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Wikipedia

CAMK4

December 01, 2023

Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.[5]

CAMK4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCAMK4, CaMK IV, CaMK-GR, IV, caMK, calcium/calmodulin-dependent protein kinase IV, calcium/calmodulin dependent protein kinase IV, CaMKIV
External IDsOMIM: 114080 MGI: 88258 HomoloGene: 100780 GeneCards: CAMK4
Orthologs
SpeciesHumanMouse
Entrez

814

12326

Ensembl

ENSG00000152495

ENSMUSG00000038128

UniProt

Q16566

P08414
Q8BGR3

RefSeq (mRNA)

NM_001744
NM_001323374
NM_001323375
NM_001323376
NM_001323377

NM_009793

RefSeq (protein)

NP_001310303
NP_001310304
NP_001310305
NP_001310306
NP_001735

NP_033923

Location (UCSC)Chr 5: 111.22 – 111.49 MbChr 18: 33.07 – 33.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The product of this gene belongs to the serine/threonine protein kinase cluster, and to the Ca2+/calmodulin-dependent protein kinase (CAMK) group. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons, and male germ cells.[6]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000152495 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038128 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sikela JM, Law ML, Kao FT, Hartz JA, Wei Q, Hahn WE (Mar 1989). "Chromosomal localization of the human gene for brain Ca2+/calmodulin-dependent protein kinase type IV". Genomics. 4 (1): 21–7. doi:10.1016/0888-7543(89)90309-1. PMID 2536634.
  6. ^ "Entrez Gene: CAMK4 calcium/calmodulin-dependent protein kinase IV".

Further reading edit

  • Bredt DS, Ferris CD, Snyder SH (1992). "Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites". J. Biol. Chem. 267 (16): 10976–81. doi:10.1016/S0021-9258(19)49862-1. PMID 1375933.
  • Jensen KF, Ohmstede CA, Fisher RS, Sahyoun N (1991). "Nuclear and axonal localization of Ca2+/calmodulin-dependent protein kinase type Gr in rat cerebellar cortex". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2850–3. Bibcode:1991PNAS...88.2850J. doi:10.1073/pnas.88.7.2850. PMC 51337. PMID 2011593.
  • Selbert MA, Anderson KA, Huang QH, et al. (1995). "Phosphorylation and activation of Ca2+-calmodulin-dependent protein kinase IV by Ca2+-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation". J. Biol. Chem. 270 (29): 17616–21. doi:10.1074/jbc.270.29.17616. PMID 7615569.
  • Kitani T, Okuno S, Fujisawa H (1994). "cDNA cloning and expression of human calmodulin-dependent protein kinase IV". J. Biochem. 115 (4): 637–40. doi:10.1093/oxfordjournals.jbchem.a124387. PMID 8089075.
  • Mosialos G, Hanissian SH, Jawahar S, et al. (1994). "A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1". J. Virol. 68 (3): 1697–705. doi:10.1128/JVI.68.3.1697-1705.1994. PMC 236629. PMID 8107230.
  • Bland MM, Monroe RS, Ohmstede CA (1994). "The cDNA sequence and characterization of the Ca2+/calmodulin-dependent protein kinase-Gr from human brain and thymus". Gene. 142 (2): 191–7. doi:10.1016/0378-1119(94)90260-7. PMID 8194751.
  • Tokumitsu H, Soderling TR (1996). "Requirements for calcium and calmodulin in the calmodulin kinase activation cascade". J. Biol. Chem. 271 (10): 5617–22. doi:10.1074/jbc.271.10.5617. PMID 8621423.
  • Chatila T, Anderson KA, Ho N, Means AR (1996). "A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR". J. Biol. Chem. 271 (35): 21542–8. doi:10.1074/jbc.271.35.21542. PMID 8702940.
  • Melander Gradin H, Marklund U, Larsson N, et al. (1997). "Regulation of microtubule dynamics by Ca2+/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18". Mol. Cell. Biol. 17 (6): 3459–67. doi:10.1128/mcb.17.6.3459. PMC 232199. PMID 9154845.
  • Matsushita M, Nairn AC (1998). "Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase". J. Biol. Chem. 273 (34): 21473–81. doi:10.1074/jbc.273.34.21473. PMID 9705275.
  • Anderson KA, Means RL, Huang QH, et al. (1998). "Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta". J. Biol. Chem. 273 (48): 31880–9. doi:10.1074/jbc.273.48.31880. PMID 9822657.
  • Hayashi Y, Nishio M, Naito Y, et al. (1999). "Regulation of neuronal nitric-oxide synthase by calmodulin kinases". J. Biol. Chem. 274 (29): 20597–602. doi:10.1074/jbc.274.29.20597. PMID 10400690.
  • Blaeser F, Ho N, Prywes R, Chatila TA (2000). "Ca2+-dependent gene expression mediated by MEF2 transcription factors". J. Biol. Chem. 275 (1): 197–209. doi:10.1074/jbc.275.1.197. PMID 10617605.
  • Moreno CS, Park S, Nelson K, et al. (2000). "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A". J. Biol. Chem. 275 (8): 5257–63. doi:10.1074/jbc.275.8.5257. PMC 3505218. PMID 10681496.
  • Komeima K, Hayashi Y, Naito Y, Watanabe Y (2000). "Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells". J. Biol. Chem. 275 (36): 28139–43. doi:10.1074/jbc.M003198200. PMID 10874031.
  • Wu JY, Ribar TJ, Cummings DE, et al. (2000). "Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4". Nat. Genet. 25 (4): 448–52. doi:10.1038/78153. PMID 10932193. S2CID 10803791.
  • Jang MK, Goo YH, Sohn YC, et al. (2001). "Ca2+/calmodulin-dependent protein kinase IV stimulates nuclear factor-kappa B transactivation via phosphorylation of the p65 subunit". J. Biol. Chem. 276 (23): 20005–10. doi:10.1074/jbc.M010211200. PMID 11274168.
  • Hsu LS, Chen GD, Lee LS, et al. (2001). "Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity". J. Biol. Chem. 276 (33): 31113–23. doi:10.1074/jbc.M011720200. PMID 11395482.
  • Zhao X, Ito A, Kane CD, et al. (2001). "The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking". J. Biol. Chem. 276 (37): 35042–8. doi:10.1074/jbc.M105086200. PMID 11470791.
  • Ainhoa Bilbaoa; Jan Rodriguez Parkitnab; David Engblomb; Stéphanie Perreau-Lenza; Carles Sanchis-Seguraa; Miriam Schneidera; Witold Konopkab; Magdalena Westphalb; Gerome Breenc; Sylvane Desrivieresc; Matthias Klugmannd; Camila Guindalinie; Homero Valladag; Ronaldo Laranjeirae; Fernando Rodriguez de Fonsecah; Gunter Schumannc; Günther Schützb & Rainer Spanagela (2008). "Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine". Proceedings of the National Academy of Sciences of the United States of America. PNAS. 105 (45): 17549–54. Bibcode:2008PNAS..10517549B. doi:10.1073/pnas.0803959105. PMC 2582267. PMID 19001277.
  • Feliciano DM, Edelman AM (2009). "Repression of Ca2+/calmodulin-dependent protein kinase IV signaling accelerates retinoic acid-induced differentiation of human neuroblastoma cells". J. Biol. Chem. 284 (39): 26466–81. doi:10.1074/jbc.M109.027680. PMC 2785335. PMID 19633294.

External links edit


 

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

December 01, 2023
camk4, calcium, calmodulin, dependent, protein, kinase, type, enzyme, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2w4oidentifiersaliases, camk, camk, camk, calcium, calmodulin, dependent, protein, kinase, calcium. Calcium calmodulin dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene 5 CAMK4Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2W4OIdentifiersAliasesCAMK4 CaMK IV CaMK GR IV caMK calcium calmodulin dependent protein kinase IV calcium calmodulin dependent protein kinase IV CaMKIVExternal IDsOMIM 114080 MGI 88258 HomoloGene 100780 GeneCards CAMK4Gene location Human Chr Chromosome 5 human 1 Band5q22 1Start111 223 653 bp 1 End111 494 886 bp 1 Gene location Mouse Chr Chromosome 18 mouse 2 Band18 B1 18 18 15 cMStart33 067 984 bp 2 End33 324 281 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed incerebellar vermiscerebellar hemispheremiddle temporal gyrusganglionic eminencenucleus accumbenssuperior frontal gyrusexternal globus pallidusBrodmann area 23entorhinal cortexprefrontal cortexTop expressed incerebellar cortexsuperior frontal gyrusthymusseminiferous tubulecerebellar vermisspermatidolfactory tuberclesupraoptic nucleusprimary motor cortexsecondary oocyteMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiontransferase activity nucleotide binding protein kinase activity calcium dependent protein serine threonine kinase activity calmodulin binding kinase activity protein serine threonine kinase activity calmodulin dependent protein kinase activity ATP bindingCellular componentcytoplasm cytosol nucleoplasm extracellular exosome nucleus fibrillar center postsynapse glutamatergic synapseBiological processintracellular signal transduction adaptive immune response myeloid dendritic cell cytokine production phosphorylation immune system process myeloid dendritic cell differentiation positive regulation of transcription DNA templated regulation of T cell differentiation in thymus protein phosphorylation regulation of osteoclast differentiation long term memory peptidyl serine phosphorylation protein autophosphorylation inflammatory response signal transductionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez81412326EnsemblENSG00000152495ENSMUSG00000038128UniProtQ16566P08414Q8BGR3RefSeq mRNA NM 001744NM 001323374NM 001323375NM 001323376NM 001323377NM 009793RefSeq protein NP 001310303NP 001310304NP 001310305NP 001310306NP 001735NP 033923Location UCSC Chr 5 111 22 111 49 MbChr 18 33 07 33 32 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe product of this gene belongs to the serine threonine protein kinase cluster and to the Ca2 calmodulin dependent protein kinase CAMK group This enzyme is a multifunctional serine threonine protein kinase with limited tissue distribution that has been implicated in transcriptional regulation in lymphocytes neurons and male germ cells 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000152495 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000038128 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Sikela JM Law ML Kao FT Hartz JA Wei Q Hahn WE Mar 1989 Chromosomal localization of the human gene for brain Ca2 calmodulin dependent protein kinase type IV Genomics 4 1 21 7 doi 10 1016 0888 7543 89 90309 1 PMID 2536634 Entrez Gene CAMK4 calcium calmodulin dependent protein kinase IV Further reading editBredt DS Ferris CD Snyder SH 1992 Nitric oxide synthase regulatory sites Phosphorylation by cyclic AMP dependent protein kinase protein kinase C and calcium calmodulin protein kinase identification of flavin and calmodulin binding sites J Biol Chem 267 16 10976 81 doi 10 1016 S0021 9258 19 49862 1 PMID 1375933 Jensen KF Ohmstede CA Fisher RS Sahyoun N 1991 Nuclear and axonal localization of Ca2 calmodulin dependent protein kinase type Gr in rat cerebellar cortex Proc Natl Acad Sci U S A 88 7 2850 3 Bibcode 1991PNAS 88 2850J doi 10 1073 pnas 88 7 2850 PMC 51337 PMID 2011593 Selbert MA Anderson KA Huang QH et al 1995 Phosphorylation and activation of Ca2 calmodulin dependent protein kinase IV by Ca2 calmodulin dependent protein kinase Ia kinase Phosphorylation of threonine 196 is essential for activation J Biol Chem 270 29 17616 21 doi 10 1074 jbc 270 29 17616 PMID 7615569 Kitani T Okuno S Fujisawa H 1994 cDNA cloning and expression of human calmodulin dependent protein kinase IV J Biochem 115 4 637 40 doi 10 1093 oxfordjournals jbchem a124387 PMID 8089075 Mosialos G Hanissian SH Jawahar S et al 1994 A Ca2 calmodulin dependent protein kinase CaM kinase Gr expressed after transformation of primary human B lymphocytes by Epstein Barr virus EBV is induced by the EBV oncogene LMP1 J Virol 68 3 1697 705 doi 10 1128 JVI 68 3 1697 1705 1994 PMC 236629 PMID 8107230 Bland MM Monroe RS Ohmstede CA 1994 The cDNA sequence and characterization of the Ca2 calmodulin dependent protein kinase Gr from human brain and thymus Gene 142 2 191 7 doi 10 1016 0378 1119 94 90260 7 PMID 8194751 Tokumitsu H Soderling TR 1996 Requirements for calcium and calmodulin in the calmodulin kinase activation cascade J Biol Chem 271 10 5617 22 doi 10 1074 jbc 271 10 5617 PMID 8621423 Chatila T Anderson KA Ho N Means AR 1996 A unique phosphorylation dependent mechanism for the activation of Ca2 calmodulin dependent protein kinase type IV GR J Biol Chem 271 35 21542 8 doi 10 1074 jbc 271 35 21542 PMID 8702940 Melander Gradin H Marklund U Larsson N et al 1997 Regulation of microtubule dynamics by Ca2 calmodulin dependent kinase IV Gr dependent phosphorylation of oncoprotein 18 Mol Cell Biol 17 6 3459 67 doi 10 1128 mcb 17 6 3459 PMC 232199 PMID 9154845 Matsushita M Nairn AC 1998 Characterization of the mechanism of regulation of Ca2 calmodulin dependent protein kinase I by calmodulin and by Ca2 calmodulin dependent protein kinase kinase J Biol Chem 273 34 21473 81 doi 10 1074 jbc 273 34 21473 PMID 9705275 Anderson KA Means RL Huang QH et al 1998 Components of a calmodulin dependent protein kinase cascade Molecular cloning functional characterization and cellular localization of Ca2 calmodulin dependent protein kinase kinase beta J Biol Chem 273 48 31880 9 doi 10 1074 jbc 273 48 31880 PMID 9822657 Hayashi Y Nishio M Naito Y et al 1999 Regulation of neuronal nitric oxide synthase by calmodulin kinases J Biol Chem 274 29 20597 602 doi 10 1074 jbc 274 29 20597 PMID 10400690 Blaeser F Ho N Prywes R Chatila TA 2000 Ca2 dependent gene expression mediated by MEF2 transcription factors J Biol Chem 275 1 197 209 doi 10 1074 jbc 275 1 197 PMID 10617605 Moreno CS Park S Nelson K et al 2000 WD40 repeat proteins striatin and S G 2 nuclear autoantigen are members of a novel family of calmodulin binding proteins that associate with protein phosphatase 2A J Biol Chem 275 8 5257 63 doi 10 1074 jbc 275 8 5257 PMC 3505218 PMID 10681496 Komeima K Hayashi Y Naito Y Watanabe Y 2000 Inhibition of neuronal nitric oxide synthase by calcium calmodulin dependent protein kinase IIalpha through Ser847 phosphorylation in NG108 15 neuronal cells J Biol Chem 275 36 28139 43 doi 10 1074 jbc M003198200 PMID 10874031 Wu JY Ribar TJ Cummings DE et al 2000 Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4 Nat Genet 25 4 448 52 doi 10 1038 78153 PMID 10932193 S2CID 10803791 Jang MK Goo YH Sohn YC et al 2001 Ca2 calmodulin dependent protein kinase IV stimulates nuclear factor kappa B transactivation via phosphorylation of the p65 subunit J Biol Chem 276 23 20005 10 doi 10 1074 jbc M010211200 PMID 11274168 Hsu LS Chen GD Lee LS et al 2001 Human Ca2 calmodulin dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity J Biol Chem 276 33 31113 23 doi 10 1074 jbc M011720200 PMID 11395482 Zhao X Ito A Kane CD et al 2001 The modular nature of histone deacetylase HDAC4 confers phosphorylation dependent intracellular trafficking J Biol Chem 276 37 35042 8 doi 10 1074 jbc M105086200 PMID 11470791 Ainhoa Bilbaoa Jan Rodriguez Parkitnab David Engblomb Stephanie Perreau Lenza Carles Sanchis Seguraa Miriam Schneidera Witold Konopkab Magdalena Westphalb Gerome Breenc Sylvane Desrivieresc Matthias Klugmannd Camila Guindalinie Homero Valladag Ronaldo Laranjeirae Fernando Rodriguez de Fonsecah Gunter Schumannc Gunther Schutzb amp Rainer Spanagela 2008 Loss of the Ca2 calmodulin dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine Proceedings of the National Academy of Sciences of the United States of America PNAS 105 45 17549 54 Bibcode 2008PNAS 10517549B doi 10 1073 pnas 0803959105 PMC 2582267 PMID 19001277 Feliciano DM Edelman AM 2009 Repression of Ca2 calmodulin dependent protein kinase IV signaling accelerates retinoic acid induced differentiation of human neuroblastoma cells J Biol Chem 284 39 26466 81 doi 10 1074 jbc M109 027680 PMC 2785335 PMID 19633294 External links editHuman CAMK4 genome location and CAMK4 gene details page in the UCSC Genome Browser Portal nbsp Biology nbsp This article on a gene on human chromosome 5 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CAMK4 amp oldid 1121974290, wikipedia, wiki, book, books, library,

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