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Blasticidin-S deaminase

In enzymology, a blasticidin-S deaminase (EC 3.5.4.23) is an enzyme that catalyzes the chemical reaction

blasticidin-S deaminase
Identifiers
EC no.3.5.4.23
CAS no.54576-55-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
blasticidin S + H2O deaminohydroxyblasticidin S + NH3

Thus, the two substrates of this enzyme are blasticidin S and H2O, whereas its two products are deaminohydroxyblasticidin S and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is blasticidin-S aminohydrolase.

Structural studies edit

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1WN5 and 1WN6.

References edit

  • Yamaguchi I, Shibata H, Seto H, Misato T (January 1975). "Isolation and purification of blasticidin S deaminase from Aspergillus terreus". J. Antibiot. 28 (1). Tokyo: 7–14. doi:10.7164/antibiotics.28.7. PMID 236272.


blasticidin, deaminase, enzymology, blasticidin, deaminase, enzyme, that, catalyzes, chemical, reactionblasticidin, deaminaseidentifiersec, 23cas, 54576, 5databasesintenzintenz, viewbrendabrenda, entryexpasynicezyme, viewkeggkegg, entrymetacycmetabolic, pathwa. In enzymology a blasticidin S deaminase EC 3 5 4 23 is an enzyme that catalyzes the chemical reactionblasticidin S deaminaseIdentifiersEC no 3 5 4 23CAS no 54576 55 5DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumGene OntologyAmiGO QuickGOSearchPMCarticlesPubMedarticlesNCBIproteins blasticidin S H2O displaystyle rightleftharpoons deaminohydroxyblasticidin S NH3Thus the two substrates of this enzyme are blasticidin S and H2O whereas its two products are deaminohydroxyblasticidin S and NH3 This enzyme belongs to the family of hydrolases those acting on carbon nitrogen bonds other than peptide bonds specifically in cyclic amidines The systematic name of this enzyme class is blasticidin S aminohydrolase Structural studies editAs of late 2007 two structures have been solved for this class of enzymes with PDB accession codes 1WN5 and 1WN6 References editYamaguchi I Shibata H Seto H Misato T January 1975 Isolation and purification of blasticidin S deaminase from Aspergillus terreus J Antibiot 28 1 Tokyo 7 14 doi 10 7164 antibiotics 28 7 PMID 236272 Portal nbsp Biology This EC 3 5 enzyme related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Blasticidin S deaminase amp oldid 1172341383, wikipedia, wiki, book, books, library,

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