Benign infantile epilepsy (BIE), also known as benign infantile seizures (BIS), is an epilepsy syndrome of which several forms have been described. The International League Against Epilepsy (ILAE) classify two main forms of the syndrome (familial and nonfamilial)[1] though several other forms have been described in the academic literature. Affected children, who have no other health or developmental problems, develop seizures during infancy. These seizures have focal origin within the brain but may then spread to become generalized seizures. The seizures may occur several times a day, often grouped in clusters over one to three days followed by a gap of one to three months.[2] Treatment with anticonvulsant drugs is not necessary but they are often prescribed and are effective at controlling the seizures. Sodium channel blockers in particular have been shown to be effective for benign infantile epilepsy.[3] This form of epilepsy resolves after one or two years, and appears to be completely benign. The EEG of these children, between seizures, is normal. The brain appears normal on MRI scan.[4][5]
The familial and nonfamilial forms have overlapping features and the presence of a family history of infantile seizures may be the only distinguishing criterion. The nonfamiliar form has a larger range of the onset of seizures: from three to twenty months with most occurring between five and six months. There is no difference between the sexes. With benign familial infantile epilepsy, the seizures onset from four to eight months of age.[4]
Some cases of nonfamilial benign infantile seizures occur during a case of mild gastroenteritis. Called benign infantile seizures associated with mild gastroenteritis (BIS with MG), the seizures only occur during this illness and do not recur. Infection with rotavirus is the most common cause.[4]
Although children with benign infantile epilepsy typically have a normal EEG between seizures, some infants have been found to have a characteristic abnormal EEG during sleep. Called benign infantile focal epilepsy with midline spikes and waves during sleep, these infants have few seizures and there may often be a family history.[4]
Referencesedit
^Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr;51(4):676-85. 2010 Feb 26. PMID 20196795. doi:10.1111/j.1528-1167.2010.02522.x.
^Treadwell, Jonathan (2024-02-16). "Systematic Review: Management of Infantile Epilepsies" (PDF). pcori.org.
^ abcdVigevano F, Specchio N, Caraballo R, Watanabe K. Benign familial and nonfamilial seizures. In: Dichter MA, Engel J, Pedley TA, Aicardi J, editors. Epilepsy: a comprehensive textbook. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2008. ch. 227. ISBN0-7817-5777-0
^Panayiotopoulos CP. The Epilepsies: Seizures, Syndromes and Management. Oxfordshire: Bladon Medical Publishing; 2005. ch. 6. ISBN1-904218-34-2. PMID 20821848.
January 01, 1970
benign, infantile, epilepsy, also, known, benign, infantile, seizures, epilepsy, syndrome, which, several, forms, have, been, described, international, league, against, epilepsy, ilae, classify, main, forms, syndrome, familial, nonfamilial, though, several, ot. Benign infantile epilepsy BIE also known as benign infantile seizures BIS is an epilepsy syndrome of which several forms have been described The International League Against Epilepsy ILAE classify two main forms of the syndrome familial and nonfamilial 1 though several other forms have been described in the academic literature Affected children who have no other health or developmental problems develop seizures during infancy These seizures have focal origin within the brain but may then spread to become generalized seizures The seizures may occur several times a day often grouped in clusters over one to three days followed by a gap of one to three months 2 Treatment with anticonvulsant drugs is not necessary but they are often prescribed and are effective at controlling the seizures Sodium channel blockers in particular have been shown to be effective for benign infantile epilepsy 3 This form of epilepsy resolves after one or two years and appears to be completely benign The EEG of these children between seizures is normal The brain appears normal on MRI scan 4 5 The familial and nonfamilial forms have overlapping features and the presence of a family history of infantile seizures may be the only distinguishing criterion The nonfamiliar form has a larger range of the onset of seizures from three to twenty months with most occurring between five and six months There is no difference between the sexes With benign familial infantile epilepsy the seizures onset from four to eight months of age 4 Some cases of nonfamilial benign infantile seizures occur during a case of mild gastroenteritis Called benign infantile seizures associated with mild gastroenteritis BIS with MG the seizures only occur during this illness and do not recur Infection with rotavirus is the most common cause 4 Although children with benign infantile epilepsy typically have a normal EEG between seizures some infants have been found to have a characteristic abnormal EEG during sleep Called benign infantile focal epilepsy with midline spikes and waves during sleep these infants have few seizures and there may often be a family history 4 References edit Berg AT Berkovic SF Brodie MJ Buchhalter J Cross JH et al Revised terminology and concepts for organization of seizures and epilepsies report of the ILAE Commission on Classification and Terminology 2005 2009 Epilepsia 2010 Apr 51 4 676 85 2010 Feb 26 PMID 20196795 doi 10 1111 j 1528 1167 2010 02522 x Treadwell Jonathan 2024 02 16 Systematic Review Management of Infantile Epilepsies PDF pcori org Numoto Shingo Kurahashi Hirokazu Takagi Mizuki Azuma Yoshiteru Iwayama Hideyuki Okumura Akihisa November 2021 Sodium channel blockers are effective for benign infantile epilepsy Seizure 92 207 210 doi 10 1016 j seizure 2021 09 008 a b c d Vigevano F Specchio N Caraballo R Watanabe K Benign familial and nonfamilial seizures In Dichter MA Engel J Pedley TA Aicardi J editors Epilepsy a comprehensive textbook Philadelphia Wolters Kluwer Health Lippincott Williams amp Wilkins 2008 ch 227 ISBN 0 7817 5777 0 Panayiotopoulos CP The Epilepsies Seizures Syndromes and Management Oxfordshire Bladon Medical Publishing 2005 ch 6 ISBN 1 904218 34 2 PMID 20821848 Retrieved from https en wikipedia org w index php title Benign infantile epilepsy amp oldid 1219004132, wikipedia, wiki, book, books, library,
