CGK733 was a synthetic chemical substance which was reported in 2006 to have remarkable properties in reversing cell senescence (aging).[1] However, the entire work behind the discovery of this compound has since been found to be falsified and the authors of the original reports have retracted all their claims.[2][3]
CGK733 was claimed to be an inhibitor of ATM/ATR kinases,[4][5] which are involved in DNA damage repair. CGK was claimed to extend the lifetime of cultured cells by approximately 20 divisions, or roughly 25%, specifically in mammalian cells.
The original report garnered scientific attention,[6] but was retracted in 2008.[7] The retraction states that the screen to identify CGK733 as an anti-senescence agent was not carried out; experiments exploring the cellular effects of CGK733 were misrepresented; the identification of ATM as the target of CGK733 was fabricated; a compound which was essential for ATM target validation had not been synthesized; and the chemical structure of CGK733 was misrepresented.[7]
^Won J, Kim M, Kim N, Ahn JH, Lee WG, Kim SS, Chang KY, Yi YW, Kim TK (July 2006). "Small molecule-based reversible reprogramming of cellular lifespan". Nat. Chem. Biol. 2 (7): 369–74. doi:10.1038/nchembio800. PMID 16767085. S2CID 85372472. (Retracted, see PMID 18560433)
^ abDennis Normile; Jennifer Couzin (March 5, 2008). . Science Now. Archived from the original on 2008-03-09. Retrieved 2008-03-17.
^Kenneth J. Moore (2008). "Data Duping". Chemical & Engineering News. Retrieved 2008-04-01.
^Bhattacharya S, Ray RM, Johnson LR (December 2008). "Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells". Cell. Signal. 21 (4): 509–22. doi:10.1016/j.cellsig.2008.12.003. PMID 19136059.
^Crescenzi E, Palumbo G, de Boer J, Brady HJ (March 2008). "Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy". Clin. Cancer Res. 14 (6): 1877–87. doi:10.1158/1078-0432.CCR-07-4298. PMID 18347191.
^Sarah Everts (2006). "Aging Cells Get New Lease On Life - Small molecule is found to extend lifetime of mammalian cells". Chemical & Engineering News. Retrieved 2007-03-09.
^ abWon J, Kim M, Kim N, et al. (July 2008). "Retraction: small molecule-based reversible reprogramming of cellular lifespan". Nat. Chem. Biol. 4 (7): 431. doi:10.1038/nchembio0708-431. PMID 18560433.
January 01, 1970
cgk733, fraud, cgk733, synthetic, chemical, substance, which, reported, 2006, have, remarkable, properties, reversing, cell, senescence, aging, however, entire, work, behind, discovery, this, compound, since, been, found, falsified, authors, original, reports,. CGK733 was a synthetic chemical substance which was reported in 2006 to have remarkable properties in reversing cell senescence aging 1 However the entire work behind the discovery of this compound has since been found to be falsified and the authors of the original reports have retracted all their claims 2 3 CGK733 was claimed to be an inhibitor of ATM ATR kinases 4 5 which are involved in DNA damage repair CGK was claimed to extend the lifetime of cultured cells by approximately 20 divisions or roughly 25 specifically in mammalian cells The original report garnered scientific attention 6 but was retracted in 2008 7 The retraction states that the screen to identify CGK733 as an anti senescence agent was not carried out experiments exploring the cellular effects of CGK733 were misrepresented the identification of ATM as the target of CGK733 was fabricated a compound which was essential for ATM target validation had not been synthesized and the chemical structure of CGK733 was misrepresented 7 The principal investigator Tae Kook Kim and several associates were consequently suspended from their positions at the Korea Advanced Institute of Science amp Technology 2 References edit Won J Kim M Kim N Ahn JH Lee WG Kim SS Chang KY Yi YW Kim TK July 2006 Small molecule based reversible reprogramming of cellular lifespan Nat Chem Biol 2 7 369 74 doi 10 1038 nchembio800 PMID 16767085 S2CID 85372472 Retracted see PMID 18560433 a b Dennis Normile Jennifer Couzin March 5 2008 South Korean researcher suspended over charges of scientific misconduct Science Now Archived from the original on 2008 03 09 Retrieved 2008 03 17 Kenneth J Moore 2008 Data Duping Chemical amp Engineering News Retrieved 2008 04 01 Bhattacharya S Ray RM Johnson LR December 2008 Role of polyamines in p53 dependent apoptosis of intestinal epithelial cells Cell Signal 21 4 509 22 doi 10 1016 j cellsig 2008 12 003 PMID 19136059 Crescenzi E Palumbo G de Boer J Brady HJ March 2008 Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug induced senescent tumor cells implications for chemotherapy Clin Cancer Res 14 6 1877 87 doi 10 1158 1078 0432 CCR 07 4298 PMID 18347191 Sarah Everts 2006 Aging Cells Get New Lease On Life Small molecule is found to extend lifetime of mammalian cells Chemical amp Engineering News Retrieved 2007 03 09 a b Won J Kim M Kim N et al July 2008 Retraction small molecule based reversible reprogramming of cellular lifespan Nat Chem Biol 4 7 431 doi 10 1038 nchembio0708 431 PMID 18560433 Retrieved from https en wikipedia org w index php title CGK733 fraud amp oldid 1079621105, wikipedia, wiki, book, books, library,
