The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported.[5]
ReferencesEdit
^ abcGRCh38: Ensembl release 89: ENSG00000143776 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026490 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ab"Entrez Gene: CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)".
External linksEdit
Human CDC42BPA genome location and CDC42BPA gene details page in the UCSC Genome Browser.
Further readingEdit
Zhao Y, Loyer P, Li H, et al. (1997). "Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases". J. Biol. Chem. 272 (15): 10013–20. doi:10.1074/jbc.272.15.10013. PMID 9092543.
Leung T, Chen XQ, Tan I, et al. (1998). "Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization". Mol. Cell. Biol. 18 (1): 130–40. doi:10.1128/mcb.18.1.130. PMC121465. PMID 9418861.
Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
Moncrieff CL, Bailey ME, Morrison N, Johnson KJ (1999). "Cloning and chromosomal localization of human Cdc42-binding protein kinase beta". Genomics. 57 (2): 297–300. doi:10.1006/geno.1999.5769. PMID 10198171.
Edwards DC, Sanders LC, Bokoch GM, Gill GN (1999). "Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics". Nat. Cell Biol. 1 (5): 253–9. doi:10.1038/12963. PMID 10559936. S2CID 25250183.
Ohashi K, Nagata K, Maekawa M, et al. (2000). "Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop". J. Biol. Chem. 275 (5): 3577–82. doi:10.1074/jbc.275.5.3577. PMID 10652353.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC16267. PMID 10737800.
Nakamura N, Oshiro N, Fukata Y, et al. (2000). "Phosphorylation of ERM proteins at filopodia induced by Cdc42". Genes Cells. 5 (7): 571–81. doi:10.1046/j.1365-2443.2000.00348.x. PMID 10947843. S2CID 10022990.
Lam LT, Pham YC, Nguyen TM, Morris GE (2000). "Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart". Hum. Mol. Genet. 9 (14): 2167–73. doi:10.1093/hmg/9.14.2167. PMID 10958655.
Tan I, Seow KT, Lim L, Leung T (2001). "Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha". Mol. Cell. Biol. 21 (8): 2767–78. doi:10.1128/MCB.21.8.2767-2778.2001. PMC86907. PMID 11283256.
Sumi T, Matsumoto K, Shibuya A, Nakamura T (2001). "Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha". J. Biol. Chem. 276 (25): 23092–6. doi:10.1074/jbc.C100196200. PMID 11340065.
Lemercier C, Brocard MP, Puvion-Dutilleul F, et al. (2002). "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". J. Biol. Chem. 277 (24): 22045–52. doi:10.1074/jbc.M201736200. PMID 11929873.
Dong JM, Leung T, Manser E, Lim L (2003). "Cdc42 antagonizes inductive action of cAMP on cell shape, via effects of the myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) on myosin light chain phosphorylation". Eur. J. Cell Biol. 81 (4): 231–42. doi:10.1078/0171-9335-00238. PMID 12018391.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Tan I, Cheong A, Lim L, Leung T (2003). "Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase alpha reveals multiple alternative splicing and functional diversity". Gene. 304: 107–15. doi:10.1016/S0378-1119(02)01185-X. PMID 12568720.
Wilkinson S, Paterson HF, Marshall CJ (2005). "Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion". Nat. Cell Biol. 7 (3): 255–61. doi:10.1038/ncb1230. PMID 15723050. S2CID 34732713.
Cmejla R, Petrak J, Cmejlova J (2006). "A novel iron responsive element in the 3'UTR of human MRCKalpha". Biochem. Biophys. Res. Commun. 341 (1): 158–66. doi:10.1016/j.bbrc.2005.12.155. PMID 16412980.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Lefort K, Mandinova A, Ostano P, et al. (2007). "Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases". Genes Dev. 21 (5): 562–77. doi:10.1101/gad.1484707. PMC1820898. PMID 17344417.
This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.
cdc42bpa, serine, threonine, protein, kinase, mrck, alpha, enzyme, that, humans, encoded, gene, identifiersaliases, mrck, mrcka, pk428, cdc42, binding, protein, kinase, alphaexternal, idsomim, 603412, 2441841, homologene, 55765, genecards, gene, location, huma. Serine threonine protein kinase MRCK alpha is an enzyme that in humans is encoded by the CDC42BPA gene 5 CDC42BPAIdentifiersAliasesCDC42BPA MRCK MRCKA PK428 CDC42 binding protein kinase alphaExternal IDsOMIM 603412 MGI 2441841 HomoloGene 55765 GeneCards CDC42BPAGene location Human Chr Chromosome 1 human 1 Band1q42 13Start226 989 865 bp 1 End227 318 492 bp 1 Gene location Mouse Chr Chromosome 1 mouse 2 Band1 1 H4Start179 788 037 bp 2 End179 993 168 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed ininternal globus palliduspylorustibiasecondary oocyteexternal globus pallidusrenal medullaBrodmann area 23corpus callosuminferior ganglion of vagus nervecardiaTop expressed insuperior frontal gyruscerebellar cortexmedial geniculate nucleussuperior colliculuscerebellar vermissecondary oocytesupraoptic nucleuslateral geniculate nucleusinferior colliculussubiculumMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiontransferase activity nucleotide binding protein serine threonine kinase activity protein kinase activity protein binding ATP binding magnesium ion binding metal ion binding identical protein binding kinase activityCellular componentcytoplasm actomyosin extracellular exosome cell leading edge cell cell junction lamellipodium cell projection cytoskeletonBiological processprotein phosphorylation actomyosin structure organization intracellular signal transduction cell migration phosphorylation actin cytoskeleton reorganization actin cytoskeleton organization peptidyl threonine phosphorylationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez8476226751EnsemblENSG00000143776ENSMUSG00000026490UniProtQ5VT25Q3UU96RefSeq mRNA NM 003607NM 014826NM 001366010NM 001366011NM 001366019NM 001387550NM 001394014NM 001033285NM 001346804NM 001346805NM 001359541NM 001359542NM 001359543NM 001359544NM 001359545NM 001359546NM 001359547NM 001359548NM 001359549RefSeq protein NP 003598NP 055641NP 001352939NP 001352940NP 001352948NP 001028457NP 001333733NP 001333734NP 001346470NP 001346471NP 001346472NP 001346473NP 001346474NP 001346475NP 001346476NP 001346477NP 001346478Location UCSC Chr 1 226 99 227 32 MbChr 1 179 79 179 99 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe protein encoded by this gene is a member of the Serine Threonine protein kinase family This kinase contains multiple functional domains Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase DMPK This kinase also contains a Rac interactive binding CRIB domain and has been shown to bind CDC42 It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation and promoting cytoskeletal reorganization Multiple alternatively spliced transcript variants have been described and the full length nature of two of them has been reported 5 References Edit a b c GRCh38 Ensembl release 89 ENSG00000143776 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000026490 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene CDC42BPA CDC42 binding protein kinase alpha DMPK like External links EditHuman CDC42BPA genome location and CDC42BPA gene details page in the UCSC Genome Browser Further reading EditZhao Y Loyer P Li H et al 1997 Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases J Biol Chem 272 15 10013 20 doi 10 1074 jbc 272 15 10013 PMID 9092543 Leung T Chen XQ Tan I et al 1998 Myotonic dystrophy kinase related Cdc42 binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization Mol Cell Biol 18 1 130 40 doi 10 1128 mcb 18 1 130 PMC 121465 PMID 9418861 Seki N Ohira M Nagase T et al 1998 Characterization of cDNA clones in size fractionated cDNA libraries from human brain DNA Res 4 5 345 9 doi 10 1093 dnares 4 5 345 PMID 9455484 Moncrieff CL Bailey ME Morrison N Johnson KJ 1999 Cloning and chromosomal localization of human Cdc42 binding protein kinase beta Genomics 57 2 297 300 doi 10 1006 geno 1999 5769 PMID 10198171 Edwards DC Sanders LC Bokoch GM Gill GN 1999 Activation of LIM kinase by Pak1 couples Rac Cdc42 GTPase signalling to actin cytoskeletal dynamics Nat Cell Biol 1 5 253 9 doi 10 1038 12963 PMID 10559936 S2CID 25250183 Ohashi K Nagata K Maekawa M et al 2000 Rho associated kinase ROCK activates LIM kinase 1 by phosphorylation at threonine 508 within the activation loop J Biol Chem 275 5 3577 82 doi 10 1074 jbc 275 5 3577 PMID 10652353 Dias Neto E Correa RG Verjovski Almeida S et al 2000 Shotgun sequencing of the human transcriptome with ORF expressed sequence tags Proc Natl Acad Sci U S A 97 7 3491 6 Bibcode 2000PNAS 97 3491D doi 10 1073 pnas 97 7 3491 PMC 16267 PMID 10737800 Nakamura N Oshiro N Fukata Y et al 2000 Phosphorylation of ERM proteins at filopodia induced by Cdc42 Genes Cells 5 7 571 81 doi 10 1046 j 1365 2443 2000 00348 x PMID 10947843 S2CID 10022990 Lam LT Pham YC Nguyen TM Morris GE 2000 Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase DMPK is expressed almost exclusively in muscle and heart Hum Mol Genet 9 14 2167 73 doi 10 1093 hmg 9 14 2167 PMID 10958655 Tan I Seow KT Lim L Leung T 2001 Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase related Cdc42 binding kinase alpha Mol Cell Biol 21 8 2767 78 doi 10 1128 MCB 21 8 2767 2778 2001 PMC 86907 PMID 11283256 Sumi T Matsumoto K Shibuya A Nakamura T 2001 Activation of LIM kinases by myotonic dystrophy kinase related Cdc42 binding kinase alpha J Biol Chem 276 25 23092 6 doi 10 1074 jbc C100196200 PMID 11340065 Lemercier C Brocard MP Puvion Dutilleul F et al 2002 Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor J Biol Chem 277 24 22045 52 doi 10 1074 jbc M201736200 PMID 11929873 Dong JM Leung T Manser E Lim L 2003 Cdc42 antagonizes inductive action of cAMP on cell shape via effects of the myotonic dystrophy kinase related Cdc42 binding kinase MRCK on myosin light chain phosphorylation Eur J Cell Biol 81 4 231 42 doi 10 1078 0171 9335 00238 PMID 12018391 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Tan I Cheong A Lim L Leung T 2003 Genomic organization of human myotonic dystrophy kinase related Cdc42 binding kinase alpha reveals multiple alternative splicing and functional diversity Gene 304 107 15 doi 10 1016 S0378 1119 02 01185 X PMID 12568720 Wilkinson S Paterson HF Marshall CJ 2005 Cdc42 MRCK and Rho ROCK signalling cooperate in myosin phosphorylation and cell invasion Nat Cell Biol 7 3 255 61 doi 10 1038 ncb1230 PMID 15723050 S2CID 34732713 Cmejla R Petrak J Cmejlova J 2006 A novel iron responsive element in the 3 UTR of human MRCKalpha Biochem Biophys Res Commun 341 1 158 66 doi 10 1016 j bbrc 2005 12 155 PMID 16412980 Gregory SG Barlow KF McLay KE et al 2006 The DNA sequence and biological annotation of human chromosome 1 Nature 441 7091 315 21 Bibcode 2006Natur 441 315G doi 10 1038 nature04727 PMID 16710414 Lefort K Mandinova A Ostano P et al 2007 Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1 2 and MRCKalpha kinases Genes Dev 21 5 562 77 doi 10 1101 gad 1484707 PMC 1820898 PMID 17344417 nbsp This article on a gene on human chromosome 1 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CDC42BPA amp oldid 1170401923, wikipedia, wiki, book, books, library,
