Basopenia (or basocytopenia) is a form of agranulocytosis associated with a deficiency of basophils.[1] It has been proposed as an indicator of ovulation.[2] It is difficult to detect without flow cytometry, because normal levels are so low.[3] It can be defined as less than 0.01 x 109 / L.[4] Basopenia has been observed in a number of conditions, including after the administration of corticosteroids and in disease states such as chronic urticaria and lupus.[5]
Basophils, which account for a small proportion of the total leukocyte count, are phagocytic. Heparin, histamine, and serotonin are found in the basophilic granules. Mast cells are tissue basophils that are similar to blood basophils. Mast cells are normally not found in peripheral blood and are only rarely found in healthy bone marrow. Chronic inflammation is assessed using basophil counts. Although there is a positive correlation between higher basophil counts and high blood histamine concentrations, this correlation is not indicative of cause and effect.[6]
Leukocytosis (in association with diverse disorders)
Referencesedit
^"Definition: basophilic leukopenia from Online Medical Dictionary".
^Soni R, Bose S, Gada D, Potnis V (October 1996). "Basopenia as an indicator of ovulation (a short term clinical study)". Indian J. Physiol. Pharmacol. 40 (4): 385–8. PMID 9055113.
^Lourenço FD, Azor MH, Santos JC (May 2008). "Activated status of basophils in chronic urticaria leads to interleukin-3 hyper-responsiveness and enhancement of histamine release induced by anti-IgE stimulus". Br. J. Dermatol. 158 (5): 979–86. doi:10.1111/j.1365-2133.2008.08499.x. PMID 18341658. S2CID 2935740.
^Grattan CE, Dawn G, Gibbs S, Francis DM (March 2003). "Blood basophil numbers in chronic ordinary urticaria and healthy controls: diurnal variation, influence of loratadine and prednisolone and relationship to disease activity". Clin. Exp. Allergy. 33 (3): 337–41. doi:10.1046/j.1365-2222.2003.01589.x. PMID 12614448. S2CID 30477970.
^Grattan CE, Walpole D, Francis DM (December 1997). "Flow cytometric analysis of basophil numbers in chronic urticaria: basopenia is related to serum histamine releasing activity". Clin. Exp. Allergy. 27 (12): 1417–24. doi:10.1111/j.1365-2222.1997.tb02986.x. PMID 9433937.
External linksedit
April 11, 2024
basopenia, basocytopenia, form, agranulocytosis, associated, with, deficiency, basophils, been, proposed, indicator, ovulation, difficult, detect, without, flow, cytometry, because, normal, levels, defined, less, than, been, observed, number, conditions, inclu. Basopenia or basocytopenia is a form of agranulocytosis associated with a deficiency of basophils 1 It has been proposed as an indicator of ovulation 2 It is difficult to detect without flow cytometry because normal levels are so low 3 It can be defined as less than 0 01 x 109 L 4 Basopenia has been observed in a number of conditions including after the administration of corticosteroids and in disease states such as chronic urticaria and lupus 5 BasopeniaA peripheral blood basophil stained with a Romanovsky stain SpecialtyHematology Contents 1 Mechanism 2 Associated conditions 3 References 4 External linksMechanism editMain article Basophils Basophils which account for a small proportion of the total leukocyte count are phagocytic Heparin histamine and serotonin are found in the basophilic granules Mast cells are tissue basophils that are similar to blood basophils Mast cells are normally not found in peripheral blood and are only rarely found in healthy bone marrow Chronic inflammation is assessed using basophil counts Although there is a positive correlation between higher basophil counts and high blood histamine concentrations this correlation is not indicative of cause and effect 6 Associated conditions editHereditary absence of basophils very rare Elevated levels of glucocorticoids Hyperthyroidism or treatment with thyroid hormones Ovulation Hypersensitivity reactionsurticaria 7 8 9 Anaphylaxis Drug induced reactionsLeukocytosis in association with diverse disorders References edit Definition basophilic leukopenia from Online Medical Dictionary Soni R Bose S Gada D Potnis V October 1996 Basopenia as an indicator of ovulation a short term clinical study Indian J Physiol Pharmacol 40 4 385 8 PMID 9055113 CLS 3223 Unit 03 WBC Archived from the original on 2009 01 30 Pathology Shah Hemali Eisenbarth Stephanie Tormey Christopher A Siddon Alexa J January 1 2021 Behind the scenes with basophils an emerging therapeutic target Immunotherapy Advances 1 1 Oxford University Press OUP doi 10 1093 immadv ltab008 ISSN 2732 4303 PMC 9327101 Retrieved November 14 2023 Basophil count Nursing Critical Care 14 4 Ovid Technologies Wolters Kluwer Health 35 35 2019 doi 10 1097 01 ccn 0000559778 07144 9d ISSN 1558 447X Retrieved November 16 2023 Lourenco FD Azor MH Santos JC May 2008 Activated status of basophils in chronic urticaria leads to interleukin 3 hyper responsiveness and enhancement of histamine release induced by anti IgE stimulus Br J Dermatol 158 5 979 86 doi 10 1111 j 1365 2133 2008 08499 x PMID 18341658 S2CID 2935740 Grattan CE Dawn G Gibbs S Francis DM March 2003 Blood basophil numbers in chronic ordinary urticaria and healthy controls diurnal variation influence of loratadine and prednisolone and relationship to disease activity Clin Exp Allergy 33 3 337 41 doi 10 1046 j 1365 2222 2003 01589 x PMID 12614448 S2CID 30477970 Grattan CE Walpole D Francis DM December 1997 Flow cytometric analysis of basophil numbers in chronic urticaria basopenia is related to serum histamine releasing activity Clin Exp Allergy 27 12 1417 24 doi 10 1111 j 1365 2222 1997 tb02986 x PMID 9433937 External links edit Retrieved from https en wikipedia org w index php title Basopenia amp oldid 1193597300, wikipedia, wiki, book, books, library,
