T-cell surface glycoprotein CD3 zeta chain also known as T-cell receptor T3 zeta chain or CD247 (Cluster of Differentiation 247) is a protein that in humans is encoded by the CD247gene.[5]
The gene is located on the long arm of chromosome 1 at location 1q22-q25 on the Crick (negative) strand. The encoded protein is 164 amino acids long with a predicted weight of 18.696 kiloDaltons.
Functionedit
T-cell receptor zeta (ζ), together with T-cell receptor alpha/beta and gamma/delta heterodimers and CD3-gamma, -delta, and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000198821 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000005763 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Weissman AM, Hou D, Orloff DG, Modi WS, Seuanez H, O'Brien SJ, Klausner RD (December 1988). "Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex". Proc. Natl. Acad. Sci. U.S.A. 85 (24): 9709–13. Bibcode:1988PNAS...85.9709W. doi:10.1073/pnas.85.24.9709. PMC282845. PMID 2974162.
^Clayton LK, D'Adamio L, Howard FD, Sieh M, Hussey RE, Koyasu S, Reinherz EL (June 1991). "CD3 eta and CD3 zeta are alternatively spliced products of a common genetic locus and are transcriptionally and/or post-transcriptionally regulated during T-cell development". Proceedings of the National Academy of Sciences of the United States of America. 88 (12): 5202–6. doi:10.1073/pnas.88.12.5202. PMC51840. PMID 1828894.
^Tomita K, Saijo K, Yamasaki S, Iida T, Nakatsu F, Arase H, Ohno H, Shirasawa T, Kuriyama T, O'Shea JJ, Saito T (Jul 2001). "Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex". J. Biol. Chem. 276 (27): 25378–85. doi:10.1074/jbc.M011363200. PMID 11349123.
^Gorska MM, Stafford SJ, Cen O, Sur S, Alam R (Feb 2004). "Unc119, a novel activator of Lck/Fyn, is essential for T cell activation". J. Exp. Med. 199 (3): 369–79. doi:10.1084/jem.20030589. PMC2211793. PMID 14757743.
Human CD247 genome location and CD247 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: P20963 (Human T-cell surface glycoprotein CD3 zeta chain (CD247)) at the PDBe-KB.
This membrane protein–related article is a stub. You can help Wikipedia by expanding it.
cell, surface, glycoprotein, zeta, chain, also, known, cell, receptor, zeta, chain, cd247, cluster, differentiation, protein, that, humans, encoded, cd247, gene, cd247available, structurespdbortholog, search, pdbe, rcsblist, codes1tce, 1ygr, 2hac, 2oq1, 3ik5, . T cell surface glycoprotein CD3 zeta chain also known as T cell receptor T3 zeta chain or CD247 Cluster of Differentiation 247 is a protein that in humans is encoded by the CD247 gene 5 CD247Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ 4XZ1IdentifiersAliasesCD247 CD3 ZETA CD3H CD3Q CD3Z IMD25 T3Z TCRZ CD247 molecule CD3zetaExternal IDsOMIM 186780 MGI 88334 HomoloGene 12818 GeneCards CD247Gene location Human Chr Chromosome 1 human 1 Band1q24 2Start167 430 640 bp 1 End167 518 610 bp 1 Gene location Mouse Chr Chromosome 1 mouse 2 Band1 H2 3 1 73 14 cMStart165 616 250 bp 2 End165 704 846 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inthymusbloodlymph nodespleenappendixbone marrowbone marrow cellsupper lobe of left lungjejunal mucosaright lungTop expressed inthymusbloodaortic valveascending aortaspleensubcutaneous adipose tissuespermatidsupraoptic nucleusmoruladuodenumMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding transmembrane signaling receptor activity identical protein binding protein homodimerization activity protein tyrosine kinase bindingCellular componentcytoplasm integral component of membrane alpha beta T cell receptor complex plasma membrane T cell receptor complex membraneBiological processcell surface receptor signaling pathway mitigation of host defenses by virus T cell receptor signaling pathway Fc gamma receptor signaling pathway involved in phagocytosis regulation of immune response viral process protein homotetramerization protein homotrimerization adaptive immune response immune system process interleukin 2 production positive regulation of protein localization to cell surfaceSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez91912503EnsemblENSG00000198821ENSMUSG00000005763UniProtP20963Q3UU54P24161RefSeq mRNA NM 000734NM 198053NM 001378515NM 001378516NM 001113391NM 001113392NM 001113393NM 001113394NM 031162RefSeq protein NP 000725NP 932170NP 001365444NP 001365445NP 112439 1NP 001106862 1NP 001106862NP 001106863NP 001106864NP 112439Location UCSC Chr 1 167 43 167 52 MbChr 1 165 62 165 7 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseSome older literature mention a similar protein called CD3 eta in mice It is now understood to be an isoform differing in the last exon 6 Contents 1 Genomics 2 Function 3 Interactions 4 See also 5 References 6 Further reading 7 External linksGenomics editThe gene is located on the long arm of chromosome 1 at location 1q22 q25 on the Crick negative strand The encoded protein is 164 amino acids long with a predicted weight of 18 696 kiloDaltons Function editT cell receptor zeta z together with T cell receptor alpha beta and gamma delta heterodimers and CD3 gamma delta and epsilon forms the T cell receptor CD3 complex The zeta chain plays an important role in coupling antigen recognition to several intracellular signal transduction pathways Low expression of the antigen results in impaired immune response Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene 7 Interactions editCD247 has been shown to interact with Janus kinase 3 8 and Protein unc 119 homolog 9 See also editCluster of differentiation ZAP70References edit a b c GRCh38 Ensembl release 89 ENSG00000198821 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000005763 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Weissman AM Hou D Orloff DG Modi WS Seuanez H O Brien SJ Klausner RD December 1988 Molecular cloning and chromosomal localization of the human T cell receptor zeta chain distinction from the molecular CD3 complex Proc Natl Acad Sci U S A 85 24 9709 13 Bibcode 1988PNAS 85 9709W doi 10 1073 pnas 85 24 9709 PMC 282845 PMID 2974162 Clayton LK D Adamio L Howard FD Sieh M Hussey RE Koyasu S Reinherz EL June 1991 CD3 eta and CD3 zeta are alternatively spliced products of a common genetic locus and are transcriptionally and or post transcriptionally regulated during T cell development Proceedings of the National Academy of Sciences of the United States of America 88 12 5202 6 doi 10 1073 pnas 88 12 5202 PMC 51840 PMID 1828894 Entrez Gene CD247 CD247 molecule Tomita K Saijo K Yamasaki S Iida T Nakatsu F Arase H Ohno H Shirasawa T Kuriyama T O Shea JJ Saito T Jul 2001 Cytokine independent Jak3 activation upon T cell receptor TCR stimulation through direct association of Jak3 and the TCR complex J Biol Chem 276 27 25378 85 doi 10 1074 jbc M011363200 PMID 11349123 Gorska MM Stafford SJ Cen O Sur S Alam R Feb 2004 Unc119 a novel activator of Lck Fyn is essential for T cell activation J Exp Med 199 3 369 79 doi 10 1084 jem 20030589 PMC 2211793 PMID 14757743 Further reading editGeyer M Fackler OT Peterlin BM 2001 Structure function relationships in HIV 1 Nef EMBO Rep 2 7 580 5 doi 10 1093 embo reports kve141 PMC 1083955 PMID 11463741 Greenway AL Holloway G McPhee DA Ellis P Cornall A Lidman M 2004 HIV 1 Nef control of cell signalling molecules multiple strategies to promote virus replication J Biosci 28 3 323 35 doi 10 1007 BF02970151 PMID 12734410 S2CID 33749514 Stove V Verhasselt B 2006 Modelling thymic HIV 1 Nef effects Curr HIV Res 4 1 57 64 doi 10 2174 157016206775197583 PMID 16454711 External links editCD247 protein human at the U S National Library of Medicine Medical Subject Headings MeSH Human CD247 genome location and CD247 gene details page in the UCSC Genome Browser Overview of all the structural information available in the PDB for UniProt P20963 Human T cell surface glycoprotein CD3 zeta chain CD247 at the PDBe KB nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title T cell surface glycoprotein CD3 zeta chain amp oldid 1142684823, wikipedia, wiki, book, books, library,
