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Wikipedia

CLDN7

December 17, 2023

Claudin-7 is a protein that in humans is encoded by the CLDN7 gene.[5][6] It belongs to the group of claudins.

CLDN7
Identifiers
AliasesCLDN7, CEPTRL2, CLDN-7, CPETRL2, Hs.84359, claudin-1, claudin 7
External IDsOMIM: 609131 MGI: 1859285 HomoloGene: 9649 GeneCards: CLDN7
Orthologs
SpeciesHumanMouse
Entrez

1366

53624

Ensembl

ENSG00000181885
ENSG00000288292

ENSMUSG00000018569

UniProt

O95471

Q9Z261

RefSeq (mRNA)

NM_001307
NM_001185022
NM_001185023

NM_001193619
NM_016887

RefSeq (protein)

NP_001171951
NP_001171952
NP_001298

NP_001180548
NP_058583

Location (UCSC)Chr 17: 7.26 – 7.26 MbChr 11: 69.86 – 69.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Claudins, such as CLDN7, are involved in the formation of tight junctions between epithelial cells. Tight junctions restrict lateral diffusion of lipids and membrane proteins, and thereby physically define the border between the apical and basolateral compartments of epithelial cells (Zheng et al., 2003).[supplied by OMIM][6]

References edit

  1. ^ a b c ENSG00000288292 GRCh38: Ensembl release 89: ENSG00000181885, ENSG00000288292 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018569 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Morita K, Furuse M, Fujimoto K, Tsukita S (Mar 1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc Natl Acad Sci U S A. 96 (2): 511–6. Bibcode:1999PNAS...96..511M. doi:10.1073/pnas.96.2.511. PMC 15167. PMID 9892664.
  6. ^ a b "Entrez Gene: CLDN7 claudin 7".

External links edit

Further reading edit

  • Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502. S2CID 26473781.
  • Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307.
  • Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
  • Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
  • González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Peacock RE, Keen TJ, Inglehearn CF (1998). "Analysis of a human gene homologous to rat ventral prostate.1 protein". Genomics. 46 (3): 443–9. doi:10.1006/geno.1997.5033. PMID 9441748.
  • Itoh M, Furuse M, Morita K, et al. (2000). "Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins". J. Cell Biol. 147 (6): 1351–63. doi:10.1083/jcb.147.6.1351. PMC 2168087. PMID 10601346.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kominsky SL, Argani P, Korz D, et al. (2003). "Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast". Oncogene. 22 (13): 2021–33. doi:10.1038/sj.onc.1206199. PMID 12673207.
  • Ban Y, Dota A, Cooper LJ, et al. (2003). "Tight junction-related protein expression and distribution in human corneal epithelium". Exp. Eye Res. 76 (6): 663–9. doi:10.1016/S0014-4835(03)00054-X. PMID 12742348.
  • Zheng JY, Yu D, Foroohar M, et al. (2004). "Regulation of the expression of the prostate-specific antigen by claudin-7". J. Membr. Biol. 194 (3): 187–97. doi:10.1007/s00232-003-2038-4. PMID 14502431. S2CID 8482475.
  • Resnick MB, Konkin T, Routhier J, et al. (2005). "Claudin-1 is a strong prognostic indicator in stage II colonic cancer: a tissue microarray study". Mod. Pathol. 18 (4): 511–8. doi:10.1038/modpathol.3800301. PMID 15475928.
  • Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.


 

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

December 17, 2023
cldn7, claudin, protein, that, humans, encoded, gene, belongs, group, claudins, identifiersaliases, ceptrl2, cldn, cpetrl2, 84359, claudin, claudin, 7external, idsomim, 609131, 1859285, homologene, 9649, genecards, gene, location, human, chromosome, human, ban. Claudin 7 is a protein that in humans is encoded by the CLDN7 gene 5 6 It belongs to the group of claudins CLDN7IdentifiersAliasesCLDN7 CEPTRL2 CLDN 7 CPETRL2 Hs 84359 claudin 1 claudin 7External IDsOMIM 609131 MGI 1859285 HomoloGene 9649 GeneCards CLDN7Gene location Human Chr Chromosome 17 human 1 Band17p13 1Start7 259 903 bp 1 End7 263 983 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 11 B3Start69 855 605 bp 2 End69 858 711 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed induodenumrectumright uterine tubeminor salivary glandbody of pancreasleft lobe of thyroid glandislet of Langerhansright lobe of thyroid glandupper lobe of left lungkidneyTop expressed incrypt of lieberkuhn of small intestineleft colonileumduodenumyolk sacmedullary collecting ductjejunummucosa of urinary bladderintestinal epitheliumintestinal villusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionstructural molecule activity identical protein binding protein binding cell adhesion molecule bindingCellular componentbicellular tight junction cell junction basolateral plasma membrane membrane lateral plasma membrane integral component of membrane apicolateral plasma membrane plasma membraneBiological processnegative regulation of protein homooligomerization negative regulation of cell adhesion positive regulation of cell motility negative regulation of apoptotic process positive regulation of cell population proliferation calcium independent cell cell adhesion via plasma membrane cell adhesion molecules response to ethanolSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez136653624EnsemblENSG00000181885ENSG00000288292ENSMUSG00000018569UniProtO95471Q9Z261RefSeq mRNA NM 001307NM 001185022NM 001185023NM 001193619NM 016887RefSeq protein NP 001171951NP 001171952NP 001298NP 001180548NP 058583Location UCSC Chr 17 7 26 7 26 MbChr 11 69 86 69 86 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseClaudins such as CLDN7 are involved in the formation of tight junctions between epithelial cells Tight junctions restrict lateral diffusion of lipids and membrane proteins and thereby physically define the border between the apical and basolateral compartments of epithelial cells Zheng et al 2003 supplied by OMIM 6 References edit a b c ENSG00000288292 GRCh38 Ensembl release 89 ENSG00000181885 ENSG00000288292 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000018569 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Morita K Furuse M Fujimoto K Tsukita S Mar 1999 Claudin multigene family encoding four transmembrane domain protein components of tight junction strands Proc Natl Acad Sci U S A 96 2 511 6 Bibcode 1999PNAS 96 511M doi 10 1073 pnas 96 2 511 PMC 15167 PMID 9892664 a b Entrez Gene CLDN7 claudin 7 External links editHuman CLDN7 genome location and CLDN7 gene details page in the UCSC Genome Browser Further reading editKniesel U Wolburg H 2000 Tight junctions of the blood brain barrier Cell Mol Neurobiol 20 1 57 76 doi 10 1023 A 1006995910836 PMID 10690502 S2CID 26473781 Heiskala M Peterson PA Yang Y 2001 The roles of claudin superfamily proteins in paracellular transport Traffic 2 2 93 8 doi 10 1034 j 1600 0854 2001 020203 x PMID 11247307 Tsukita S Furuse M Itoh M 2001 Multifunctional strands in tight junctions Nat Rev Mol Cell Biol 2 4 285 93 doi 10 1038 35067088 PMID 11283726 S2CID 36524601 Tsukita S Furuse M 2003 Claudin based barrier in simple and stratified cellular sheets Curr Opin Cell Biol 14 5 531 6 doi 10 1016 S0955 0674 02 00362 9 PMID 12231346 Gonzalez Mariscal L Betanzos A Nava P Jaramillo BE 2003 Tight junction proteins Prog Biophys Mol Biol 81 1 1 44 doi 10 1016 S0079 6107 02 00037 8 PMID 12475568 Maruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Suzuki Y Yoshitomo Nakagawa K Maruyama K et al 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Peacock RE Keen TJ Inglehearn CF 1998 Analysis of a human gene homologous to rat ventral prostate 1 protein Genomics 46 3 443 9 doi 10 1006 geno 1997 5033 PMID 9441748 Itoh M Furuse M Morita K et al 2000 Direct Binding of Three Tight Junction Associated Maguks Zo 1 Zo 2 and Zo 3 with the Cooh Termini of Claudins J Cell Biol 147 6 1351 63 doi 10 1083 jcb 147 6 1351 PMC 2168087 PMID 10601346 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Kominsky SL Argani P Korz D et al 2003 Loss of the tight junction protein claudin 7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast Oncogene 22 13 2021 33 doi 10 1038 sj onc 1206199 PMID 12673207 Ban Y Dota A Cooper LJ et al 2003 Tight junction related protein expression and distribution in human corneal epithelium Exp Eye Res 76 6 663 9 doi 10 1016 S0014 4835 03 00054 X PMID 12742348 Zheng JY Yu D Foroohar M et al 2004 Regulation of the expression of the prostate specific antigen by claudin 7 J Membr Biol 194 3 187 97 doi 10 1007 s00232 003 2038 4 PMID 14502431 S2CID 8482475 Resnick MB Konkin T Routhier J et al 2005 Claudin 1 is a strong prognostic indicator in stage II colonic cancer a tissue microarray study Mod Pathol 18 4 511 8 doi 10 1038 modpathol 3800301 PMID 15475928 Liu F Koval M Ranganathan S Fanayan S Hancock WS Lundberg EK Beavis RC Lane L Duek P McQuade L Kelleher NL Baker MS 2015 A systems proteomics view of the endogenous human claudin protein family J Proteome Res 15 2 339 359 doi 10 1021 acs jproteome 5b00769 PMC 4777318 PMID 26680015 nbsp This article on a gene on human chromosome 17 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CLDN7 amp oldid 1170994859, wikipedia, wiki, book, books, library,

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