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Wikipedia

CAMK2D

January 01, 1970

Calcium/calmodulin-dependent protein kinase type II delta chain is an enzyme that in humans is encoded by the CAMK2D gene.[5]

CAMK2D
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCAMK2D, CAMKD, calcium/calmodulin dependent protein kinase II delta
External IDsOMIM: 607708 MGI: 1341265 HomoloGene: 55561 GeneCards: CAMK2D
Orthologs
SpeciesHumanMouse
Entrez

817

108058

Ensembl

ENSG00000145349

ENSMUSG00000053819

UniProt

Q13557

Q6PHZ2

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 4: 113.42 – 113.76 MbChr 3: 126.39 – 126.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca2+/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Four alternatively spliced transcript variants that encode three different isoforms have been characterized to date. Distinct isoforms of this chain have different expression patterns.[5]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145349 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053819 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: CAMK2D calcium/calmodulin-dependent protein kinase (CaM kinase) II delta".

Further reading edit

  • Hook SS, Means AR (2001). "Ca2+/CaM-dependent kinases: from activation to function". Annu. Rev. Pharmacol. Toxicol. 41 (1): 471–505. doi:10.1146/annurev.pharmtox.41.1.471. PMID 11264466.
  • Yamamoto H (2002). "[Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions]". Tanpakushitsu Kakusan Koso. 47 (3): 241–7. PMID 11889801.
  • de Groot RP, den Hertog J, Vandenheede JR, et al. (1993). "Multiple and cooperative phosphorylation events regulate the CREM activator function". EMBO J. 12 (10): 3903–11. doi:10.1002/j.1460-2075.1993.tb06068.x. PMC 413673. PMID 8404858.
  • Tombes RM, Krystal GW (1997). "Identification of novel human tumor cell-specific CaMK-II variants". Biochim. Biophys. Acta. 1355 (3): 281–92. doi:10.1016/S0167-4889(96)00141-3. PMID 9060999.
  • Moyers JS, Bilan PJ, Zhu J, Kahn CR (1997). "Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II". J. Biol. Chem. 272 (18): 11832–9. doi:10.1074/jbc.272.18.11832. PMID 9115241.
  • Möhlig M, Wolter S, Mayer P, et al. (1997). "Insulinoma cells contain an isoform of Ca2+/calmodulin-dependent protein kinase II delta associated with insulin secretion vesicles". Endocrinology. 138 (6): 2577–84. doi:10.1210/endo.138.6.5168. PMID 9165051.
  • Bauch A, Campbell KS, Reth M (1998). "Interaction of the CD5 cytoplasmic domain with the Ca2+/calmodulin-dependent kinase IIdelta". Eur. J. Immunol. 28 (7): 2167–77. doi:10.1002/(SICI)1521-4141(199807)28:07<2167::AID-IMMU2167>3.0.CO;2-L. PMID 9692886.
  • Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Hoch B, Meyer R, Hetzer R, et al. (1999). "Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium". Circ. Res. 84 (6): 713–21. doi:10.1161/01.res.84.6.713. PMID 10189359.
  • Tombes RM, Mikkelsen RB, Jarvis WD, Grant S (1999). "Downregulation of delta CaM kinase II in human tumor cells". Biochim. Biophys. Acta. 1452 (1): 1–11. doi:10.1016/S0167-4889(99)00113-5. PMID 10525155.
  • Rochlitz H, Voigt A, Lankat-Buttgereit B, et al. (2000). "Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells". Diabetologia. 43 (4): 465–73. doi:10.1007/s001250051330. PMID 10819240.
  • Inagaki N, Nishizawa M, Arimura N, et al. (2000). "Activation of Ca2+/calmodulin-dependent protein kinase II within post-synaptic dendritic spines of cultured hippocampal neurons". J. Biol. Chem. 275 (35): 27165–71. doi:10.1074/jbc.M003751200. PMID 10852918.
  • Nair JS, DaFonseca CJ, Tjernberg A, et al. (2002). "Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma". Proc. Natl. Acad. Sci. U.S.A. 99 (9): 5971–6. Bibcode:2002PNAS...99.5971N. doi:10.1073/pnas.052159099. PMC 122886. PMID 11972023.
  • Mishra-Gorur K, Singer HA, Castellot JJ (2002). "The S18 ribosomal protein is a putative substrate for Ca2+/calmodulin-activated protein kinase II". J. Biol. Chem. 277 (37): 33537–40. doi:10.1074/jbc.C200342200. PMID 12145273.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gaertner TR, Kolodziej SJ, Wang D, et al. (2004). "Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II". J. Biol. Chem. 279 (13): 12484–94. doi:10.1074/jbc.M313597200. PMID 14722083.
  • Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.

External links edit


 

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

January 01, 1970
camk2d, calcium, calmodulin, dependent, protein, kinase, type, delta, chain, enzyme, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2vn9, 2w2c, 2wel, 3gp2identifiersaliases, camkd, calcium, calmodulin, dependent, pr. Calcium calmodulin dependent protein kinase type II delta chain is an enzyme that in humans is encoded by the CAMK2D gene 5 CAMK2DAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes2VN9 2W2C 2WEL 3GP2IdentifiersAliasesCAMK2D CAMKD calcium calmodulin dependent protein kinase II deltaExternal IDsOMIM 607708 MGI 1341265 HomoloGene 55561 GeneCards CAMK2DGene location Human Chr Chromosome 4 human 1 Band4q26Start113 418 054 bp 1 End113 761 927 bp 1 Gene location Mouse Chr Chromosome 3 mouse 2 Band3 3 G1 G2Start126 389 951 bp 2 End126 639 975 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmiddle temporal gyrusBrodmann area 23right ventricleentorhinal cortextibialis anterior muscledeltoid muscleendothelial cellpancreatic ductal cellvastus lateralis musclebiceps brachiiTop expressed incerebellar vermismedial geniculate nucleusdorsomedial hypothalamic nucleusatriumlateral hypothalamusventral tegmental arealateral geniculate nucleuspontine nucleimedial dorsal nucleuspineal glandMore reference expression dataBioGPSn aGene ontologyMolecular functionkinase activity ATP binding protein kinase activity titin binding transferase activity protein homodimerization activity protein binding nucleotide binding sodium channel inhibitor activity calmodulin dependent protein kinase activity protein serine threonine kinase activity transmembrane transporter binding calmodulin binding identical protein bindingCellular componentendocytic vesicle membrane membrane sarcoplasmic reticulum membrane plasma membrane nucleoplasm sarcoplasmic reticulum sarcolemma neuron projection nucleus cytoplasm cytosol calcium channel complexBiological processregulation of heart contraction interferon gamma mediated signaling pathway regulation of transcription by RNA polymerase II regulation of membrane depolarization positive regulation of cardiac muscle hypertrophy protein phosphorylation cellular response to calcium ion regulation of cardiac muscle cell action potential involved in regulation of contraction regulation of histone deacetylase activity regulation of cellular localization negative regulation of sodium ion transmembrane transport phosphorylation regulation of the force of heart contraction regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of ryanodine sensitive calcium release channel activity negative regulation of sodium ion transmembrane transporter activity MAPK cascade protein complex oligomerization regulation of cell growth regulation of cellular response to heat regulation of cell communication by electrical coupling involved in cardiac conduction regulation of heart rate by cardiac conduction nervous system development cell differentiation regulation of cell communication by electrical coupling positive regulation of cardiac muscle cell apoptotic process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum peptidyl serine phosphorylation peptidyl threonine phosphorylation endoplasmic reticulum calcium ion homeostasis protein autophosphorylation relaxation of cardiac muscle cardiac muscle cell contraction regulation of cardiac muscle cell action potential regulation of relaxation of cardiac muscle regulation of calcium ion transmembrane transport via high voltage gated calcium channelSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez817108058EnsemblENSG00000145349ENSMUSG00000053819UniProtQ13557Q6PHZ2RefSeq mRNA NM 001221NM 172114NM 172115NM 172127NM 172128NM 172129NM 001321566NM 001321567NM 001321568NM 001321569NM 001321570NM 001321571NM 001321572NM 001321573NM 001321574NM 001321575NM 001321576NM 001321577NM 001321578NM 001321579NM 001321580NM 001321581NM 001321582NM 001321583NM 001321584NM 001321585NM 001321586NM 001321587NM 001321588NM 001321589NM 001321590NM 001321591NM 001321592NM 001396964NM 001396965NM 001396966NM 001396967NM 001399855NM 001399856NM 001399857NM 001399858NM 001399859NM 001399860NM 001399861NM 001399862NM 001399863NM 001399864NM 001399865NM 001025438NM 001025439NM 001293663NM 001293664NM 001293665NM 001293666NM 023813NM 001346635NM 001346636RefSeq protein NP 001212NP 001308495NP 001308496NP 001308497NP 001308498NP 001308499NP 001308500NP 001308501NP 001308502NP 001308503NP 001308504NP 001308505NP 001308506NP 001308507NP 001308508NP 001308509NP 001308510NP 001308511NP 001308512NP 001308513NP 001308514NP 001308515NP 001308516NP 001308517NP 001308518NP 001308519NP 001308520NP 001308521NP 742112NP 742113NP 742125NP 742126NP 742127NP 001020609NP 001020610NP 001280592NP 001280593NP 001280594NP 001280595NP 001333564NP 001333565NP 076302Location UCSC Chr 4 113 42 113 76 MbChr 3 126 39 126 64 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse The product of this gene belongs to the serine threonine protein kinase family and to the Ca2 calmodulin dependent protein kinase subfamily Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses In mammalian cells the enzyme is composed of four different chains alpha beta gamma and delta The product of this gene is a delta chain Four alternatively spliced transcript variants that encode three different isoforms have been characterized to date Distinct isoforms of this chain have different expression patterns 5 References edit a b c GRCh38 Ensembl release 89 ENSG00000145349 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000053819 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene CAMK2D calcium calmodulin dependent protein kinase CaM kinase II delta Further reading editHook SS Means AR 2001 Ca2 CaM dependent kinases from activation to function Annu Rev Pharmacol Toxicol 41 1 471 505 doi 10 1146 annurev pharmtox 41 1 471 PMID 11264466 Yamamoto H 2002 Molecular mechanisms of the intracellular localizations of Ca2 calmodulin dependent protein kinase II isoforms and their physiological functions Tanpakushitsu Kakusan Koso 47 3 241 7 PMID 11889801 de Groot RP den Hertog J Vandenheede JR et al 1993 Multiple and cooperative phosphorylation events regulate the CREM activator function EMBO J 12 10 3903 11 doi 10 1002 j 1460 2075 1993 tb06068 x PMC 413673 PMID 8404858 Tombes RM Krystal GW 1997 Identification of novel human tumor cell specific CaMK II variants Biochim Biophys Acta 1355 3 281 92 doi 10 1016 S0167 4889 96 00141 3 PMID 9060999 Moyers JS Bilan PJ Zhu J Kahn CR 1997 Rad and Rad related GTPases interact with calmodulin and calmodulin dependent protein kinase II J Biol Chem 272 18 11832 9 doi 10 1074 jbc 272 18 11832 PMID 9115241 Mohlig M Wolter S Mayer P et al 1997 Insulinoma cells contain an isoform of Ca2 calmodulin dependent protein kinase II delta associated with insulin secretion vesicles Endocrinology 138 6 2577 84 doi 10 1210 endo 138 6 5168 PMID 9165051 Bauch A Campbell KS Reth M 1998 Interaction of the CD5 cytoplasmic domain with the Ca2 calmodulin dependent kinase IIdelta Eur J Immunol 28 7 2167 77 doi 10 1002 SICI 1521 4141 199807 28 07 lt 2167 AID IMMU2167 gt 3 0 CO 2 L PMID 9692886 Sanger Centre The Washington University Genome Sequencing Cente The 1999 Toward a complete human genome sequence Genome Res 8 11 1097 108 doi 10 1101 gr 8 11 1097 PMID 9847074 Hoch B Meyer R Hetzer R et al 1999 Identification and expression of delta isoforms of the multifunctional Ca2 calmodulin dependent protein kinase in failing and nonfailing human myocardium Circ Res 84 6 713 21 doi 10 1161 01 res 84 6 713 PMID 10189359 Tombes RM Mikkelsen RB Jarvis WD Grant S 1999 Downregulation of delta CaM kinase II in human tumor cells Biochim Biophys Acta 1452 1 1 11 doi 10 1016 S0167 4889 99 00113 5 PMID 10525155 Rochlitz H Voigt A Lankat Buttgereit B et al 2000 Cloning and quantitative determination of the human Ca2 calmodulin dependent protein kinase II CaMK II isoforms in human beta cells Diabetologia 43 4 465 73 doi 10 1007 s001250051330 PMID 10819240 Inagaki N Nishizawa M Arimura N et al 2000 Activation of Ca2 calmodulin dependent protein kinase II within post synaptic dendritic spines of cultured hippocampal neurons J Biol Chem 275 35 27165 71 doi 10 1074 jbc M003751200 PMID 10852918 Nair JS DaFonseca CJ Tjernberg A et al 2002 Requirement of Ca2 and CaMKII for Stat1 Ser 727 phosphorylation in response to IFN gamma Proc Natl Acad Sci U S A 99 9 5971 6 Bibcode 2002PNAS 99 5971N doi 10 1073 pnas 052159099 PMC 122886 PMID 11972023 Mishra Gorur K Singer HA Castellot JJ 2002 The S18 ribosomal protein is a putative substrate for Ca2 calmodulin activated protein kinase II J Biol Chem 277 37 33537 40 doi 10 1074 jbc C200342200 PMID 12145273 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Gaertner TR Kolodziej SJ Wang D et al 2004 Comparative analyses of the three dimensional structures and enzymatic properties of alpha beta gamma and delta isoforms of Ca2 calmodulin dependent protein kinase II J Biol Chem 279 13 12484 94 doi 10 1074 jbc M313597200 PMID 14722083 Ballif BA Villen J Beausoleil SA et al 2005 Phosphoproteomic analysis of the developing mouse brain Mol Cell Proteomics 3 11 1093 101 doi 10 1074 mcp M400085 MCP200 PMID 15345747 External links editHuman CAMK2D genome location and CAMK2D gene details page in the UCSC Genome Browser Portal nbsp Biology nbsp This article on a gene on human chromosome 4 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CAMK2D amp oldid 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