CR6261 is a monoclonal antibody[1] that binds to a broad range of the influenza virus including the 1918 "Spanish flu" (SC1918/H1) and to a virus of the H5N1 class of avian influenza that jumped from chickens to a human in Vietnam in 2004 (Viet04/H5). In contrast to most antibodies generated by exposure to influenza, which can only neutralize a few strains from within a single virus subtype, CR6261 neutralizes numerous strains from multiple subtypes. CR6261 recognizes a highly conserved helical region in the membrane-proximal stem of hemagglutinin, the predominant protein on the surface of the influenza virus. Based upon the conservation of the amino acid sequence on this part of hemagglutinin, CR6261 is predicted to neutralize roughly 50% of all flu viruses. It was found by The Scripps Research Institute and the Dutch biopharmaceutical company, Crucell.
^Friesen RH, Koudstaal W, Koldijk MH, Weverling GJ, Brakenhoff JP, Lenting PJ, et al. (February 2010). Zhang L (ed.). "New class of monoclonal antibodies against severe influenza: prophylactic and therapeutic efficacy in ferrets". PLOS ONE. 5 (2): e9106. Bibcode:2010PLoSO...5.9106F. doi:10.1371/journal.pone.0009106. PMC2817000. PMID 20161706.
Further readingedit
"Research team finds immune molecule that attacks wide range of flu viruses". physorg.com. 26 February 2009.
"Immune Molecule That Attacks Wide Range Of Flu Viruses Discovered". ScienceDaily. 27 February 2009.
Ekiert DC, Bhabha G, Elsliger MA, Friesen RH, Jongeneelen M, Throsby M, Goudsmit J, Wilson IA (April 2009). "Antibody recognition of a highly conserved influenza virus epitope". Science. New York, N.Y. 324 (5924): 246–51. Bibcode:2009Sci...324..246E. doi:10.1126/science.1171491. PMC2758658. PMID 19251591.
cr6261, monoclonal, antibody, that, binds, broad, range, influenza, virus, including, 1918, spanish, sc1918, virus, h5n1, class, avian, influenza, that, jumped, from, chickens, human, vietnam, 2004, viet04, contrast, most, antibodies, generated, exposure, infl. CR6261 is a monoclonal antibody 1 that binds to a broad range of the influenza virus including the 1918 Spanish flu SC1918 H1 and to a virus of the H5N1 class of avian influenza that jumped from chickens to a human in Vietnam in 2004 Viet04 H5 In contrast to most antibodies generated by exposure to influenza which can only neutralize a few strains from within a single virus subtype CR6261 neutralizes numerous strains from multiple subtypes CR6261 recognizes a highly conserved helical region in the membrane proximal stem of hemagglutinin the predominant protein on the surface of the influenza virus Based upon the conservation of the amino acid sequence on this part of hemagglutinin CR6261 is predicted to neutralize roughly 50 of all flu viruses It was found by The Scripps Research Institute and the Dutch biopharmaceutical company Crucell CR6261Monoclonal antibodyType SourceHumanTargetInfluenza A hemagglutininClinical dataPregnancycategoryN AATC codenoneLegal statusLegal statusInvestigational animal studies IdentifiersChemSpidernone N Y what is this verify See also editImmunologyReferences edit Friesen RH Koudstaal W Koldijk MH Weverling GJ Brakenhoff JP Lenting PJ et al February 2010 Zhang L ed New class of monoclonal antibodies against severe influenza prophylactic and therapeutic efficacy in ferrets PLOS ONE 5 2 e9106 Bibcode 2010PLoSO 5 9106F doi 10 1371 journal pone 0009106 PMC 2817000 PMID 20161706 Further reading edit Research team finds immune molecule that attacks wide range of flu viruses physorg com 26 February 2009 Immune Molecule That Attacks Wide Range Of Flu Viruses Discovered ScienceDaily 27 February 2009 Ekiert DC Bhabha G Elsliger MA Friesen RH Jongeneelen M Throsby M Goudsmit J Wilson IA April 2009 Antibody recognition of a highly conserved influenza virus epitope Science New York N Y 324 5924 246 51 Bibcode 2009Sci 324 246E doi 10 1126 science 1171491 PMC 2758658 PMID 19251591 nbsp This monoclonal antibody related article is a stub You can help Wikipedia by expanding it vte nbsp This antiinfective drug article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CR6261 amp oldid 1154681948, wikipedia, wiki, book, books, library,
