The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. Specifically, it is thought to fulfil this role by bundling and stabilising microtubules. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in 3 transcript variants encoding distinct isoforms.[6]
CDC14B has been shown to interact with p53, potentially de-phosphorylate p53 at Serine 315 and thereby stabilize p53.[7] S315-phosphorylated p53, in contrast to other p53 phosphorylation, was shown to facilitate p53 degradation.[8] At the patho-physiological level, mice with CDC14B deletion were shown to exhibit early-onset ageing phenotypes. [9]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000081377 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000033102 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Li L, Ernsting BR, Wishart MJ, Lohse DL, Dixon JE (November 1997). "A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast". The Journal of Biological Chemistry. 272 (47): 29403–29406. doi:10.1074/jbc.272.47.29403. PMID 9367992.
^ ab"Entrez Gene: CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae)".
^Li L, Ljungman M, Dixon JE (January 2000). "The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53". The Journal of Biological Chemistry. 275 (4): 2410–2414. doi:10.1074/jbc.275.4.2410. PMID 10644693.
^Li, Y; Cui K; Zhang Q; Li X; Lin X; Tang Y; Prochownik E; Li Y (July 2021). "FBXL6 degrades phosphorylated p53 to promote tumor growth". Cell Death Differ. 28 (7): 2112–2125. doi:10.1038/s41418-021-00739-6. ISSN 1350-9047. PMC8257708. PMID 33568778.
^Wei Z, Peddibhotla S, Lin H, Fang X, Li M, Rosen M, Zhang P (April 2011). "Early-onset aging and defective DNA damage response in Cdc14b-deficient mice". Mol. Cell. Biol. 31 (7): 1470–1477. doi:10.1128/MCB.01330-10. PMC3135283. PMID 21262768.
Further readingedit
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Li L, Ljungman M, Dixon JE (January 2000). "The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53". The Journal of Biological Chemistry. 275 (4): 2410–2414. doi:10.1074/jbc.275.4.2410. PMID 10644693.
Mailand N, Lukas C, Kaiser BK, Jackson PK, Bartek J, Lukas J (April 2002). "Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation". Nature Cell Biology. 4 (4): 317–322. doi:10.1038/ncb777. PMID 11901424. S2CID 28955777.
Kaiser BK, Zimmerman ZA, Charbonneau H, Jackson PK (July 2002). "Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase". Molecular Biology of the Cell. 13 (7): 2289–2300. doi:10.1091/mbc.01-11-0535. PMC117313. PMID 12134069.
Dryden SC, Nahhas FA, Nowak JE, Goustin AS, Tainsky MA (May 2003). "Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle". Molecular and Cellular Biology. 23 (9): 3173–3185. doi:10.1128/MCB.23.9.3173-3185.2003. PMC153197. PMID 12697818.
Gray CH, Good VM, Tonks NK, Barford D (July 2003). "The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase". The EMBO Journal. 22 (14): 3524–3535. doi:10.1093/emboj/cdg348. PMC165618. PMID 12853468.
Nalepa G, Harper JW (October 2004). "Visualization of a highly organized intranuclear network of filaments in living mammalian cells". Cell Motility and the Cytoskeleton. 59 (2): 94–108. doi:10.1002/cm.20023. PMID 15362113.
Cho HP, Liu Y, Gomez M, Dunlap J, Tyers M, Wang Y (June 2005). "The dual-specificity phosphatase CDC14B bundles and stabilizes microtubules". Molecular and Cellular Biology. 25 (11): 4541–4551. doi:10.1128/MCB.25.11.4541-4551.2005. PMC1140622. PMID 15899858.
Vázquez-Novelle MD, Esteban V, Bueno A, Sacristán MP (August 2005). "Functional homology among human and fission yeast Cdc14 phosphatases". The Journal of Biological Chemistry. 280 (32): 29144–29150. doi:10.1074/jbc.M413328200. PMID 15911625.
External linksedit
Human CDC14B genome location and CDC14B gene details page in the UCSC Genome Browser.
This protein-related article is a stub. You can help Wikipedia by expanding it.
cdc14b, dual, specificity, protein, phosphatase, enzyme, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1ohc, 1ohd, 1oheidentifiersaliases, cdc14b1, cdc14b2, hcell, division, cycle, 14bexternal, idsomim, 603505, 244. Dual specificity protein phosphatase CDC14B is an enzyme that in humans is encoded by the CDC14B gene 5 6 CDC14BAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes1OHC 1OHD 1OHEIdentifiersAliasesCDC14B CDC14B3 Cdc14B1 Cdc14B2 hcell division cycle 14BExternal IDsOMIM 603505 MGI 2441808 HomoloGene 104197 GeneCards CDC14BGene location Human Chr Chromosome 9 human 1 Band9q22 32 q22 33Start96 490 241 bp 1 End96 619 843 bp 1 Gene location Mouse Chr Chromosome 13 mouse 2 Band13 13 B3Start64 189 268 bp 2 End64 275 290 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed incorpus callosuminternal globus pallidusoptic nerveretinal pigment epitheliuminferior ganglion of vagus nervebronchial epithelial cellseminal vesiculaspermjejunal mucosainferior olivary nucleusTop expressed inhandspermatidprimitive streakmaxillary prominenceleft lobe of liveratriummorulairisatrioventricular valveciliary bodyMore reference expression dataBioGPSn aGene ontologyMolecular functionprotein tyrosine phosphatase activity phosphoprotein phosphatase activity hydrolase activity protein tyrosine serine threonine phosphatase activity phosphatase activity protein binding protein serine threonine phosphatase activityCellular componentnucleus nucleolus cytoplasm nucleoplasm spindle pole centrosome mitotic spindleBiological processDNA repair cellular response to DNA damage stimulus dephosphorylation protein dephosphorylation peptidyl tyrosine dephosphorylation positive regulation of ubiquitin protein ligase activity regulation of exit from mitosis mitotic spindle midzone assembly cilium assembly mitotic G2 DNA damage checkpoint signaling microtubule cytoskeleton organization mitotic cell cycle positive regulation of cytokinesisSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez8555218294EnsemblENSG00000081377ENSMUSG00000033102UniProtO60729Q6PFY9RefSeq mRNA NM 001077181NM 003671NM 033331NM 033332NM 001351567NM 001351568NM 001351569NM 001351570NM 001122989NM 172587RefSeq protein NP 001070649NP 003662NP 201588NP 001338496NP 001338497NP 001338498NP 001338499NP 001116461NP 766175Location UCSC Chr 9 96 49 96 62 MbChr 13 64 19 64 28 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family This protein is highly similar to Saccharomyces cerevisiae Cdc14 a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication which suggests the role in cell cycle control Specifically it is thought to fulfil this role by bundling and stabilising microtubules This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53 and is thought to regulate the function of p53 Alternative splicing of this gene results in 3 transcript variants encoding distinct isoforms 6 Contents 1 Interactions and Functions 2 References 3 Further reading 4 External linksInteractions and Functions editCDC14B has been shown to interact with p53 potentially de phosphorylate p53 at Serine 315 and thereby stabilize p53 7 S315 phosphorylated p53 in contrast to other p53 phosphorylation was shown to facilitate p53 degradation 8 At the patho physiological level mice with CDC14B deletion were shown to exhibit early onset ageing phenotypes 9 References edit a b c GRCh38 Ensembl release 89 ENSG00000081377 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000033102 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Li L Ernsting BR Wishart MJ Lohse DL Dixon JE November 1997 A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast The Journal of Biological Chemistry 272 47 29403 29406 doi 10 1074 jbc 272 47 29403 PMID 9367992 a b Entrez Gene CDC14B CDC14 cell division cycle 14 homolog B S cerevisiae Li L Ljungman M Dixon JE January 2000 The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53 The Journal of Biological Chemistry 275 4 2410 2414 doi 10 1074 jbc 275 4 2410 PMID 10644693 Li Y Cui K Zhang Q Li X Lin X Tang Y Prochownik E Li Y July 2021 FBXL6 degrades phosphorylated p53 to promote tumor growth Cell Death Differ 28 7 2112 2125 doi 10 1038 s41418 021 00739 6 ISSN 1350 9047 PMC 8257708 PMID 33568778 Wei Z Peddibhotla S Lin H Fang X Li M Rosen M Zhang P April 2011 Early onset aging and defective DNA damage response in Cdc14b deficient mice Mol Cell Biol 31 7 1470 1477 doi 10 1128 MCB 01330 10 PMC 3135283 PMID 21262768 Further reading editMaruyama K Sugano S January 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 174 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Suzuki Y Yoshitomo Nakagawa K Maruyama K Suyama A Sugano S October 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 156 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Li L Ljungman M Dixon JE January 2000 The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53 The Journal of Biological Chemistry 275 4 2410 2414 doi 10 1074 jbc 275 4 2410 PMID 10644693 Mailand N Lukas C Kaiser BK Jackson PK Bartek J Lukas J April 2002 Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation Nature Cell Biology 4 4 317 322 doi 10 1038 ncb777 PMID 11901424 S2CID 28955777 Kaiser BK Zimmerman ZA Charbonneau H Jackson PK July 2002 Disruption of centrosome structure chromosome segregation and cytokinesis by misexpression of human Cdc14A phosphatase Molecular Biology of the Cell 13 7 2289 2300 doi 10 1091 mbc 01 11 0535 PMC 117313 PMID 12134069 Dryden SC Nahhas FA Nowak JE Goustin AS Tainsky MA May 2003 Role for human SIRT2 NAD dependent deacetylase activity in control of mitotic exit in the cell cycle Molecular and Cellular Biology 23 9 3173 3185 doi 10 1128 MCB 23 9 3173 3185 2003 PMC 153197 PMID 12697818 Gray CH Good VM Tonks NK Barford D July 2003 The structure of the cell cycle protein Cdc14 reveals a proline directed protein phosphatase The EMBO Journal 22 14 3524 3535 doi 10 1093 emboj cdg348 PMC 165618 PMID 12853468 Nalepa G Harper JW October 2004 Visualization of a highly organized intranuclear network of filaments in living mammalian cells Cell Motility and the Cytoskeleton 59 2 94 108 doi 10 1002 cm 20023 PMID 15362113 Cho HP Liu Y Gomez M Dunlap J Tyers M Wang Y June 2005 The dual specificity phosphatase CDC14B bundles and stabilizes microtubules Molecular and Cellular Biology 25 11 4541 4551 doi 10 1128 MCB 25 11 4541 4551 2005 PMC 1140622 PMID 15899858 Vazquez Novelle MD Esteban V Bueno A Sacristan MP August 2005 Functional homology among human and fission yeast Cdc14 phosphatases The Journal of Biological Chemistry 280 32 29144 29150 doi 10 1074 jbc M413328200 PMID 15911625 External links editHuman CDC14B genome location and CDC14B gene details page in the UCSC Genome Browser nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CDC14B amp oldid 1116717435, wikipedia, wiki, book, books, library,
