This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas.
Cadherin-3 was first described in 1986 by Masatoshi Takeichi's laboratory as a new cadherin molecule most abundant in the developing mouse placenta – hence "P-cadherin".[10][11]
^ abcGRCh38: Ensembl release 89: ENSG00000062038 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000061048 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (Oct 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics. 14 (2): 488–90. doi:10.1016/S0888-7543(05)80247-2. PMID 1427864.
^ ab"Entrez Gene: CDH3 cadherin 3, type 1, P-cadherin (placental)".
^ abcdKlingelhöfer J, Troyanovsky RB, Laur OY, Troyanovsky S (Aug 2000). "Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions". Journal of Cell Science. 113 (16): 2829–36. doi:10.1242/jcs.113.16.2829. PMID 10910767.
^ abSchmeiser K, Grand RJ (Apr 1999). "The fate of E- and P-cadherin during the early stages of apoptosis". Cell Death and Differentiation. 6 (4): 377–86. doi:10.1038/sj.cdd.4400504. PMID 10381631.
^Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG (Sep 2004). "Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin". The American Journal of Pathology. 165 (3): 923–36. doi:10.1016/S0002-9440(10)63354-8. PMC1618613. PMID 15331416.
^Vieira AF, Paredes J (October 2015). "P-cadherin and the journey to cancer metastasis". Mol Cancer. 14: 178. doi:10.1186/s12943-015-0448-4. PMC4595126. PMID 26438065.
^Nose A, Takeichi M (December 1986). "A novel cadherin cell adhesion molecule: its expression patterns associated with implantation and organogenesis of mouse embryos". J Cell Biol. 103 (6 Pt 2): 2649–58. doi:10.1083/jcb.103.6.2649. PMC2114609. PMID 3539943.
Further readingedit
Herrenknecht K, Ozawa M, Eckerskorn C, Lottspeich F, Lenter M, Kemler R (Oct 1991). "The uvomorulin-anchorage protein alpha catenin is a vinculin homologue". Proceedings of the National Academy of Sciences of the United States of America. 88 (20): 9156–60. Bibcode:1991PNAS...88.9156H. doi:10.1073/pnas.88.20.9156. PMC52671. PMID 1924379.
Shimoyama Y, Hirohashi S, Hirano S, Noguchi M, Shimosato Y, Takeichi M, Abe O (Apr 1989). "Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas". Cancer Research. 49 (8): 2128–33. PMID 2702654.
Shimoyama Y, Yoshida T, Terada M, Shimosato Y, Abe O, Hirohashi S (Oct 1989). "Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues". The Journal of Cell Biology. 109 (4 Pt 1): 1787–94. doi:10.1083/jcb.109.4.1787. PMC2115800. PMID 2793940.
Palacios J, Benito N, Pizarro A, Suárez A, Espada J, Cano A, Gamallo C (Mar 1995). "Anomalous expression of P-cadherin in breast carcinoma. Correlation with E-cadherin expression and pathological features". The American Journal of Pathology. 146 (3): 605–12. PMC1869170. PMID 7534041.
van der Linden PJ, de Goeij AF, Dunselman GA, Erkens HW, Evers JL (Jun 1995). "Expression of cadherins and integrins in human endometrium throughout the menstrual cycle". Fertility and Sterility. 63 (6): 1210–6. doi:10.1016/s0015-0282(16)57599-2. PMID 7538474.
Tang A, Eller MS, Hara M, Yaar M, Hirohashi S, Gilchrest BA (Apr 1994). "E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro". Journal of Cell Science. 107 (4): 983–92. doi:10.1242/jcs.107.4.983. PMID 8056851.
Tassin MT, Beziau A, Gubler MC, Boyer B (Mar 1994). "Spatiotemporal expression of molecules associated with junctional complexes during the in vivo maturation of renal podocytes". The International Journal of Developmental Biology. 38 (1): 45–54. PMID 8074995.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Navarro P, Lozano E, Cano A (Aug 1993). "Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin". Journal of Cell Science. 105 (4): 923–34. doi:10.1242/jcs.105.4.923. hdl:10261/78716. PMID 8227214.
Reynolds AB, Daniel JM, Mo YY, Wu J, Zhang Z (Jun 1996). "The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts". Experimental Cell Research. 225 (2): 328–37. doi:10.1006/excr.1996.0183. PMID 8660921.
Soler AP, Harner GD, Knudsen KA, McBrearty FX, Grujic E, Salazar H, Han AC, Keshgegian AA (Aug 1997). "Expression of P-cadherin identifies prostate-specific-antigen-negative cells in epithelial tissues of male sexual accessory organs and in prostatic carcinomas. Implications for prostate cancer biology". The American Journal of Pathology. 151 (2): 471–8. PMC1858007. PMID 9250159.
Wakita H, Furukawa F, Baba S, Takigawa M (Nov 1997). "Human squamous-cell-carcinoma cell line (DJM-1) cells synthesize P-cadherin molecules via an elevation of extracellular calcium: calcium regulates P-cadherin-gene expression at the translational level via protein tyrosine phosphorylation". International Journal of Cancer. 73 (3): 432–9. doi:10.1002/(SICI)1097-0215(19971104)73:3<432::AID-IJC19>3.0.CO;2-E. PMID 9359492. S2CID 6333793.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (May 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
Jarrard DF, Paul R, van Bokhoven A, Nguyen SH, Bova GS, Wheelock MJ, Johnson KR, Schalken J, Bussemakers M, Isaacs WB (Nov 1997). "P-Cadherin is a basal cell-specific epithelial marker that is not expressed in prostate cancer". Clinical Cancer Research. 3 (11): 2121–8. PMID 9815605.
Schmeiser K, Grand RJ (Apr 1999). "The fate of E- and P-cadherin during the early stages of apoptosis". Cell Death and Differentiation. 6 (4): 377–86. doi:10.1038/sj.cdd.4400504. PMID 10381631.
Rufas O, Fisch B, Ziv S, Shalgi R (Feb 2000). "Expression of cadherin adhesion molecules on human gametes". Molecular Human Reproduction. 6 (2): 163–9. doi:10.1093/molehr/6.2.163. PMID 10655458.
Klingelhöfer J, Troyanovsky RB, Laur OY, Troyanovsky S (Aug 2000). "Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions". Journal of Cell Science. 113 (16): 2829–36. doi:10.1242/jcs.113.16.2829. PMID 10910767.
Han AC, Edelson MI, Peralta Soler A, Knudsen KA, Lifschitz-Mercer B, Czernobilsky B, Rosenblum NG, Salazar H (Nov 2000). "Cadherin expression in glandular tumors of the cervix". Cancer. 89 (10): 2053–8. doi:10.1002/1097-0142(20001115)89:10<2053::AID-CNCR4>3.0.CO;2-C. PMID 11066045. S2CID 39826325.
Bauer K, Gosau M, Reinders J, Oefner P, Reichert TE, Bauer R (Nov 2013). "Presenilin 1/γ-secretase modulates P-cadherin processing and influences cell adhesion in oral squamous cell carcinoma cell lines". Carcinogenesis. 34 (11): 2622–8. doi:10.1093/carcin/bgt211. PMID 23740836.
cdh3, gene, cadherin, also, known, cadherin, protein, that, humans, encoded, cdh3, gene, cdh3available, structurespdbortholog, search, pdbe, rcsblist, codes4oy9identifiersaliasescdh3, cdhp, hjmd, pcad, cadherin, 3external, idsomim, 114021, 88356, homologene, 2. Cadherin 3 also known as P Cadherin is a protein that in humans is encoded by the CDH3 gene 5 6 CDH3Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes4OY9IdentifiersAliasesCDH3 CDHP HJMD PCAD cadherin 3External IDsOMIM 114021 MGI 88356 HomoloGene 20425 GeneCards CDH3Gene location Human Chr Chromosome 16 human 1 Band16q22 1Start68 636 189 bp 1 End68 727 468 bp 1 Gene location Mouse Chr Chromosome 8 mouse 2 Band8 D3 8 53 16 cMStart107 237 523 bp 2 End107 283 929 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insecondary oocytelactiferous ductretinal pigment epitheliumperiodontal fiberhair follicleleft uterine tubegerminal epitheliumskin of abdomenpalpebral conjunctivaminor salivary glandsTop expressed inlipsacculesecondary oocytemolaryolk sacotic placodeurethraskin of backmaxillary prominenceabdominal wallMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioncalcium ion binding metal ion binding molecular function cytoskeletal protein binding protein homodimerization activity cadherin bindingCellular componentcytoplasm integral component of membrane membrane plasma membrane cell surface catenin complexBiological processhair cycle process positive regulation of keratinocyte proliferation negative regulation of timing of catagen response to stimulus keratinization wound healing regulation of hair cycle by canonical Wnt signaling pathway negative regulation of transforming growth factor beta2 production positive regulation of tyrosinase activity retina homeostasis positive regulation of gene expression cell adhesion positive regulation of insulin like growth factor receptor signaling pathway canonical Wnt signaling pathway positive regulation of melanin biosynthetic process positive regulation of melanosome transport adherens junction organization visual perception homophilic cell adhesion via plasma membrane adhesion molecules cell cell adhesion positive regulation of canonical Wnt signaling pathway cell cell junction assembly calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules cell cell adhesion mediated by cadherin cell morphogenesisSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez100112560EnsemblENSG00000062038ENSMUSG00000061048UniProtP22223P10287RefSeq mRNA NM 001793NM 001317195NM 001317196NM 001037809NM 007665RefSeq protein NP 001304124NP 001304125NP 001784NP 001032898NP 031691Location UCSC Chr 16 68 64 68 73 MbChr 8 107 24 107 28 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Clinical significance 3 Interactions 4 History 5 See also 6 References 7 Further reading 8 External linksFunction editThis gene is a classical cadherin from the cadherin superfamily The encoded protein is a calcium dependent cell cell adhesion glycoprotein composed of five extracellular cadherin repeats a transmembrane region and a highly conserved cytoplasmic tail This gene is located in a six cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer In addition aberrant expression of this protein is observed in cervical adenocarcinomas Clinical significance editMutations in this gene have been associated with congenital hypotrichosis with juvenile macular dystrophy 6 Interactions editCDH3 gene has been shown to interact with Beta catenin 7 8 CDH1 7 Catenin cadherin associated protein alpha 1 7 8 Nephrin 9 and Plakoglobin 7 History editCadherin 3 was first described in 1986 by Masatoshi Takeichi s laboratory as a new cadherin molecule most abundant in the developing mouse placenta hence P cadherin 10 11 See also editEEM syndromeReferences edit a b c GRCh38 Ensembl release 89 ENSG00000062038 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000061048 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Kaupmann K Becker Follmann J Scherer G Jockusch H Starzinski Powitz A Oct 1992 The gene for the cell adhesion molecule M cadherin maps to mouse chromosome 8 and human chromosome 16q24 1 qter and is near the E cadherin uvomorulin locus in both species Genomics 14 2 488 90 doi 10 1016 S0888 7543 05 80247 2 PMID 1427864 a b Entrez Gene CDH3 cadherin 3 type 1 P cadherin placental a b c d Klingelhofer J Troyanovsky RB Laur OY Troyanovsky S Aug 2000 Amino terminal domain of classic cadherins determines the specificity of the adhesive interactions Journal of Cell Science 113 16 2829 36 doi 10 1242 jcs 113 16 2829 PMID 10910767 a b Schmeiser K Grand RJ Apr 1999 The fate of E and P cadherin during the early stages of apoptosis Cell Death and Differentiation 6 4 377 86 doi 10 1038 sj cdd 4400504 PMID 10381631 Lehtonen S Lehtonen E Kudlicka K Holthofer H Farquhar MG Sep 2004 Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin Darby canine kidney cells expressing nephrin The American Journal of Pathology 165 3 923 36 doi 10 1016 S0002 9440 10 63354 8 PMC 1618613 PMID 15331416 Vieira AF Paredes J October 2015 P cadherin and the journey to cancer metastasis Mol Cancer 14 178 doi 10 1186 s12943 015 0448 4 PMC 4595126 PMID 26438065 Nose A Takeichi M December 1986 A novel cadherin cell adhesion molecule its expression patterns associated with implantation and organogenesis of mouse embryos J Cell Biol 103 6 Pt 2 2649 58 doi 10 1083 jcb 103 6 2649 PMC 2114609 PMID 3539943 Further reading editHerrenknecht K Ozawa M Eckerskorn C Lottspeich F Lenter M Kemler R Oct 1991 The uvomorulin anchorage protein alpha catenin is a vinculin homologue Proceedings of the National Academy of Sciences of the United States of America 88 20 9156 60 Bibcode 1991PNAS 88 9156H doi 10 1073 pnas 88 20 9156 PMC 52671 PMID 1924379 Shimoyama Y Hirohashi S Hirano S Noguchi M Shimosato Y Takeichi M Abe O Apr 1989 Cadherin cell adhesion molecules in human epithelial tissues and carcinomas Cancer Research 49 8 2128 33 PMID 2702654 Shimoyama Y Yoshida T Terada M Shimosato Y Abe O Hirohashi S Oct 1989 Molecular cloning of a human Ca2 dependent cell cell adhesion molecule homologous to mouse placental cadherin its low expression in human placental tissues The Journal of Cell Biology 109 4 Pt 1 1787 94 doi 10 1083 jcb 109 4 1787 PMC 2115800 PMID 2793940 Palacios J Benito N Pizarro A Suarez A Espada J Cano A Gamallo C Mar 1995 Anomalous expression of P cadherin in breast carcinoma Correlation with E cadherin expression and pathological features The American Journal of Pathology 146 3 605 12 PMC 1869170 PMID 7534041 van der Linden PJ de Goeij AF Dunselman GA Erkens HW Evers JL Jun 1995 Expression of cadherins and integrins in human endometrium throughout the menstrual cycle Fertility and Sterility 63 6 1210 6 doi 10 1016 s0015 0282 16 57599 2 PMID 7538474 Tang A Eller MS Hara M Yaar M Hirohashi S Gilchrest BA Apr 1994 E cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro Journal of Cell Science 107 4 983 92 doi 10 1242 jcs 107 4 983 PMID 8056851 Tassin MT Beziau A Gubler MC Boyer B Mar 1994 Spatiotemporal expression of molecules associated with junctional complexes during the in vivo maturation of renal podocytes The International Journal of Developmental Biology 38 1 45 54 PMID 8074995 Maruyama K Sugano S Jan 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Navarro P Lozano E Cano A Aug 1993 Expression of E or P cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells Possible involvement of plakoglobin Journal of Cell Science 105 4 923 34 doi 10 1242 jcs 105 4 923 hdl 10261 78716 PMID 8227214 Reynolds AB Daniel JM Mo YY Wu J Zhang Z Jun 1996 The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts Experimental Cell Research 225 2 328 37 doi 10 1006 excr 1996 0183 PMID 8660921 Soler AP Harner GD Knudsen KA McBrearty FX Grujic E Salazar H Han AC Keshgegian AA Aug 1997 Expression of P cadherin identifies prostate specific antigen negative cells in epithelial tissues of male sexual accessory organs and in prostatic carcinomas Implications for prostate cancer biology The American Journal of Pathology 151 2 471 8 PMC 1858007 PMID 9250159 Wakita H Furukawa F Baba S Takigawa M Nov 1997 Human squamous cell carcinoma cell line DJM 1 cells synthesize P cadherin molecules via an elevation of extracellular calcium calcium regulates P cadherin gene expression at the translational level via protein tyrosine phosphorylation International Journal of Cancer 73 3 432 9 doi 10 1002 SICI 1097 0215 19971104 73 3 lt 432 AID IJC19 gt 3 0 CO 2 E PMID 9359492 S2CID 6333793 Suzuki Y Yoshitomo Nakagawa K Maruyama K Suyama A Sugano S Oct 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Kremmidiotis G Baker E Crawford J Eyre HJ Nahmias J Callen DF May 1998 Localization of human cadherin genes to chromosome regions exhibiting cancer related loss of heterozygosity Genomics 49 3 467 71 doi 10 1006 geno 1998 5281 PMID 9615235 Jarrard DF Paul R van Bokhoven A Nguyen SH Bova GS Wheelock MJ Johnson KR Schalken J Bussemakers M Isaacs WB Nov 1997 P Cadherin is a basal cell specific epithelial marker that is not expressed in prostate cancer Clinical Cancer Research 3 11 2121 8 PMID 9815605 Schmeiser K Grand RJ Apr 1999 The fate of E and P cadherin during the early stages of apoptosis Cell Death and Differentiation 6 4 377 86 doi 10 1038 sj cdd 4400504 PMID 10381631 Rufas O Fisch B Ziv S Shalgi R Feb 2000 Expression of cadherin adhesion molecules on human gametes Molecular Human Reproduction 6 2 163 9 doi 10 1093 molehr 6 2 163 PMID 10655458 Klingelhofer J Troyanovsky RB Laur OY Troyanovsky S Aug 2000 Amino terminal domain of classic cadherins determines the specificity of the adhesive interactions Journal of Cell Science 113 16 2829 36 doi 10 1242 jcs 113 16 2829 PMID 10910767 Han AC Edelson MI Peralta Soler A Knudsen KA Lifschitz Mercer B Czernobilsky B Rosenblum NG Salazar H Nov 2000 Cadherin expression in glandular tumors of the cervix Cancer 89 10 2053 8 doi 10 1002 1097 0142 20001115 89 10 lt 2053 AID CNCR4 gt 3 0 CO 2 C PMID 11066045 S2CID 39826325 Bauer K Gosau M Reinders J Oefner P Reichert TE Bauer R Nov 2013 Presenilin 1 g secretase modulates P cadherin processing and influences cell adhesion in oral squamous cell carcinoma cell lines Carcinogenesis 34 11 2622 8 doi 10 1093 carcin bgt211 PMID 23740836 External links editCDH3 human gene location in the UCSC Genome Browser CDH3 human gene details in the UCSC Genome Browser nbsp This article on a gene on human chromosome 16 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CDH3 gene amp oldid 1188049769, wikipedia, wiki, book, books, library,
