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Wikipedia

CHRNB3

April 27, 2024

Neuronal acetylcholine receptor subunit beta-3 is a protein that in humans is encoded by the CHRNB3 gene.[5][6] This gene has been identified as a candidate for predisposition to tobacco dependence.

CHRNB3
Identifiers
AliasesCHRNB3, cholinergic receptor nicotinic beta 3 subunit
External IDsOMIM: 118508 MGI: 106212 HomoloGene: 36035 GeneCards: CHRNB3
Orthologs
SpeciesHumanMouse
Entrez

1142

108043

Ensembl

ENSG00000147432

ENSMUSG00000031492

UniProt

Q05901

Q8BMN3

RefSeq (mRNA)

NM_000749
NM_001347717

NM_027454
NM_173212

RefSeq (protein)

NP_000740
NP_001334646

NP_081730
NP_775304

Location (UCSC)Chr 8: 42.7 – 42.74 MbChr 8: 27.86 – 27.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147432 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031492 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988.
  6. ^ "Entrez Gene: CHRNB3 cholinergic receptor, nicotinic, beta 3".

Further reading edit

  • Green WN, Millar NS (1995). "Ion-channel assembly". Trends Neurosci. 18 (6): 280–7. doi:10.1016/0166-2236(95)93915-K. PMID 7571003.
  • Hogg RC, Raggenbass M, Bertrand D (2003). "Nicotinic acetylcholine receptors: from structure to brain function". Reviews of Physiology, Biochemistry and Pharmacology. Vol. 147. pp. 1–46. doi:10.1007/s10254-003-0005-1. ISBN 978-3-540-01365-5. PMID 12783266. {{cite book}}: |journal= ignored (help)
  • Willoughby JJ, Ninkina NN, Beech MM, et al. (1993). "Molecular cloning of a human neuronal nicotinic acetylcholine receptor beta 3-like subunit". Neurosci. Lett. 155 (2): 136–9. doi:10.1016/0304-3940(93)90691-D. PMID 7690916. S2CID 39225391.
  • Koyama K, Sudo K, Nakamura Y (1994). "Mapping of the human nicotinic acetylcholine receptor beta 3 gene (CHRNB3) within chromosome 8p11.2". Genomics. 21 (2): 460–1. doi:10.1006/geno.1994.1300. PMID 8088849.
  • Elliott KJ, Ellis SB, Berckhan KJ, et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–28. doi:10.1007/BF02736842. PMID 8906617. S2CID 45737923.
  • Groot Kormelink PJ, Luyten WH (1997). "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32". FEBS Lett. 400 (3): 309–14. doi:10.1016/S0014-5793(96)01383-X. PMID 9009220. S2CID 82364119.
  • Navaneetham D, Penn A, Howard J, Conti-Fine BM (1997). "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses". Cell. Mol. Biol. (Noisy-le-grand). 43 (3): 433–42. PMID 9193799.
  • Groot-Kormelink PJ, Luyten WH, Colquhoun D, Sivilotti LG (1998). "A reporter mutation approach shows incorporation of the "orphan" subunit beta3 into a functional nicotinic receptor". J. Biol. Chem. 273 (25): 15317–20. doi:10.1074/jbc.273.25.15317. PMID 9624109.
  • Sato KZ, Fujii T, Watanabe Y, et al. (1999). "Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines". Neurosci. Lett. 266 (1): 17–20. doi:10.1016/S0304-3940(99)00259-1. PMID 10336173. S2CID 43548155.
  • Boorman JP, Groot-Kormelink PJ, Sivilotti LG (2001). "Stoichiometry of human recombinant neuronal nicotinic receptors containing the β3 subunit expressed in Xenopus oocytes". J. Physiol. 529 Pt 3 (Pt 3): 565–77. doi:10.1111/j.1469-7793.2000.00565.x. PMC 2270211. PMID 11118490.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Boorman JP, Beato M, Groot-Kormelink PJ, et al. (2004). "The effects of beta3 subunit incorporation on the pharmacology and single channel properties of oocyte-expressed human alpha3beta4 neuronal nicotinic receptors". J. Biol. Chem. 278 (45): 44033–40. doi:10.1074/jbc.M211719200. PMID 12912995.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


 

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April 27, 2024
chrnb3, neuronal, acetylcholine, receptor, subunit, beta, protein, that, humans, encoded, gene, this, gene, been, identified, candidate, predisposition, tobacco, dependence, identifiersaliases, cholinergic, receptor, nicotinic, beta, subunitexternal, idsomim, . Neuronal acetylcholine receptor subunit beta 3 is a protein that in humans is encoded by the CHRNB3 gene 5 6 This gene has been identified as a candidate for predisposition to tobacco dependence CHRNB3IdentifiersAliasesCHRNB3 cholinergic receptor nicotinic beta 3 subunitExternal IDsOMIM 118508 MGI 106212 HomoloGene 36035 GeneCards CHRNB3Gene location Human Chr Chromosome 8 human 1 Band8p11 21Start42 697 366 bp 1 End42 737 407 bp 1 Gene location Mouse Chr Chromosome 8 mouse 2 Band8 8 A2Start27 858 739 bp 2 End27 889 758 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inpancreatic ductal celltibialis anterior musclecerebellar cortexcerebellar hemisphereprefrontal cortexsubstantia nigrabody of pancreasBrodmann area 9cingulate gyrustrigeminal ganglionTop expressed ininner nuclear layerganglion cell layerhabenulaouter nuclear layerventral tegmental areaspinal gangliameningessuperior frontal gyruspituitary glandlensMore reference expression dataBioGPSn aGene ontologyMolecular functionchannel activity ion channel activity extracellular ligand gated ion channel activity ligand gated ion channel activity acetylcholine gated cation selective channel activity transmembrane signaling receptor activity acetylcholine binding acetylcholine receptor activityCellular componentintegral component of membrane postsynaptic membrane membrane plasma membrane synapse cell junction acetylcholine gated channel complex dopaminergic synapse integral component of plasma membrane neuron projectionBiological processresponse to nicotine synaptic transmission cholinergic ion transport neuromuscular synaptic transmission signal transduction regulation of postsynaptic membrane potential excitatory postsynaptic potential cation transmembrane transport ion transmembrane transport regulation of synaptic vesicle exocytosis chemical synaptic transmission regulation of membrane potential nervous system process protein heterooligomerizationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1142108043EnsemblENSG00000147432ENSMUSG00000031492UniProtQ05901Q8BMN3RefSeq mRNA NM 000749NM 001347717NM 027454NM 173212RefSeq protein NP 000740NP 001334646NP 081730NP 775304Location UCSC Chr 8 42 7 42 74 MbChr 8 27 86 27 89 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 See also 2 References 3 Further reading 4 External linksSee also editNicotinic acetylcholine receptorReferences edit a b c GRCh38 Ensembl release 89 ENSG00000147432 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000031492 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Anand R Lindstrom J Sep 1992 Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans Genomics 13 4 962 7 doi 10 1016 0888 7543 92 90008 G PMID 1505988 Entrez Gene CHRNB3 cholinergic receptor nicotinic beta 3 Further reading editGreen WN Millar NS 1995 Ion channel assembly Trends Neurosci 18 6 280 7 doi 10 1016 0166 2236 95 93915 K PMID 7571003 Hogg RC Raggenbass M Bertrand D 2003 Nicotinic acetylcholine receptors from structure to brain function Reviews of Physiology Biochemistry and Pharmacology Vol 147 pp 1 46 doi 10 1007 s10254 003 0005 1 ISBN 978 3 540 01365 5 PMID 12783266 a href Template Cite book html title Template Cite book cite book a journal ignored help Willoughby JJ Ninkina NN Beech MM et al 1993 Molecular cloning of a human neuronal nicotinic acetylcholine receptor beta 3 like subunit Neurosci Lett 155 2 136 9 doi 10 1016 0304 3940 93 90691 D PMID 7690916 S2CID 39225391 Koyama K Sudo K Nakamura Y 1994 Mapping of the human nicotinic acetylcholine receptor beta 3 gene CHRNB3 within chromosome 8p11 2 Genomics 21 2 460 1 doi 10 1006 geno 1994 1300 PMID 8088849 Elliott KJ Ellis SB Berckhan KJ et al 1997 Comparative structure of human neuronal alpha 2 alpha 7 and beta 2 beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2 alpha 3 alpha 4 alpha 7 beta 2 and beta 4 subunits J Mol Neurosci 7 3 217 28 doi 10 1007 BF02736842 PMID 8906617 S2CID 45737923 Groot Kormelink PJ Luyten WH 1997 Cloning and sequence of full length cDNAs encoding the human neuronal nicotinic acetylcholine receptor nAChR subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH SY5Y and or IMR 32 FEBS Lett 400 3 309 14 doi 10 1016 S0014 5793 96 01383 X PMID 9009220 S2CID 82364119 Navaneetham D Penn A Howard J Conti Fine BM 1997 Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses Cell Mol Biol Noisy le grand 43 3 433 42 PMID 9193799 Groot Kormelink PJ Luyten WH Colquhoun D Sivilotti LG 1998 A reporter mutation approach shows incorporation of the orphan subunit beta3 into a functional nicotinic receptor J Biol Chem 273 25 15317 20 doi 10 1074 jbc 273 25 15317 PMID 9624109 Sato KZ Fujii T Watanabe Y et al 1999 Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines Neurosci Lett 266 1 17 20 doi 10 1016 S0304 3940 99 00259 1 PMID 10336173 S2CID 43548155 Boorman JP Groot Kormelink PJ Sivilotti LG 2001 Stoichiometry of human recombinant neuronal nicotinic receptors containing the b3 subunit expressed in Xenopus oocytes J Physiol 529 Pt 3 Pt 3 565 77 doi 10 1111 j 1469 7793 2000 00565 x PMC 2270211 PMID 11118490 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Boorman JP Beato M Groot Kormelink PJ et al 2004 The effects of beta3 subunit incorporation on the pharmacology and single channel properties of oocyte expressed human alpha3beta4 neuronal nicotinic receptors J Biol Chem 278 45 44033 40 doi 10 1074 jbc M211719200 PMID 12912995 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 External links editCHRNB3 protein human at the U S National Library of Medicine Medical Subject Headings MeSH Human CHRNB3 genome location and CHRNB3 gene details page in the UCSC Genome Browser This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CHRNB3 amp oldid 1173375750, wikipedia, wiki, book, books, library,

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