW 1997 CENP E is a plus end directed kinetochore motor required for metaphase chromosome alignment Cell 91 3 357 66 doi 10 1016 S0092 8674 00 80419 5 PMID 9363944 S2CID 12216144 Cooke CA Schaar B Yen TJ Earnshaw WC 1998 Localization of CENP E in the fibrous corona and outer plate of mammalian kinetochores from prometaphase through anaphase Chromosoma 106 7 446 55 doi 10 1007 s004120050266 PMID 9391217 S2CID 18884489 Zecevic M Catling AD Eblen ST Renzi L Hittle JC Yen TJ et al 1998 Active MAP kinase in mitosis localization at kinetochores and association with the motor protein CENP E J Cell Biol 142 6 1547 58 doi 10 1083 jcb 142 6 1547 PMC 2141767 PMID 9744883 Chan GK Schaar BT Yen TJ 1998 Characterization of the kinetochore binding domain of CENP E reveals interactions with the kinetochore proteins CENP F and hBUBR1 J Cell Biol 143 1 49 63 doi 10 1083 jcb 143 1 49 PMC 2132809 PMID 9763420 Chan GK Jablonski SA Sudakin V Hittle JC Yen TJ 1999 Human BUBR1 is a mitotic checkpoint kinase that monitors CENP E functions at kinetochores and binds the cyclosome APC J Cell Biol 146 5 941 54 doi 10 1083 jcb 146 5 941 PMC 2169490 PMID 10477750 Ashar HR James L Gray K Carr D Black S Armstrong L et al 2000 Farnesyl transferase inhibitors block the farnesylation of CENP E and CENP F and alter the association of CENP E with the microtubules J Biol Chem 275 39 30451 7 doi 10 1074 jbc M003469200 PMID 10852915 Uren AG Wong L Pakusch M Fowler KJ Burrows FJ Vaux DL et al 2001 Survivin and the inner centromere protein INCENP show similar cell cycle localization and gene knockout phenotype Curr Biol 10 21 1319 28 Bibcode 2000CBio 10 1319U doi 10 1016 S0960 9822 00 00769 7 PMID 11084331 S2CID 18455745 Suzuki Y Tsunoda T Sese J Taira H Mizushima Sugano J Hata H et al 2001 Identification and characterization of the potential promoter regions of 1031 kinds of human genes Genome Res 11 5 677 84 doi 10 1101 gr gr 1640r PMC 311086 PMID 11337467 Liu ST Chan GK Hittle JC Fujii G Lees E Yen TJ 2003 Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP E from kinetochores Mol Biol Cell 14 4 1638 51 doi 10 1091 mbc 02 05 0074 PMC 153128 PMID 12686615 Brandenberger R Wei H Zhang S Lei S Murage J Fisk GJ et al 2005 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation Nat Biotechnol 22 6 707 16 doi 10 1038 nbt971 PMID 15146197 S2CID 27764390 Garcia Saez I Blot D Kahn R Kozielski F 2005 Crystallization and preliminary crystallographic analysis of the motor domain of human kinetochore associated protein CENP E using an automated crystallization procedure Acta Crystallogr D 60 Pt 6 1158 60 doi 10 1107 S0907444904009564 PMID 15159587 Tanudji M Shoemaker J L Italien L Russell L Chin G Schebye XM 2005 Gene silencing of CENP E by small interfering RNA in HeLa cells leads to missegregation of chromosomes after a mitotic delay Mol Biol Cell 15 8 3771 81 doi 10 1091 mbc E03 07 0482 PMC 491836 PMID 15181147 Garcia Saez I Yen T Wade RH Kozielski F 2004 Crystal structure of the motor domain of the human kinetochore protein CENP E J Mol Biol 340 5 1107 16 doi 10 1016 j jmb 2004 05 053 PMID 15236970 Kurasawa Y Earnshaw WC Mochizuki Y Dohmae N Todokoro K 2005 Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation EMBO J 23 16 3237 48 doi 10 1038 sj emboj 7600347 PMC 514520 PMID 15297875 Mao Y Desai A Cleveland DW 2005 Microtubule capture by CENP E silences BubR1 dependent mitotic checkpoint signaling J Cell Biol 170 6 873 80 doi 10 1083 jcb 200505040 PMC 2171436 PMID 16144904 Nousiainen M Sillje HH Sauer G Nigg EA Korner R 2006 Phosphoproteome analysis of the human mitotic spindle Proc Natl Acad Sci U S A 103 14 5391 6 Bibcode 2006PNAS 103 5391N doi 10 1073 pnas 0507066103 PMC 1459365 PMID 16565220 nbsp This article on a gene on human chromosome 4 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Centromere protein E amp oldid 1215571625, wikipedia, wiki, book, books, library,
