Claudin-15 is a protein that in humans is encoded by the CLDN15gene.[5] It belongs to the group of claudins. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Tight junction. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN10.[6]
^Database, GeneCards Human Gene. "CLDN15 Gene - GeneCards | CLD15 Protein | CLD15 Antibody". www.genecards.org. Retrieved 2017-04-14.
External linksedit
Human CLDN15 genome location and CLDN15 gene details page in the UCSC Genome Browser.
Further readingedit
Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502. S2CID 26473781.
Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. S2CID 12132159.
Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
Yi X, Wang Y, Yu FS (2000). "Corneal epithelial tight junctions and their response to lipopolysaccharide challenge". Invest. Ophthalmol. Vis. Sci. 41 (13): 4093–100. PMID 11095601.
Kiuchi-Saishin Y, Gotoh S, Furuse M, et al. (2002). "Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments". J. Am. Soc. Nephrol. 13 (4): 875–86. doi:10.1681/ASN.V134875. PMID 11912246.
Colegio OR, Van Itallie CM, McCrea HJ, et al. (2002). "Claudins create charge-selective channels in the paracellular pathway between epithelial cells" (PDF). Am. J. Physiol., Cell Physiol. 283 (1): C142–7. doi:10.1152/ajpcell.00038.2002. PMID 12055082. S2CID 9555118.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Van Itallie CM, Fanning AS, Anderson JM (2003). "Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins". Am. J. Physiol. Renal Physiol. 285 (6): F1078–84. doi:10.1152/ajprenal.00116.2003. PMID 13129853.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC4777318. PMID 26680015.
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cldn15, claudin, protein, that, humans, encoded, gene, belongs, group, claudins, among, related, pathways, blood, brain, barrier, immune, cell, transmigration, vcam, cd106, signaling, pathways, tight, junction, annotations, related, this, gene, include, identi. Claudin 15 is a protein that in humans is encoded by the CLDN15 gene 5 It belongs to the group of claudins Among its related pathways are Blood Brain Barrier and Immune Cell Transmigration VCAM 1 CD106 Signaling Pathways and Tight junction GO annotations related to this gene include identical protein binding and structural molecule activity An important paralog of this gene is CLDN10 6 CLDN15Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes4P79IdentifiersAliasesCLDN15 claudin 15External IDsOMIM 615778 MGI 1913103 HomoloGene 8646 GeneCards CLDN15Gene location Human Chr Chromosome 7 human 1 Band7q22 1Start101 232 092 bp 1 End101 238 820 bp 1 Gene location Mouse Chr Chromosome 5 mouse 2 Band5 5 G2Start136 995 470 bp 2 End137 004 712 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed injejunal mucosaduodenumgerminal epitheliumparietal pleuraright lobe of liverleft uterine tubespleensubcutaneous adipose tissuetibial nervecanal of the cervixTop expressed induodenumcrypt of lieberkuhn of small intestineintestinal villusjejunumPaneth cellileumleft colonoocytesecondary oocytewhite adipose tissueMore reference expression dataBioGPSn aGene ontologyMolecular functionstructural molecule activity identical protein bindingCellular componentintegral component of membrane cell junction plasma membrane lateral plasma membrane membrane bicellular tight junctionBiological processcalcium independent cell cell adhesion via plasma membrane cell adhesion molecules ion transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez2414660363EnsemblENSG00000106404ENSMUSG00000001739UniProtP56746Q9Z0S5RefSeq mRNA NM 138429NM 001185080NM 014343NM 021719RefSeq protein NP 001172009NP 055158NP 068365Location UCSC Chr 7 101 23 101 24 MbChr 5 137 137 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseReferences edit a b c GRCh38 Ensembl release 89 ENSG00000106404 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000001739 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene CLDN15 claudin 15 Database GeneCards Human Gene CLDN15 Gene GeneCards CLD15 Protein CLD15 Antibody www genecards org Retrieved 2017 04 14 External links editHuman CLDN15 genome location and CLDN15 gene details page in the UCSC Genome Browser Further reading editKniesel U Wolburg H 2000 Tight junctions of the blood brain barrier Cell Mol Neurobiol 20 1 57 76 doi 10 1023 A 1006995910836 PMID 10690502 S2CID 26473781 Heiskala M Peterson PA Yang Y 2001 The roles of claudin superfamily proteins in paracellular transport Traffic 2 2 93 8 doi 10 1034 j 1600 0854 2001 020203 x PMID 11247307 S2CID 12132159 Tsukita S Furuse M Itoh M 2001 Multifunctional strands in tight junctions Nat Rev Mol Cell Biol 2 4 285 93 doi 10 1038 35067088 PMID 11283726 S2CID 36524601 Tsukita S Furuse M 2003 Claudin based barrier in simple and stratified cellular sheets Curr Opin Cell Biol 14 5 531 6 doi 10 1016 S0955 0674 02 00362 9 PMID 12231346 Gonzalez Mariscal L Betanzos A Nava P Jaramillo BE 2003 Tight junction proteins Prog Biophys Mol Biol 81 1 1 44 doi 10 1016 S0079 6107 02 00037 8 PMID 12475568 Yi X Wang Y Yu FS 2000 Corneal epithelial tight junctions and their response to lipopolysaccharide challenge Invest Ophthalmol Vis Sci 41 13 4093 100 PMID 11095601 Kiuchi Saishin Y Gotoh S Furuse M et al 2002 Differential expression patterns of claudins tight junction membrane proteins in mouse nephron segments J Am Soc Nephrol 13 4 875 86 doi 10 1681 ASN V134875 PMID 11912246 Colegio OR Van Itallie CM McCrea HJ et al 2002 Claudins create charge selective channels in the paracellular pathway between epithelial cells PDF Am J Physiol Cell Physiol 283 1 C142 7 doi 10 1152 ajpcell 00038 2002 PMID 12055082 S2CID 9555118 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Van Itallie CM Fanning AS Anderson JM 2003 Reversal of charge selectivity in cation or anion selective epithelial lines by expression of different claudins Am J Physiol Renal Physiol 285 6 F1078 84 doi 10 1152 ajprenal 00116 2003 PMID 13129853 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Liu F Koval M Ranganathan S Fanayan S Hancock WS Lundberg EK Beavis RC Lane L Duek P McQuade L Kelleher NL Baker MS 2015 A systems proteomics view of the endogenous human claudin protein family J Proteome Res 15 2 339 359 doi 10 1021 acs jproteome 5b00769 PMC 4777318 PMID 26680015 nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en 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