bevenopran, usan, former, developmental, code, names, 5945, 5945, 2402, opra, peripherally, acting, opioid, receptor, antagonist, that, also, acts, opioid, receptors, under, development, cubist, pharmaceuticals, treatment, chronic, opioid, induced, constipatio. Bevenopran INN USAN former developmental code names CB 5945 ADL 5945 MK 2402 OpRA III is a peripherally acting m opioid receptor antagonist that also acts on d opioid receptors and was under development by Cubist Pharmaceuticals for the treatment of chronic opioid induced constipation 1 2 3 It reached phase III clinical trials for this indication before being discontinued 4 5 BevenopranLegal statusLegal statusInvestigationalIdentifiersIUPAC name 5 2 Methoxy 4 2 oxan 4 yl ethylamino methyl phenoxy pyrazine 2 carboxamideCAS Number676500 67 7PubChem CID10452732ChemSpider8628148UNIIIC58Q2EHPJKEGGD10349CompTox Dashboard EPA DTXSID90217963Chemical and physical dataFormulaC 20H 26N 4O 4Molar mass386 452 g mol 13D model JSmol Interactive imageSMILES COC1 C C CC C1 CNCCC2CCOCC2 OC3 NC C N C3 C O NInChI InChI 1S C20H26N4O4 c1 26 18 10 15 11 22 7 4 14 5 8 27 9 6 14 2 3 17 18 28 19 13 23 16 12 24 19 20 21 25 h2 3 10 12 14 22H 4 9 11H2 1H3 H2 21 25 Key ZGCYVRNZWGUXNQ UHFFFAOYSA NSee also editAlvimopan Axelopran Eluxadoline Methylnaltrexone Naldemedine NaloxegolReferences edit Diego L Atayee R Helmons P Hsiao G von Gunten CF 2011 Novel opioid antagonists for opioid induced bowel dysfunction Expert Opin Investig Drugs 20 8 1047 56 doi 10 1517 13543784 2011 592830 PMID 21663526 S2CID 207475985 Siemens W Gaertner J Becker G 2015 Advances in pharmacotherapy for opioid induced constipation a systematic review Expert Opin Pharmacother 16 4 515 32 doi 10 1517 14656566 2015 995625 PMID 25539282 S2CID 34614812 Annual Reports in Medicinal Chemistry Elsevier Science 13 September 2013 pp 451 ISBN 978 0 12 417151 0 Combating Opioid Induced Constipation New and Emerging Therapies Bevenopran nbsp This drug article relating to the gastrointestinal system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Bevenopran amp oldid 1125428544, wikipedia, wiki, book, books, library,