This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The function of the enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was renamed to B4GALT5. In the literature it is also referred to as beta4GalT2.[7]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000158470 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000017929 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lo NW, Shaper JH, Pevsner J, Shaper NL (Aug 1998). "The expanding beta 4-galactosyltransferase gene family: messages from the databanks". Glycobiology. 8 (5): 517–26. doi:10.1093/glycob/8.5.517. PMID 9597550.
^Sato T, Furukawa K, Bakker H, Van den Eijnden DH, Van Die I (Feb 1998). "Molecular cloning of a human cDNA encoding β-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc β-1,4-galactosyltransferase". Proc Natl Acad Sci U S A. 95 (2): 472–7. Bibcode:1998PNAS...95..472S. doi:10.1073/pnas.95.2.472. PMC18444. PMID 9435216.
Human B4GALT5 genome location and B4GALT5 gene details page in the UCSC Genome Browser.
Further readingedit
Amado M, Almeida R, Schwientek T, Clausen H (2000). "Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions". Biochim. Biophys. Acta. 1473 (1): 35–53. doi:10.1016/S0304-4165(99)00168-3. PMID 10580128.
Sato T, Aoki N, Matsuda T, Furukawa K (1998). "Differential effect of alpha-lactalbumin on beta-1,4-galactosyltransferase IV activities". Biochem. Biophys. Res. Commun. 244 (3): 637–41. doi:10.1006/bbrc.1998.8327. PMID 9535717.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Jia L, Young MF, Powell J, et al. (2002). "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis". Genomics. 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID 11827452.
Xu S, Zhang S, Chen C, et al. (2003). "Over-expression of beta-1,4-galactosyltransferase V increases the growth of astrocytoma cell line". J. Exp. Clin. Cancer Res. 21 (3): 409–14. PMID 12385586.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Sato T, Furukawa K (2004). "Transcriptional regulation of the human beta-1,4-galactosyltransferase V gene in cancer cells: essential role of transcription factor Sp1". J. Biol. Chem. 279 (38): 39574–83. doi:10.1074/jbc.M405805200. PMID 15263012.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Jiang J, Chen X, Shen J, et al. (2006). "Beta1,4-galactosyltransferase V functions as a positive growth regulator in glioma". J. Biol. Chem. 281 (14): 9482–9. doi:10.1074/jbc.M504489200. PMID 16461357.
Sato T, Furukawa K (2007). "Sequential action of Ets-1 and Sp1 in the activation of the human beta-1,4-galactosyltransferase V gene involved in abnormal glycosylation characteristic of cancer cells". J. Biol. Chem. 282 (38): 27702–12. doi:10.1074/jbc.M611862200. PMID 17656364.
Kitayama K, Hayashida Y, Nishida K, Akama TO (2007). "Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans". J. Biol. Chem. 282 (41): 30085–96. doi:10.1074/jbc.M703695200. PMID 17690104.
This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.
b4galt5, beta, galactosyltransferase, enzyme, that, humans, encoded, gene, identifiersaliases, b4gal, beta4, galt, beta4gal, beta4galt, beta, galactosyltransferase, 5external, idsomim, 604016, 1927169, homologene, 3507, genecards, gene, location, human, chromo. Beta 1 4 galactosyltransferase 5 is an enzyme that in humans is encoded by the B4GALT5 gene 5 6 7 B4GALT5IdentifiersAliasesB4GALT5 B4Gal T5 BETA4 GALT IV beta4Gal T5 beta4GalT V gt V beta 1 4 galactosyltransferase 5External IDsOMIM 604016 MGI 1927169 HomoloGene 3507 GeneCards B4GALT5Gene location Human Chr Chromosome 20 human 1 Band20q13 13Start49 632 945 bp 1 End49 713 878 bp 1 Gene location Mouse Chr Chromosome 2 mouse 2 Band2 2 H3Start167 140 364 bp 2 End167 191 103 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inpalpebral conjunctivatracheaspongy bonepericardiummucosa of urinary bladdertibialis anterior musclesecondary oocytepancreatic ductal cellbone marrowlower lobe of lungTop expressed inyolk sacproximal tubulesecondary oocytespermatocytebloodileumadrenal glandvisual cortexmedial dorsal nucleustrigeminal ganglionMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionglycosyltransferase activity transferase activity galactosyltransferase activity metal ion binding beta N acetylglucosaminylglycopeptide beta 1 4 galactosyltransferase activity N acetyllactosamine synthase activity UDP galactose glucosylceramide beta 1 4 galactosyltransferase activityCellular componentintegral component of membrane Golgi cisterna membrane Golgi membrane Golgi apparatus membraneBiological processprotein glycosylation keratan sulfate biosynthetic process O glycan processing carbohydrate metabolic process poly N acetyllactosamine biosynthetic process ganglioside biosynthetic process via lactosylceramide central nervous system neuron axonogenesis central nervous system myelination regulation of protein stability positive regulation of embryonic development neuron maturation lipid metabolism sphingolipid metabolic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez933456336EnsemblENSG00000158470ENSMUSG00000017929UniProtO43286Q9JMK0RefSeq mRNA NM 004776NM 019835RefSeq protein NP 004767NP 062809Location UCSC Chr 20 49 63 49 71 MbChr 2 167 14 167 19 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene is one of seven beta 1 4 galactosyltransferase beta4GalT genes They encode type II membrane bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP galactose all transfer galactose in a beta1 4 linkage to similar acceptor sugars GlcNAc Glc and Xyl Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures As type II membrane proteins they have an N terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor By sequence similarity the beta4GalTs form four groups beta4GalT1 and beta4GalT2 beta4GalT3 and beta4GalT4 beta4GalT5 and beta4GalT6 and beta4GalT7 The function of the enzyme encoded by this gene is not clear This gene was previously designated as B4GALT4 but was renamed to B4GALT5 In the literature it is also referred to as beta4GalT2 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000158470 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000017929 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Lo NW Shaper JH Pevsner J Shaper NL Aug 1998 The expanding beta 4 galactosyltransferase gene family messages from the databanks Glycobiology 8 5 517 26 doi 10 1093 glycob 8 5 517 PMID 9597550 Sato T Furukawa K Bakker H Van den Eijnden DH Van Die I Feb 1998 Molecular cloning of a human cDNA encoding b 1 4 galactosyltransferase with 37 identity to mammalian UDP Gal GlcNAc b 1 4 galactosyltransferase Proc Natl Acad Sci U S A 95 2 472 7 Bibcode 1998PNAS 95 472S doi 10 1073 pnas 95 2 472 PMC 18444 PMID 9435216 a b Entrez Gene B4GALT5 UDP Gal betaGlcNAc beta 1 4 galactosyltransferase polypeptide 5 External links editHuman B4GALT5 genome location and B4GALT5 gene details page in the UCSC Genome Browser Further reading editAmado M Almeida R Schwientek T Clausen H 2000 Identification and characterization of large galactosyltransferase gene families galactosyltransferases for all functions Biochim Biophys Acta 1473 1 35 53 doi 10 1016 S0304 4165 99 00168 3 PMID 10580128 Sato T Aoki N Matsuda T Furukawa K 1998 Differential effect of alpha lactalbumin on beta 1 4 galactosyltransferase IV activities Biochem Biophys Res Commun 244 3 637 41 doi 10 1006 bbrc 1998 8327 PMID 9535717 Deloukas P Matthews LH Ashurst J et al 2002 The DNA sequence and comparative analysis of human chromosome 20 Nature 414 6866 865 71 Bibcode 2001Natur 414 865D doi 10 1038 414865a PMID 11780052 Jia L Young MF Powell J et al 2002 Gene expression profile of human bone marrow stromal cells high throughput expressed sequence tag sequencing analysis Genomics 79 1 7 17 doi 10 1006 geno 2001 6683 PMID 11827452 Xu S Zhang S Chen C et al 2003 Over expression of beta 1 4 galactosyltransferase V increases the growth of astrocytoma cell line J Exp Clin Cancer Res 21 3 409 14 PMID 12385586 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Sato T Furukawa K 2004 Transcriptional regulation of the human beta 1 4 galactosyltransferase V gene in cancer cells essential role of transcription factor Sp1 J Biol Chem 279 38 39574 83 doi 10 1074 jbc M405805200 PMID 15263012 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Jiang J Chen X Shen J et al 2006 Beta1 4 galactosyltransferase V functions as a positive growth regulator in glioma J Biol Chem 281 14 9482 9 doi 10 1074 jbc M504489200 PMID 16461357 Sato T Furukawa K 2007 Sequential action of Ets 1 and Sp1 in the activation of the human beta 1 4 galactosyltransferase V gene involved in abnormal glycosylation characteristic of cancer cells J Biol Chem 282 38 27702 12 doi 10 1074 jbc M611862200 PMID 17656364 Kitayama K Hayashida Y Nishida K Akama TO 2007 Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans J Biol Chem 282 41 30085 96 doi 10 1074 jbc M703695200 PMID 17690104 nbsp This article on a gene on human chromosome 20 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title B4GALT5 amp oldid 1189378878, wikipedia, wiki, book, books, library,
