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Wikipedia

C3a receptor

April 12, 2024

The C3a receptor also known as complement component 3a receptor 1 (C3AR1) is a G protein-coupled receptor protein involved in the complement system.[5][6]

C3AR1
Identifiers
AliasesC3AR1, AZ3B, C3AR, HNFAG09, complement component 3a receptor 1, complement C3a receptor 1
External IDsOMIM: 605246 MGI: 1097680 HomoloGene: 2992 GeneCards: C3AR1
Orthologs
SpeciesHumanMouse
Entrez

719

12267

Ensembl

ENSG00000171860

ENSMUSG00000040552

UniProt

Q16581

O09047

RefSeq (mRNA)

NM_004054
NM_001326475
NM_001326477

NM_009779

RefSeq (protein)

NP_001313404
NP_001313406
NP_004045

NP_033909

Location (UCSC)Chr 12: 8.06 – 8.07 MbChr 6: 122.82 – 122.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The receptor binds to complement component C3a, although there is limited evidence that this receptor also binds C4a in lesser mammals. This has yet to be proven true in humans.[7] C3a receptor modulates immunity,[8] arthritis, diet-induced obesity[9] and cancers.[10]

Agonists and antagonists edit

Potent and selective agonists[11] and antagonists[12] for C3aR have been discovered.

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171860 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040552 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Roglic A, Prossnitz ER, Cavanagh SL, Pan Z, Zou A, Ye RD (February 1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1305 (1–2): 39–43. doi:10.1016/0167-4781(95)00209-x. PMID 8605247.
  6. ^ Ali H, Panettieri RA (February 2005). "Anaphylatoxin C3a receptors in asthma". Respiratory Research. 6 (1): 19. doi:10.1186/1465-9921-6-19. PMC 551592. PMID 15723703.
  7. ^ Klos A, Wende E, Wareham KJ, Monk PN (January 2013). "International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews. 65 (1): 500–43. doi:10.1124/pr.111.005223. PMID 23383423.
  8. ^ Cravedi P, Leventhal J, Lakhani P, Ward SC, Donovan MJ, Heeger PS (October 2013). "Immune cell-derived C3a and C5a costimulate human T cell alloimmunity". American Journal of Transplantation. 13 (10): 2530–9. doi:10.1111/ajt.12405. PMC 3809075. PMID 24033923.
  9. ^ Lim J, Iyer A, Suen JY, Seow V, Reid RC, Brown L, Fairlie DP (February 2013). "C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling". FASEB Journal. 27 (2): 822–31. doi:10.1096/fj.12-220582. PMID 23118029. S2CID 25562647.
  10. ^ Sayegh ET, Bloch O, Parsa AT (August 2014). "Complement anaphylatoxins as immune regulators in cancer". Cancer Medicine. 3 (4): 747–58. doi:10.1002/cam4.241. PMC 4303144. PMID 24711204.
  11. ^ Reid RC, Yau MK, Singh R, Hamidon JK, Reed AN, Chu P, Suen JY, Stoermer MJ, Blakeney JS, Lim J, Faber JM, Fairlie DP (2013). "Downsizing a human inflammatory protein to a small molecule with equal potency and functionality". Nature Communications. 4: 2802. Bibcode:2013NatCo...4.2802R. doi:10.1038/ncomms3802. PMID 24257095.
  12. ^ Reid RC, Yau MK, Singh R, Lim J, Fairlie DP (August 2014). "Stereoelectronic effects dictate molecular conformation and biological function of heterocyclic amides". Journal of the American Chemical Society. 136 (34): 11914–7. doi:10.1021/ja506518t. PMID 25102224.

Further reading edit

  • Sim RB, Laich A (October 2000). "Serine proteases of the complement system". Biochemical Society Transactions. 28 (5): 545–50. doi:10.1042/bst0280545. PMID 11044372.
  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Roglic A, Prossnitz ER, Cavanagh SL, Pan Z, Zou A, Ye RD (February 1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1305 (1–2): 39–43. doi:10.1016/0167-4781(95)00209-x. PMID 8605247.
  • Ames RS, Li Y, Sarau HM, Nuthulaganti P, Foley JJ, Ellis C, Zeng Z, Su K, Jurewicz AJ, Hertzberg RP, Bergsma DJ, Kumar C (August 1996). "Molecular cloning and characterization of the human anaphylatoxin C3a receptor". The Journal of Biological Chemistry. 271 (34): 20231–4. doi:10.1074/jbc.271.34.20231. PMID 8702752.
  • Crass T, Raffetseder U, Martin U, Grove M, Klos A, Köhl J, Bautsch W (August 1996). "Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells". European Journal of Immunology. 26 (8): 1944–50. doi:10.1002/eji.1830260840. PMID 8765043. S2CID 24586216.
  • Ames RS, Nuthulaganti P, Kumar C (October 1996). "In Xenopus oocytes the human C3a and C5a receptors elicit a promiscuous response to the anaphylatoxins". FEBS Letters. 395 (2–3): 157–9. doi:10.1016/0014-5793(96)01018-6. PMID 8898085. S2CID 39187651.
  • Martin U, Bock D, Arseniev L, Tornetta MA, Ames RS, Bautsch W, Köhl J, Ganser A, Klos A (July 1997). "The human C3a receptor is expressed on neutrophils and monocytes, but not on B or T lymphocytes". The Journal of Experimental Medicine. 186 (2): 199–207. doi:10.1084/jem.186.2.199. PMC 2198980. PMID 9221749.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hollmann TJ, Haviland DL, Kildsgaard J, Watts K, Wetsel RA (February 1998). "Cloning, expression, sequence determination, and chromosome localization of the mouse complement C3a anaphylatoxin receptor gene". Molecular Immunology. 35 (3): 137–48. doi:10.1016/S0161-5890(98)00021-2. PMID 9694514.
  • Lienenklaus S, Ames RS, Tornetta MA, Sarau HM, Foley JJ, Crass T, Sohns B, Raffetseder U, Grove M, Hölzer A, Klos A, Köhl J, Bautsch W (September 1998). "Human anaphylatoxin C4a is a potent agonist of the guinea pig but not the human C3a receptor". Journal of Immunology. 161 (5): 2089–93. doi:10.4049/jimmunol.161.5.2089. PMID 9725198. S2CID 29247962.
  • Davoust N, Jones J, Stahel PF, Ames RS, Barnum SR (May 1999). "Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells". Glia. 26 (3): 201–11. doi:10.1002/(SICI)1098-1136(199905)26:3<201::AID-GLIA2>3.0.CO;2-M. PMID 10340761. S2CID 38751182.
  • Settmacher B, Bock D, Saad H, Gärtner S, Rheinheimer C, Köhl J, Bautsch W, Klos A (June 1999). "Modulation of C3a activity: internalization of the human C3a receptor and its inhibition by C5a". Journal of Immunology. 162 (12): 7409–16. doi:10.4049/jimmunol.162.12.7409. PMID 10358194. S2CID 9269285.
  • Feild JA, Foley JJ, Testa TT, Nuthulaganti P, Ellis C, Sarau HM, Ames RS (October 1999). "Cloning and characterization of a rabbit ortholog of human Galpha16 and mouse G(alpha)15". FEBS Letters. 460 (1): 53–6. doi:10.1016/S0014-5793(99)01317-4. PMID 10571060. S2CID 86483726.
  • Petering H, Köhl J, Weyergraf A, Dulkys Y, Kimmig D, Smolarski R, Kapp A, Elsner J (April 2000). "Characterization of synthetic C3a analog peptides on human eosinophils in comparison to the native complement component C3a". Journal of Immunology. 164 (7): 3783–9. doi:10.4049/jimmunol.164.7.3783. PMID 10725738.
  • Drouin SM, Kildsgaard J, Haviland J, Zabner J, Jia HP, McCray PB, Tack BF, Wetsel RA (February 2001). "Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma". Journal of Immunology. 166 (3): 2025–32. doi:10.4049/jimmunol.166.3.2025. PMID 11160252.
  • Ames RS, Lee D, Foley JJ, Jurewicz AJ, Tornetta MA, Bautsch W, Settmacher B, Klos A, Erhard KF, Cousins RD, Sulpizio AC, Hieble JP, McCafferty G, Ward KW, Adams JL, Bondinell WE, Underwood DC, Osborn RR, Badger AM, Sarau HM (May 2001). "Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models". Journal of Immunology. 166 (10): 6341–8. doi:10.4049/jimmunol.166.10.6341. PMID 11342658.
  • Kirchhoff K, Weinmann O, Zwirner J, Begemann G, Götze O, Kapp A, Werfel T (June 2001). "Detection of anaphylatoxin receptors on CD83+ dendritic cells derived from human skin". Immunology. 103 (2): 210–7. doi:10.1046/j.1365-2567.2001.01197.x. PMC 1783227. PMID 11412308.
  • Reca R, Mastellos D, Majka M, Marquez L, Ratajczak J, Franchini S, Glodek A, Honczarenko M, Spruce LA, Janowska-Wieczorek A, Lambris JD, Ratajczak MZ (May 2003). "Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1". Blood. 101 (10): 3784–93. doi:10.1182/blood-2002-10-3233. PMID 12511407. S2CID 12692309.

External links edit

  • . IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-10-25.
  • C3AR1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • Human C3AR1 genome location and C3AR1 gene details page in the UCSC Genome Browser.
 

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

April 12, 2024
receptor, also, known, complement, component, receptor, c3ar1, protein, coupled, receptor, protein, involved, complement, system, c3ar1identifiersaliasesc3ar1, az3b, c3ar, hnfag09, complement, component, receptor, complement, 1external, idsomim, 605246, 109768. The C3a receptor also known as complement component 3a receptor 1 C3AR1 is a G protein coupled receptor protein involved in the complement system 5 6 C3AR1IdentifiersAliasesC3AR1 AZ3B C3AR HNFAG09 complement component 3a receptor 1 complement C3a receptor 1External IDsOMIM 605246 MGI 1097680 HomoloGene 2992 GeneCards C3AR1Gene location Human Chr Chromosome 12 human 1 Band12p13 31Start8 056 844 bp 1 End8 066 359 bp 1 Gene location Mouse Chr Chromosome 6 mouse 2 Band6 6 F2Start122 824 097 bp 2 End122 833 120 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmonocytespongy boneamniotic fluidbone marrowbloodappendixlower lobe of lungbone marrow cellssuperficial temporal arteryright ventricleTop expressed incalvariaankle jointankleinternal carotid arteryexternal carotid arterysciatic nervewhite adipose tissuecarotid bodyright ventricleaortic valveMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionsignal transducer activity complement receptor activity complement component C3a receptor activity G protein coupled receptor activityCellular componentintegral component of membrane integral component of plasma membrane membrane plasma membrane azurophil granule membrane specific granule membraneBiological processblood circulation signal transduction chemotaxis positive regulation of neutrophil chemotaxis positive regulation of angiogenesis positive regulation of macrophage chemotaxis inflammatory response positive regulation of vascular endothelial growth factor production G protein coupled receptor signaling pathway regulation of complement activation phospholipase C activating G protein coupled receptor signaling pathway neutrophil degranulation leukocyte migration cell chemotaxis complement receptor mediated signaling pathway positive regulation of cytosolic calcium ion concentration positive regulation of cytosolic calcium ion concentration involved in phospholipase C activating G protein coupled signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez71912267EnsemblENSG00000171860ENSMUSG00000040552UniProtQ16581O09047RefSeq mRNA NM 004054NM 001326475NM 001326477NM 009779RefSeq protein NP 001313404NP 001313406NP 004045NP 033909Location UCSC Chr 12 8 06 8 07 MbChr 6 122 82 122 83 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe receptor binds to complement component C3a although there is limited evidence that this receptor also binds C4a in lesser mammals This has yet to be proven true in humans 7 C3a receptor modulates immunity 8 arthritis diet induced obesity 9 and cancers 10 Contents 1 Agonists and antagonists 2 References 3 Further reading 4 External linksAgonists and antagonists editPotent and selective agonists 11 and antagonists 12 for C3aR have been discovered References edit a b c GRCh38 Ensembl release 89 ENSG00000171860 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000040552 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Roglic A Prossnitz ER Cavanagh SL Pan Z Zou A Ye RD February 1996 cDNA cloning of a novel G protein coupled receptor with a large extracellular loop structure Biochimica et Biophysica Acta BBA Gene Structure and Expression 1305 1 2 39 43 doi 10 1016 0167 4781 95 00209 x PMID 8605247 Ali H Panettieri RA February 2005 Anaphylatoxin C3a receptors in asthma Respiratory Research 6 1 19 doi 10 1186 1465 9921 6 19 PMC 551592 PMID 15723703 Klos A Wende E Wareham KJ Monk PN January 2013 International Union of Basic and Clinical Pharmacology corrected LXXXVII Complement peptide C5a C4a and C3a receptors Pharmacological Reviews 65 1 500 43 doi 10 1124 pr 111 005223 PMID 23383423 Cravedi P Leventhal J Lakhani P Ward SC Donovan MJ Heeger PS October 2013 Immune cell derived C3a and C5a costimulate human T cell alloimmunity American Journal of Transplantation 13 10 2530 9 doi 10 1111 ajt 12405 PMC 3809075 PMID 24033923 Lim J Iyer A Suen JY Seow V Reid RC Brown L Fairlie DP February 2013 C5aR and C3aR antagonists each inhibit diet induced obesity metabolic dysfunction and adipocyte and macrophage signaling FASEB Journal 27 2 822 31 doi 10 1096 fj 12 220582 PMID 23118029 S2CID 25562647 Sayegh ET Bloch O Parsa AT August 2014 Complement anaphylatoxins as immune regulators in cancer Cancer Medicine 3 4 747 58 doi 10 1002 cam4 241 PMC 4303144 PMID 24711204 Reid RC Yau MK Singh R Hamidon JK Reed AN Chu P Suen JY Stoermer MJ Blakeney JS Lim J Faber JM Fairlie DP 2013 Downsizing a human inflammatory protein to a small molecule with equal potency and functionality Nature Communications 4 2802 Bibcode 2013NatCo 4 2802R doi 10 1038 ncomms3802 PMID 24257095 Reid RC Yau MK Singh R Lim J Fairlie DP August 2014 Stereoelectronic effects dictate molecular conformation and biological function of heterocyclic amides Journal of the American Chemical Society 136 34 11914 7 doi 10 1021 ja506518t PMID 25102224 Further reading editSim RB Laich A October 2000 Serine proteases of the complement system Biochemical Society Transactions 28 5 545 50 doi 10 1042 bst0280545 PMID 11044372 Maruyama K Sugano S January 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Roglic A Prossnitz ER Cavanagh SL Pan Z Zou A Ye RD February 1996 cDNA cloning of a novel G protein coupled receptor with a large extracellular loop structure Biochimica et Biophysica Acta BBA Gene Structure and Expression 1305 1 2 39 43 doi 10 1016 0167 4781 95 00209 x PMID 8605247 Ames RS Li Y Sarau HM Nuthulaganti P Foley JJ Ellis C Zeng Z Su K Jurewicz AJ Hertzberg RP Bergsma DJ Kumar C August 1996 Molecular cloning and characterization of the human anaphylatoxin C3a receptor The Journal of Biological Chemistry 271 34 20231 4 doi 10 1074 jbc 271 34 20231 PMID 8702752 Crass T Raffetseder U Martin U Grove M Klos A Kohl J Bautsch W August 1996 Expression cloning of the human C3a anaphylatoxin receptor C3aR from differentiated U 937 cells European Journal of Immunology 26 8 1944 50 doi 10 1002 eji 1830260840 PMID 8765043 S2CID 24586216 Ames RS Nuthulaganti P Kumar C October 1996 In Xenopus oocytes the human C3a and C5a receptors elicit a promiscuous response to the anaphylatoxins FEBS Letters 395 2 3 157 9 doi 10 1016 0014 5793 96 01018 6 PMID 8898085 S2CID 39187651 Martin U Bock D Arseniev L Tornetta MA Ames RS Bautsch W Kohl J Ganser A Klos A July 1997 The human C3a receptor is expressed on neutrophils and monocytes but not on B or T lymphocytes The Journal of Experimental Medicine 186 2 199 207 doi 10 1084 jem 186 2 199 PMC 2198980 PMID 9221749 Suzuki Y Yoshitomo Nakagawa K Maruyama K Suyama A Sugano S October 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Hollmann TJ Haviland DL Kildsgaard J Watts K Wetsel RA February 1998 Cloning expression sequence determination and chromosome localization of the mouse complement C3a anaphylatoxin receptor gene Molecular Immunology 35 3 137 48 doi 10 1016 S0161 5890 98 00021 2 PMID 9694514 Lienenklaus S Ames RS Tornetta MA Sarau HM Foley JJ Crass T Sohns B Raffetseder U Grove M Holzer A Klos A Kohl J Bautsch W September 1998 Human anaphylatoxin C4a is a potent agonist of the guinea pig but not the human C3a receptor Journal of Immunology 161 5 2089 93 doi 10 4049 jimmunol 161 5 2089 PMID 9725198 S2CID 29247962 Davoust N Jones J Stahel PF Ames RS Barnum SR May 1999 Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells Glia 26 3 201 11 doi 10 1002 SICI 1098 1136 199905 26 3 lt 201 AID GLIA2 gt 3 0 CO 2 M PMID 10340761 S2CID 38751182 Settmacher B Bock D Saad H Gartner S Rheinheimer C Kohl J Bautsch W Klos A June 1999 Modulation of C3a activity internalization of the human C3a receptor and its inhibition by C5a Journal of Immunology 162 12 7409 16 doi 10 4049 jimmunol 162 12 7409 PMID 10358194 S2CID 9269285 Feild JA Foley JJ Testa TT Nuthulaganti P Ellis C Sarau HM Ames RS October 1999 Cloning and characterization of a rabbit ortholog of human Galpha16 and mouse G alpha 15 FEBS Letters 460 1 53 6 doi 10 1016 S0014 5793 99 01317 4 PMID 10571060 S2CID 86483726 Petering H Kohl J Weyergraf A Dulkys Y Kimmig D Smolarski R Kapp A Elsner J April 2000 Characterization of synthetic C3a analog peptides on human eosinophils in comparison to the native complement component C3a Journal of Immunology 164 7 3783 9 doi 10 4049 jimmunol 164 7 3783 PMID 10725738 Drouin SM Kildsgaard J Haviland J Zabner J Jia HP McCray PB Tack BF Wetsel RA February 2001 Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma Journal of Immunology 166 3 2025 32 doi 10 4049 jimmunol 166 3 2025 PMID 11160252 Ames RS Lee D Foley JJ Jurewicz AJ Tornetta MA Bautsch W Settmacher B Klos A Erhard KF Cousins RD Sulpizio AC Hieble JP McCafferty G Ward KW Adams JL Bondinell WE Underwood DC Osborn RR Badger AM Sarau HM May 2001 Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models Journal of Immunology 166 10 6341 8 doi 10 4049 jimmunol 166 10 6341 PMID 11342658 Kirchhoff K Weinmann O Zwirner J Begemann G Gotze O Kapp A Werfel T June 2001 Detection of anaphylatoxin receptors on CD83 dendritic cells derived from human skin Immunology 103 2 210 7 doi 10 1046 j 1365 2567 2001 01197 x PMC 1783227 PMID 11412308 Reca R Mastellos D Majka M Marquez L Ratajczak J Franchini S Glodek A Honczarenko M Spruce LA Janowska Wieczorek A Lambris JD Ratajczak MZ May 2003 Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem progenitor cells and C3a enhances their homing related responses to SDF 1 Blood 101 10 3784 93 doi 10 1182 blood 2002 10 3233 PMID 12511407 S2CID 12692309 External links edit Anaphylatoxin Receptors C3a IUPHAR Database of Receptors and Ion Channels International Union of Basic and Clinical Pharmacology Archived from the original on 2016 03 03 Retrieved 2007 10 25 C3AR1 protein human at the U S National Library of Medicine Medical Subject Headings MeSH Human C3AR1 genome location and C3AR1 gene details page in the UCSC Genome Browser nbsp This article on a gene on human chromosome 12 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title C3a receptor amp oldid 1214935930, wikipedia, wiki, book, books, library,

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