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Casper Hoogenraad

January 01, 1970

Casper Hoogenraad is a Dutch Cell Biologist who specializes in molecular neuroscience. The focus of his research is the basic molecular and cellular mechanisms that regulate the development and function of the brain. As of January 2020, he serves as Vice President of Neuroscience at Genentech Research and Early Development.

Casper Hoogenraad
Born (1973-01-31) January 31, 1973 (age 51)
Delft, The Netherlands
NationalityDutch
CitizenshipThe Netherlands
Alma mater
Known forMolecular Neuroscience
Scientific career
FieldsNeuroscience
Institutions
Doctoral advisorFrank Grosveld, Chris De Zeeuw
Other academic advisorsMorgan Sheng
Websitehttps://www.gene.com/scientists/our-scientists/casper-hoogenraad

Biography and academic career edit

Casper Hoogenraad was born in 1973 in Delft and grew up in Gouda, in The Netherlands. He received his B.S. in Biochemistry and M.S. in Molecular Biology from Utrecht University, and his doctorate in Cell Biology from the Erasmus University Rotterdam.[1] In 2002, Hoogenraad started his post-doctoral research at Massachusetts Institute of Technology in Cambridge, USA. In 2005, he returned to the Netherlands and joined the faculty of the Erasmus University Medical Center in Rotterdam as Associate Professor in the Department of Neuroscience. In 2011 he joined Utrecht University as full Professor of Molecular Neuroscience, and served as Chair of Cell Biology, Neurobiology and Biophysics for 10 years.[2] He is Adjunct Professor in Department of Biochemistry and Biophysics at University of California, San Francisco (UCSF).[3]

During his career, he discovered molecular mechanisms and cell biological processes that control cytoskeleton remodeling and cargo trafficking during the development and function of the brain. Hoogenraad published over 250 research articles, reviews and books, focused on synaptic function [4] [5] [6] [7] dendritic spine plasticity [8] [9] [10] [11] neuronal polarity [12] [13] [14] [15] organelle sorting mechanisms [16] [17] [18] [19] [20] the axon initial segment [21] [22] [23] [24] [25] cytoskeleton remodeling [26] [27] [28] [29] microtubule dynamics [30] [31] [32] [33] [34] fundamental transport mechanisms [35] [36] [37] [38] [39] axon regeneration [40] [41] and neurodegeneration.[42][43][44][45] See for full publication record - Pubmed,[46] Google Scholar,[47] ORCID[48]

Industrial career edit

Hoogenraad was recruited to Genentech, a member of the Roche Group, as Senior Fellow and head of Neuroscience.[49] As of January 2020, he is Vice President of Neuroscience at Genentech Research and Early Development.[50] In this role, he is Head of the Neuroscience Department, responsible for research and drug discovery activities in Neuroscience and oversees Genentech’s Neuroscience disease pipeline programs. He is also responsible for Translational Neuroscience, Neuroscience Stem Cell group, Department of Translational Imaging, and Department of Molecular Biology.

Honors and Awards edit

He is an elected member of the European Molecular Biology Organization,[51] The Young Academy’ of the Royal Netherlands Academy of Sciences,[52] Young Academy of Europe [53] and the Editorial Board of Neuron[54] and The EMBO Journal.[55] In 2016 he became the 10th recipient of the IBRO-Kemali Prize, in the field of basic and clinical Neuroscience.[56] Some of his awards: NWO Talent stipendium, Human Frontiers Long-Term Fellowship, European Younng Investigators (EURYI) award, Dutch Innovational Research VIDI and VICI, European Research Council (ERC) - consolidator grant.

Science outreach edit

In 2013, his laboratory made an animation movie, named 'A Day in the Life of a Motor Protein', which has received >1 million views on youtube.[57] During this short five-minute movie, we follow John, a motor protein, who has to transport a large package through the narrow streets in the city of Utrecht, illustrating the importance and challenges of intracellular transport.

References edit

  1. ^ PhD thesis. 12 September 2001. ISBN 978-90-77017-07-4. {{cite book}}: |newspaper= ignored (help)
  2. ^ "Utrecht lab". UU, Utrecht University. 20 December 2023.
  3. ^ "UCSF lab".
  4. ^ Sheng M, Hoogenraad CC (2007). "The postsynaptic architecture of excitatory synapses: a more quantitative view". Annu Rev Biochem. 76: 823–47. doi:10.1146/annurev.biochem.76.060805.160029. PMID 17243894.
  5. ^ Hoogenraad CC, Milstein AD, Ethell IM, Henkemeyer M, Sheng M (2005). "GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking". Nat Neurosci. 8 (7): 906–15. doi:10.1038/nn1487. PMID 15965473. S2CID 23686585.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  6. ^ Hoogenraad CC, Popa I, Futai K, Martinez-Sanchez E, Wulf PS, van Vlijmen T; et al. (2010). "Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes". PLOS Biol. 8 (1): e1000283. doi:10.1371/journal.pbio.1000283. PMC 2808209. PMID 20098723.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  7. ^ Lindhout FW, Cao Y, Kevenaar JT, Bodzęta A, Stucchi R, Boumpoutsari MM; et al. (2019). "VAP-SCRN1 interaction regulates dynamic endoplasmic reticulum remodeling and presynaptic function". EMBO J. 38 (20): e101345. doi:10.15252/embj.2018101345. PMC 6792018. PMID 31441084.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  8. ^ Jaworski J, Kapitein LC, Gouveia SM, Dortland BR, Wulf PS, Grigoriev I; et al. (2009). "Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity". Neuron. 61 (1): 85–100. doi:10.1016/j.neuron.2008.11.013. PMID 19146815.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  9. ^ Hotulainen P, Hoogenraad CC (2010). "Actin in dendritic spines: connecting dynamics to function". J Cell Biol. 189 (4): 619–29. doi:10.1083/jcb.201003008. PMC 2872912. PMID 20457765.
  10. ^ Esteves da Silva M, Adrian M, Schätzle P, Lipka J, Watanabe T, Cho S; et al. (2015). "Positioning of AMPA Receptor-Containing Endosomes Regulates Synapse Architecture". Cell Rep. 13 (5): 933–43. doi:10.1016/j.celrep.2015.09.062. PMID 26565907.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  11. ^ Schätzle P, Esteves da Silva M, Tas RP, Katrukha EA, Hu HY, Wierenga CJ; et al. (2018). "Activity-Dependent Actin Remodeling at the Base of Dendritic Spines Promotes Microtubule Entry". Curr Biol. 28 (13): 2081–2093.e6. Bibcode:2018CBio...28E2081S. doi:10.1016/j.cub.2018.05.004. PMID 29910073.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  12. ^ Kuijpers M, van de Willige D, Freal A, Chazeau A, Franker MA, Hofenk J; et al. (2016). "Dynein Regulator NDEL1 Controls Polarized Cargo Transport at the Axon Initial Segment". Neuron. 89 (3): 461–71. doi:10.1016/j.neuron.2016.01.022. PMID 26844830.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  13. ^ Franker MA, Esteves da Silva M, Tas RP, Tortosa E, Cao Y, Frias CP; et al. (2016). "Three-Step Model for Polarized Sorting of KIF17 into Dendrites". Curr Biol. 26 (13): 1705–1712. Bibcode:2016CBio...26.1705F. doi:10.1016/j.cub.2016.04.057. PMID 27265394.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  14. ^ Tortosa E, Adolfs Y, Fukata M, Pasterkamp RJ, Kapitein LC, Hoogenraad CC (2017). "Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization". Neuron. 94 (4): 809–825.e7. doi:10.1016/j.neuron.2017.04.042. PMID 28521134.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  15. ^ Farías GG, Fréal A, Tortosa E, Stucchi R, Pan X, Portegies S; et al. (2019). "Feedback-Driven Mechanisms between Microtubules and the Endoplasmic Reticulum Instruct Neuronal Polarity". Neuron. 102 (1): 184–201.e8. doi:10.1016/j.neuron.2019.01.030. PMID 30772082.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  16. ^ van Spronsen M, Mikhaylova M, Lipka J, Schlager MA, van den Heuvel DJ, Kuijpers M; et al. (2013). "TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites". Neuron. 77 (3): 485–502. doi:10.1016/j.neuron.2012.11.027. PMID 23395375.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  17. ^ Lipka J, Kapitein LC, Jaworski J, Hoogenraad CC (2016). "Microtubule-binding protein doublecortin-like kinase 1 (DCLK1) guides kinesin-3-mediated cargo transport to dendrites". EMBO J. 35 (3): 302–18. doi:10.15252/embj.201592929. PMC 4741305. PMID 26758546.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  18. ^ Gumy LF, Katrukha EA, Grigoriev I, Jaarsma D, Kapitein LC, Akhmanova A; et al. (2017). "MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons". Neuron. 94 (2): 347–362.e7. doi:10.1016/j.neuron.2017.03.046. PMID 28426968.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  19. ^ Pan X, Cao Y, Stucchi R, Hooikaas PJ, Portegies S, Will L; et al. (2019). "MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon". Cell Rep. 26 (8): 1988–1999.e6. doi:10.1016/j.celrep.2019.01.084. PMC 6381606. PMID 30784582.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  20. ^ Zahavi EE, Hummel JJA, Han Y, Bar C, Stucchi R, Altelaar M; et al. (2021). "Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers". Dev Cell. 56 (4): 494–508.e7. doi:10.1016/j.devcel.2021.01.010. PMC 7907685. PMID 33571451.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  21. ^ van Beuningen SFB, Will L, Harterink M, Chazeau A, van Battum EY, Frias CP; et al. (2015). "TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays". Neuron. 88 (6): 1208–1226. doi:10.1016/j.neuron.2015.11.012. PMID 26671463.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  22. ^ Fréal A, Fassier C, Le Bras B, Bullier E, De Gois S, Hazan J; et al. (2016). "Cooperative Interactions between 480 kDa Ankyrin-G and EB Proteins Assemble the Axon Initial Segment". J Neurosci. 36 (16): 4421–33. doi:10.1523/JNEUROSCI.3219-15.2016. PMC 6601828. PMID 27098687.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  23. ^ Janssen AFJ, Tas RP, van Bergeijk P, Oost R, Hoogenraad CC, Kapitein LC (2017). "Myosin-V Induces Cargo Immobilization and Clustering at the Axon Initial Segment". Front Cell Neurosci. 11: 260. doi:10.3389/fncel.2017.00260. PMC 5581344. PMID 28894417.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  24. ^ Fréal A, Rai D, Tas RP, Pan X, Katrukha EA, van de Willige D; et al. (2019). "Feedback-Driven Assembly of the Axon Initial Segment". Neuron. 104 (2): 305–321.e8. doi:10.1016/j.neuron.2019.07.029. PMC 6839619. PMID 31474508.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  25. ^ Özkan N, Koppers M, van Soest I, van Harten A, Jurriens D, Liv N; et al. (2021). "ER - lysosome contacts at a pre-axonal region regulate axonal lysosome availability". Nature Communications. 12 (1): 4493. Bibcode:2021NatCo..12.4493O. doi:10.1038/s41467-021-24713-5. PMC 8302662. PMID 34301956.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  26. ^ Stiess M, Maghelli N, Kapitein LC, Gomis-Rüth S, Wilsch-Bräuninger M, Hoogenraad CC; et al. (2010). "Axon extension occurs independently of centrosomal microtubule nucleation". Science. 327 (5966): 704–7. Bibcode:2010Sci...327..704S. doi:10.1126/science.1182179. PMID 20056854.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  27. ^ Kapitein LC, Hoogenraad CC (2015) Building the Neuronal Microtubule Cytoskeleton. Neuron 87 (3):492-506. DOI:10.1016/j.neuron.2015.05.046 PMID: 26247859
  28. ^ Harterink M, da Silva ME, Will L, Turan J, Ibrahim A, Lang AE; et al. (2017). "DeActs: genetically encoded tools for perturbing the actin cytoskeleton in single cells". Nat Methods. 14 (5): 479–482. doi:10.1038/nmeth.4257. PMC 5419720. PMID 28394337.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  29. ^ Lindhout FW, Portegies S, Kooistra R, Herstel LJ, Stucchi R, Hummel JJA; et al. (2021). "Centrosome-mediated microtubule remodeling during axon formation in human iPSC-derived neurons". EMBO J. 40 (10): e106798. doi:10.15252/embj.2020106798. PMC 8126955. PMID 33835529.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  30. ^ Akhmanova A, Hoogenraad CC, Drabek K, Stepanova T, Dortland B, Verkerk T; et al. (2001). "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts". Cell. 104 (6): 923–35. doi:10.1016/s0092-8674(01)00288-4. PMID 11290329.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  31. ^ Stepanova T, Slemmer J, Hoogenraad CC, Lansbergen G, Dortland B, De Zeeuw CI; et al. (2003). "Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein)". J Neurosci. 23 (7): 2655–64. doi:10.1523/JNEUROSCI.23-07-02655.2003. PMC 6742099. PMID 12684451.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  32. ^ Yau KW, van Beuningen SF, Cunha-Ferreira I, Cloin BM, van Battum EY, Will L; et al. (2014). "Microtubule minus-end binding protein CAMSAP2 controls axon specification and dendrite development". Neuron. 82 (5): 1058–73. doi:10.1016/j.neuron.2014.04.019. PMID 24908486.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  33. ^ Yau KW, Schätzle P, Tortosa E, Pagès S, Holtmaat A, Kapitein LC; et al. (2016). "Dendrites In Vitro and In Vivo Contain Microtubules of Opposite Polarity and Axon Formation Correlates with Uniform Plus-End-Out Microtubule Orientation". J Neurosci. 36 (4): 1071–85. doi:10.1523/JNEUROSCI.2430-15.2016. PMC 4728718. PMID 26818498.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  34. ^ Cunha-Ferreira I, Chazeau A, Buijs RR, Stucchi R, Will L, Pan X; et al. (2018). "The HAUS Complex Is a Key Regulator of Non-centrosomal Microtubule Organization during Neuronal Development". Cell Rep. 24 (4): 791–800. doi:10.1016/j.celrep.2018.06.093. PMC 6083040. PMID 30044976.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  35. ^ Hoogenraad CC, Akhmanova A, Howell SA, Dortland BR, De Zeeuw CI, Willemsen R; et al. (2001). "Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes". EMBO J. 20 (15): 4041–54. doi:10.1093/emboj/20.15.4041. PMC 149157. PMID 11483508.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  36. ^ Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T; et al. (2002). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nat Cell Biol. 4 (12): 986–92. doi:10.1038/ncb891. PMID 12447383. S2CID 7953140.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  37. ^ van Bergeijk P, Adrian M, Hoogenraad CC, Kapitein LC (2015). "Optogenetic control of organelle transport and positioning". Nature. 518 (7537): 111–114. Bibcode:2015Natur.518..111V. doi:10.1038/nature14128. PMC 5063096. PMID 25561173.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  38. ^ Kevenaar JT, Bianchi S, van Spronsen M, Olieric N, Lipka J, Frias CP; et al. (2016). "Kinesin-Binding Protein Controls Microtubule Dynamics and Cargo Trafficking by Regulating Kinesin Motor Activity". Curr Biol. 26 (7): 849–61. Bibcode:2016CBio...26..849K. doi:10.1016/j.cub.2016.01.048. PMID 26948876.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  39. ^ Hummel JJA, Hoogenraad CC (2021). "Inducible manipulation of motor-cargo interaction using engineered kinesin motors". J Cell Sci. 134 (15). doi:10.1242/jcs.258776. PMC 8353518. PMID 34342354.
  40. ^ Erez H, Malkinson G, Prager-Khoutorsky M, De Zeeuw CI, Hoogenraad CC, Spira ME (2007). "Formation of microtubule-based traps controls the sorting and concentration of vesicles to restricted sites of regenerating neurons after axotomy". J Cell Biol. 176 (4): 497–507. doi:10.1083/jcb.200607098. PMC 2063984. PMID 17283182.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  41. ^ Hellal F, Hurtado A, Ruschel J, Flynn KC, Laskowski CJ, Umlauf M; et al. (2011). "Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury". Science. 331 (6019): 928–31. Bibcode:2011Sci...331..928H. doi:10.1126/science.1201148. PMC 3330754. PMID 21273450.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  42. ^ Teuling E, Ahmed S, Haasdijk E, Demmers J, Steinmetz MO, Akhmanova A; et al. (2007). "Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates". J Neurosci. 27 (36): 9801–15. doi:10.1523/JNEUROSCI.2661-07.2007. PMC 6672975. PMID 17804640.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  43. ^ Kuijpers M, Yu KL, Teuling E, Akhmanova A, Jaarsma D, Hoogenraad CC (2013). "The ALS8 protein VAPB interacts with the ER-Golgi recycling protein YIF1A and regulates membrane delivery into dendrites". EMBO J. 32 (14): 2056–72. doi:10.1038/emboj.2013.131. PMC 3715857. PMID 23736259.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  44. ^ Tortosa E, Sengupta Ghosh A, Li Q, Wong WR, Hinkle T, Sandoval W; et al. (2022). "Stress-induced vesicular assemblies of dual leucine zipper kinase are signaling hubs involved in kinase activation and neurodegeneration". EMBO J. 41 (14): e110155. doi:10.15252/embj.2021110155. PMC 9289706. PMID 35611591.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  45. ^ Adrian M, Weber M, Tsai MC, Glock C, Kahn OI, Phu L; et al. (2023). "Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release". Nat Commun. 14 (1): 6322. Bibcode:2023NatCo..14.6322A. doi:10.1038/s41467-023-41891-6. PMC 10562429. PMID 37813836.{{cite journal}}: CS1 maint: multiple names: authors list (link)
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  48. ^ "Casper Hoogenraad ORCID profile".
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  51. ^ . EMBO Press. Archived from the original on 2015-12-01.
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  53. ^ "Casper Hoogenraad - YAE". 18 December 2016. Retrieved 2020-08-02.
  54. ^ "Editorial Board: Neuron". Cell Press.
  55. ^ "Editorial Board: The EMBO Journal". EMBO Press.
  56. ^ . IBRO, IBRO, the International Brain Research Organization. Archived from the original on 2015-09-05.
  57. ^ A Day in the Life of a Motor Protein (Youtube). REDRUM, Ede, The Netherlands.

January 01, 1970
casper, hoogenraad, dutch, cell, biologist, specializes, molecular, neuroscience, focus, research, basic, molecular, cellular, mechanisms, that, regulate, development, function, brain, january, 2020, serves, vice, president, neuroscience, genentech, research, . Casper Hoogenraad is a Dutch Cell Biologist who specializes in molecular neuroscience The focus of his research is the basic molecular and cellular mechanisms that regulate the development and function of the brain As of January 2020 he serves as Vice President of Neuroscience at Genentech Research and Early Development Casper HoogenraadBorn 1973 01 31 January 31 1973 age 51 Delft The NetherlandsNationalityDutchCitizenshipThe NetherlandsAlma materUtrecht UniversityErasmus University RotterdamKnown forMolecular NeuroscienceScientific careerFieldsNeuroscienceInstitutionsErasmus UniversityMassachusetts Institute of TechnologyUtrecht UniversityGenentechDoctoral advisorFrank Grosveld Chris De ZeeuwOther academic advisorsMorgan ShengWebsitehttps www gene com scientists our scientists casper hoogenraad Contents 1 Biography and academic career 2 Industrial career 3 Honors and Awards 4 Science outreach 5 ReferencesBiography and academic career editCasper Hoogenraad was born in 1973 in Delft and grew up in Gouda in The Netherlands He received his B S in Biochemistry and M S in Molecular Biology from Utrecht University and his doctorate in Cell Biology from the Erasmus University Rotterdam 1 In 2002 Hoogenraad started his post doctoral research at Massachusetts Institute of Technology in Cambridge USA In 2005 he returned to the Netherlands and joined the faculty of the Erasmus University Medical Center in Rotterdam as Associate Professor in the Department of Neuroscience In 2011 he joined Utrecht University as full Professor of Molecular Neuroscience and served as Chair of Cell Biology Neurobiology and Biophysics for 10 years 2 He is Adjunct Professor in Department of Biochemistry and Biophysics at University of California San Francisco UCSF 3 During his career he discovered molecular mechanisms and cell biological processes that control cytoskeleton remodeling and cargo trafficking during the development and function of the brain Hoogenraad published over 250 research articles reviews and books focused on synaptic function 4 5 6 7 dendritic spine plasticity 8 9 10 11 neuronal polarity 12 13 14 15 organelle sorting mechanisms 16 17 18 19 20 the axon initial segment 21 22 23 24 25 cytoskeleton remodeling 26 27 28 29 microtubule dynamics 30 31 32 33 34 fundamental transport mechanisms 35 36 37 38 39 axon regeneration 40 41 and neurodegeneration 42 43 44 45 See for full publication record Pubmed 46 Google Scholar 47 ORCID 48 Industrial career editHoogenraad was recruited to Genentech a member of the Roche Group as Senior Fellow and head of Neuroscience 49 As of January 2020 he is Vice President of Neuroscience at Genentech Research and Early Development 50 In this role he is Head of the Neuroscience Department responsible for research and drug discovery activities in Neuroscience and oversees Genentech s Neuroscience disease pipeline programs He is also responsible for Translational Neuroscience Neuroscience Stem Cell group Department of Translational Imaging and Department of Molecular Biology Honors and Awards editHe is an elected member of the European Molecular Biology Organization 51 The Young Academy of the Royal Netherlands Academy of Sciences 52 Young Academy of Europe 53 and the Editorial Board of Neuron 54 and The EMBO Journal 55 In 2016 he became the 10th recipient of the IBRO Kemali Prize in the field of basic and clinical Neuroscience 56 Some of his awards NWO Talent stipendium Human Frontiers Long Term Fellowship European Younng Investigators EURYI award Dutch Innovational Research VIDI and VICI European Research Council ERC consolidator grant Science outreach editIn 2013 his laboratory made an animation movie named A Day in the Life of a Motor Protein which has received gt 1 million views on youtube 57 During this short five minute movie we follow John a motor protein who has to transport a large package through the narrow streets in the city of Utrecht illustrating the importance and challenges of intracellular transport References edit PhD thesis 12 September 2001 ISBN 978 90 77017 07 4 a href Template Cite book html title Template Cite book cite book a newspaper ignored help Utrecht lab UU Utrecht University 20 December 2023 UCSF lab Sheng M Hoogenraad CC 2007 The postsynaptic architecture of excitatory synapses a more quantitative view Annu Rev Biochem 76 823 47 doi 10 1146 annurev biochem 76 060805 160029 PMID 17243894 Hoogenraad CC Milstein AD Ethell IM Henkemeyer M Sheng M 2005 GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking Nat Neurosci 8 7 906 15 doi 10 1038 nn1487 PMID 15965473 S2CID 23686585 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Hoogenraad CC Popa I Futai K Martinez Sanchez E Wulf PS van Vlijmen T et al 2010 Neuron specific Rab4 effector GRASP 1 coordinates membrane specialization and maturation of recycling endosomes PLOS Biol 8 1 e1000283 doi 10 1371 journal pbio 1000283 PMC 2808209 PMID 20098723 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Lindhout FW Cao Y Kevenaar JT Bodzeta A Stucchi R Boumpoutsari MM et al 2019 VAP SCRN1 interaction regulates dynamic endoplasmic reticulum remodeling and presynaptic function EMBO J 38 20 e101345 doi 10 15252 embj 2018101345 PMC 6792018 PMID 31441084 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Jaworski J Kapitein LC Gouveia SM Dortland BR Wulf PS Grigoriev I et al 2009 Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity Neuron 61 1 85 100 doi 10 1016 j neuron 2008 11 013 PMID 19146815 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Hotulainen P Hoogenraad CC 2010 Actin in dendritic spines connecting dynamics to function J Cell Biol 189 4 619 29 doi 10 1083 jcb 201003008 PMC 2872912 PMID 20457765 Esteves da Silva M Adrian M Schatzle P Lipka J Watanabe T Cho S et al 2015 Positioning of AMPA Receptor Containing Endosomes Regulates Synapse Architecture Cell Rep 13 5 933 43 doi 10 1016 j celrep 2015 09 062 PMID 26565907 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Schatzle P Esteves da Silva M Tas RP Katrukha EA Hu HY Wierenga CJ et al 2018 Activity Dependent Actin Remodeling at the Base of Dendritic Spines Promotes Microtubule Entry Curr Biol 28 13 2081 2093 e6 Bibcode 2018CBio 28E2081S doi 10 1016 j cub 2018 05 004 PMID 29910073 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Kuijpers M van de Willige D Freal A Chazeau A Franker MA Hofenk J et al 2016 Dynein Regulator NDEL1 Controls Polarized Cargo Transport at the Axon Initial Segment Neuron 89 3 461 71 doi 10 1016 j neuron 2016 01 022 PMID 26844830 a href 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reactive microglia and drives cytokine release Nat Commun 14 1 6322 Bibcode 2023NatCo 14 6322A doi 10 1038 s41467 023 41891 6 PMC 10562429 PMID 37813836 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Casper Hoogenraad Pubmed Casper Hoogenraad Google Scholar profile Casper Hoogenraad ORCID profile ASCB profile ASCB Press Mary Spiro 8 July 2020 Genentech lab Genentech member of the Roche group EMBO member EMBO Press Archived from the original on 2015 12 01 Casper Hoogenraad DJA KNAW Retrieved 2020 08 02 Casper Hoogenraad YAE 18 December 2016 Retrieved 2020 08 02 Editorial Board Neuron Cell Press Editorial Board The EMBO Journal EMBO Press IBRO Kemali Prize IBRO IBRO the International Brain Research Organization Archived from the original on 2015 09 05 A Day in the Life of a Motor Protein Youtube REDRUM Ede The Netherlands Retrieved from https en wikipedia org w index php title Casper Hoogenraad amp oldid 1223444621, 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