^ abcGRCh38: Ensembl release 89: ENSG00000117971 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000035200 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Eng CM, Kozak CA, Beaudet AL, Zoghbi HY (Apr 1991). "Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse". Genomics. 9 (2): 278–282. doi:10.1016/0888-7543(91)90253-B. PMID 2004777.
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Boulter J, O'Shea-Greenfield A, Duvoisin RM, et al. (1990). "Alpha 3, alpha 5, and beta 4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster". J. Biol. Chem. 265 (8): 4472–82. doi:10.1016/S0021-9258(19)39588-2. PMID 1689727.
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chrnb4, neuronal, acetylcholine, receptor, subunit, beta, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2asgidentifiersaliases, cholinergic, receptor, nicotinic, beta, subunitexternal, idsomim, 118509, 878. Neuronal acetylcholine receptor subunit beta 4 is a protein that in humans is encoded by the CHRNB4 gene 5 6 CHRNB4Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2ASGIdentifiersAliasesCHRNB4 cholinergic receptor nicotinic beta 4 subunitExternal IDsOMIM 118509 MGI 87892 HomoloGene 20196 GeneCards CHRNB4Gene location Human Chr Chromosome 15 human 1 Band15q25 1Start78 624 111 bp 1 End78 727 754 bp 1 Gene location Mouse Chr Chromosome 9 mouse 2 Band9 9 BStart54 935 438 bp 2 End54 956 063 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inganglionic eminencesural nerveright adrenal glandappendixthymuslymph noderectumsmooth muscle tissueislet of Langerhanstransverse colonTop expressed inhabenulapineal glandciliary bodypretectal areairisPaneth celladrenal glandcarotid bodymirrorileumMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionacetylcholine binding acetylcholine receptor activity ion channel activity ligand gated ion channel activity protein heterodimerization activity extracellular ligand gated ion channel activity protein binding acetylcholine gated cation selective channel activity transmembrane signaling receptor activity transmitter gated ion channel activity involved in regulation of postsynaptic membrane potentialCellular componentacetylcholine gated channel complex integral component of membrane postsynaptic membrane membrane plasma membrane synapse integral component of plasma membrane cell junction neuron projection specific granule membrane tertiary granule membrane cholinergic synapseBiological processsmooth muscle contraction locomotory behavior regulation of smooth muscle contraction protein heterooligomerization positive regulation of transmission of nerve impulse regulation of membrane potential response to nicotine synaptic transmission cholinergic ion transport regulation of neurotransmitter secretion behavioral response to nicotine synaptic transmission involved in micturition action potential signal transduction neutrophil degranulation regulation of postsynaptic membrane potential excitatory postsynaptic potential ion transmembrane transport chemical synaptic transmission neuromuscular synaptic transmission nervous system processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1143108015EnsemblENSG00000117971ENSMUSG00000035200UniProtP30926Q8R493RefSeq mRNA NM 000750NM 001256567NM 148944RefSeq protein NP 000741NP 001243496NP 683746Location UCSC Chr 15 78 62 78 73 MbChr 9 54 94 54 96 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Interactive pathway map 2 See also 3 References 4 Further reading 5 External linksInteractive pathway map EditClick on genes proteins and metabolites below to link to respective Wikipedia articles 1 File nbsp nbsp alt Nicotine Activity on Chromaffin Cells edit Nicotine Activity on Chromaffin Cells edit The interactive pathway map can be edited at WikiPathways NicotineActivityonChromaffinCells WP1603 See also EditNicotinic acetylcholine receptorReferences Edit a b c GRCh38 Ensembl release 89 ENSG00000117971 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000035200 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Eng CM Kozak CA Beaudet AL Zoghbi HY Apr 1991 Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse Genomics 9 2 278 282 doi 10 1016 0888 7543 91 90253 B PMID 2004777 Entrez Gene CHRNB4 cholinergic receptor nicotinic beta 4 Further reading EditGreen WN Millar NS 1995 Ion channel assembly Trends Neurosci 18 6 280 287 doi 10 1016 0166 2236 95 93915 K PMID 7571003 Hogg RC Raggenbass M Bertrand D 2003 Nicotinic acetylcholine receptors from structure to brain function Rev Physiol Biochem Pharmacol Reviews of Physiology Biochemistry and Pharmacology 147 1 46 doi 10 1007 s10254 003 0005 1 ISBN 978 3 540 01365 5 PMID 12783266 Tarroni P Rubboli F Chini B et al 1992 Neuronal type nicotinic receptors in human neuroblastoma and small cell lung carcinoma cell lines FEBS Lett 312 1 66 70 doi 10 1016 0014 5793 92 81411 E PMID 1330682 Anand R Lindstrom J 1992 Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans Genomics 13 4 962 967 doi 10 1016 0888 7543 92 90008 G PMID 1505988 Raimondi E Rubboli F Moralli D et al 1992 Chromosomal localization and physical linkage of the genes encoding the human alpha 3 alpha 5 and beta 4 neuronal nicotinic receptor subunits Genomics 12 4 849 50 doi 10 1016 0888 7543 92 90324 L PMID 1572664 Boulter J O Shea Greenfield A Duvoisin RM et al 1990 Alpha 3 alpha 5 and beta 4 three members of the rat neuronal nicotinic acetylcholine receptor related gene family form a gene cluster J Biol Chem 265 8 4472 82 doi 10 1016 S0021 9258 19 39588 2 PMID 1689727 Papke RL Heinemann SF 1992 The role of the beta 4 subunit in determining the kinetic properties of rat neuronal nicotinic acetylcholine alpha 3 receptors J Physiol 440 95 112 doi 10 1113 jphysiol 1991 sp018698 PMC 1180142 PMID 1725184 Elliott KJ Ellis SB Berckhan KJ et al 1997 Comparative structure of human neuronal alpha 2 alpha 7 and beta 2 beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2 alpha 3 alpha 4 alpha 7 beta 2 and beta 4 subunits J Mol Neurosci 7 3 217 228 doi 10 1007 BF02736842 PMID 8906617 S2CID 45737923 Chavez Noriega LE Crona JH Washburn MS et al 1997 Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2 h alpha 2 beta 4 h alpha 3 beta 2 h alpha 3 beta 4 h alpha 4 beta 2 h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes J Pharmacol Exp Ther 280 1 346 56 PMID 8996215 Groot Kormelink PJ Luyten WH 1997 Cloning and sequence of full length cDNAs encoding the human neuronal nicotinic acetylcholine receptor nAChR subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH SY5Y and or IMR 32 FEBS Lett 400 3 309 314 doi 10 1016 S0014 5793 96 01383 X PMID 9009220 Navaneetham D Penn A Howard J Conti Fine BM 1997 Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses Cell Mol Biol Noisy le grand 43 3 433 42 PMID 9193799 Gerzanich V Kuryatov A Anand R Lindstrom J 1997 Orphan alpha6 nicotinic AChR subunit can form a functional heteromeric acetylcholine receptor Mol Pharmacol 51 2 320 7 doi 10 1124 mol 51 2 320 PMID 9203638 Gerzanich V Wang F Kuryatov A Lindstrom J 1998 alpha 5 Subunit alters desensitization pharmacology Ca permeability and Ca modulation of human neuronal alpha 3 nicotinic receptors J Pharmacol Exp Ther 286 1 311 20 PMID 9655874 Hellstrom Lindahl E Gorbounova O Seiger A et al 1998 Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord Brain Res Dev Brain Res 108 1 2 147 160 doi 10 1016 S0165 3806 98 00046 7 PMID 9693793 Sato KZ Fujii T Watanabe Y et al 1999 Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines Neurosci Lett 266 1 17 20 doi 10 1016 S0304 3940 99 00259 1 PMID 10336173 S2CID 43548155 Boorman JP Groot Kormelink PJ Sivilotti LG 2001 Stoichiometry of human recombinant neuronal nicotinic receptors containing the b3 subunit expressed in Xenopus oocytes J Physiol 529 3 565 77 doi 10 1111 j 1469 7793 2000 00565 x PMC 2270211 PMID 11118490 Lev Lehman E Bercovich D Xu W et al 2001 Characterization of the human beta4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4 J Hum Genet 46 7 362 366 doi 10 1007 PL00010921 PMID 11450844 Groot Kormelink PJ Boorman JP Sivilotti LG 2001 Formation of functional alpha3beta4alpha5 human neuronal nicotinic receptors in Xenopus oocytes a reporter mutation approach Br J Pharmacol 134 4 789 796 doi 10 1038 sj bjp 0704313 PMC 1573006 PMID 11606319 External links EditCHRNB4 protein human at the U S National Library of Medicine Medical Subject Headings MeSH Human CHRNB4 genome location and CHRNB4 gene details page in the UCSC Genome Browser This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CHRNB4 amp oldid 1142730966, wikipedia, wiki, book, books, library,
