Beclamide (marketed as Chloracon, Hibicon, Posedrine, Nydrane, Seclar, and other names) is a drug that possesses anticonvulsant activity.[2] It is no longer used.
It was studied in the 1950s for its anticonvulsant properties, as a treatment for generalised tonic-clonic seizures. It was not effective for absence seizures.
Interest in the drug resumed in the 1990s for its psychiatric properties as an adjunct in the treatment of schizophrenia.[3]
Side effectsedit
Side effects are uncommon but include stomach pain, nervousness, giddiness, skin rash and leukopenia. It is counter-indicated in breast feeding as it is passed in the milk.
Administration and pharmacologyedit
Administration is oral, though it has an unpleasant taste. It is quickly absorbed and elimination is renal and complete within 48 hours. Beclamide is possibly metabolized to 3-chloropropanoic acidin vivo,[citation needed] which binds to the GHB receptor.
Referencesedit
^Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). from the original on 2023-08-03. Retrieved 2023-08-16.
^Ahmadi M, Nicholls PJ, Smith HJ, Spencer PS, Preet-Ryatt MS, Spragg BP (October 1995). "Metabolism of beclamide after a single oral dose in man: quantitative studies". The Journal of Pharmacy and Pharmacology. 47 (10): 876–8. doi:10.1111/j.2042-7158.1995.tb05757.x. PMID 8583359. S2CID 19556266.
^Raptis C, Garcia-Borreguero D, Weber MM, Dose M, Bremer D, Emrich HM (February 1990). "Anticonvulsants as adjuncts for the neuroleptic treatment of schizophrenic psychoses: a clinical study with beclamide". Acta Psychiatrica Scandinavica. 81 (2): 162–7. doi:10.1111/j.1600-0447.1990.tb06472.x. PMID 2183543. S2CID 26772370.
The Medical Treatment of Epilepsy by Stanley R Resor. Published by Marcel Dekker (1991). ISBN0-8247-8549-5.
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beclamide, marketed, chloracon, hibicon, posedrine, nydrane, seclar, other, names, drug, that, possesses, anticonvulsant, activity, longer, used, clinical, dataroutes, ofadministrationby, mouthatc, coden03ax30, legal, statuslegal, statusbr, class, other, contr. Beclamide marketed as Chloracon Hibicon Posedrine Nydrane Seclar and other names is a drug that possesses anticonvulsant activity 2 It is no longer used BeclamideClinical dataRoutes ofadministrationBy mouthATC codeN03AX30 WHO Legal statusLegal statusBR Class C1 Other controlled substances 1 IdentifiersIUPAC name N Benzyl 3 chloropropanamideCAS Number501 68 8 YPubChem CID10391ChemSpider9962 YUNIIF5N0ALI65VKEGGD07300 YChEMBLChEMBL64195 YCompTox Dashboard EPA DTXSID5057755ECHA InfoCard100 007 207Chemical and physical dataFormulaC 10H 12Cl N OMolar mass197 66 g mol 13D model JSmol Interactive imageMelting point94 C 201 F SMILES ClCCC O NCc1ccccc1InChI InChI 1S C10H12ClNO c11 7 6 10 13 12 8 9 4 2 1 3 5 9 h1 5H 6 8H2 H 12 13 YKey JPYQFYIEOUVJDU UHFFFAOYSA N Y verify Contents 1 Uses 2 Side effects 3 Administration and pharmacology 4 ReferencesUses editIt has been used as a sedative and as an anticonvulsant It was studied in the 1950s for its anticonvulsant properties as a treatment for generalised tonic clonic seizures It was not effective for absence seizures Interest in the drug resumed in the 1990s for its psychiatric properties as an adjunct in the treatment of schizophrenia 3 Side effects editSide effects are uncommon but include stomach pain nervousness giddiness skin rash and leukopenia It is counter indicated in breast feeding as it is passed in the milk Administration and pharmacology editAdministration is oral though it has an unpleasant taste It is quickly absorbed and elimination is renal and complete within 48 hours Beclamide is possibly metabolized to 3 chloropropanoic acid in vivo citation needed which binds to the GHB receptor References edit Anvisa 2023 03 31 RDC Nº 784 Listas de Substancias Entorpecentes Psicotropicas Precursoras e Outras sob Controle Especial Collegiate Board Resolution No 784 Lists of Narcotic Psychotropic Precursor and Other Substances under Special Control in Brazilian Portuguese Diario Oficial da Uniao published 2023 04 04 Archived from the original on 2023 08 03 Retrieved 2023 08 16 Ahmadi M Nicholls PJ Smith HJ Spencer PS Preet Ryatt MS Spragg BP October 1995 Metabolism of beclamide after a single oral dose in man quantitative studies The Journal of Pharmacy and Pharmacology 47 10 876 8 doi 10 1111 j 2042 7158 1995 tb05757 x PMID 8583359 S2CID 19556266 Raptis C Garcia Borreguero D Weber MM Dose M Bremer D Emrich HM February 1990 Anticonvulsants as adjuncts for the neuroleptic treatment of schizophrenic psychoses a clinical study with beclamide Acta Psychiatrica Scandinavica 81 2 162 7 doi 10 1111 j 1600 0447 1990 tb06472 x PMID 2183543 S2CID 26772370 The Medical Treatment of Epilepsy by Stanley R Resor Published by Marcel Dekker 1991 ISBN 0 8247 8549 5 nbsp This anticonvulsant related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Beclamide amp oldid 1170630337, wikipedia, wiki, book, books, library,
