CECXG (3'-ethyl-LY-341,495) is a research drug which acts as a potent and selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3), with reasonable selectivity for mGluR3. While it is some five times less potent than LY-341,495 at mGluR3, it has 38x higher affinity for mGluR3 over mGluR2,[1] making it one of the few ligands available that is able to distinguish between these two closely related receptor subtypes.[2][3][4]
^Collado I, Ezquerra J, Mazón A, Pedregal C, Yruretagoyena B, Kingston AE, et al. (October 1998). "2,3'-disubstituted-2-(2'-carboxycyclopropyl)glycines as potent and selective antagonists of metabotropic glutamate receptors". Bioorganic & Medicinal Chemistry Letters. 8 (20): 2849–2854. doi:10.1016/S0960-894X(98)00510-1. PMID 9873635.
^Schoepp DD, Jane DE, Monn JA (2002). "Pharmacology of metabotropic glutamate receptors". In Egebjerg J, Krogsgaard-Larsen P, Schousboe A (eds.). Glutamate and GABA receptors and transporters: structure, function and pharmacology. Taylor & Francis. pp. 171–173. ISBN0-7484-0881-9.
^Sørensen US, Bleisch TJ, Kingston AE, Wright RA, Johnson BG, Schoepp DD, Ornstein PL (January 2003). "Synthesis and structure-activity relationship studies of novel 2-diarylethyl substituted (2-carboxycycloprop-1-yl)glycines as high-affinity group II metabotropic glutamate receptor ligands". Bioorganic & Medicinal Chemistry. 11 (2): 197–205. doi:10.1016/S0968-0896(02)00387-5. PMID 12470714.
^Ure J, Baudry M, Perassolo M (August 2006). "Metabotropic glutamate receptors and epilepsy". Journal of the Neurological Sciences. 247 (1): 1–9. doi:10.1016/j.jns.2006.03.018. PMID 16697014. S2CID 22777207.
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cecxg, ethyl, research, drug, which, acts, potent, selective, antagonist, group, metabotropic, glutamate, receptors, mglur2, with, reasonable, selectivity, mglur3, while, some, five, times, less, potent, than, mglur3, higher, affinity, mglur3, over, mglur2, ma. CECXG 3 ethyl LY 341 495 is a research drug which acts as a potent and selective antagonist for the group II metabotropic glutamate receptors mGluR2 3 with reasonable selectivity for mGluR3 While it is some five times less potent than LY 341 495 at mGluR3 it has 38x higher affinity for mGluR3 over mGluR2 1 making it one of the few ligands available that is able to distinguish between these two closely related receptor subtypes 2 3 4 CECXGIdentifiersIUPAC name 2 1 SR 2 SR 3 SR 2 carboxy 3 ethylcyclopropyl 2 9 xanthylmethyl glycinePubChem CID44329042ChemSpider28190823 NChemical and physical dataFormulaC 22H 23N O 5Molar mass381 428 g mol 13D model JSmol Interactive imageSMILES c4cccc2c4Oc3ccccc3C2CC N C O O C1C C O O C1CCInChI InChI 1S C22H23NO5 c1 2 12 18 20 24 25 19 12 22 23 21 26 27 11 15 13 7 3 5 9 16 13 28 17 10 6 4 8 14 15 17 h3 10 12 15 18 19H 2 11 23H2 1H3 H 24 25 H 26 27 t12 18 19 22 m1 s1 NKey NBAKIHCDPVZWRB KQLBNOIASA N N N Y what is this verify References edit Collado I Ezquerra J Mazon A Pedregal C Yruretagoyena B Kingston AE et al October 1998 2 3 disubstituted 2 2 carboxycyclopropyl glycines as potent and selective antagonists of metabotropic glutamate receptors Bioorganic amp Medicinal Chemistry Letters 8 20 2849 2854 doi 10 1016 S0960 894X 98 00510 1 PMID 9873635 Schoepp DD Jane DE Monn JA 2002 Pharmacology of metabotropic glutamate receptors In Egebjerg J Krogsgaard Larsen P Schousboe A eds Glutamate and GABA receptors and transporters structure function and pharmacology Taylor amp Francis pp 171 173 ISBN 0 7484 0881 9 Sorensen US Bleisch TJ Kingston AE Wright RA Johnson BG Schoepp DD Ornstein PL January 2003 Synthesis and structure activity relationship studies of novel 2 diarylethyl substituted 2 carboxycycloprop 1 yl glycines as high affinity group II metabotropic glutamate receptor ligands Bioorganic amp Medicinal Chemistry 11 2 197 205 doi 10 1016 S0968 0896 02 00387 5 PMID 12470714 Ure J Baudry M Perassolo M August 2006 Metabotropic glutamate receptors and epilepsy Journal of the Neurological Sciences 247 1 1 9 doi 10 1016 j jns 2006 03 018 PMID 16697014 S2CID 22777207 nbsp This drug article relating to the nervous system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CECXG amp oldid 1190944341, wikipedia, wiki, book, books, library,
