A collagen- and thrombin-activated (COAT) platelet defect is a platelet function disorder that is due to a reduced ability to generate procoagulant platelets. It is associated with a clinically relevant bleeding phenotype.
COAT platelet defect
Other names
Collagen and thrombin-activated platelet defect.
During physiological platelet activation, a fraction of platelets expresses phosphatidylserine on their surface and become highly efficient in sustaining thrombin generation. These so-called COAT platelets, can be generated by dual-agonist stimulation with collagen and thrombin in a laboratory setting. COAT platelet defects should be distinguished from Scott syndrome, a rare bleeding disorder in which patients have impaired phospholipid scrambling and do not express negatively charged phospholipids on their surface even after treatment with calcium ionophores.[1]
Mechanismedit
Procoagulant platelets are a functional subgroup of platelets with distinct properties in physiological hemostasis. Following strong activation, procoagulant platelets express phosphatidylserine on their surface and become highly efficient in sustaining thrombin generation and parallelly gain pro-haemostatic function by retaining α-granule proteins on their membranes.[1] While a low level of procoagulant platelets is associated with impaired platelet function and bleeding diathesis high levels have been shown to worsen thrombotic events.[1][2]
Referencesedit
^ abcAliotta, A; Alberio, L (Feb 24, 2021). "Thrombocytopathies: Not Just Aggregation Defects — The clinical relevance of Procoagulant Platelets". J Clin Med. 10 (5): 894. doi:10.3390/jcm10050894. PMC7956450. PMID 33668091. This article incorporates text available under the CC BY 4.0 license.
^Agbani, E; Poole, A (Nov 16, 2017). "Procoagulant platelets: generation, function, and therapeutic targeting in thrombosis". Blood. 130 (20): 2171–2179. doi:10.1182/blood-2017-05-787259. hdl:1983/75ed79a3-9349-48f6-a1b3-803d416ce612. PMID 28972013. S2CID 206954340.
April 11, 2024
coat, platelet, defect, collagen, thrombin, activated, coat, platelet, defect, platelet, function, disorder, that, reduced, ability, generate, procoagulant, platelets, associated, with, clinically, relevant, bleeding, phenotype, other, namescollagen, thrombin,. A collagen and thrombin activated COAT platelet defect is a platelet function disorder that is due to a reduced ability to generate procoagulant platelets It is associated with a clinically relevant bleeding phenotype COAT platelet defectOther namesCollagen and thrombin activated platelet defect During physiological platelet activation a fraction of platelets expresses phosphatidylserine on their surface and become highly efficient in sustaining thrombin generation These so called COAT platelets can be generated by dual agonist stimulation with collagen and thrombin in a laboratory setting COAT platelet defects should be distinguished from Scott syndrome a rare bleeding disorder in which patients have impaired phospholipid scrambling and do not express negatively charged phospholipids on their surface even after treatment with calcium ionophores 1 Mechanism editProcoagulant platelets are a functional subgroup of platelets with distinct properties in physiological hemostasis Following strong activation procoagulant platelets express phosphatidylserine on their surface and become highly efficient in sustaining thrombin generation and parallelly gain pro haemostatic function by retaining a granule proteins on their membranes 1 While a low level of procoagulant platelets is associated with impaired platelet function and bleeding diathesis high levels have been shown to worsen thrombotic events 1 2 References edit a b c Aliotta A Alberio L Feb 24 2021 Thrombocytopathies Not Just Aggregation Defects The clinical relevance of Procoagulant Platelets J Clin Med 10 5 894 doi 10 3390 jcm10050894 PMC 7956450 PMID 33668091 nbsp This article incorporates text available under the CC BY 4 0 license Agbani E Poole A Nov 16 2017 Procoagulant platelets generation function and therapeutic targeting in thrombosis Blood 130 20 2171 2179 doi 10 1182 blood 2017 05 787259 hdl 1983 75ed79a3 9349 48f6 a1b3 803d416ce612 PMID 28972013 S2CID 206954340 Retrieved from https en wikipedia org w index php title COAT platelet defect amp oldid 1185824016, wikipedia, wiki, book, books, library,
