Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. In the MEROPS protease enzyme classification system, they are members of clan CA (papain-like proteases).[6] The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks a critical catalytic triad residue in its active site (cysteine nucleophile mutated to lysine) and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis.
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000077274 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000067276 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ . National Center for Biotechnology Information. U.S. National Library of Medicine. Archived from the original on 18 November 2020. Retrieved 2013-03-05.
^"Summary for clan CA". MEROPS. Retrieved 20 December 2021.
This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.
calpain, also, known, calpamodulin, protein, humans, that, encoded, capn6, gene, capn6identifiersaliasescapn6, canpx, capnx, calpm, dj914p14, calpain, calpamodulinexternal, idsomim, 300146, 1100850, homologene, 7252, genecards, capn6gene, location, human, chro. Calpain 6 also known as calpamodulin is a protein in humans that is encoded by the CAPN6 gene 5 CAPN6IdentifiersAliasesCAPN6 CANPX CAPNX CalpM DJ914P14 1 calpain 6 calpamodulinExternal IDsOMIM 300146 MGI 1100850 HomoloGene 7252 GeneCards CAPN6Gene location Human Chr X chromosome human 1 BandXq23Start111 245 099 bp 1 End111 270 483 bp 1 Gene location Mouse Chr X chromosome mouse 2 BandX X F2Start142 585 227 bp 2 End142 610 410 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed incaput epididymistibiacorpus epididymisplacentaseminal vesiculagallbladderrectumparotid glandrenal medullasmooth muscle tissueTop expressed incondylesacculeatriumhandfossamaxillary prominencevas deferensinternal carotid arterybelly cordabdominal wallMore reference expression dataBioGPSn aGene ontologyMolecular functionmicrotubule binding calcium dependent cysteine type endopeptidase activityCellular componentcytoplasm perinuclear region of cytoplasm spindle spindle microtubule microtubule intracellular anatomical structure cytoskeleton cytosolBiological processregulation of cytoskeleton organization microtubule bundle formation proteolysisSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez82712338EnsemblENSG00000077274ENSMUSG00000067276UniProtQ9Y6Q1O35646RefSeq mRNA NM 014289NM 007603RefSeq protein NP 055104NP 031629Location UCSC Chr X 111 25 111 27 MbChr X 142 59 142 61 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Calpains are a ubiquitous well conserved family of calcium dependent cysteine proteases In the MEROPS protease enzyme classification system they are members of clan CA papain like proteases 6 The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits The large subunit possesses a cysteine protease domain and both subunits possess calcium binding domains Calpains have been implicated in neurodegenerative processes as their activation can be triggered by calcium influx and oxidative stress The protein encoded by this gene is highly expressed in the placenta Its C terminal region lacks any homology to the calmodulin like domain of other calpains The protein lacks a critical catalytic triad residue in its active site cysteine nucleophile mutated to lysine and thus is suggested to be proteolytically inactive The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis References edit a b c GRCh38 Ensembl release 89 ENSG00000077274 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000067276 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene Calpain 6 National Center for Biotechnology Information U S National Library of Medicine Archived from the original on 18 November 2020 Retrieved 2013 03 05 Summary for clan CA MEROPS Retrieved 20 December 2021 nbsp This article on a gene on the human X chromosome and or its associated protein is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Calpain 6 amp oldid 1167846216, wikipedia, wiki, book, books, library,
