5F-CUMYL-PEGACLONE (5F-SGT-151, SGT-269) is a gamma-carboline based synthetic cannabinoid that has been sold as a designer drug, first being identified in Germany in 2017. It acts as a potent full agonist of the CB1 receptor. [1][2] It appears to be more toxic than related compounds such as CUMYL-PEGACLONE, and has been linked to numerous serious adverse reactions, some fatal.[3]
^Mogler L, Halter S, Wilde M, Franz F, Auwärter V (2019). "Human phase I metabolism of the novel synthetic cannabinoid 5F-CUMYL-PEGACLONE". Forensic Toxicology. 37 (1): 154–163. doi:10.1007/s11419-018-0447-4. PMC6315001. PMID 30636984.
^Janssens L, Cannaert A, Connolly MJ, Liu H, Stove CP (June 2020). "In vitro activity profiling of Cumyl-PEGACLONE variants at the CB1 receptor: Fluorination versus isomer exploration". Drug Testing and Analysis. 12 (9): 1336–1343. doi:10.1002/dta.2870. hdl:1854/LU-8687072. PMID 32490586. S2CID 219285656.
^Giorgetti A, Mogler L, Halter S, Haschimi B, Alt A, Rentsch D, Schmidt B, Thoma V, Vogt S, Auwärter V (2019). "Four cases of death involving the novel synthetic cannabinoid 5F-Cumyl-PEGACLONE". Forensic Toxicology. 38 (2): 314–326. doi:10.1007/s11419-019-00514-w. hdl:11585/878663. S2CID 209449526.
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cumyl, pegaclone, gamma, carboline, based, synthetic, cannabinoid, that, been, sold, designer, drug, first, being, identified, germany, 2017, acts, potent, full, agonist, receptor, appears, more, toxic, than, related, compounds, such, cumyl, pegaclone, been, l. 5F CUMYL PEGACLONE 5F SGT 151 SGT 269 is a gamma carboline based synthetic cannabinoid that has been sold as a designer drug first being identified in Germany in 2017 It acts as a potent full agonist of the CB1 receptor 1 2 It appears to be more toxic than related compounds such as CUMYL PEGACLONE and has been linked to numerous serious adverse reactions some fatal 3 5F CUMYL PEGACLONELegal statusLegal statusCA Schedule II DE NpSG Industrial and scientific use only UK Under Psychoactive Substances ActIdentifiersIUPAC name 2 5 Dihydro 2 1 methyl 1 phenylethyl 5 5 fluoropentyl 1H pyrido 4 3 b indol 1 oneCAS Number2377403 49 9PubChem CID134818048ChemSpider73962276UNII7S7IFQ9PPGChemical and physical dataFormulaC 25H 27F N 2OMolar mass390 502 g mol 13D model JSmol Interactive imageSMILES CC C c1ccccc1 N4C Cc3n CCCCCF c2ccccc2c3C4 OInChI InChI 1S C25H27FN2O c1 25 2 19 11 5 3 6 12 19 28 18 15 22 23 24 28 29 20 13 7 8 14 21 20 27 22 17 10 4 9 16 26 h3 5 8 11 15 18H 4 9 10 16 17H2 1 2H3Key SMRRORRDOWXERZ UHFFFAOYSA NSee also edit5F CUMYL PINACA CUMYL 5F P7AICAReferences edit Mogler L Halter S Wilde M Franz F Auwarter V 2019 Human phase I metabolism of the novel synthetic cannabinoid 5F CUMYL PEGACLONE Forensic Toxicology 37 1 154 163 doi 10 1007 s11419 018 0447 4 PMC 6315001 PMID 30636984 Janssens L Cannaert A Connolly MJ Liu H Stove CP June 2020 In vitro activity profiling of Cumyl PEGACLONE variants at the CB1 receptor Fluorination versus isomer exploration Drug Testing and Analysis 12 9 1336 1343 doi 10 1002 dta 2870 hdl 1854 LU 8687072 PMID 32490586 S2CID 219285656 Giorgetti A Mogler L Halter S Haschimi B Alt A Rentsch D Schmidt B Thoma V Vogt S Auwarter V 2019 Four cases of death involving the novel synthetic cannabinoid 5F Cumyl PEGACLONE Forensic Toxicology 38 2 314 326 doi 10 1007 s11419 019 00514 w hdl 11585 878663 S2CID 209449526 nbsp This cannabinoid related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title 5F CUMYL PEGACLONE amp oldid 1205098179, wikipedia, wiki, book, books, library,
