Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.[6]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000134072 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000030272 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Haribabu B, Hook SS, Selbert MA, Goldstein EG, Tomhave ED, Edelman AM, Snyderman R, Means AR (Sep 1995). "Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase". EMBO J. 14 (15): 3679–86. doi:10.1002/j.1460-2075.1995.tb00037.x. PMC394442. PMID 7641687.
^ ab"Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I".
Further readingedit
Bredt DS, Ferris CD, Snyder SH (1992). "Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites". J. Biol. Chem. 267 (16): 10976–81. doi:10.1016/S0021-9258(19)49862-1. PMID 1375933.
Yokokura H, Picciotto MR, Nairn AC, Hidaka H (1995). "The regulatory region of calcium/calmodulin-dependent protein kinase I contains closely associated autoinhibitory and calmodulin-binding domains". J. Biol. Chem. 270 (40): 23851–9. doi:10.1074/jbc.270.40.23851. PMID 7559563.
Liu F, Thompson MA, Wagner S, et al. (1993). "Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation". J. Biol. Chem. 268 (9): 6714–20. doi:10.1016/S0021-9258(18)53308-1. PMID 8384217.
Chin D, Winkler KE, Means AR (1998). "Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I". J. Biol. Chem. 272 (50): 31235–40. doi:10.1074/jbc.272.50.31235. PMID 9395448.
Hsu LS, Tsou AP, Chi CW, et al. (1998). "Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase". J. Biomed. Sci. 5 (2): 141–9. doi:10.1007/bf02258368. PMID 9662074.
Matsushita M, Nairn AC (1998). "Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase". J. Biol. Chem. 273 (34): 21473–81. doi:10.1074/jbc.273.34.21473. PMID 9705275.
Anderson KA, Means RL, Huang QH, et al. (1998). "Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta". J. Biol. Chem. 273 (48): 31880–9. doi:10.1074/jbc.273.48.31880. PMID 9822657.
Matsushita M, Nairn AC (1999). "Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase". J. Biol. Chem. 274 (15): 10086–93. doi:10.1074/jbc.274.15.10086. PMID 10187789.
Hayashi Y, Nishio M, Naito Y, et al. (1999). "Regulation of neuronal nitric-oxide synthase by calmodulin kinases". J. Biol. Chem. 274 (29): 20597–602. doi:10.1074/jbc.274.29.20597. PMID 10400690.
Hosaka M, Hammer RE, Südhof TC (1999). "A phospho-switch controls the dynamic association of synapsins with synaptic vesicles". Neuron. 24 (2): 377–87. doi:10.1016/S0896-6273(00)80851-X. PMID 10571231. S2CID 14103027.
Komeima K, Hayashi Y, Naito Y, Watanabe Y (2000). "Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells". J. Biol. Chem. 275 (36): 28139–43. doi:10.1074/jbc.M003198200. PMID 10874031.
McKinsey TA, Zhang CL, Lu J, Olson EN (2000). "Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation". Nature. 408 (6808): 106–11. Bibcode:2000Natur.408..106M. doi:10.1038/35040593. PMC4459600. PMID 11081517.
McKinsey TA, Zhang CL, Olson EN (2001). "Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14400–5. doi:10.1073/pnas.260501497. PMC18930. PMID 11114197.
Hsu LS, Chen GD, Lee LS, et al. (2001). "Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity". J. Biol. Chem. 276 (33): 31113–23. doi:10.1074/jbc.M011720200. PMID 11395482.
Condon JC, Pezzi V, Drummond BM, et al. (2002). "Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase". Endocrinology. 143 (9): 3651–7. doi:10.1210/en.2001-211359. PMID 12193581.
Sakurada K, Kato H, Nagumo H, et al. (2003). "Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin". J. Biol. Chem. 277 (47): 45473–9. doi:10.1074/jbc.M206673200. PMID 12237306.
Clapperton JA, Martin SR, Smerdon SJ, et al. (2003). "Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism". Biochemistry. 41 (50): 14669–79. doi:10.1021/bi026660t. PMID 12475216.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
External linksedit
Human CAMK1 genome location and CAMK1 gene details page in the UCSC Genome Browser.
camk1, calcium, calmodulin, dependent, protein, kinase, type, enzyme, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes4fg7, 4fg8, 4fg9, 4fgbidentifiersaliases, camki, calcium, calmodulin, dependent, protein, kinase, . Calcium calmodulin dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene 5 6 CAMK1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes4FG7 4FG8 4FG9 4FGBIdentifiersAliasesCAMK1 CAMKI calcium calmodulin dependent protein kinase I CaMKI alpha CaM kinase I alphaExternal IDsOMIM 604998 MGI 1098535 HomoloGene 117458 GeneCards CAMK1Gene location Human Chr Chromosome 3 human 1 Band3p25 3Start9 757 347 bp 1 End9 769 992 bp 1 Gene location Mouse Chr Chromosome 6 mouse 2 Band6 E3 6 52 75 cMStart113 311 085 bp 2 End113 320 945 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed innucleus accumbensprefrontal cortexcaudate nucleusmonocyteamygdalaleft uterine tubeputamencingulate gyrusleft coronary arteryBrodmann area 9Top expressed insuperior frontal gyrusexternal carotid arterydorsomedial hypothalamic nucleusinternal carotid arteryarcuate nucleusmyocardium of ventricleventromedial nucleuscalvarialateral hypothalamusmammillary bodyMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiontransferase activity nucleotide binding protein kinase activity kinase activity protein serine threonine kinase activity protein binding catalytic activity ATP binding calmodulin dependent protein kinase activity calmodulin bindingCellular componentcytoplasm nucleus intracellular anatomical structure postsynaptic density glutamatergic synapse cytosolBiological processcell differentiation positive regulation of synapse structural plasticity positive regulation of muscle cell differentiation regulation of muscle cell differentiation phosphorylation positive regulation of syncytium formation by plasma membrane fusion regulation of histone H3 K9 acetylation negative regulation of protein binding positive regulation of dendritic spine development nervous system development positive regulation of peptidyl serine phosphorylation positive regulation of protein serine threonine kinase activity positive regulation of protein acetylation regulation of protein localization positive regulation of protein export from nucleus multicellular organism development protein phosphorylation nucleocytoplasmic transport positive regulation of neuron projection development cell cycle metabolism regulation of protein binding positive regulation of transcription by RNA polymerase II signal transduction peptidyl threonine phosphorylation intracellular signal transduction regulation of synapse organizationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez853652163EnsemblENSG00000134072ENSMUSG00000030272UniProtQ14012Q91YS8RefSeq mRNA NM 003656NM 133926RefSeq protein NP 003647NP 003647 1NP 598687Location UCSC Chr 3 9 76 9 77 MbChr 6 113 31 113 32 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseCalcium calmodulin dependent protein kinase I is expressed in many tissues and is a component of a calmodulin dependent protein kinase cascade Calcium calmodulin directly activates calcium calmodulin dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium calmodulin dependent protein kinase I kinase 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000134072 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000030272 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Haribabu B Hook SS Selbert MA Goldstein EG Tomhave ED Edelman AM Snyderman R Means AR Sep 1995 Human calcium calmodulin dependent protein kinase I cDNA cloning domain structure and activation by phosphorylation at threonine 177 by calcium calmodulin dependent protein kinase I kinase EMBO J 14 15 3679 86 doi 10 1002 j 1460 2075 1995 tb00037 x PMC 394442 PMID 7641687 a b Entrez Gene CAMK1 calcium calmodulin dependent protein kinase I Further reading editBredt DS Ferris CD Snyder SH 1992 Nitric oxide synthase regulatory sites Phosphorylation by cyclic AMP dependent protein kinase protein kinase C and calcium calmodulin protein kinase identification of flavin and calmodulin binding sites J Biol Chem 267 16 10976 81 doi 10 1016 S0021 9258 19 49862 1 PMID 1375933 Yokokura H Picciotto MR Nairn AC Hidaka H 1995 The regulatory region of calcium calmodulin dependent protein kinase I contains closely associated autoinhibitory and calmodulin binding domains J Biol Chem 270 40 23851 9 doi 10 1074 jbc 270 40 23851 PMID 7559563 Liu F Thompson MA Wagner S et al 1993 Activating transcription factor 1 can mediate Ca 2 and cAMP inducible transcriptional activation J Biol Chem 268 9 6714 20 doi 10 1016 S0021 9258 18 53308 1 PMID 8384217 Chin D Winkler KE Means AR 1998 Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin dependent protein kinase I J Biol Chem 272 50 31235 40 doi 10 1074 jbc 272 50 31235 PMID 9395448 Hsu LS Tsou AP Chi CW et al 1998 Cloning expression and chromosomal localization of human Ca2 calmodulin dependent protein kinase kinase J Biomed Sci 5 2 141 9 doi 10 1007 bf02258368 PMID 9662074 Matsushita M Nairn AC 1998 Characterization of the mechanism of regulation of Ca2 calmodulin dependent protein kinase I by calmodulin and by Ca2 calmodulin dependent protein kinase kinase J Biol Chem 273 34 21473 81 doi 10 1074 jbc 273 34 21473 PMID 9705275 Anderson KA Means RL Huang QH et al 1998 Components of a calmodulin dependent protein kinase cascade Molecular cloning functional characterization and cellular localization of Ca2 calmodulin dependent protein kinase kinase beta J Biol Chem 273 48 31880 9 doi 10 1074 jbc 273 48 31880 PMID 9822657 Matsushita M Nairn AC 1999 Inhibition of the Ca2 calmodulin dependent protein kinase I cascade by cAMP dependent protein kinase J Biol Chem 274 15 10086 93 doi 10 1074 jbc 274 15 10086 PMID 10187789 Hayashi Y Nishio M Naito Y et al 1999 Regulation of neuronal nitric oxide synthase by calmodulin kinases J Biol Chem 274 29 20597 602 doi 10 1074 jbc 274 29 20597 PMID 10400690 Hosaka M Hammer RE Sudhof TC 1999 A phospho switch controls the dynamic association of synapsins with synaptic vesicles Neuron 24 2 377 87 doi 10 1016 S0896 6273 00 80851 X PMID 10571231 S2CID 14103027 Komeima K Hayashi Y Naito Y Watanabe Y 2000 Inhibition of neuronal nitric oxide synthase by calcium calmodulin dependent protein kinase IIalpha through Ser847 phosphorylation in NG108 15 neuronal cells J Biol Chem 275 36 28139 43 doi 10 1074 jbc M003198200 PMID 10874031 McKinsey TA Zhang CL Lu J Olson EN 2000 Signal dependent nuclear export of a histone deacetylase regulates muscle differentiation Nature 408 6808 106 11 Bibcode 2000Natur 408 106M doi 10 1038 35040593 PMC 4459600 PMID 11081517 McKinsey TA Zhang CL Olson EN 2001 Activation of the myocyte enhancer factor 2 transcription factor by calcium calmodulin dependent protein kinase stimulated binding of 14 3 3 to histone deacetylase 5 Proc Natl Acad Sci U S A 97 26 14400 5 doi 10 1073 pnas 260501497 PMC 18930 PMID 11114197 Hsu LS Chen GD Lee LS et al 2001 Human Ca2 calmodulin dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity J Biol Chem 276 33 31113 23 doi 10 1074 jbc M011720200 PMID 11395482 Condon JC Pezzi V Drummond BM et al 2002 Calmodulin dependent kinase I regulates adrenal cell expression of aldosterone synthase Endocrinology 143 9 3651 7 doi 10 1210 en 2001 211359 PMID 12193581 Sakurada K Kato H Nagumo H et al 2003 Synapsin I is phosphorylated at Ser603 by p21 activated kinases PAKs in vitro and in PC12 cells stimulated with bradykinin J Biol Chem 277 47 45473 9 doi 10 1074 jbc M206673200 PMID 12237306 Clapperton JA Martin SR Smerdon SJ et al 2003 Structure of the complex of calmodulin with the target sequence of calmodulin dependent protein kinase I studies of the kinase activation mechanism Biochemistry 41 50 14669 79 doi 10 1021 bi026660t PMID 12475216 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Izmailova E Bertley FM Huang Q et al 2003 HIV 1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages Nat Med 9 2 191 7 doi 10 1038 nm822 PMID 12539042 S2CID 26145639 External links editHuman CAMK1 genome location and CAMK1 gene details page in the UCSC Genome Browser Portal nbsp Biology nbsp This article on a gene on human chromosome 3 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CAMK1 amp oldid 1142696181, wikipedia, wiki, book, books, library,
