CU-CPT4a is a drug which acts as a selective antagonist of Toll-like receptor 3 (TLR3), with an IC50 of 3.44 μM. It is used for research into the function of TRL3 and its role in inflammation, autoimmune disorders and cancer.[1][2]
^Martin-Gayo E, Cole MB, Kolb KE, Ouyang Z, Cronin J, Kazer SW, et al. (January 2018). "A Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers". Genome Biology. 19 (1): 10. doi:10.1186/s13059-017-1385-x. PMC5789701. PMID 29378643.
^Lomphithak T, Choksi S, Mutirangura A, Tohtong R, Tencomnao T, Usubuchi H, Unno M, Sasano H, Jitkaew S (October 2020). "Receptor-interacting protein kinase 1 is a key mediator in TLR3 ligand and Smac mimetic-induced cell death and suppresses TLR3 ligand-promoted invasion in cholangiocarcinoma". Cell Communication and Signaling. 18 (1): 161. doi:10.1186/s12964-020-00661-3. PMC7545934. PMID 33036630.
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cpt4a, drug, which, acts, selective, antagonist, toll, like, receptor, tlr3, with, ic50, used, research, into, function, trl3, role, inflammation, autoimmune, disorders, cancer, identifiersiupac, name, chloro, fluoro, benzothiophene, carbonyl, amino, phenylpro. CU CPT4a is a drug which acts as a selective antagonist of Toll like receptor 3 TLR3 with an IC50 of 3 44 mM It is used for research into the function of TRL3 and its role in inflammation autoimmune disorders and cancer 1 2 CU CPT4aIdentifiersIUPAC name 2R 2 3 chloro 6 fluoro 1 benzothiophene 2 carbonyl amino 3 phenylpropanoic acidCAS Number1279713 77 7PubChem CID53242268ChemSpider30774264ChEMBLChEMBL4303728Chemical and physical dataFormulaC 18H 13Cl F N O 3SMolar mass377 81 g mol 13D model JSmol Interactive imageSMILES C1 CC C C C1 C C H C O O NC O C2 C C3 C S2 C C C C3 F ClInChI InChI 1S C18H13ClFNO3S c19 15 12 7 6 11 20 9 14 12 25 16 15 17 22 21 13 18 23 24 8 10 4 2 1 3 5 10 h1 7 9 13H 8H2 H 21 22 H 23 24 t13 m1 s1Key IAASQMCXDRISAV CYBMUJFWSA NThis article provides insufficient context for those unfamiliar with the subject Please help improve the article by providing more context for the reader March 2021 Learn how and when to remove this template message See also editCU CPT9aReferences edit Martin Gayo E Cole MB Kolb KE Ouyang Z Cronin J Kazer SW et al January 2018 A Reproducibility Based Computational Framework Identifies an Inducible Enhanced Antiviral State in Dendritic Cells from HIV 1 Elite Controllers Genome Biology 19 1 10 doi 10 1186 s13059 017 1385 x PMC 5789701 PMID 29378643 Lomphithak T Choksi S Mutirangura A Tohtong R Tencomnao T Usubuchi H Unno M Sasano H Jitkaew S October 2020 Receptor interacting protein kinase 1 is a key mediator in TLR3 ligand and Smac mimetic induced cell death and suppresses TLR3 ligand promoted invasion in cholangiocarcinoma Cell Communication and Signaling 18 1 161 doi 10 1186 s12964 020 00661 3 PMC 7545934 PMID 33036630 nbsp This pharmacology related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CU CPT4a amp oldid 1182789555, wikipedia, wiki, book, books, library,
