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cAMP responsive element modulator

May 02, 2024

cAMP responsive element modulator is a protein that in humans is encoded by the CREM gene,[5][6][7] and it belongs to the cAMP-responsive element binding protein family. It has multiple isoforms, which act either as repressors or activators.[8] CREB family is important for in regulating transcription in response to various stresses, metabolic and developmental signals.[9] CREM transcription factors also play an important role in many physiological systems, such as cardiac function,[10] circadian rhythms,[11] locomotion and spermatogenesis.[12]

CREM
Identifiers
AliasesCREM, CREM-2, ICER, hCREM-2, cAMP responsive element modulator
External IDsOMIM: 123812 MGI: 88495 HomoloGene: 84591 GeneCards: CREM
Orthologs
SpeciesHumanMouse
Entrez

1390

12916

Ensembl

ENSG00000095794

ENSMUSG00000063889

UniProt

Q03060

P27699

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 10: 35.13 – 35.21 MbChr 18: 3.27 – 3.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.[7]

Gene location edit

The chromosomal location of CREM gene is at 10p11.21, where it starts at 35415769 and ends at 35501886 bp from pter ( according to hg19-Feb_2009)[13]

Interactions edit

CAMP responsive element modulator has been shown to interact with FHL5.[14][15]

Disease relevance of CREM edit

Panic disorder edit

One study reported the DNA sequence variations in the gene for CREM in panic disorder patients. It showed a significant excess of the shorter eight-repeat allele and of genotypes containing the eight-repeat allele in panic disorder patients.[16] The observed associations were limited to panic disorder without agoraphobia, and they were more prominent in females. But, the independent Italian and Spanish samples in this study did not support their results. Another family-based study showed little evidence of any susceptibility locus for panic disorder either within the CREM gene or in a nearby region on chromosome 10p11[17]

Spermiogenesis deficiency edit

CREM has been shown to be a master-switch regulator in testis.[18] It plays an important role in the regulation of the expression of post-meiotic genes, and this has been supported by several studies using CREM-mutation mice.[19] The results showed the first step in the process of sperm formation would be blocked if the germ cell development in mice CREM gene were disrupted. The cAMP response element sites can be found in the promoter region of some postmeiotic genes, so that the CREM can target and regulate these genes.[18]

Two studies proved that treat the rats with Salvia hypoleuca and Alpina galanga can significantly increased the CREM gene expression.[20][21]

Systemic lupus erythematousus edit

Less IL-2 will be produced from T cells in humans or mice with systemic lupus erythematousus (SLE). Some studies showed that an increased level CREM was presented in the nucleus of T lymphocytes from SLE patients. The CREM bound to the -180 site of the IL-2 promoter to repress its transcription.[22]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000095794 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063889 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Meyer TE, Habener JF (Nov 1992). "Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes". Nucleic Acids Research. 20 (22): 6106. doi:10.1093/nar/20.22.6106. PMC 334485. PMID 1461747.
  6. ^ Masquilier D, Foulkes NS, Mattei MG, Sassone-Corsi P (Nov 1993). "Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript". Cell Growth & Differentiation. 4 (11): 931–7. PMID 7916662.
  7. ^ a b "Entrez Gene: CREM cAMP responsive element modulator".
  8. ^ Foulkes NS, Sassone-Corsi P (1992-02-07). "More is better: activators and repressors from the same gene". Cell. 68 (3): 411–414. doi:10.1016/0092-8674(92)90178-f. ISSN 0092-8674. PMID 1739963. S2CID 34290449.
  9. ^ Sassone-Corsi P (1995-01-01). "Transcription factors responsive to cAMP". Annual Review of Cell and Developmental Biology. 11: 355–377. doi:10.1146/annurev.cb.11.110195.002035. ISSN 1081-0706. PMID 8689562.
  10. ^ Isoda T, Paolocci N, Haghighi K, Wang C, Wang Y, Georgakopoulos D, Servillo G, Della Fazia MA, Kranias EG (2003-02-01). "Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator)". FASEB Journal. 17 (2): 144–151. doi:10.1096/fj.01-0981com. ISSN 1530-6860. PMID 12554693. S2CID 17890025.
  11. ^ Sassone-Corsi P (2000-06-01). "CREM: a master-switch regulating the balance between differentiation and apoptosis in male germ cells". Molecular Reproduction and Development. 56 (2 Suppl): 228–229. doi:10.1002/(SICI)1098-2795(200006)56:2+<228::AID-MRD2>3.0.CO;2-B. ISSN 1040-452X. PMID 10824972. S2CID 21160055.
  12. ^ Sassone-Corsi P (1998-08-01). "CREM: a master-switch governing male germ cells differentiation and apoptosis". Seminars in Cell & Developmental Biology. 9 (4): 475–482. doi:10.1006/scdb.1998.0200. ISSN 1084-9521. PMID 9813195.
  13. ^ "CREM (cAMP responsive element modulator)". atlasgeneticsoncology.org. Retrieved 2016-10-16.
  14. ^ Fimia GM, De Cesare D, Sassone-Corsi P (Nov 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Molecular and Cellular Biology. 20 (22): 8613–22. doi:10.1128/MCB.20.22.8613-8622.2000. PMC 102166. PMID 11046156.
  15. ^ Fimia GM, De Cesare D, Sassone-Corsi P (Mar 1999). "CBP-independent activation of CREM and CREB by the LIM-only protein ACT". Nature. 398 (6723): 165–9. Bibcode:1999Natur.398..165F. doi:10.1038/18237. PMID 10086359. S2CID 4424908.
  16. ^ Domschke K, Kuhlenbäumer G, Schirmacher A, Lorenzi C, Armengol L, DiBella D, Gratacos M, Garritsen HS, Nöthen MM (2003-02-01). "Human nuclear transcription factor gene CREM: genomic organization, mutation screening, and association analysis in panic disorder". American Journal of Medical Genetics Part B. 117B (1): 70–78. doi:10.1002/ajmg.b.10018. ISSN 1552-4841. PMID 12555239. S2CID 8884044.
  17. ^ Hamilton SP, Slager SL, Mayo D, Heiman GA, Klein DF, Hodge SE, Fyer AJ, Weissman MM, Knowles JA (2004-04-01). "Investigation of polymorphisms in the CREM gene in panic disorder". American Journal of Medical Genetics Part B. 126B (1): 111–115. doi:10.1002/ajmg.b.20121. ISSN 1552-4841. PMID 15048659. S2CID 43810849.
  18. ^ a b Krausz C, Sassone-Corsi P (2005-01-01). "Genetic control of spermiogenesis: insights from the CREM gene and implications for human infertility". Reproductive BioMedicine Online. 10 (1): 64–71. doi:10.1016/S1472-6483(10)60805-X. PMID 15705296.
  19. ^ Nantel F, Monaco L, Foulkes NS, Masquilier D, LeMeur M, Henriksén K, Dierich A, Parvinen M, Sassone-Corsi P (1996-03-14). "Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice". Nature. 380 (6570): 159–162. Bibcode:1996Natur.380..159N. doi:10.1038/380159a0. ISSN 0028-0836. PMID 8600390. S2CID 4278745.
  20. ^ Jasem E, Nasim J, Gholamreza M, Naser S, Nader M, Maryam SL, Abbas N, Vahid R (2010-10-01). "Evaluation of the effects of Salvia hypoleuca on the cAMP-responsive element modulator (CREM) gene expression and spermatogenesis in rat". Middle East Fertility Society Journal. 15 (4): 274–277. doi:10.1016/j.mefs.2010.08.002.
  21. ^ Mazaheri M, Shahdadi V, Nazari Boron A (2016-10-16). "Molecullar and biochemical effect of alcoholic extract of Alpinia galanga on rat spermatogenesis process". Iranian Journal of Reproductive Medicine. 12 (11): 765–770. ISSN 1680-6433. PMC 4330656. PMID 25709632.
  22. ^ Juang YT, Wang Y, Solomou EE, Li Y, Mawrin C, Tenbrock K, Kyttaris VC, Tsokos GC (2005-04-01). "Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV". Journal of Clinical Investigation. 115 (4): 996–1005. doi:10.1172/JCI22854. ISSN 0021-9738. PMC 1070410. PMID 15841182.

Further reading edit

  • Don J, Stelzer G (Feb 2002). "The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis". Molecular and Cellular Endocrinology. 187 (1–2): 115–24. doi:10.1016/S0303-7207(01)00696-7. PMID 11988318. S2CID 23023082.
  • Yan C, Miller CL, Abe J (Mar 2007). "Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heart". Circulation Research. 100 (4): 489–501. doi:10.1161/01.RES.0000258451.44949.d7. PMC 4115784. PMID 17332439.
  • Pongubala JM, Atchison ML (Apr 1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate the activity of the immunoglobulin kappa 3' enhancer". The Journal of Biological Chemistry. 270 (17): 10304–13. doi:10.1074/jbc.270.17.10304. PMID 7730336.
  • Walker WH, Sanborn BM, Habener JF (Dec 1994). "An isoform of transcription factor CREM expressed during spermatogenesis lacks the phosphorylation domain and represses cAMP-induced transcription". Proceedings of the National Academy of Sciences of the United States of America. 91 (26): 12423–7. Bibcode:1994PNAS...9112423W. doi:10.1073/pnas.91.26.12423. PMC 45450. PMID 7809053.
  • Fujimoto T, Fujisawa J, Yoshida M (Feb 1994). "Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA". Journal of Biochemistry. 115 (2): 298–303. doi:10.1093/oxfordjournals.jbchem.a124332. PMID 8206879.
  • de Groot RP, den Hertog J, Vandenheede JR, Goris J, Sassone-Corsi P (Oct 1993). "Multiple and cooperative phosphorylation events regulate the CREM activator function". The EMBO Journal. 12 (10): 3903–11. doi:10.1002/j.1460-2075.1993.tb06068.x. PMC 413673. PMID 8404858.
  • Bodor J, Walker W, Flemington E, Spetz AL, Habener JF (Dec 1995). "Modulation of Tax and PKA-mediated expression of HTLV-I promoter via cAMP response element binding and modulator proteins CREB and CREM". FEBS Letters. 377 (3): 413–8. doi:10.1016/0014-5793(95)01299-0. PMID 8549766. S2CID 45422227.
  • Nantel F, Monaco L, Foulkes NS, Masquilier D, LeMeur M, Henriksén K, Dierich A, Parvinen M, Sassone-Corsi P (Mar 1996). "Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice". Nature. 380 (6570): 159–62. Bibcode:1996Natur.380..159N. doi:10.1038/380159a0. PMID 8600390. S2CID 4278745.
  • Blendy JA, Kaestner KH, Weinbauer GF, Nieschlag E, Schütz G (Mar 1996). "Severe impairment of spermatogenesis in mice lacking the CREM gene". Nature. 380 (6570): 162–5. Bibcode:1996Natur.380..162B. doi:10.1038/380162a0. PMID 8600391. S2CID 4337719.
  • Bodor J, Spetz AL, Strominger JL, Habener JF (Apr 1996). "cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes". Proceedings of the National Academy of Sciences of the United States of America. 93 (8): 3536–41. Bibcode:1996PNAS...93.3536B. doi:10.1073/pnas.93.8.3536. PMC 39645. PMID 8622971.
  • Gellersen B, Kempf R, Telgmann R (Jan 1997). "Human endometrial stromal cells express novel isoforms of the transcriptional modulator CREM and up-regulate ICER in the course of decidualization". Molecular Endocrinology. 11 (1): 97–113. doi:10.1210/mend.11.1.9875. PMID 8994192.
  • Laurance ME, Kwok RP, Huang MS, Richards JP, Lundblad JR, Goodman RH (Jan 1997). "Differential activation of viral and cellular promoters by human T-cell lymphotropic virus-1 tax and cAMP-responsive element modulator isoforms". The Journal of Biological Chemistry. 272 (5): 2646–51. doi:10.1074/jbc.272.5.2646. PMID 9006899.
  • Bonny C, Cooker LA, Goldberg E (Mar 1998). "Deoxyribonucleic acid-protein interactions and expression of the human testis-specific lactate dehydrogenase promoter: transcription factor Sp1 plays a major role". Biology of Reproduction. 58 (3): 754–9. doi:10.1095/biolreprod58.3.754. PMID 9510963.
  • Müller FU, Bokník P, Knapp J, Neumann J, Vahlensieck U, Oetjen E, Scheld HH, Schmitz W (Sep 1998). "Identification and expression of a novel isoform of cAMP response element modulator in the human heart". FASEB Journal. 12 (12): 1191–9. doi:10.1096/fasebj.12.12.1191. PMID 9737722. S2CID 34554530.
  • Fimia GM, De Cesare D, Sassone-Corsi P (Mar 1999). "CBP-independent activation of CREM and CREB by the LIM-only protein ACT". Nature. 398 (6723): 165–9. Bibcode:1999Natur.398..165F. doi:10.1038/18237. PMID 10086359. S2CID 4424908.
  • Pati D, Meistrich ML, Plon SE (Jul 1999). "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis". Molecular and Cellular Biology. 19 (7): 5001–13. doi:10.1128/mcb.19.7.5001. PMC 84326. PMID 10373550.
  • Inada A, Someya Y, Yamada Y, Ihara Y, Kubota A, Ban N, Watanabe R, Tsuda K, Seino Y (Jul 1999). "The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription factor IID". The Journal of Biological Chemistry. 274 (30): 21095–103. doi:10.1074/jbc.274.30.21095. PMID 10409662.
  • Zauli G, Secchiero P, Rodella L, Gibellini D, Mirandola P, Mazzoni M, Milani D, Dowd DR, Capitani S, Vitale M (Feb 2000). "HIV-1 Tat-mediated inhibition of the tyrosine hydroxylase gene expression in dopaminergic neuronal cells". The Journal of Biological Chemistry. 275 (6): 4159–65. doi:10.1074/jbc.275.6.4159. PMID 10660577.

External links edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

May 02, 2024
camp, responsive, element, modulator, protein, that, humans, encoded, crem, gene, belongs, camp, responsive, element, binding, protein, family, multiple, isoforms, which, either, repressors, activators, creb, family, important, regulating, transcription, respo. cAMP responsive element modulator is a protein that in humans is encoded by the CREM gene 5 6 7 and it belongs to the cAMP responsive element binding protein family It has multiple isoforms which act either as repressors or activators 8 CREB family is important for in regulating transcription in response to various stresses metabolic and developmental signals 9 CREM transcription factors also play an important role in many physiological systems such as cardiac function 10 circadian rhythms 11 locomotion and spermatogenesis 12 CREMIdentifiersAliasesCREM CREM 2 ICER hCREM 2 cAMP responsive element modulatorExternal IDsOMIM 123812 MGI 88495 HomoloGene 84591 GeneCards CREMGene location Human Chr Chromosome 10 human 1 Band10p11 21Start35 126 791 bp 1 End35 212 958 bp 1 Gene location Mouse Chr Chromosome 18 mouse 2 Band18 18 A1Start3 266 048 bp 2 End3 337 748 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inspermgallbladderanterior pituitaryleft uterine tubeislet of Langerhansright lungleft ventriclestromal cell of endometriumcaudate nucleuscanal of the cervixTop expressed inspermatidspermatocyteseminiferous tubuleadrenal glandproximal tubuleislet of Langerhansatrioventricular valveendocardial cushionleft lobe of livertemporal muscleMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding cAMP response element binding protein binding DNA binding transcription factor activity protein binding RNA polymerase II transcription regulatory region sequence specific DNA binding DNA binding transcription repressor activity RNA polymerase II specific DNA binding transcription factor activity RNA polymerase II specificCellular componentcytoplasm transcription regulator complex nucleusBiological processcell differentiation regulation of transcription DNA templated glycosphingolipid metabolic process rhythmic process transcription DNA templated fatty acid metabolic process multicellular organism development retinoic acid receptor signaling pathway regulation of circadian rhythm spermatogenesis glucose metabolic process positive regulation of transcription by RNA polymerase II signal transduction negative regulation of transcription by RNA polymerase IISources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez139012916EnsemblENSG00000095794ENSMUSG00000063889UniProtQ03060P27699RefSeq mRNA NM 001267562NM 001267563NM 001267564NM 001267565NM 001267566NM 001267567NM 001267568NM 001267569NM 001267570NM 001881NM 181571NM 182717NM 182718NM 182719NM 182720NM 182721NM 182722NM 182723NM 182724NM 182725NM 182769NM 182770NM 182771NM 182772NM 182850NM 182853NM 183011NM 183012NM 183013NM 183060NM 001352445NM 001352446NM 001352465NM 001352466NM 001352467NM 001394595NM 001394598NM 001394600NM 001394602NM 001394603NM 001394605NM 001394608NM 001394610NM 001394613NM 001394614NM 001394615NM 001394616NM 001394617NM 001394618NM 001394619NM 001394620NM 001394621NM 001394622NM 001394623NM 001394625NM 001394626NM 001394627NM 001394628NM 001394629NM 001394630NM 001394631NM 001110850NM 001110851NM 001110852NM 001110853NM 001110854NM 001110855NM 001110856NM 001110857NM 001110858NM 001110859NM 001271503NM 001271504NM 001271505NM 001271506NM 013498NM 001311066NM 001311067NM 001374833RefSeq protein NP 001254491NP 001254492NP 001254493NP 001254494NP 001254495NP 001254496NP 001254497NP 001254498NP 001254499NP 001872NP 853549NP 874386NP 874387NP 874388NP 874389NP 874390NP 874392NP 874393NP 877570NP 877571NP 877572NP 877573NP 898829NP 898830NP 898831NP 898883NP 001339374NP 001339375NP 001339394NP 001339395NP 001339396NP 001104320NP 001104321NP 001104322NP 001104323NP 001104324NP 001104325NP 001104326NP 001104327NP 001104328NP 001104329NP 001258432NP 001258433NP 001258434NP 001258435NP 001297995NP 001297996NP 038526NP 001361762Location UCSC Chr 10 35 13 35 21 MbChr 18 3 27 3 34 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Gene location 3 Interactions 4 Disease relevance of CREM 4 1 Panic disorder 4 2 Spermiogenesis deficiency 4 3 Systemic lupus erythematousus 5 References 6 Further reading 7 External linksFunction editThis gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters It is an important component of cAMP mediated signal transduction during the spermatogenetic cycle as well as other complex processes Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene with some of them functioning as activators and some as repressors of transcription 7 Gene location editThe chromosomal location of CREM gene is at 10p11 21 where it starts at 35415769 and ends at 35501886 bp from pter according to hg19 Feb 2009 13 Interactions editCAMP responsive element modulator has been shown to interact with FHL5 14 15 Disease relevance of CREM editPanic disorder edit One study reported the DNA sequence variations in the gene for CREM in panic disorder patients It showed a significant excess of the shorter eight repeat allele and of genotypes containing the eight repeat allele in panic disorder patients 16 The observed associations were limited to panic disorder without agoraphobia and they were more prominent in females But the independent Italian and Spanish samples in this study did not support their results Another family based study showed little evidence of any susceptibility locus for panic disorder either within the CREM gene or in a nearby region on chromosome 10p11 17 Spermiogenesis deficiency edit CREM has been shown to be a master switch regulator in testis 18 It plays an important role in the regulation of the expression of post meiotic genes and this has been supported by several studies using CREM mutation mice 19 The results showed the first step in the process of sperm formation would be blocked if the germ cell development in mice CREM gene were disrupted The cAMP response element sites can be found in the promoter region of some postmeiotic genes so that the CREM can target and regulate these genes 18 Two studies proved that treat the rats with Salvia hypoleuca and Alpina galanga can significantly increased the CREM gene expression 20 21 Systemic lupus erythematousus edit Less IL 2 will be produced from T cells in humans or mice with systemic lupus erythematousus SLE Some studies showed that an increased level CREM was presented in the nucleus of T lymphocytes from SLE patients The CREM bound to the 180 site of the IL 2 promoter to repress its transcription 22 References edit a b c GRCh38 Ensembl release 89 ENSG00000095794 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000063889 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Meyer TE Habener JF Nov 1992 Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes Nucleic Acids Research 20 22 6106 doi 10 1093 nar 20 22 6106 PMC 334485 PMID 1461747 Masquilier D Foulkes NS Mattei MG Sassone Corsi P Nov 1993 Human CREM gene evolutionary conservation chromosomal localization and inducibility of the transcript Cell Growth amp Differentiation 4 11 931 7 PMID 7916662 a b Entrez Gene CREM cAMP responsive element modulator Foulkes NS Sassone Corsi P 1992 02 07 More is better activators and repressors from the same gene Cell 68 3 411 414 doi 10 1016 0092 8674 92 90178 f ISSN 0092 8674 PMID 1739963 S2CID 34290449 Sassone Corsi P 1995 01 01 Transcription factors responsive to cAMP Annual Review of Cell and Developmental Biology 11 355 377 doi 10 1146 annurev cb 11 110195 002035 ISSN 1081 0706 PMID 8689562 Isoda T Paolocci N Haghighi K Wang C Wang Y Georgakopoulos D Servillo G Della Fazia MA Kranias EG 2003 02 01 Novel regulation of cardiac force frequency relation by CREM cAMP response element modulator FASEB Journal 17 2 144 151 doi 10 1096 fj 01 0981com ISSN 1530 6860 PMID 12554693 S2CID 17890025 Sassone Corsi P 2000 06 01 CREM a master switch regulating the balance between differentiation and apoptosis in male germ cells Molecular Reproduction and Development 56 2 Suppl 228 229 doi 10 1002 SICI 1098 2795 200006 56 2 lt 228 AID MRD2 gt 3 0 CO 2 B ISSN 1040 452X PMID 10824972 S2CID 21160055 Sassone Corsi P 1998 08 01 CREM a master switch governing male germ cells differentiation and apoptosis Seminars in Cell amp Developmental Biology 9 4 475 482 doi 10 1006 scdb 1998 0200 ISSN 1084 9521 PMID 9813195 CREM cAMP responsive element modulator atlasgeneticsoncology org Retrieved 2016 10 16 Fimia GM De Cesare D Sassone Corsi P Nov 2000 A family of LIM only transcriptional coactivators tissue specific expression and selective activation of CREB and CREM Molecular and Cellular Biology 20 22 8613 22 doi 10 1128 MCB 20 22 8613 8622 2000 PMC 102166 PMID 11046156 Fimia GM De Cesare D Sassone Corsi P Mar 1999 CBP independent activation of CREM and CREB by the LIM only protein ACT Nature 398 6723 165 9 Bibcode 1999Natur 398 165F doi 10 1038 18237 PMID 10086359 S2CID 4424908 Domschke K Kuhlenbaumer G Schirmacher A Lorenzi C Armengol L DiBella D Gratacos M Garritsen HS Nothen MM 2003 02 01 Human nuclear transcription factor gene CREM genomic organization mutation screening and association analysis in panic disorder American Journal of Medical Genetics Part B 117B 1 70 78 doi 10 1002 ajmg b 10018 ISSN 1552 4841 PMID 12555239 S2CID 8884044 Hamilton SP Slager SL Mayo D Heiman GA Klein DF Hodge SE Fyer AJ Weissman MM Knowles JA 2004 04 01 Investigation of polymorphisms in the CREM gene in panic disorder American Journal of Medical Genetics Part B 126B 1 111 115 doi 10 1002 ajmg b 20121 ISSN 1552 4841 PMID 15048659 S2CID 43810849 a b Krausz C Sassone Corsi P 2005 01 01 Genetic control of spermiogenesis insights from the CREM gene and implications for human infertility Reproductive BioMedicine Online 10 1 64 71 doi 10 1016 S1472 6483 10 60805 X PMID 15705296 Nantel F Monaco L Foulkes NS Masquilier D LeMeur M Henriksen K Dierich A Parvinen M Sassone Corsi P 1996 03 14 Spermiogenesis deficiency and germ cell apoptosis in CREM mutant mice Nature 380 6570 159 162 Bibcode 1996Natur 380 159N doi 10 1038 380159a0 ISSN 0028 0836 PMID 8600390 S2CID 4278745 Jasem E Nasim J Gholamreza M Naser S Nader M Maryam SL Abbas N Vahid R 2010 10 01 Evaluation of the effects of Salvia hypoleuca on the cAMP responsive element modulator CREM gene expression and spermatogenesis in rat Middle East Fertility Society Journal 15 4 274 277 doi 10 1016 j mefs 2010 08 002 Mazaheri M Shahdadi V Nazari Boron A 2016 10 16 Molecullar and biochemical effect of alcoholic extract of Alpinia galanga on rat spermatogenesis process Iranian Journal of Reproductive Medicine 12 11 765 770 ISSN 1680 6433 PMC 4330656 PMID 25709632 Juang YT Wang Y Solomou EE Li Y Mawrin C Tenbrock K Kyttaris VC Tsokos GC 2005 04 01 Systemic lupus erythematosus serum IgG increases CREM binding to the IL 2 promoter and suppresses IL 2 production through CaMKIV Journal of Clinical Investigation 115 4 996 1005 doi 10 1172 JCI22854 ISSN 0021 9738 PMC 1070410 PMID 15841182 Further reading editDon J Stelzer G Feb 2002 The expanding family of CREB CREM transcription factors that are involved with spermatogenesis Molecular and Cellular Endocrinology 187 1 2 115 24 doi 10 1016 S0303 7207 01 00696 7 PMID 11988318 S2CID 23023082 Yan C Miller CL Abe J Mar 2007 Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heart Circulation Research 100 4 489 501 doi 10 1161 01 RES 0000258451 44949 d7 PMC 4115784 PMID 17332439 Pongubala JM Atchison ML Apr 1995 Activating transcription factor 1 and cyclic AMP response element modulator can modulate the activity of the immunoglobulin kappa 3 enhancer The Journal of Biological Chemistry 270 17 10304 13 doi 10 1074 jbc 270 17 10304 PMID 7730336 Walker WH Sanborn BM Habener JF Dec 1994 An isoform of transcription factor CREM expressed during spermatogenesis lacks the phosphorylation domain and represses cAMP induced transcription Proceedings of the National Academy of Sciences of the United States of America 91 26 12423 7 Bibcode 1994PNAS 9112423W doi 10 1073 pnas 91 26 12423 PMC 45450 PMID 7809053 Fujimoto T Fujisawa J Yoshida M Feb 1994 Novel isoforms of human cyclic AMP responsive element modulator hCREM mRNA Journal of Biochemistry 115 2 298 303 doi 10 1093 oxfordjournals jbchem a124332 PMID 8206879 de Groot RP den Hertog J Vandenheede JR Goris J Sassone Corsi P Oct 1993 Multiple and cooperative phosphorylation events regulate the CREM activator function The EMBO Journal 12 10 3903 11 doi 10 1002 j 1460 2075 1993 tb06068 x PMC 413673 PMID 8404858 Bodor J Walker W Flemington E Spetz AL Habener JF Dec 1995 Modulation of Tax and PKA mediated expression of HTLV I promoter via cAMP response element binding and modulator proteins CREB and CREM FEBS Letters 377 3 413 8 doi 10 1016 0014 5793 95 01299 0 PMID 8549766 S2CID 45422227 Nantel F Monaco L Foulkes NS Masquilier D LeMeur M Henriksen K Dierich A Parvinen M Sassone Corsi P Mar 1996 Spermiogenesis deficiency and germ cell apoptosis in CREM mutant mice Nature 380 6570 159 62 Bibcode 1996Natur 380 159N doi 10 1038 380159a0 PMID 8600390 S2CID 4278745 Blendy JA Kaestner KH Weinbauer GF Nieschlag E Schutz G Mar 1996 Severe impairment of spermatogenesis in mice lacking the CREM gene Nature 380 6570 162 5 Bibcode 1996Natur 380 162B doi 10 1038 380162a0 PMID 8600391 S2CID 4337719 Bodor J Spetz AL Strominger JL Habener JF Apr 1996 cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes Proceedings of the National Academy of Sciences of the United States of America 93 8 3536 41 Bibcode 1996PNAS 93 3536B doi 10 1073 pnas 93 8 3536 PMC 39645 PMID 8622971 Gellersen B Kempf R Telgmann R Jan 1997 Human endometrial stromal cells express novel isoforms of the transcriptional modulator CREM and up regulate ICER in the course of decidualization Molecular Endocrinology 11 1 97 113 doi 10 1210 mend 11 1 9875 PMID 8994192 Laurance ME Kwok RP Huang MS Richards JP Lundblad JR Goodman RH Jan 1997 Differential activation of viral and cellular promoters by human T cell lymphotropic virus 1 tax and cAMP responsive element modulator isoforms The Journal of Biological Chemistry 272 5 2646 51 doi 10 1074 jbc 272 5 2646 PMID 9006899 Bonny C Cooker LA Goldberg E Mar 1998 Deoxyribonucleic acid protein interactions and expression of the human testis specific lactate dehydrogenase promoter transcription factor Sp1 plays a major role Biology of Reproduction 58 3 754 9 doi 10 1095 biolreprod58 3 754 PMID 9510963 Muller FU Boknik P Knapp J Neumann J Vahlensieck U Oetjen E Scheld HH Schmitz W Sep 1998 Identification and expression of a novel isoform of cAMP response element modulator in the human heart FASEB Journal 12 12 1191 9 doi 10 1096 fasebj 12 12 1191 PMID 9737722 S2CID 34554530 Fimia GM De Cesare D Sassone Corsi P Mar 1999 CBP independent activation of CREM and CREB by the LIM only protein ACT Nature 398 6723 165 9 Bibcode 1999Natur 398 165F doi 10 1038 18237 PMID 10086359 S2CID 4424908 Pati D Meistrich ML Plon SE Jul 1999 Human Cdc34 and Rad6B ubiquitin conjugating enzymes target repressors of cyclic AMP induced transcription for proteolysis Molecular and Cellular Biology 19 7 5001 13 doi 10 1128 mcb 19 7 5001 PMC 84326 PMID 10373550 Inada A Someya Y Yamada Y Ihara Y Kubota A Ban N Watanabe R Tsuda K Seino Y Jul 1999 The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription factor IID The Journal of Biological Chemistry 274 30 21095 103 doi 10 1074 jbc 274 30 21095 PMID 10409662 Zauli G Secchiero P Rodella L Gibellini D Mirandola P Mazzoni M Milani D Dowd DR Capitani S Vitale M Feb 2000 HIV 1 Tat mediated inhibition of the tyrosine hydroxylase gene expression in dopaminergic neuronal cells The Journal of Biological Chemistry 275 6 4159 65 doi 10 1074 jbc 275 6 4159 PMID 10660577 External links editCREM protein human at the U S National Library of Medicine Medical Subject Headings MeSH Human CREM genome location and CREM gene details page in the UCSC Genome Browser This article incorporates text from the United States National Library of Medicine which is in the public domain Retrieved from https en wikipedia org w index php title CAMP responsive element modulator amp oldid 1214948513, wikipedia, wiki, book, 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