BU-48 is a drug that is used in scientific research. It is from the oripavine family, related to better-known drugs such as etorphine and buprenorphine.
The parent compound from which BU-48 was derived (with N-methyl rather than methylcyclopropyl on the nitrogen and lacking the aliphatic hydroxyl group) is a powerful μ-opioid agonist 1000 times more potent than morphine,[1] but in contrast BU-48 has only weak analgesic effects and instead acts primarily as a δ-opioidagonist. Its main effects are to produce convulsions,[2] but it may also have antidepressant effects.[3]
^Lewis JW, Bentley KW, Cowan A (1971). "Narcotic analgesics and antagonists". Annual Review of Pharmacology. 11: 241–70. doi:10.1146/annurev.pa.11.040171.001325. PMID 4948499.
^Broom DC, Guo L, Coop A, Husbands SM, Lewis JW, Woods JH, Traynor JR (September 2000). "BU48: a novel buprenorphine analog that exhibits delta-opioid-mediated convulsions but not delta-opioid-mediated antinociception in mice". The Journal of Pharmacology and Experimental Therapeutics. 294 (3): 1195–200. PMID 10945877.
^Broom DC, Jutkiewicz EM, Rice KC, Traynor JR, Woods JH (September 2002). "Behavioral effects of delta-opioid receptor agonists: potential antidepressants?". Japanese Journal of Pharmacology. 90 (1): 1–6. doi:10.1254/jjp.90.1. PMID 12396021.
This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.
drug, that, used, scientific, research, from, oripavine, family, related, better, known, drugs, such, etorphine, buprenorphine, identifiersiupac, name, cyclopropylmethyl, cyclohexano, hydroxy, endo, ethenotetrahydronororipavinepubchem, cid10003114chemspider581. BU 48 is a drug that is used in scientific research It is from the oripavine family related to better known drugs such as etorphine and buprenorphine BU 48IdentifiersIUPAC name N Cyclopropylmethyl 7a 8a 2 3 cyclohexano 1 S hydroxy 6 14 endo ethenotetrahydronororipavinePubChem CID10003114ChemSpider58178410Chemical and physical dataFormulaC 27H 33N O 4Molar mass435 564 g mol 13D model JSmol Interactive imageSMILES CO C 12C C C 3 C H 4 C H 1 C H CCC4 O C H 5Cc6ccc c7c6 C 3 C H 2O7 CCN5CC8CC8 OInChI InChI 1S C27H33NO4 c1 31 27 10 9 25 17 3 2 4 18 29 22 17 27 20 13 16 7 8 19 30 23 21 16 26 25 24 27 32 23 11 12 28 20 14 15 5 6 15 h7 10 15 17 18 20 22 24 29 30H 2 6 11 14H2 1H3 t17 18 20 22 24 25 26 27 m1 s1Key LMFRYUPWVALVRA QDFTYCMYSA N verify The parent compound from which BU 48 was derived with N methyl rather than methylcyclopropyl on the nitrogen and lacking the aliphatic hydroxyl group is a powerful m opioid agonist 1000 times more potent than morphine 1 but in contrast BU 48 has only weak analgesic effects and instead acts primarily as a d opioid agonist Its main effects are to produce convulsions 2 but it may also have antidepressant effects 3 See also editBU72 BU08028References edit Lewis JW Bentley KW Cowan A 1971 Narcotic analgesics and antagonists Annual Review of Pharmacology 11 241 70 doi 10 1146 annurev pa 11 040171 001325 PMID 4948499 Broom DC Guo L Coop A Husbands SM Lewis JW Woods JH Traynor JR September 2000 BU48 a novel buprenorphine analog that exhibits delta opioid mediated convulsions but not delta opioid mediated antinociception in mice The Journal of Pharmacology and Experimental Therapeutics 294 3 1195 200 PMID 10945877 Broom DC Jutkiewicz EM Rice KC Traynor JR Woods JH September 2002 Behavioral effects of delta opioid receptor agonists potential antidepressants Japanese Journal of Pharmacology 90 1 1 6 doi 10 1254 jjp 90 1 PMID 12396021 nbsp This drug article relating to the nervous system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title BU 48 amp oldid 1182464962, wikipedia, wiki, book, books, library,
