Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are composed of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intron-less gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares amino acid sequence similarity with a putative apoptosis-related protein found in rat.[5]
^ abCoyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG (Nov 2003). "Role of claudin interactions in airway tight junctional permeability". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (5): L1166-78. doi:10.1152/ajplung.00182.2003. PMID 12909588.
External linksEdit
Human CLDN3 genome location and CLDN3 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: Q9Z0G9 (Mouse Claudin-3) at the PDBe-KB.
Further readingEdit
Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502. S2CID 26473781.
Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307.
Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
Tsukita S, Furuse M (2002). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
Katahira J, Sugiyama H, Inoue N, Horiguchi Y, Matsuda M, Sugimoto N (1997). "Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo". J. Biol. Chem. 272 (42): 26652–8. doi:10.1074/jbc.272.42.26652. PMID 9334247.
Peacock RE, Keen TJ, Inglehearn CF (1997). "Analysis of a human gene homologous to rat ventral prostate.1 protein". Genomics. 46 (3): 443–9. doi:10.1006/geno.1997.5033. PMID 9441748.
Morita K, Furuse M, Fujimoto K, Tsukita S (1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc. Natl. Acad. Sci. U.S.A. 96 (2): 511–6. Bibcode:1999PNAS...96..511M. doi:10.1073/pnas.96.2.511. PMC15167. PMID 9892664.
Furuse M, Sasaki H, Tsukita S (1999). "Manner of interaction of heterogeneous claudin species within and between tight junction strands". J. Cell Biol. 147 (4): 891–903. doi:10.1083/jcb.147.4.891. PMC2156154. PMID 10562289.
Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S (1999). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins". J. Cell Biol. 147 (6): 1351–63. doi:10.1083/jcb.147.6.1351. PMC2168087. PMID 10601346.
Miyamori H, Takino T, Kobayashi Y, Tokai H, Itoh Y, Seiki M, Sato H (2001). "Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinases". J. Biol. Chem. 276 (30): 28204–11. doi:10.1074/jbc.M103083200. PMID 11382769.
Long H, Crean CD, Lee WH, Cummings OW, Gabig TG (2001). "Expression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in prostate cancer epithelium". Cancer Res. 61 (21): 7878–81. PMID 11691807.
Katoh M, Katoh M (2003). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family". Int. J. Mol. Med. 11 (6): 683–9. doi:10.3892/ijmm.11.6.683. PMID 12736707.
Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC4777318. PMID 26680015.
This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.
cldn3, claudin, also, known, protein, which, humans, encoded, gene, member, claudin, protein, family, identifiersaliases, c7orf1, cpetr2, hrvp1, rvp1, claudin, 3external, idsomim, 602910, 1329044, homologene, 1001, genecards, gene, location, human, chromosome,. Claudin 3 also known as CLDN3 is a protein which in humans is encoded by the CLDN3 gene 5 It is a member of the claudin protein family CLDN3IdentifiersAliasesCLDN3 C7orf1 CPE R2 CPETR2 HRVP1 RVP1 claudin 3External IDsOMIM 602910 MGI 1329044 HomoloGene 1001 GeneCards CLDN3Gene location Human Chr Chromosome 7 human 1 Band7q11 23Start73 768 997 bp 1 End73 770 270 bp 1 Gene location Mouse Chr Chromosome 5 mouse 2 Band5 G2 5 74 93 cMStart135 015 068 bp 2 End135 016 326 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright uterine tubeleft lobe of thyroid glandbronchial epithelial cellright lobe of thyroid glandbody of pancreasjejunal mucosaduodenumcaput epididymisparotid glandright lobe of liverTop expressed inlarge intestineleft coloncrypt of lieberkuhn of small intestinejejunumseminal vesiculalacrimal glandduodenumleft lungleft lung loberight lung lobeMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiontransmembrane signaling receptor activity structural molecule activity identical protein bindingCellular componentmembrane integral component of membrane cell junction apicolateral plasma membrane plasma membrane integral component of plasma membrane lateral plasma membrane bicellular tight junction cytoplasmBiological processcalcium independent cell cell adhesion via plasma membrane cell adhesion molecules response to hypoxia protein homooligomerization epithelial cell morphogenesis protein heterooligomerization bicellular tight junction assembly signal transduction response to ethanolSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez136512739EnsemblENSG00000165215ENSMUSG00000070473UniProtO15551Q9Z0G9RefSeq mRNA NM 001306NM 009902RefSeq protein NP 001297NP 034032Location UCSC Chr 7 73 77 73 77 MbChr 5 135 02 135 02 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseTight junctions represent one mode of cell to cell adhesion in epithelial or endothelial cell sheets forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space These junctions are composed of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet with complementary grooves in the inwardly facing extracytoplasmic leaflet The protein encoded by this intron less gene a member of the claudin family is an integral membrane protein and a component of tight junction strands It is also a low affinity receptor for Clostridium perfringens enterotoxin and shares amino acid sequence similarity with a putative apoptosis related protein found in rat 5 Contents 1 Interactions 2 References 3 External links 4 Further readingInteractions EditCLDN3 has been shown to interact with CLDN1 6 and CLDN5 6 References Edit a b c GRCh38 Ensembl release 89 ENSG00000165215 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000070473 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene CLDN3 claudin 3 a b Coyne CB Gambling TM Boucher RC Carson JL Johnson LG Nov 2003 Role of claudin interactions in airway tight junctional permeability Am J Physiol Lung Cell Mol Physiol 285 5 L1166 78 doi 10 1152 ajplung 00182 2003 PMID 12909588 External links EditHuman CLDN3 genome location and CLDN3 gene details page in the UCSC Genome Browser Overview of all the structural information available in the PDB for UniProt Q9Z0G9 Mouse Claudin 3 at the PDBe KB Further reading EditKniesel U Wolburg H 2000 Tight junctions of the blood brain barrier Cell Mol Neurobiol 20 1 57 76 doi 10 1023 A 1006995910836 PMID 10690502 S2CID 26473781 Heiskala M Peterson PA Yang Y 2001 The roles of claudin superfamily proteins in paracellular transport Traffic 2 2 93 8 doi 10 1034 j 1600 0854 2001 020203 x PMID 11247307 Tsukita S Furuse M Itoh M 2001 Multifunctional strands in tight junctions Nat Rev Mol Cell Biol 2 4 285 93 doi 10 1038 35067088 PMID 11283726 S2CID 36524601 Tsukita S Furuse M 2002 Claudin based barrier in simple and stratified cellular sheets Curr Opin Cell Biol 14 5 531 6 doi 10 1016 S0955 0674 02 00362 9 PMID 12231346 Gonzalez Mariscal L Betanzos A Nava P Jaramillo BE 2003 Tight junction proteins Prog Biophys Mol Biol 81 1 1 44 doi 10 1016 S0079 6107 02 00037 8 PMID 12475568 Katahira J Sugiyama H Inoue N Horiguchi Y Matsuda M Sugimoto N 1997 Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo J Biol Chem 272 42 26652 8 doi 10 1074 jbc 272 42 26652 PMID 9334247 Peacock RE Keen TJ Inglehearn CF 1997 Analysis of a human gene homologous to rat ventral prostate 1 protein Genomics 46 3 443 9 doi 10 1006 geno 1997 5033 PMID 9441748 Morita K Furuse M Fujimoto K Tsukita S 1999 Claudin multigene family encoding four transmembrane domain protein components of tight junction strands Proc Natl Acad Sci U S A 96 2 511 6 Bibcode 1999PNAS 96 511M doi 10 1073 pnas 96 2 511 PMC 15167 PMID 9892664 Furuse M Sasaki H Tsukita S 1999 Manner of interaction of heterogeneous claudin species within and between tight junction strands J Cell Biol 147 4 891 903 doi 10 1083 jcb 147 4 891 PMC 2156154 PMID 10562289 Itoh M Furuse M Morita K Kubota K Saitou M Tsukita S 1999 Direct binding of three tight junction associated MAGUKs ZO 1 ZO 2 and ZO 3 with the COOH termini of claudins J Cell Biol 147 6 1351 63 doi 10 1083 jcb 147 6 1351 PMC 2168087 PMID 10601346 Miyamori H Takino T Kobayashi Y Tokai H Itoh Y Seiki M Sato H 2001 Claudin promotes activation of pro matrix metalloproteinase 2 mediated by membrane type matrix metalloproteinases J Biol Chem 276 30 28204 11 doi 10 1074 jbc M103083200 PMID 11382769 Long H Crean CD Lee WH Cummings OW Gabig TG 2001 Expression of Clostridium perfringens enterotoxin receptors claudin 3 and claudin 4 in prostate cancer epithelium Cancer Res 61 21 7878 81 PMID 11691807 Katoh M Katoh M 2003 CLDN23 gene frequently down regulated in intestinal type gastric cancer is a novel member of CLAUDIN gene family Int J Mol Med 11 6 683 9 doi 10 3892 ijmm 11 6 683 PMID 12736707 Liu F Koval M Ranganathan S Fanayan S Hancock WS Lundberg EK Beavis RC Lane L Duek P McQuade L Kelleher NL Baker MS 2015 A systems proteomics view of the endogenous human claudin protein family J Proteome Res 15 2 339 359 doi 10 1021 acs jproteome 5b00769 PMC 4777318 PMID 26680015 This article on a gene on human chromosome 7 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CLDN3 amp oldid 1142710496, wikipedia, wiki, book, books, library,
