This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytotic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.[3] Transcript levels of the CD1A gene are upregulated in the lung parenchyma of smokers.[4]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000158477 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Pintarelli G, Noci S, Maspero D, Pettinicchio A, Dugo M, De Cecco L, Incarbone M, Tosi D, Santambrogio L, Dragani TA, Colombo F (September 2019). "Cigarette smoke alters the transcriptome of non-involved lung tissue in lung adenocarcinoma patients". Scientific Reports. 9 (1): 13039. Bibcode:2019NatSR...913039P. doi:10.1038/s41598-019-49648-2. PMC6736939. PMID 31506599.
External linksedit
Human CD1A genome location and CD1A gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: P06126 (Human T-cell surface glycoprotein CD1a) at the PDBe-KB.
Further readingedit
Melián A, Beckman EM, Porcelli SA, Brenner MB (1996). "Antigen presentation by CD1 and MHC-encoded class I-like molecules". Curr. Opin. Immunol. 8 (1): 82–8. doi:10.1016/S0952-7915(96)80109-9. PMID 8729450.
Park SH, Bendelac A (2000). "CD1-restricted T-cell responses and microbial infection". Nature. 406 (6797): 788–92. Bibcode:2000Natur.406..788P. doi:10.1038/35021233. PMID 10963609. S2CID 4373172.
Brigl M, Brenner MB (2004). "CD1: antigen presentation and T cell function". Annu. Rev. Immunol. 22 (1): 817–90. doi:10.1146/annurev.immunol.22.012703.104608. PMID 15032598.
Coventry B, Heinzel S (2004). "CD1a in human cancers: a new role for an old molecule". Trends Immunol. 25 (5): 242–8. doi:10.1016/j.it.2004.03.002. PMID 15099564.
Moody DB, Zajonc DM, Wilson IA (2005). "Anatomy of CD1-lipid antigen complexes". Nat. Rev. Immunol. 5 (5): 387–99. doi:10.1038/nri1605. PMID 15864273. S2CID 1387491.
Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects". Curr. HIV Res. 4 (1): 57–64. doi:10.2174/157016206775197583. PMID 16454711.
Quaranta MG, Mattioli B, Giordani L, Viora M (2006). "The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS". FASEB J. 20 (13): 2198–208. doi:10.1096/fj.06-6260rev. PMID 17077296. S2CID 3111709.
Oakey RJ, Watson ML, Seldin MF (1993). "Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA". Hum. Mol. Genet. 1 (8): 613–20. doi:10.1093/hmg/1.8.613. PMID 1301170.
Martin LH, Calabi F, Lefebvre FA, et al. (1988). "Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c". Proc. Natl. Acad. Sci. U.S.A. 84 (24): 9189–93. doi:10.1073/pnas.84.24.9189. PMC299718. PMID 2447586.
Moseley WS, Watson ML, Kingsmore SF, Seldin MF (1989). "CD1 defines conserved linkage group border between human chromosomes 1 and mouse chromosomes 1 and 3". Immunogenetics. 30 (5): 378–82. doi:10.1007/BF02425278. PMID 2478463. S2CID 9361881.
Yu CY, Milstein C (1990). "A physical map linking the five CD1 human thymocyte differentiation antigen genes". EMBO J. 8 (12): 3727–32. doi:10.1002/j.1460-2075.1989.tb08548.x. PMC402056. PMID 2583117.
Aruffo A, Seed B (1989). "Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts". J. Immunol. 143 (5): 1723–30. doi:10.4049/jimmunol.143.5.1723. PMID 2701945. S2CID 23168239.
Longley J, Kraus J, Alonso M, Edelson R (1989). "Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules". J. Invest. Dermatol. 92 (4): 628–31. doi:10.1111/1523-1747.ep12712175. PMID 2784820.
Albertson DG, Fishpool R, Sherrington P, et al. (1988). "Sensitive and high resolution in situ hybridization to human chromosomes using biotin labelled probes: assignment of the human thymocyte CD1 antigen genes to chromosome 1". EMBO J. 7 (9): 2801–5. doi:10.1002/j.1460-2075.1988.tb03135.x. PMC457071. PMID 3053166.
Calabi F, Milstein C (1986). "A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6". Nature. 323 (6088): 540–3. Bibcode:1986Natur.323..540C. doi:10.1038/323540a0. PMID 3093894. S2CID 4274219.
Martin LH, Calabi F, Milstein C (1987). "Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9154–8. doi:10.1073/pnas.83.23.9154. PMC387093. PMID 3097645.
Woolfson A, Milstein C (1994). "Alternative splicing generates secretory isoforms of human CD1". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6683–7. Bibcode:1994PNAS...91.6683W. doi:10.1073/pnas.91.14.6683. PMC44267. PMID 7517559.
Han M, Hannick LI, DiBrino M, Robinson MA (2000). "Polymorphism of human CD1 genes". Tissue Antigens. 54 (2): 122–7. doi:10.1034/j.1399-0039.1999.540202.x. PMID 10488738.
Sugita M, Grant EP, van Donselaar E, et al. (2000). "Separate pathways for antigen presentation by CD1 molecules". Immunity. 11 (6): 743–52. doi:10.1016/S1074-7613(00)80148-X. PMID 10626896.
cd1a, cd1a, cluster, differentiation, human, protein, encoded, gene, available, structurespdbhuman, uniprot, search, pdbe, rcsblist, codes1onq, 1xz0, 4x6c, 4x6d, 4x6e, 4x6fidentifiersaliases, fcb6, hta1, cd1a, moleculeexternal, idsomim, 188370, homologene, 113. CD1a Cluster of Differentiation 1a is a human protein encoded by the CD1A gene 3 CD1AAvailable structuresPDBHuman UniProt search PDBe RCSBList of PDB id codes1ONQ 1XZ0 4X6C 4X6D 4X6E 4X6FIdentifiersAliasesCD1A CD1 FCB6 HTA1 R4 T6 CD1a moleculeExternal IDsOMIM 188370 HomoloGene 113556 GeneCards CD1AGene location Human Chr Chromosome 1 human 1 Band1q23 1Start158 254 424 bp 1 End158 258 269 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inthymusgumsskin of abdomenmonocytevulvaoral cavitycervix epitheliumlymph nodeappendixgallbladdern aMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionbeta 2 microglobulin binding endogenous lipid antigen binding protein binding exogenous lipid antigen binding lipopeptide bindingCellular componentintegral component of membrane membrane raft endosome integral component of plasma membrane endosome membrane membrane plasma membrane cell surface extracellular space external side of plasma membraneBiological processantigen processing and presentation exogenous lipid antigen via MHC class Ib adaptive immune response immune system process immune response regulation of immune response positive regulation of T cell mediated cytotoxicity antigen processing and presentation endogenous lipid antigen via MHC class IbSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez909n aEnsemblENSG00000158477n aUniProtP06126n aRefSeq mRNA NM 001763NM 001320652n aRefSeq protein NP 001307581NP 001754n aLocation UCSC Chr 1 158 25 158 26 Mbn aPubMed search 2 n aWikidataView Edit HumanThis gene encodes a member of the CD1 family of transmembrane glycoproteins which are structurally related to the major histocompatibility complex MHC proteins and form heterodimers with beta 2 microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytotic system Alternatively spliced transcript variants have been observed but their biological validity has not been determined 3 Transcript levels of the CD1A gene are upregulated in the lung parenchyma of smokers 4 References edit a b c GRCh38 Ensembl release 89 ENSG00000158477 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene CD1A CD1a molecule Pintarelli G Noci S Maspero D Pettinicchio A Dugo M De Cecco L Incarbone M Tosi D Santambrogio L Dragani TA Colombo F September 2019 Cigarette smoke alters the transcriptome of non involved lung tissue in lung adenocarcinoma patients Scientific Reports 9 1 13039 Bibcode 2019NatSR 913039P doi 10 1038 s41598 019 49648 2 PMC 6736939 PMID 31506599 External links editHuman CD1A genome location and CD1A gene details page in the UCSC Genome Browser Overview of all the structural information available in the PDB for UniProt P06126 Human T cell surface glycoprotein CD1a at the PDBe KB Further reading editMelian A Beckman EM Porcelli SA Brenner MB 1996 Antigen presentation by CD1 and MHC encoded class I like molecules Curr Opin Immunol 8 1 82 8 doi 10 1016 S0952 7915 96 80109 9 PMID 8729450 Park SH Bendelac A 2000 CD1 restricted T cell responses and microbial infection Nature 406 6797 788 92 Bibcode 2000Natur 406 788P doi 10 1038 35021233 PMID 10963609 S2CID 4373172 Brigl M Brenner MB 2004 CD1 antigen presentation and T cell function Annu Rev Immunol 22 1 817 90 doi 10 1146 annurev immunol 22 012703 104608 PMID 15032598 Coventry B Heinzel S 2004 CD1a in human cancers a new role for an old molecule Trends Immunol 25 5 242 8 doi 10 1016 j it 2004 03 002 PMID 15099564 Moody DB Zajonc DM Wilson IA 2005 Anatomy of CD1 lipid antigen complexes Nat Rev Immunol 5 5 387 99 doi 10 1038 nri1605 PMID 15864273 S2CID 1387491 Stove V Verhasselt B 2006 Modelling thymic HIV 1 Nef effects Curr HIV Res 4 1 57 64 doi 10 2174 157016206775197583 PMID 16454711 Quaranta MG Mattioli B Giordani L Viora M 2006 The immunoregulatory effects of HIV 1 Nef on dendritic cells and the pathogenesis of AIDS FASEB J 20 13 2198 208 doi 10 1096 fj 06 6260rev PMID 17077296 S2CID 3111709 Oakey RJ Watson ML Seldin MF 1993 Construction of a physical map on mouse and human chromosome 1 comparison of 13 Mb of mouse and 11 Mb of human DNA Hum Mol Genet 1 8 613 20 doi 10 1093 hmg 1 8 613 PMID 1301170 Martin LH Calabi F Lefebvre FA et al 1988 Structure and expression of the human thymocyte antigens CD1a CD1b and CD1c Proc Natl Acad Sci U S A 84 24 9189 93 doi 10 1073 pnas 84 24 9189 PMC 299718 PMID 2447586 Moseley WS Watson ML Kingsmore SF Seldin MF 1989 CD1 defines conserved linkage group border between human chromosomes 1 and mouse chromosomes 1 and 3 Immunogenetics 30 5 378 82 doi 10 1007 BF02425278 PMID 2478463 S2CID 9361881 Yu CY Milstein C 1990 A physical map linking the five CD1 human thymocyte differentiation antigen genes EMBO J 8 12 3727 32 doi 10 1002 j 1460 2075 1989 tb08548 x PMC 402056 PMID 2583117 Aruffo A Seed B 1989 Expression of cDNA clones encoding the thymocyte antigens CD1a b c demonstrates a hierarchy of exclusion in fibroblasts J Immunol 143 5 1723 30 doi 10 4049 jimmunol 143 5 1723 PMID 2701945 S2CID 23168239 Longley J Kraus J Alonso M Edelson R 1989 Molecular cloning of CD1a T6 a human epidermal dendritic cell marker related to class I MHC molecules J Invest Dermatol 92 4 628 31 doi 10 1111 1523 1747 ep12712175 PMID 2784820 Albertson DG Fishpool R Sherrington P et al 1988 Sensitive and high resolution in situ hybridization to human chromosomes using biotin labelled probes assignment of the human thymocyte CD1 antigen genes to chromosome 1 EMBO J 7 9 2801 5 doi 10 1002 j 1460 2075 1988 tb03135 x PMC 457071 PMID 3053166 Calabi F Milstein C 1986 A novel family of human major histocompatibility complex related genes not mapping to chromosome 6 Nature 323 6088 540 3 Bibcode 1986Natur 323 540C doi 10 1038 323540a0 PMID 3093894 S2CID 4274219 Martin LH Calabi F Milstein C 1987 Isolation of CD1 genes a family of major histocompatibility complex related differentiation antigens Proc Natl Acad Sci U S A 83 23 9154 8 doi 10 1073 pnas 83 23 9154 PMC 387093 PMID 3097645 Woolfson A Milstein C 1994 Alternative splicing generates secretory isoforms of human CD1 Proc Natl Acad Sci U S A 91 14 6683 7 Bibcode 1994PNAS 91 6683W doi 10 1073 pnas 91 14 6683 PMC 44267 PMID 7517559 Han M Hannick LI DiBrino M Robinson MA 2000 Polymorphism of human CD1 genes Tissue Antigens 54 2 122 7 doi 10 1034 j 1399 0039 1999 540202 x PMID 10488738 Sugita M Grant EP van Donselaar E et al 2000 Separate pathways for antigen presentation by CD1 molecules Immunity 11 6 743 52 doi 10 1016 S1074 7613 00 80148 X PMID 10626896 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