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Wikipedia

BCL11B

April 12, 2024

B-cell lymphoma/leukemia 11B is a protein that in humans is encoded by the BCL11B gene.[5][6][7]

BCL11B
Identifiers
AliasesBCL11B, ATL1, ATL1-alpha, ATL1-beta, ATL1-delta, ATL1-gamma, CTIP-2, CTIP2, RIT1, ZNF856B, hRIT1-alpha, B-cell CLL/lymphoma 11B, IMD49, B cell CLL/lymphoma 11B, IDDFSTA, BAF complex component, BAF chromatin remodeling complex subunit SMARCM2
External IDsOMIM: 606558 MGI: 1929913 HomoloGene: 10974 GeneCards: BCL11B
Orthologs
SpeciesHumanMouse
Entrez

64919

58208

Ensembl

ENSG00000127152

ENSMUSG00000048251

UniProt

Q9C0K0

Q99PV8

RefSeq (mRNA)

NM_001282237
NM_001282238
NM_022898
NM_138576

NM_001079883
NM_001286343
NM_021399

RefSeq (protein)

NP_001269166
NP_001269167
NP_075049
NP_612808

NP_001073352
NP_001273272
NP_067374

Location (UCSC)Chr 14: 99.17 – 99.27 MbChr 12: 107.88 – 107.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gene location edit

BCL11B is located on human chromosome 14p32.2.[8] The mouse analogue is called Rit1 or Bcl11b and is located on mouse chromosome 12.[9]

Function edit

This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined, but it could also be involved in some malignancies. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.[7]

Research suggests that BCL11B is crucial for ameloblasts (the cells that produce tooth enamel) to form and work properly.[10]

Interactions edit

BCL11B has been shown to interact with COUP-TFI.[11]

Pathology edit

BCL11B is closely connected with immune regulation and for so its mutation can lead to a SCID phenotype. This so-called Immunodeficiency 49 (OMIM #617237) is classified as T-B+NK+ SCID.[12] It is characterised by a lack of T lymphocytes and its malfunctioning specifically in proliferative response. On the other hand, B cells and NK cells counts and functions are not impaired.[13] The symptoms of SCID caused by BCL11B mutation - apart from immunity defects - typically include teeth abnormalities, craniofacial dimorphism, different types of dermatitis. As well the intellectual development is significantly impaired. The disease has a very early onset and the only known treatment is hematopoietic stem cell transplantation from a healthy donor.[14][13] The immunodeficiency has a dominant negative mode of inheritance as all so far described patients with it has been after sequencing identified as heterozygotes in the BCL11B gene.[13][14]

Research projects edit

A mouse model based study showed, that Bcl11b also plays an important role in pathogenesis of inflammatory bowel disease. Bcl11b gene knock-out in certain T cell population led to development of IBD. The mechanisms behind are supposed to be reduced suppressor activity of T regulatory cells and changes in cytokine environment. Bcl11b is suspected to interact with Foxp3 and IL10 gene promoters and thus impair its suppressive function in the intestines.[15]

Bcl11b (mouse analogue of human BCL11B) has been proven to contribute to malignant growth for example in case of mouse lymphomas. That is suspected to be caused by interaction with p53, a well-known tumor suppressor gene.[9]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127152 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048251 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Satterwhite E, Sonoki T, Willis TG, Harder L, Nowak R, Arriola EL, et al. (December 2001). "The BCL11 gene family: involvement of BCL11A in lymphoid malignancies". Blood. 98 (12): 3413–20. doi:10.1182/blood.V98.12.3413. PMID 11719382.
  6. ^ Topark-Ngarm A, Golonzhka O, Peterson VJ, Barrett B, Martinez B, Crofoot K, et al. (October 2006). "CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene". The Journal of Biological Chemistry. 281 (43): 32272–83. doi:10.1074/jbc.M602776200. PMC 2547407. PMID 16950772.
  7. ^ a b "Entrez Gene: BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)".
  8. ^ "OMIM Entry - * 606558 - B-CELL CLL/LYMPHOMA 11B; BCL11B". www.omim.org. Retrieved 2019-07-29.
  9. ^ a b Wakabayashi Y, Inoue J, Takahashi Y, Matsuki A, Kosugi-Okano H, Shinbo T, et al. (February 2003). "Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas". Biochemical and Biophysical Research Communications. 301 (2): 598–603. doi:10.1016/S0006-291X(02)03069-3. PMID 12565905.
  10. ^ Golonzhka O, Metzger D, Bornert JM, Bay BK, Gross MK, Kioussi C, Leid M (March 2009). "Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis". Proceedings of the National Academy of Sciences of the United States of America. 106 (11): 4278–83. Bibcode:2009PNAS..106.4278G. doi:10.1073/pnas.0900568106. PMC 2657370. PMID 19251658.*Lay summary in: "Gene could allow lab-grown teeth". BBC News. February 24, 2009.
  11. ^ Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (April 2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". The Journal of Biological Chemistry. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719.
  12. ^ Alt F (2018). Advances in immunology. Cambridge, MA: Academic Press. ISBN 978-0-12-815529-5. OCLC 1035016036.
  13. ^ a b c Punwani D, Zhang Y, Yu J, Cowan MJ, Rana S, Kwan A, et al. (December 2016). "Multisystem Anomalies in Severe Combined Immunodeficiency with Mutant BCL11B". The New England Journal of Medicine. 375 (22): 2165–2176. doi:10.1056/nejmoa1509164. PMC 5215776. PMID 27959755.
  14. ^ a b Lessel D, Gehbauer C, Bramswig NC, Schluth-Bolard C, Venkataramanappa S, van Gassen KL, et al. (August 2018). "BCL11B mutations in patients affected by a neurodevelopmental disorder with reduced type 2 innate lymphoid cells". Brain. 141 (8): 2299–2311. doi:10.1093/brain/awy173. PMC 6061686. PMID 29985992.
  15. ^ Vanvalkenburgh J, Albu DI, Bapanpally C, Casanova S, Califano D, Jones DM, et al. (September 2011). "Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel disease". The Journal of Experimental Medicine. 208 (10): 2069–81. doi:10.1084/jem.20102683. PMC 3182057. PMID 21875956.

Further reading edit

  • Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (April 2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". The Journal of Biological Chemistry. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719.
  • Avram D, Fields A, Senawong T, Topark-Ngarm A, Leid M (December 2002). "COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein". The Biochemical Journal. 368 (Pt 2): 555–63. doi:10.1042/BJ20020496. PMC 1223006. PMID 12196208.
  • Wakabayashi Y, Inoue J, Takahashi Y, Matsuki A, Kosugi-Okano H, Shinbo T, et al. (February 2003). "Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas". Biochemical and Biophysical Research Communications. 301 (2): 598–603. doi:10.1016/S0006-291X(02)03069-3. PMID 12565905.
  • Rohr O, Lecestre D, Chasserot-Golaz S, Marban C, Avram D, Aunis D, et al. (May 2003). "Recruitment of Tat to heterochromatin protein HP1 via interaction with CTIP2 inhibits human immunodeficiency virus type 1 replication in microglial cells". Journal of Virology. 77 (9): 5415–27. doi:10.1128/JVI.77.9.5415-5427.2003. PMC 153947. PMID 12692243.
  • Senawong T, Peterson VJ, Avram D, Shepherd DM, Frye RA, Minucci S, Leid M (October 2003). "Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression". The Journal of Biological Chemistry. 278 (44): 43041–50. doi:10.1074/jbc.M307477200. PMC 2819354. PMID 12930829.
  • Bezrookove V, van Zelderen-Bhola SL, Brink A, Szuhai K, Raap AK, Barge R, et al. (February 2004). "A novel t(6;14)(q25-q27;q32) in acute myelocytic leukemia involves the BCL11B gene". Cancer Genetics and Cytogenetics. 149 (1): 72–6. doi:10.1016/S0165-4608(03)00302-9. PMID 15104287.
  • MacLeod RA, Nagel S, Drexler HG (August 2004). "BCL11B rearrangements probably target T-cell neoplasia rather than acute myelocytic leukemia". Cancer Genetics and Cytogenetics. 153 (1): 88–9. doi:10.1016/j.cancergencyto.2004.02.020. PMID 15325104.
  • Przybylski GK, Dik WA, Wanzeck J, Grabarczyk P, Majunke S, Martin-Subero JI, et al. (February 2005). "Disruption of the BCL11B gene through inv(14)(q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transcripts in T-ALL". Leukemia. 19 (2): 201–8. doi:10.1038/sj.leu.2403619. PMID 15668700. S2CID 27146016.
  • Cismasiu VB, Adamo K, Gecewicz J, Duque J, Lin Q, Avram D (October 2005). "BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter". Oncogene. 24 (45): 6753–64. doi:10.1038/sj.onc.1208904. PMID 16091750. S2CID 14198939.
  • Marban C, Suzanne S, Dequiedt F, de Walque S, Redel L, Van Lint C, et al. (January 2007). "Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing". The EMBO Journal. 26 (2): 412–23. doi:10.1038/sj.emboj.7601516. PMC 1783449. PMID 17245431.
  • Nagel S, Scherr M, Kel A, Hornischer K, Crawford GE, Kaufmann M, et al. (February 2007). "Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1". Cancer Research. 67 (4): 1461–71. doi:10.1158/0008-5472.CAN-06-2615. PMID 17308084.
  • Kamimura K, Mishima Y, Obata M, Endo T, Aoyagi Y, Kominami R (August 2007). "Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages". Oncogene. 26 (40): 5840–50. doi:10.1038/sj.onc.1210388. PMID 17369851. S2CID 29677572.

External links edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


 

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

April 12, 2024
bcl11b, cell, lymphoma, leukemia, protein, that, humans, encoded, gene, identifiersaliases, atl1, atl1, alpha, atl1, beta, atl1, delta, atl1, gamma, ctip, ctip2, rit1, znf856b, hrit1, alpha, cell, lymphoma, imd49, cell, lymphoma, iddfsta, complex, component, c. B cell lymphoma leukemia 11B is a protein that in humans is encoded by the BCL11B gene 5 6 7 BCL11BIdentifiersAliasesBCL11B ATL1 ATL1 alpha ATL1 beta ATL1 delta ATL1 gamma CTIP 2 CTIP2 RIT1 ZNF856B hRIT1 alpha B cell CLL lymphoma 11B IMD49 B cell CLL lymphoma 11B IDDFSTA BAF complex component BAF chromatin remodeling complex subunit SMARCM2External IDsOMIM 606558 MGI 1929913 HomoloGene 10974 GeneCards BCL11BGene location Human Chr Chromosome 14 human 1 Band14q32 2Start99 169 287 bp 1 End99 272 197 bp 1 Gene location Mouse Chr Chromosome 12 mouse 2 Band12 F1 12 59 1 cMStart107 876 662 bp 2 End107 969 861 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inthymusnipplevulvasecondary oocyteganglionic eminencegumsRegion I of hippocampus properjejunal mucosahuman penisoral cavityTop expressed inmedial ganglionic eminenceRegion I of hippocampus properolfactory tuberclenucleus accumbensthymustemporal lobeglobus pallidusamygdalaPaneth celltrigeminal ganglionMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionsequence specific DNA binding DNA binding transcription activator activity RNA polymerase II specific metal ion binding RNA polymerase II cis regulatory region sequence specific DNA binding protein binding nucleic acid binding DNA binding transcription factor activity RNA polymerase II specific DNA binding transcription factor activityCellular componentintracellular anatomical structure neuron projection nucleusBiological processcommitment of neuronal cell to specific neuron type in forebrain regulation of neuron differentiation neurogenesis olfactory bulb axon guidance regulation of transcription DNA templated T cell differentiation in thymus axonogenesis epithelial cell morphogenesis thymus development T cell receptor V D J recombination negative regulation of apoptotic process transcription by RNA polymerase II post embryonic development positive T cell selection transcription DNA templated striatal medium spiny neuron differentiation odontogenesis of dentin containing tooth regulation of lipid metabolic process keratinocyte development post embryonic camera type eye development central nervous system neuron differentiation regulation of gene expression alpha beta T cell differentiation regulation of keratinocyte proliferation signal transduction negative regulation of cell population proliferation positive regulation of transcription by RNA polymerase II skin development hematopoietic stem cell migration lymphoid lineage cell migration into thymusSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez6491958208EnsemblENSG00000127152ENSMUSG00000048251UniProtQ9C0K0Q99PV8RefSeq mRNA NM 001282237NM 001282238NM 022898NM 138576NM 001079883NM 001286343NM 021399RefSeq protein NP 001269166NP 001269167NP 075049NP 612808NP 001073352NP 001273272NP 067374Location UCSC Chr 14 99 17 99 27 MbChr 12 107 88 107 97 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Gene location 2 Function 3 Interactions 4 Pathology 5 Research projects 6 References 7 Further reading 8 External linksGene location editBCL11B is located on human chromosome 14p32 2 8 The mouse analogue is called Rit1 or Bcl11b and is located on mouse chromosome 12 9 Function editThis gene encodes a C2H2 type zinc finger protein and is closely related to BCL11A a gene whose translocation may be associated with B cell malignancies The specific function of this gene has not yet been determined but it could also be involved in some malignancies Two alternatively spliced transcript variants which encode distinct isoforms have been reported 7 Research suggests that BCL11B is crucial for ameloblasts the cells that produce tooth enamel to form and work properly 10 Interactions editBCL11B has been shown to interact with COUP TFI 11 Pathology editBCL11B is closely connected with immune regulation and for so its mutation can lead to a SCID phenotype This so called Immunodeficiency 49 OMIM 617237 is classified as T B NK SCID 12 It is characterised by a lack of T lymphocytes and its malfunctioning specifically in proliferative response On the other hand B cells and NK cells counts and functions are not impaired 13 The symptoms of SCID caused by BCL11B mutation apart from immunity defects typically include teeth abnormalities craniofacial dimorphism different types of dermatitis As well the intellectual development is significantly impaired The disease has a very early onset and the only known treatment is hematopoietic stem cell transplantation from a healthy donor 14 13 The immunodeficiency has a dominant negative mode of inheritance as all so far described patients with it has been after sequencing identified as heterozygotes in the BCL11B gene 13 14 Research projects editA mouse model based study showed that Bcl11b also plays an important role in pathogenesis of inflammatory bowel disease Bcl11b gene knock out in certain T cell population led to development of IBD The mechanisms behind are supposed to be reduced suppressor activity of T regulatory cells and changes in cytokine environment Bcl11b is suspected to interact with Foxp3 and IL10 gene promoters and thus impair its suppressive function in the intestines 15 Bcl11b mouse analogue of human BCL11B has been proven to contribute to malignant growth for example in case of mouse lymphomas That is suspected to be caused by interaction with p53 a well known tumor suppressor gene 9 References edit a b c GRCh38 Ensembl release 89 ENSG00000127152 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000048251 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Satterwhite E Sonoki T Willis TG Harder L Nowak R Arriola EL et al December 2001 The BCL11 gene family involvement of BCL11A in lymphoid malignancies Blood 98 12 3413 20 doi 10 1182 blood V98 12 3413 PMID 11719382 Topark Ngarm A Golonzhka O Peterson VJ Barrett B Martinez B Crofoot K et al October 2006 CTIP2 associates with the NuRD complex on the promoter of p57KIP2 a newly identified CTIP2 target gene The Journal of Biological Chemistry 281 43 32272 83 doi 10 1074 jbc M602776200 PMC 2547407 PMID 16950772 a b Entrez Gene BCL11B B cell CLL lymphoma 11B zinc finger protein OMIM Entry 606558 B CELL CLL LYMPHOMA 11B BCL11B www omim org Retrieved 2019 07 29 a b Wakabayashi Y Inoue J Takahashi Y Matsuki A Kosugi Okano H Shinbo T et al February 2003 Homozygous deletions and point mutations of the Rit1 Bcl11b gene in gamma ray induced mouse thymic lymphomas Biochemical and Biophysical Research Communications 301 2 598 603 doi 10 1016 S0006 291X 02 03069 3 PMID 12565905 Golonzhka O Metzger D Bornert JM Bay BK Gross MK Kioussi C Leid M March 2009 Ctip2 Bcl11b controls ameloblast formation during mammalian odontogenesis Proceedings of the National Academy of Sciences of the United States of America 106 11 4278 83 Bibcode 2009PNAS 106 4278G doi 10 1073 pnas 0900568106 PMC 2657370 PMID 19251658 Lay summary in Gene could allow lab grown teeth BBC News February 24 2009 Avram D Fields A Pretty On Top K Nevrivy DJ Ishmael JE Leid M April 2000 Isolation of a novel family of C 2 H 2 zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor COUP TF orphan nuclear receptors The Journal of Biological Chemistry 275 14 10315 22 doi 10 1074 jbc 275 14 10315 PMC 2819356 PMID 10744719 Alt F 2018 Advances in immunology Cambridge MA Academic Press ISBN 978 0 12 815529 5 OCLC 1035016036 a b c Punwani D Zhang Y Yu J Cowan MJ Rana S Kwan A et al December 2016 Multisystem Anomalies in Severe Combined Immunodeficiency with Mutant BCL11B The New England Journal of Medicine 375 22 2165 2176 doi 10 1056 nejmoa1509164 PMC 5215776 PMID 27959755 a b Lessel D Gehbauer C Bramswig NC Schluth Bolard C Venkataramanappa S van Gassen KL et al August 2018 BCL11B mutations in patients affected by a neurodevelopmental disorder with reduced type 2 innate lymphoid cells Brain 141 8 2299 2311 doi 10 1093 brain awy173 PMC 6061686 PMID 29985992 Vanvalkenburgh J Albu DI Bapanpally C Casanova S Califano D Jones DM et al September 2011 Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel disease The Journal of Experimental Medicine 208 10 2069 81 doi 10 1084 jem 20102683 PMC 3182057 PMID 21875956 Further reading editAvram D Fields A Pretty On Top K Nevrivy DJ Ishmael JE Leid M April 2000 Isolation of a novel family of C 2 H 2 zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor COUP TF orphan nuclear receptors The Journal of Biological Chemistry 275 14 10315 22 doi 10 1074 jbc 275 14 10315 PMC 2819356 PMID 10744719 Avram D Fields A Senawong T Topark Ngarm A Leid M December 2002 COUP TF chicken ovalbumin upstream promoter transcription factor interacting protein 1 CTIP1 is a sequence specific DNA binding protein The Biochemical Journal 368 Pt 2 555 63 doi 10 1042 BJ20020496 PMC 1223006 PMID 12196208 Wakabayashi Y Inoue J Takahashi Y Matsuki A Kosugi Okano H Shinbo T et al February 2003 Homozygous deletions and point mutations of the Rit1 Bcl11b gene in gamma ray induced mouse thymic lymphomas Biochemical and Biophysical Research Communications 301 2 598 603 doi 10 1016 S0006 291X 02 03069 3 PMID 12565905 Rohr O Lecestre D Chasserot Golaz S Marban C Avram D Aunis D et al May 2003 Recruitment of Tat to heterochromatin protein HP1 via interaction with CTIP2 inhibits human immunodeficiency virus type 1 replication in microglial cells Journal of Virology 77 9 5415 27 doi 10 1128 JVI 77 9 5415 5427 2003 PMC 153947 PMID 12692243 Senawong T Peterson VJ Avram D Shepherd DM Frye RA Minucci S Leid M October 2003 Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor COUP TF interacting protein 2 mediated transcriptional repression The Journal of Biological Chemistry 278 44 43041 50 doi 10 1074 jbc M307477200 PMC 2819354 PMID 12930829 Bezrookove V van Zelderen Bhola SL Brink A Szuhai K Raap AK Barge R et al February 2004 A novel t 6 14 q25 q27 q32 in acute myelocytic leukemia involves the BCL11B gene Cancer Genetics and Cytogenetics 149 1 72 6 doi 10 1016 S0165 4608 03 00302 9 PMID 15104287 MacLeod RA Nagel S Drexler HG August 2004 BCL11B rearrangements probably target T cell neoplasia rather than acute myelocytic leukemia Cancer Genetics and Cytogenetics 153 1 88 9 doi 10 1016 j cancergencyto 2004 02 020 PMID 15325104 Przybylski GK Dik WA Wanzeck J Grabarczyk P Majunke S Martin Subero JI et al February 2005 Disruption of the BCL11B gene through inv 14 q11 2q32 31 results in the expression of BCL11B TRDC fusion transcripts and is associated with the absence of wild type BCL11B transcripts in T ALL Leukemia 19 2 201 8 doi 10 1038 sj leu 2403619 PMID 15668700 S2CID 27146016 Cismasiu VB Adamo K Gecewicz J Duque J Lin Q Avram D October 2005 BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter Oncogene 24 45 6753 64 doi 10 1038 sj onc 1208904 PMID 16091750 S2CID 14198939 Marban C Suzanne S Dequiedt F de Walque S Redel L Van Lint C et al January 2007 Recruitment of chromatin modifying enzymes by CTIP2 promotes HIV 1 transcriptional silencing The EMBO Journal 26 2 412 23 doi 10 1038 sj emboj 7601516 PMC 1783449 PMID 17245431 Nagel S Scherr M Kel A Hornischer K Crawford GE Kaufmann M et al February 2007 Activation of TLX3 and NKX2 5 in t 5 14 q35 q32 T cell acute lymphoblastic leukemia by remote 3 BCL11B enhancers and coregulation by PU 1 and HMGA1 Cancer Research 67 4 1461 71 doi 10 1158 0008 5472 CAN 06 2615 PMID 17308084 Kamimura K Mishima Y Obata M Endo T Aoyagi Y Kominami R August 2007 Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages Oncogene 26 40 5840 50 doi 10 1038 sj onc 1210388 PMID 17369851 S2CID 29677572 External links editBCL11B protein human at the U S National Library of Medicine Medical Subject Headings MeSH Human ATL1 genome location and ATL1 gene details page in the UCSC Genome Browser Human BCL11B genome location and BCL11B gene details page in the UCSC Genome Browser Human RIT1 genome location and RIT1 gene details page in the UCSC Genome Browser This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on human chromosome 14 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title BCL11B amp oldid 1193112466, wikipedia, wiki, book, books, library,

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