The butyrophenone structure—a ketone flanked by a phenyl ring and a butyl chain—forms the basis for many other chemicals containing various substituents. Some of these butyrophenones are used to treat various psychiatric disorders such as schizophrenia, as well as acting as antiemetics.[1]
Examples of butyrophenone-derived pharmaceuticals include:
Haloperidol, the most widely used classical antipsychotic drug in this class[1]
^Grogan, Charles H.; Rice, Leonard M. (1967). "Ω-Azabicyclic Butyrophenones". Journal of Medicinal Chemistry. 10 (4): 621–623. doi:10.1021/jm00316a022. PMID 6037051.
This article about a ketone is a stub. You can help Wikipedia by expanding it.
butyrophenone, organic, compound, with, formula, c6h5c, c3h7, colorless, liquid, names, preferred, iupac, name, phenylbutan, identifiers, number, model, jsmol, interactive, imageinteractive, image, chembl, chembl193524, chemspider, 9893, echa, infocard, pubche. Butyrophenone is an organic compound with the formula C6H5C O C3H7 It is a colorless liquid Butyrophenone Names Preferred IUPAC name 1 Phenylbutan 1 one Identifiers CAS Number 495 40 9 Y 3D model JSmol Interactive imageInteractive image ChEMBL ChEMBL193524 Y ChemSpider 9893 Y ECHA InfoCard 100 007 091 PubChem CID 10315 UNII 186I11WB5B Y CompTox Dashboard EPA DTXSID3047059 InChI InChI 1S C10H12O c1 2 6 10 11 9 7 4 3 5 8 9 h3 5 7 8H 2 6H2 1H3 YKey FFSAXUULYPJSKH UHFFFAOYSA N YInChI 1 C10H12O c1 2 6 10 11 9 7 4 3 5 8 9 h3 5 7 8H 2 6H2 1H3Key FFSAXUULYPJSKH UHFFFAOYAC SMILES O C c1ccccc1 CCCCCCC O c1ccccc1 Properties Chemical formula C10H12O Molar mass 148 20 g mol Appearance clear liquid Melting point 12 C 54 F 285 K Boiling point 229 C 444 F 502 K Solubility in water poor log P 2 77 Refractive index nD 1 520 Hazards NFPA 704 fire diamond 111 Flash point 99 C 210 F 372 K Except where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa Y verify what is Y N Infobox references The butyrophenone structure a ketone flanked by a phenyl ring and a butyl chain forms the basis for many other chemicals containing various substituents Some of these butyrophenones are used to treat various psychiatric disorders such as schizophrenia as well as acting as antiemetics 1 Examples of butyrophenone derived pharmaceuticals include Haloperidol the most widely used classical antipsychotic drug in this class 1 Benperidol the most potent commonly used antipsychotic 200 times more potent than chlorpromazine 1 2 Lumateperone an atypical antipsychotic used for schizophrenia and bipolar depression Droperidol Antiemetic for postoperative nausea and vomitingReferences edit a b c Keith Parker Laurence Brunton Goodman Louis Sanford Lazo John S Gilman Alfred 2006 Goodman amp Gilman s The Pharmacological Basis of Therapeutics 11th ed New York McGraw Hill ISBN 0071422803 Grogan Charles H Rice Leonard M 1967 W Azabicyclic Butyrophenones Journal of Medicinal Chemistry 10 4 621 623 doi 10 1021 jm00316a022 PMID 6037051 nbsp This article about a ketone is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Butyrophenone amp oldid 1198097292, wikipedia, wiki, book, books, library,
