Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.[7]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000135773 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000031981 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lee HJ, Sorimachi H, Jeong SY, Ishiura S, Suzuki K (May 1998). "Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract". Biol Chem. 379 (2): 175–184. doi:10.1515/bchm.1998.379.2.175. PMID 9524069. S2CID 37483841.
^Yoshikawa Y, Mukai H, Hino F, Asada K, Kato I (Jul 2000). "Isolation of two novel genes, down-regulated in gastric cancer". Jpn J Cancer Res. 91 (5): 459–63. doi:10.1111/j.1349-7006.2000.tb00967.x. PMC5926377. PMID 10835488.
Huang Y, Wang KK (2001). "The calpain family and human disease". Trends in Molecular Medicine. 7 (8): 355–362. doi:10.1016/S1471-4914(01)02049-4. PMID 11516996.
Suzuki K, Sorimachi H, Yoshizawa T, et al. (1996). "Calpain: novel family members, activation, and physiologic function". Biol. Chem. Hoppe-Seyler. 376 (9): 523–9. doi:10.1515/bchm3.1995.376.9.523. PMID 8561910.
Davis TL, Walker JR, Finerty PJ, et al. (2007). "The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition". J. Mol. Biol. 366 (1): 216–229. doi:10.1016/j.jmb.2006.11.037. PMID 17157313.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Lee HJ, Tomioka S, Kinbara K, et al. (1999). "Characterization of a human digestive tract-specific calpain, nCL-4, expressed in the baculovirus system". Arch. Biochem. Biophys. 362 (1): 22–31. doi:10.1006/abbi.1998.1021. PMID 9917325.
External linksedit
Human CAPN9 genome location and CAPN9 gene details page in the UCSC Genome Browser.
The MEROPS online database for peptidases and their inhibitors: C02.006
Overview of all the structural information available in the PDB for UniProt: O14815 (Human Calpain-9 (CAPN9)) at the PDBe-KB.
April 11, 2024
calpain, protein, that, humans, encoded, capn9, gene, capn9available, structurespdbortholog, search, pdbe, rcsblist, codes1ziv, 2p0ridentifiersaliasescapn9, gc36, calpain, 9external, idsomim, 606401, 1920897, homologene, 38208, genecards, capn9gene, location, . Calpain 9 is a protein that in humans is encoded by the CAPN9 gene 5 6 7 CAPN9Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1ZIV 2P0RIdentifiersAliasesCAPN9 GC36 nCL 4 calpain 9External IDsOMIM 606401 MGI 1920897 HomoloGene 38208 GeneCards CAPN9Gene location Human Chr Chromosome 1 human 1 Band1q42 2Start230 747 384 bp 1 End230 802 003 bp 1 Gene location Mouse Chr Chromosome 8 mouse 2 Band8 8 E2Start125 302 850 bp 2 End125 345 470 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inrectumbody of stomachgastric mucosabronchial epithelial cellpancreatic ductal cellright lungminor salivary glandamygdalaupper lobe of left lungputamenTop expressed inpyloric antrumepithelium of stomachmucous cell of stomachduodenumleft colonjejunumintestinal villusileumentorhinal cortexlipMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioncalcium ion binding peptidase activity cysteine type peptidase activity hydrolase activity metal ion binding calcium dependent cysteine type endopeptidase activityCellular componentintracellular anatomical structure cytoplasm cellular componentBiological processdigestion proteolysis sarcomere organizationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1075373647EnsemblENSG00000135773ENSMUSG00000031981UniProtO14815Q9D805RefSeq mRNA NM 006615NM 016452NM 001319676NM 023709RefSeq protein NP 001306605NP 006606NP 057536NP 076198Location UCSC Chr 1 230 75 230 8 MbChr 8 125 3 125 35 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseCalpains are ubiquitous well conserved family of calcium dependent cysteine proteases The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits The large subunit possesses a cysteine protease domain and both subunits possess calcium binding domains Calpains have been implicated in neurodegenerative processes as their activation can be triggered by calcium influx and oxidative stress The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract This gene is thought to be associated with gastric cancer Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000135773 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000031981 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Lee HJ Sorimachi H Jeong SY Ishiura S Suzuki K May 1998 Molecular cloning and characterization of a novel tissue specific calpain predominantly expressed in the digestive tract Biol Chem 379 2 175 184 doi 10 1515 bchm 1998 379 2 175 PMID 9524069 S2CID 37483841 Yoshikawa Y Mukai H Hino F Asada K Kato I Jul 2000 Isolation of two novel genes down regulated in gastric cancer Jpn J Cancer Res 91 5 459 63 doi 10 1111 j 1349 7006 2000 tb00967 x PMC 5926377 PMID 10835488 a b Entrez Gene CAPN9 calpain 9 Further reading editHuang Y Wang KK 2001 The calpain family and human disease Trends in Molecular Medicine 7 8 355 362 doi 10 1016 S1471 4914 01 02049 4 PMID 11516996 Suzuki K Sorimachi H Yoshizawa T et al 1996 Calpain novel family members activation and physiologic function Biol Chem Hoppe Seyler 376 9 523 9 doi 10 1515 bchm3 1995 376 9 523 PMID 8561910 Davis TL Walker JR Finerty PJ et al 2007 The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto inhibition J Mol Biol 366 1 216 229 doi 10 1016 j jmb 2006 11 037 PMID 17157313 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 16903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Lee HJ Tomioka S Kinbara K et al 1999 Characterization of a human digestive tract specific calpain nCL 4 expressed in the baculovirus system Arch Biochem Biophys 362 1 22 31 doi 10 1006 abbi 1998 1021 PMID 9917325 External links editHuman CAPN9 genome location and CAPN9 gene details page in the UCSC Genome Browser The MEROPS online database for peptidases and their inhibitors C02 006 Overview of all the structural information available in the PDB for UniProt O14815 Human Calpain 9 CAPN9 at the PDBe KB Retrieved from https en wikipedia org w index php title Calpain 9 amp oldid 1117077659, wikipedia, wiki, book, books, library,
