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Wikipedia

PSTPIP1

April 17, 2024

Proline-serine-threonine phosphatase-interacting protein 1 is an enzyme that in humans is encoded by the PSTPIP1 gene.[5][6]

PSTPIP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPSTPIP1, CD2BP1, CD2BP1L, CD2BP1S, H-PIP, PAPAS, PSTPIP, proline-serine-threonine phosphatase interacting protein 1
External IDsOMIM: 606347 MGI: 1321396 HomoloGene: 37867 GeneCards: PSTPIP1
Orthologs
SpeciesHumanMouse
Entrez

9051

19200

Ensembl

ENSG00000140368

ENSMUSG00000032322

UniProt

O43586

P97814

RefSeq (mRNA)

NM_003978
NM_001321135
NM_001321136
NM_001321137

NM_011193

RefSeq (protein)

NP_001308064
NP_001308065
NP_001308066
NP_003969

NP_035323

Location (UCSC)Chr 15: 76.99 – 77.04 MbChr 9: 56 – 56.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions edit

PSTPIP1 has been shown to interact with:

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000140368 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032322 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Li J, Nishizawa K, An W, Hussey RE, Lialios FE, Salgia R, Sunder-Plassmann R, Reinherz EL (February 1999). "A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion". EMBO J. 17 (24): 7320–36. doi:10.1093/emboj/17.24.7320. PMC 1171078. PMID 9857189.
  6. ^ "Entrez Gene: PSTPIP1 proline-serine-threonine phosphatase interacting protein 1".
  7. ^ Cong F, Spencer S, Côté JF, Wu Y, Tremblay ML, Lasky LA, Goff SP (December 2000). "Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation". Mol. Cell. 6 (6): 1413–23. doi:10.1016/s1097-2765(00)00138-6. PMID 11163214.
  8. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  9. ^ Dowbenko D, Spencer S, Quan C, Lasky LA (January 1998). "Identification of a novel polyproline recognition site in the cytoskeletal associated protein, proline serine threonine phosphatase interacting protein". J. Biol. Chem. 273 (2): 989–96. doi:10.1074/jbc.273.2.989. PMID 9422760.
  10. ^ Spencer S, Dowbenko D, Cheng J, Li W, Brush J, Utzig S, Simanis V, Lasky LA (August 1997). "PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase". J. Cell Biol. 138 (4): 845–60. doi:10.1083/jcb.138.4.845. PMC 2138048. PMID 9265651.
  11. ^ Wu Y, Spencer SD, Lasky LA (March 1998). "Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott–Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein". J. Biol. Chem. 273 (10): 5765–70. doi:10.1074/jbc.273.10.5765. PMID 9488710.

Further reading edit

  • Spencer S, Dowbenko D, Cheng J, Li W, Brush J, Utzig S, Simanis V, Lasky LA (1997). "PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase". J. Cell Biol. 138 (4): 845–60. doi:10.1083/jcb.138.4.845. PMC 2138048. PMID 9265651.
  • Dowbenko D, Spencer S, Quan C, Lasky LA (1998). "Identification of a novel polyproline recognition site in the cytoskeletal associated protein, proline serine threonine phosphatase interacting protein". J. Biol. Chem. 273 (2): 989–96. doi:10.1074/jbc.273.2.989. PMID 9422760.
  • Wu Y, Spencer SD, Lasky LA (1998). "Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott–Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein". J. Biol. Chem. 273 (10): 5765–70. doi:10.1074/jbc.273.10.5765. PMID 9488710.
  • Wu Y, Dowbenko D, Lasky LA (1998). "PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase". J. Biol. Chem. 273 (46): 30487–96. doi:10.1074/jbc.273.46.30487. PMID 9804817.
  • Cong F, Spencer S, Côté JF, Wu Y, Tremblay ML, Lasky LA, Goff SP (2000). "Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation". Mol. Cell. 6 (6): 1413–23. doi:10.1016/S1097-2765(00)00138-6. PMID 11163214.
  • Oda A, Ochs HD, Lasky LA, Spencer S, Ozaki K, Fujihara M, Handa M, Ikebuchi K, Ikeda H (2001). "CrkL is an adapter for Wiskott–Aldrich syndrome protein and Syk". Blood. 97 (9): 2633–9. doi:10.1182/blood.V97.9.2633. PMID 11313252.
  • Côté JF, Chung PL, Théberge JF, Hallé M, Spencer S, Lasky LA, Tremblay ML (2002). "PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP". J. Biol. Chem. 277 (4): 2973–86. doi:10.1074/jbc.M106428200. PMID 11711533.
  • Wise CA, Gillum JD, Seidman CE, Lindor NM, Veile R, Bashiardes S, Lovett M (2002). "Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder". Hum. Mol. Genet. 11 (8): 961–9. CiteSeerX 10.1.1.588.1632. doi:10.1093/hmg/11.8.961. PMID 11971877.
  • Badour K, Zhang J, Shi F, McGavin MK, Rampersad V, Hardy LA, Field D, Siminovitch KA (2003). "The Wiskott–Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse". Immunity. 18 (1): 141–54. doi:10.1016/S1074-7613(02)00516-2. PMID 12530983.
  • Shoham NG, Centola M, Mansfield E, Hull KM, Wood G, Wise CA, Kastner DL (2003). "Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway". Proc. Natl. Acad. Sci. U.S.A. 100 (23): 13501–6. Bibcode:2003PNAS..10013501S. doi:10.1073/pnas.2135380100. PMC 263843. PMID 14595024.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Baum W, Kirkin V, Fernández SB, Pick R, Lettau M, Janssen O, Zörnig M (2005). "Binding of the intracellular Fas ligand (FasL) domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL". J. Biol. Chem. 280 (48): 40012–24. doi:10.1074/jbc.M502222200. PMID 16204241.
  • Yang H, Reinherz EL (2006). "CD2BP1 modulates CD2-dependent T cell activation via linkage to protein tyrosine phosphatase (PTP)-PEST". J. Immunol. 176 (10): 5898–907. doi:10.4049/jimmunol.176.10.5898. PMID 16670297.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


 

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

April 17, 2024
pstpip1, proline, serine, threonine, phosphatase, interacting, protein, enzyme, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2dilidentifiersaliases, cd2bp1, cd2bp1l, cd2bp1s, papas, pstpip, proline, serine, threon. Proline serine threonine phosphatase interacting protein 1 is an enzyme that in humans is encoded by the PSTPIP1 gene 5 6 PSTPIP1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2DILIdentifiersAliasesPSTPIP1 CD2BP1 CD2BP1L CD2BP1S H PIP PAPAS PSTPIP proline serine threonine phosphatase interacting protein 1External IDsOMIM 606347 MGI 1321396 HomoloGene 37867 GeneCards PSTPIP1Gene location Human Chr Chromosome 15 human 1 Band15q24 3Start76 993 359 bp 1 End77 037 475 bp 1 Gene location Mouse Chr Chromosome 9 mouse 2 Band9 9 BStart55 997 246 bp 2 End56 036 172 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmonocytebloodspleenbone marrow cellslymph nodeappendixAchilles tendonupper lobe of left lungascending aortaright lungTop expressed inthymusbloodmolargastric mucosamucous cell of stomachspleenesophagusepithelium of stomachpyloric antrumbody of femurMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding identical protein binding cytoskeletal protein binding actin filament bindingCellular componentcytoplasm perinuclear region of cytoplasm cytosol plasma membrane uropod cleavage furrow cell projection cytoskeleton membrane lamellipodium actin filamentBiological processcell adhesion inflammatory response endocytosis signal transduction immune system process innate immune response actin filament polymerization cell migrationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez905119200EnsemblENSG00000140368ENSMUSG00000032322UniProtO43586P97814RefSeq mRNA NM 003978NM 001321135NM 001321136NM 001321137NM 011193RefSeq protein NP 001308064NP 001308065NP 001308066NP 003969NP 035323Location UCSC Chr 15 76 99 77 04 MbChr 9 56 56 04 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Interactions 2 See also 3 References 4 Further readingInteractions editPSTPIP1 has been shown to interact with Abl gene 7 BZW1 8 CD2 5 PTPN12 9 PTPN18 10 Wiskott Aldrich syndrome protein 11 See also editPAPA syndromeReferences edit a b c GRCh38 Ensembl release 89 ENSG00000140368 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000032322 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Li J Nishizawa K An W Hussey RE Lialios FE Salgia R Sunder Plassmann R Reinherz EL February 1999 A cdc15 like adaptor protein CD2BP1 interacts with the CD2 cytoplasmic domain and regulates CD2 triggered adhesion EMBO J 17 24 7320 36 doi 10 1093 emboj 17 24 7320 PMC 1171078 PMID 9857189 Entrez Gene PSTPIP1 proline serine threonine phosphatase interacting protein 1 Cong F Spencer S Cote JF Wu Y Tremblay ML Lasky LA Goff SP December 2000 Cytoskeletal protein PSTPIP1 directs the PEST type protein tyrosine phosphatase to the c Abl kinase to mediate Abl dephosphorylation Mol Cell 6 6 1413 23 doi 10 1016 s1097 2765 00 00138 6 PMID 11163214 Ewing RM Chu P Elisma F Li H Taylor P Climie S McBroom Cerajewski L Robinson MD O Connor L Li M Taylor R Dharsee M Ho Y Heilbut A Moore L Zhang S Ornatsky O Bukhman YV Ethier M Sheng Y Vasilescu J Abu Farha M Lambert JP Duewel HS Stewart II Kuehl B Hogue K Colwill K Gladwish K Muskat B Kinach R Adams SL Moran MF Morin GB Topaloglou T Figeys D 2007 Large scale mapping of human protein protein interactions by mass spectrometry Mol Syst Biol 3 89 doi 10 1038 msb4100134 PMC 1847948 PMID 17353931 Dowbenko D Spencer S Quan C Lasky LA January 1998 Identification of a novel polyproline recognition site in the cytoskeletal associated protein proline serine threonine phosphatase interacting protein J Biol Chem 273 2 989 96 doi 10 1074 jbc 273 2 989 PMID 9422760 Spencer S Dowbenko D Cheng J Li W Brush J Utzig S Simanis V Lasky LA August 1997 PSTPIP a tyrosine phosphorylated cleavage furrow associated protein that is a substrate for a PEST tyrosine phosphatase J Cell Biol 138 4 845 60 doi 10 1083 jcb 138 4 845 PMC 2138048 PMID 9265651 Wu Y Spencer SD Lasky LA March 1998 Tyrosine phosphorylation regulates the SH3 mediated binding of the Wiskott Aldrich syndrome protein to PSTPIP a cytoskeletal associated protein J Biol Chem 273 10 5765 70 doi 10 1074 jbc 273 10 5765 PMID 9488710 Further reading editSpencer S Dowbenko D Cheng J Li W Brush J Utzig S Simanis V Lasky LA 1997 PSTPIP a tyrosine phosphorylated cleavage furrow associated protein that is a substrate for a PEST tyrosine phosphatase J Cell Biol 138 4 845 60 doi 10 1083 jcb 138 4 845 PMC 2138048 PMID 9265651 Dowbenko D Spencer S Quan C Lasky LA 1998 Identification of a novel polyproline recognition site in the cytoskeletal associated protein proline serine threonine phosphatase interacting protein J Biol Chem 273 2 989 96 doi 10 1074 jbc 273 2 989 PMID 9422760 Wu Y Spencer SD Lasky LA 1998 Tyrosine phosphorylation regulates the SH3 mediated binding of the Wiskott Aldrich syndrome protein to PSTPIP a cytoskeletal associated protein J Biol Chem 273 10 5765 70 doi 10 1074 jbc 273 10 5765 PMID 9488710 Wu Y Dowbenko D Lasky LA 1998 PSTPIP 2 a second tyrosine phosphorylated cytoskeletal associated protein that binds a PEST type protein tyrosine phosphatase J Biol Chem 273 46 30487 96 doi 10 1074 jbc 273 46 30487 PMID 9804817 Cong F Spencer S Cote JF Wu Y Tremblay ML Lasky LA Goff SP 2000 Cytoskeletal protein PSTPIP1 directs the PEST type protein tyrosine phosphatase to the c Abl kinase to mediate Abl dephosphorylation Mol Cell 6 6 1413 23 doi 10 1016 S1097 2765 00 00138 6 PMID 11163214 Oda A Ochs HD Lasky LA Spencer S Ozaki K Fujihara M Handa M Ikebuchi K Ikeda H 2001 CrkL is an adapter for Wiskott Aldrich syndrome protein and Syk Blood 97 9 2633 9 doi 10 1182 blood V97 9 2633 PMID 11313252 Cote JF Chung PL Theberge JF Halle M Spencer S Lasky LA Tremblay ML 2002 PSTPIP is a substrate of PTP PEST and serves as a scaffold guiding PTP PEST toward a specific dephosphorylation of WASP J Biol Chem 277 4 2973 86 doi 10 1074 jbc M106428200 PMID 11711533 Wise CA Gillum JD Seidman CE Lindor NM Veile R Bashiardes S Lovett M 2002 Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome an autoinflammatory disorder Hum Mol Genet 11 8 961 9 CiteSeerX 10 1 1 588 1632 doi 10 1093 hmg 11 8 961 PMID 11971877 Badour K Zhang J Shi F McGavin MK Rampersad V Hardy LA Field D Siminovitch KA 2003 The Wiskott Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse Immunity 18 1 141 54 doi 10 1016 S1074 7613 02 00516 2 PMID 12530983 Shoham NG Centola M Mansfield E Hull KM Wood G Wise CA Kastner DL 2003 Pyrin binds the PSTPIP1 CD2BP1 protein defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway Proc Natl Acad Sci U S A 100 23 13501 6 Bibcode 2003PNAS 10013501S doi 10 1073 pnas 2135380100 PMC 263843 PMID 14595024 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Baum W Kirkin V Fernandez SB Pick R Lettau M Janssen O Zornig M 2005 Binding of the intracellular Fas ligand FasL domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL J Biol Chem 280 48 40012 24 doi 10 1074 jbc M502222200 PMID 16204241 Yang H Reinherz EL 2006 CD2BP1 modulates CD2 dependent T cell activation via linkage to protein tyrosine phosphatase PTP PEST J Immunol 176 10 5898 907 doi 10 4049 jimmunol 176 10 5898 PMID 16670297 Ewing RM Chu P Elisma F Li H Taylor P Climie S McBroom Cerajewski L Robinson MD O Connor L Li M Taylor R Dharsee M Ho Y Heilbut A Moore L Zhang S Ornatsky O Bukhman YV Ethier M Sheng Y Vasilescu J Abu Farha M Lambert JP Duewel HS Stewart II Kuehl B Hogue K Colwill K Gladwish K Muskat B Kinach R Adams SL Moran MF Morin GB Topaloglou T Figeys D 2007 Large scale mapping of human protein protein interactions by mass spectrometry Mol Syst Biol 3 1 89 doi 10 1038 msb4100134 PMC 1847948 PMID 17353931 nbsp This article on a gene on human chromosome 15 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title PSTPIP1 amp oldid 1194965356, wikipedia, wiki, book, books, library,

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